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Total 393 results found since Jan 2013.
The Relationship between Prohibitin 1 Expression, Hepatotoxicity Induced by Acetaminophen, and Hepatoprotection by S-Adenosylmethionine in AML12 Cells
In this study, we sought to understand the regulation of mRNA expression in relation to APAP and GSH metabolism by Phb1 in normal mouse AML12 hepatocytes. We used two different Phb1 silencing levels: high-efficiency (HE, >90%) and low-efficiency (LE, 50- 60%). In addition, the siRNA-transfected cells were further pretreated with 0.5 mM of Sadenosylmethionine (SAMe) for 24 h before treatment with APAP at different doses (1-2 mM) for 24 h. The expression of APAP metabolism-related and antioxidant genes such as Cyp2e1 and Ugt1a1 were increased during SAMe pretreatment. Moreover, SAMe increased intracellular GSH concentrati...
Source: Journal of Microbiology and Biotechnology - October 31, 2022 Category: Biotechnology Authors: Eunhye Cho Soohan Jung Jina Kim Kwang Suk Ko Source Type: research
BMSCs improve TNBS-induced colitis in rats by inducing Treg differentiation by expressing PD-L1
CONCLUSIONS: We found that BMSCs can induce Treg differentiation by inhibiting the Akt/mTOR pathway via PD-L1; this significantly improved symptoms and pathology in our ulcerative colitis rat models.PMID:36261682 | DOI:10.1007/s10529-022-03307-1
Source: Biotechnology Letters - October 19, 2022 Category: Biotechnology Authors: Fei Gao Dandan Cui Dongmei Zuo Zhexing Shou Jia Yang Ting Yu Yujin Liu Si Chu Feng Zhu Chunzhu Wei Source Type: research
PDZK1-interacting protein 1(PDZK1IP1) promotes subcutaneous preadipocyte proliferation in goats
Anim Biotechnol. 2022 Oct 16:1-11. doi: 10.1080/10495398.2022.2132952. Online ahead of print.ABSTRACTPDZK1-interacting protein 1(PDZK1IP1), also known as MAP17, is encoded by the PDZK1IP1 gene and is a membrane-associated protein. PDZK1IP1 have been proven to be a potent regulator of cancer cell proliferation. However, the role of PDZK1IP1 in regulating goat subcutaneous preadipocyte proliferation is unknown. Here, we cloned the full-length coding sequence of PDZK1IP1 gene, investigated the potential functional of PDZK1IP1 in goat subcutaneous preadipocyte proliferation by gaining or losing function in vitro. Our results i...
Source: Animal Biotechnology - October 16, 2022 Category: Biotechnology Authors: Dingshuang Chen Ruilong Wang Xueqing Sheng Nan Zhao Yaqiu Lin Yong Wang Jiangjiang Zhu Yanyan Li Source Type: research
MYH1F promotes the proliferation and differentiation of chicken skeletal muscle satellite cells into myotubes
Anim Biotechnol. 2022 Oct 16:1-11. doi: 10.1080/10495398.2022.2132953. Online ahead of print.ABSTRACTIn diploid organisms, interactions between alleles determine phenotypic variation. In previous experiments, only MYH1F was found to show both ASE (spatiotemporal allele-specific expression) and TRD (allelic transmission ratio distortion) characteristics in the pectoral muscle by comparing the genome-wide allele lists of hybrid populations (F1) of meat- and egg- type chickens. In addition, MYH1F is a member of the MYH gene family, which plays an important role in skeletal muscle and non-muscle cells of animals, but the speci...
Source: Animal Biotechnology - October 16, 2022 Category: Biotechnology Authors: Peng Ren Meiying Chen Jingjing Li Zhongzhen Lin Chaowu Yang Chunlin Yu Donghao Zhang Yiping Liu Source Type: research
PDZK1-interacting protein 1(PDZK1IP1) promotes subcutaneous preadipocyte proliferation in goats
Anim Biotechnol. 2022 Oct 16:1-11. doi: 10.1080/10495398.2022.2132952. Online ahead of print.ABSTRACTPDZK1-interacting protein 1(PDZK1IP1), also known as MAP17, is encoded by the PDZK1IP1 gene and is a membrane-associated protein. PDZK1IP1 have been proven to be a potent regulator of cancer cell proliferation. However, the role of PDZK1IP1 in regulating goat subcutaneous preadipocyte proliferation is unknown. Here, we cloned the full-length coding sequence of PDZK1IP1 gene, investigated the potential functional of PDZK1IP1 in goat subcutaneous preadipocyte proliferation by gaining or losing function in vitro. Our results i...
