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Specialty: Biotechnology

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Total 393 results found since Jan 2013.

Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression.
CONCLUSIONS: BACH1 is overexpressed in prostate cancer. Because this promotes invasion and migration, it may facilitate metastasis of prostate cancer. Thus, BACH1 is a potential therapeutic target for metastatic prostate cancer. BACH1 silencing therapy can be considered as a novel and effective adjuvant in prostate cancer targeted therapies. PMID: 28889753 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - September 12, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Graded functionalization of biomaterial surfaces using mussel-inspired adhesive coating of polydopamine.
In this study, by controlling oxidative polymerization of dopamine, we demonstrated universal techniques for generating chemical gradients on various materials with adaptability for secondary molecule immobilization. Diffusion-controlled oxygen supply was successfully exploited for coating of polydopamine (PD) in a gradient manner on different materials, regardless of their surface chemistry, which resulted in gradient in hydrophilicity and surface roughness. The PD gradient controlled graded adhesion and spreading of human mesenchymal stem cells (hMSCs) and endothelial cells. Furthermore, the PD gradient on these surfaces...
Source: Colloids and Surfaces - August 19, 2017 Category: Biotechnology Authors: Perikamana SKM, Shin YM, Lee JK, Lee YB, Heo Y, Ahmad T, Park SY, Shin J, Park KM, Jung HS, Cho SW, Shin H Tags: Colloids Surf B Biointerfaces Source Type: research

Synthesis and characterization of amino acid-functionalized calcium phosphate nanoparticles for siRNA delivery.
Abstract Small interfering RNAs (siRNA) are short nucleic acid fragments of about 20-27 nucleotides, which can inhibit the expression of specific genes. siRNA based RNAi technology has emerged as a promising method for the treatment of a variety of diseases. However, a major limitation in the therapeutic use of siRNA is its rapid degradation in plasma and cellular cytoplasm, resulting in short half-life. In addition, as siRNA molecules cannot penetrate into the cell efficiently, it is required to use a carrier system for its delivery. In this work, chemically and morphologically different calcium phosphate (CaP) n...
Source: Colloids and Surfaces - June 27, 2017 Category: Biotechnology Authors: Bakan F, Kara G, Cokol Cakmak M, Cokol M, Denkbas EB Tags: Colloids Surf B Biointerfaces Source Type: research

MiR-338-3p inhibits TNF- α-induced lipogenesis in human sebocytes.
CONCLUSIONS: MiR-338-3p suppresses the TNF-α-induced lipogenesis in sebocytes by targeting PREX2a and down-regulating PI3K/AKT signaling. PMID: 28597147 [PubMed - as supplied by publisher]
Source: Biotechnology Letters - June 9, 2017 Category: Biotechnology Authors: Liu J, Cao L, Feng Y, Li Y, Li T Tags: Biotechnol Lett Source Type: research

The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis
This study demonstrated that MGF treatment can inhibit the pathological apoptosis of OA chondrocytes and promote the proliferation, migration and matrix synthesis of the chondrocytes. The results also demonstrate that the degeneration of OA cartilage can be delayed by MGF treatment partially via PERK‐regulated UPR and suggest a potential therapeutic application of MGF for OA treatment. This article is protected by copyright. All rights reserved.
Source: Journal of Tissue Engineering and Regenerative Medicine - June 9, 2017 Category: Biotechnology Authors: Yang Song, Kang Xu, Can Yu, Lili Dong, Peixing Chen, Yonggang Lv, Martin Y.M. Chiang, Linhao Li, Wanqian Liu, Li Yang Tags: RESEARCH ARTICLE Source Type: research

Recent advances in mechanism-based chemotherapy drug-siRNA pairs in co-delivery systems for cancer: A review.
Abstract Co-delivery of chemotherapy drugs and siRNA for cancer therapy has achieved remarkable results according to synergistic/combined antitumor effects, and is recognized as a promising therapeutic modality. However, little attention has been paid to the extremely complex mechanisms of chemotherapy drug-siRNA pairs during co-delivery process. Proper selection of chemotherapy drug-siRNA pairs is beneficial for achieving desirable cancer therapeutic effects. Exploring the inherent principles during chemotherapy drug-siRNA pair selection for co-delivery would greatly enhanced therapeutic efficiency. To achieve id...
Source: Colloids and Surfaces - June 8, 2017 Category: Biotechnology Authors: Wang M, Wang J, Li B, Meng L, Tian Z Tags: Colloids Surf B Biointerfaces Source Type: research

Local Delivery of CTGF siRNA with Poly(sorbitol-co-PEI) Reduces Scar Contraction in Cutaneous Wound Healing
This study exemplifies a successful treatment of cutaneous wound healing using a polymer system coupled with RNA interference. Hence, the approach holds a great promise for developing new treatments with novel targets in regenerative medicines.
Source: Tissue Engineering and Regenerative Medicine - May 12, 2017 Category: Biotechnology Source Type: research

Advances in siRNA delivery in cancer therapy.
Authors: Singh A, Trivedi P, Jain NK Abstract RNA interference (RNAi)-based therapeutic approaches are under vibrant scrutinisation to seek cancer cure. siRNA suppress expression of the carcinogenic genes by targeting the mRNA expression. However, in vivo systemic siRNA therapy is hampered by the barriers such as poor cellular uptake, instability under physiological conditions, off-target effects and possible immunogenicity. To overcome these challenges, systemic siRNA therapy warrants the development of clinically suitable, safe, and effective drug delivery systems. Herein, we review the barriers, potential siRNA ...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 22, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Advances in siRNA delivery in cancer therapy
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Source: Artificial Cells, Blood Substitutes, and Biotechnology - April 20, 2017 Category: Biotechnology Authors: Aishwarya Singh Piyush Trivedi Narendra Kumar Jain Source Type: research

Lipid nanoparticle-based co-delivery of epirubicin and BCL-2 siRNA for enhanced intracellular drug release and reversing multidrug resistance.
In this study, an acid-cleavable ketal containing poly (β-amino ester) (KPAE) was used to bind siBCL-2 and the KPAE/siBCL-2 complexes were further coated by epirubicin (EPI) containing lipid to form EPI/siBCL-2 dual loaded lipid-nanoparticles. The results showed that the average size of EPI/siBCL-2-MEND was about 120 nm, and the average zeta potential was about 41 mV. The encapsulation efficiency (EE) of EPI and siBCL-2 was 86.13% and 97.07%, respectively. EPI/siBCL-2 dual loaded lipid-nanoparticles showed enhanced inhibition efficiency than individual EPI-loaded liposomes on HepG2 cells by MTT assay. Moreover, wester...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 12, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Lipid nanoparticle-based co-delivery of epirubicin and BCL-2 siRNA for enhanced intracellular drug release and reversing multidrug resistance
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Source: Artificial Cells, Blood Substitutes, and Biotechnology - April 10, 2017 Category: Biotechnology Authors: Miao Yu Shangcong Han Zhongai Kou Jialing Dai Jiao Liu Chen Wei Yitong Li Lutao Jiang Yong Sun Source Type: research

A comprehensive mathematical model of drug release kinetics from nano-liposomes, derived from optimization studies of cationic PEGylated liposomal doxorubicin formulations for drug-gene delivery.
In conclusion, we have established a predictive mathematical model for the fine-tuning of controlled drug release from liposomal formulations, while creating functional drug-delivery liposomes with potential for siRNA co-delivery to increase specificity and efficacy. [Formula: see text]. PMID: 28376641 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - April 6, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Co-delivery of insulin-like growth factor 1 receptor specific siRNA and doxorubicin using chitosan-based nanoparticles enhanced anticancer efficacy in A549 lung cancer cell line.
Authors: Shali H, Shabani M, Pourgholi F, Hajivalili M, Aghebati-Maleki L, Jadidi-Niaragh F, Baradaran B, Movassaghpour Akbari AA, Younesi V, Yousefi M Abstract Here, we investigated the effects of dual delivery of IGF-1R siRNA and doxorubicin by chitosan nanoparticles on viability of A549 lung cancer cells line by utilization of MTT and qRT-PCR. Furthermore apoptosis and migration of treated cells were assessed by Annexin-PI and wound healing assays, respectively. The chitosan nanoparticles had about 176 nm size with zeta potential and polydispersive index about 11 mV and 0.3, respectively. The IGF-1R siRNA ha...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 2, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research