Source: Animal Biotechnology - October 16, 2022 Category: Biotechnology Authors: Dingshuang Chen Ruilong Wang Xueqing Sheng Nan Zhao Yaqiu Lin Yong Wang Jiangjiang Zhu Yanyan Li Source Type: research
MYH1F promotes the proliferation and differentiation of chicken skeletal muscle satellite cells into myotubes
Anim Biotechnol. 2022 Oct 16:1-11. doi: 10.1080/10495398.2022.2132953. Online ahead of print.ABSTRACTIn diploid organisms, interactions between alleles determine phenotypic variation. In previous experiments, only MYH1F was found to show both ASE (spatiotemporal allele-specific expression) and TRD (allelic transmission ratio distortion) characteristics in the pectoral muscle by comparing the genome-wide allele lists of hybrid populations (F1) of meat- and egg- type chickens. In addition, MYH1F is a member of the MYH gene family, which plays an important role in skeletal muscle and non-muscle cells of animals, but the speci...
Source: Animal Biotechnology - October 16, 2022 Category: Biotechnology Authors: Peng Ren Meiying Chen Jingjing Li Zhongzhen Lin Chaowu Yang Chunlin Yu Donghao Zhang Yiping Liu Source Type: research
PDZK1-interacting protein 1(PDZK1IP1) promotes subcutaneous preadipocyte proliferation in goats
Anim Biotechnol. 2022 Oct 16:1-11. doi: 10.1080/10495398.2022.2132952. Online ahead of print.ABSTRACTPDZK1-interacting protein 1(PDZK1IP1), also known as MAP17, is encoded by the PDZK1IP1 gene and is a membrane-associated protein. PDZK1IP1 have been proven to be a potent regulator of cancer cell proliferation. However, the role of PDZK1IP1 in regulating goat subcutaneous preadipocyte proliferation is unknown. Here, we cloned the full-length coding sequence of PDZK1IP1 gene, investigated the potential functional of PDZK1IP1 in goat subcutaneous preadipocyte proliferation by gaining or losing function in vitro. Our results i...
Source: Animal Biotechnology - October 16, 2022 Category: Biotechnology Authors: Dingshuang Chen Ruilong Wang Xueqing Sheng Nan Zhao Yaqiu Lin Yong Wang Jiangjiang Zhu Yanyan Li Source Type: research
MYH1F promotes the proliferation and differentiation of chicken skeletal muscle satellite cells into myotubes
Anim Biotechnol. 2022 Oct 16:1-11. doi: 10.1080/10495398.2022.2132953. Online ahead of print.ABSTRACTIn diploid organisms, interactions between alleles determine phenotypic variation. In previous experiments, only MYH1F was found to show both ASE (spatiotemporal allele-specific expression) and TRD (allelic transmission ratio distortion) characteristics in the pectoral muscle by comparing the genome-wide allele lists of hybrid populations (F1) of meat- and egg- type chickens. In addition, MYH1F is a member of the MYH gene family, which plays an important role in skeletal muscle and non-muscle cells of animals, but the speci...
Source: Animal Biotechnology - October 16, 2022 Category: Biotechnology Authors: Peng Ren Meiying Chen Jingjing Li Zhongzhen Lin Chaowu Yang Chunlin Yu Donghao Zhang Yiping Liu Source Type: research
PDZK1-interacting protein 1(PDZK1IP1) promotes subcutaneous preadipocyte proliferation in goats
Anim Biotechnol. 2022 Oct 16:1-11. doi: 10.1080/10495398.2022.2132952. Online ahead of print.ABSTRACTPDZK1-interacting protein 1(PDZK1IP1), also known as MAP17, is encoded by the PDZK1IP1 gene and is a membrane-associated protein. PDZK1IP1 have been proven to be a potent regulator of cancer cell proliferation. However, the role of PDZK1IP1 in regulating goat subcutaneous preadipocyte proliferation is unknown. Here, we cloned the full-length coding sequence of PDZK1IP1 gene, investigated the potential functional of PDZK1IP1 in goat subcutaneous preadipocyte proliferation by gaining or losing function in vitro. Our results i...
Source: Animal Biotechnology - October 16, 2022 Category: Biotechnology Authors: Dingshuang Chen Ruilong Wang Xueqing Sheng Nan Zhao Yaqiu Lin Yong Wang Jiangjiang Zhu Yanyan Li Source Type: research
MYH1F promotes the proliferation and differentiation of chicken skeletal muscle satellite cells into myotubes
Anim Biotechnol. 2022 Oct 16:1-11. doi: 10.1080/10495398.2022.2132953. Online ahead of print.ABSTRACTIn diploid organisms, interactions between alleles determine phenotypic variation. In previous experiments, only MYH1F was found to show both ASE (spatiotemporal allele-specific expression) and TRD (allelic transmission ratio distortion) characteristics in the pectoral muscle by comparing the genome-wide allele lists of hybrid populations (F1) of meat- and egg- type chickens. In addition, MYH1F is a member of the MYH gene family, which plays an important role in skeletal muscle and non-muscle cells of animals, but the speci...
Source: Animal Biotechnology - October 16, 2022 Category: Biotechnology Authors: Peng Ren Meiying Chen Jingjing Li Zhongzhen Lin Chaowu Yang Chunlin Yu Donghao Zhang Yiping Liu Source Type: research
PDZK1-interacting protein 1(PDZK1IP1) promotes subcutaneous preadipocyte proliferation in goats
Anim Biotechnol. 2022 Oct 16:1-11. doi: 10.1080/10495398.2022.2132952. Online ahead of print.ABSTRACTPDZK1-interacting protein 1(PDZK1IP1), also known as MAP17, is encoded by the PDZK1IP1 gene and is a membrane-associated protein. PDZK1IP1 have been proven to be a potent regulator of cancer cell proliferation. However, the role of PDZK1IP1 in regulating goat subcutaneous preadipocyte proliferation is unknown. Here, we cloned the full-length coding sequence of PDZK1IP1 gene, investigated the potential functional of PDZK1IP1 in goat subcutaneous preadipocyte proliferation by gaining or losing function in vitro. Our results i...
Source: Animal Biotechnology - October 16, 2022 Category: Biotechnology Authors: Dingshuang Chen Ruilong Wang Xueqing Sheng Nan Zhao Yaqiu Lin Yong Wang Jiangjiang Zhu Yanyan Li Source Type: research
MYH1F promotes the proliferation and differentiation of chicken skeletal muscle satellite cells into myotubes
Anim Biotechnol. 2022 Oct 16:1-11. doi: 10.1080/10495398.2022.2132953. Online ahead of print.ABSTRACTIn diploid organisms, interactions between alleles determine phenotypic variation. In previous experiments, only MYH1F was found to show both ASE (spatiotemporal allele-specific expression) and TRD (allelic transmission ratio distortion) characteristics in the pectoral muscle by comparing the genome-wide allele lists of hybrid populations (F1) of meat- and egg- type chickens. In addition, MYH1F is a member of the MYH gene family, which plays an important role in skeletal muscle and non-muscle cells of animals, but the speci...
Source: Animal Biotechnology - October 16, 2022 Category: Biotechnology Authors: Peng Ren Meiying Chen Jingjing Li Zhongzhen Lin Chaowu Yang Chunlin Yu Donghao Zhang Yiping Liu Source Type: research
Enhanced sucrose-mediated cryoprotection of siRNA-loaded poly (lactic-co-glycolic acid) nanoparticles
Colloids Surf B Biointerfaces. 2022 Sep 28;220:112880. doi: 10.1016/j.colsurfb.2022.112880. Online ahead of print.ABSTRACTThe present study aimed to determine the effects of sucrose on the physical stability, cellular entry pathways and functional efficacy of poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs). PLGA-NPs were synthesized in the absence or presence of 10 % sucrose, using HEI-101, an unmodified small interfering RNA (siRNA), as a drug model. The newly synthesized HEI-101-loaded PLGA-NPs (HEI-101-NPs) were exposed to repeated freeze-thaw cycles and iteratively tested over a six-month evaluation period. The ...
Source: Colloids and Surfaces - October 14, 2022 Category: Biotechnology Authors: Ibrahima Youm Matthew B West Xiangping Huang Wei Li Richard D Kopke Source Type: research
