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Total 393 results found since Jan 2013.

Effects of Srxn1 on growth and Notch signalling of astrocyte induced by hydrogen peroxide.
CONCLUSION: Srxn1 may protect astrocytes from oxidative stress injury induced by H2O2 by activation of Notch signalling pathway. PMID: 31079497 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - May 15, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Cancer cell membrane cloaking nanoparticles for targeted co-delivery of doxorubicin and PD-L1 siRNA.
Authors: Chen M, Chen M, He J Abstract Nanoparticles coated with cell membranes have been garnering growing attention due to their homologous binding capability of membrane molecules and consequent self-recognition by their source cells. In the present study, we report on the construction of doxorubicin and PD-L1 siRNA-loaded PLGA nanoparticles and their biological functionalization by cancer cell-derived membrane cloaking. The resulting cancer cell membrane-coated nanoparticles (CCMNPs) presented a core-shell nanostructure with highly specific self-recognition affinity to the homotypic cells, which can be attribut...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 28, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Cancer cell membrane cloaking nanoparticles for targeted co-delivery of doxorubicin and PD-L1 siRNA
Volume 47, Issue 1, December 2019, Page 1635-1641 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - April 26, 2019 Category: Biotechnology Authors: Mushi Chen Ming Chen Jiantai He Source Type: research

Co-delivery of sorafenib and VEGF-siRNA via pH-sensitive liposomes for the synergistic treatment of hepatocellular carcinoma.
Authors: Yao Y, Wang T, Liu Y, Zhang N Abstract Non-viral nanocarrier affords a platform for drug and siRNA combination, the focus of which is to load drug and siRNA into a single carrier, allowing for co-delivery and a synergistic effect at tumour site. In our previous study, pH-sensitive carboxymethyl chitosan-modified liposomes (CMCS-SiSf-CL) were assembled for sorafenib (Sf) and Cy3-siRNA co-loaded. The present study evaluated in vitro and in vivo co-delivery of the co-loaded liposomes. Further, in vitro inhibiting hepatocellular carcinoma of the pH-sensitive sorafenib (Sf) and VEGF-siRNA co-loaded liposomes wa...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 14, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Co-delivery of sorafenib and VEGF-siRNA via pH-sensitive liposomes for the synergistic treatment of hepatocellular carcinoma
Volume 47, Issue 1, December 2019, Page 1374-1383 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - April 11, 2019 Category: Biotechnology Authors: Yao Yao Tianqi Wang Yongjun Liu Na Zhang Source Type: research

Expression analysis of proteasome maturation protein (POMP) gene in Liaoning Cashmere goat.
Abstract Liaoning Cashmere goat is a precious genetic resource of China. To explore the relationship between POMP and cashmere growth, we analyzed the expression of POMP. POMP encodes a hudrophilic protein which is most closely related to bos. RT-PCR showed that POMP was expressed in skin, heart, liver, spleen, lung, and kidney tissues. Real-time PCR showed that the expression of POMP was more active in the secondary hair follicles than the primary hair follicles in anagen. In situ hybridization showed that POMP was obviously expressed in the Inner Root Sheath (IRS) but no expression in Outer Root. The treatment o...
Source: Animal Biotechnology - April 6, 2019 Category: Biotechnology Authors: Piao J, Xu CL, Piao JA, Cao M, Huang N, Jin M Tags: Anim Biotechnol Source Type: research

Toxicological exploration of peptide-based cationic liposomes in siRNA delivery.
Abstract The toxicology of cationic liposomes was explored to advance clinical trials of liposome-mediated gene therapy through the analysis of a peptide cationic liposome with DOTAP as a positive control. We first investigated the delivery of luciferase siRNA by several peptide liposomes in mice bearing lung cancer A549 cell xenografts. Of these, a cationic liposome (CDO14) was selected for further investigation. CDO14 efficiently mediated IGF-1R-siRNA delivery and inhibited the growth of the A549 cell xenografts. The in vivo toxicity and toxicological mechanisms of the selected liposome were evaluated to assess ...
Source: Colloids and Surfaces - March 24, 2019 Category: Biotechnology Authors: Zhu Y, Meng Y, Zhao Y, Zhu J, Xu H, Zhang E, Shi L, Du L, Liu G, Zhang C, Xu X, Kang X, Zhen Y, Zhang S Tags: Colloids Surf B Biointerfaces Source Type: research

The application of the CRISPR-Cas9 genome editing machinery in food and agricultural science: Current status, future perspectives, and associated challenges.
Abstract The recent progress in genetic engineering has brought multiple benefits to the food and agricultural industry by enhancing essential characteristics of agronomic traits. Powerful tools in the field of genome editing, such as siRNA-mediated RNA interference for targeted suppression of gene expression and transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases (ZFNs) for DNA repair have been widely used for commercial purposes. However, in the last few years, the discovery of the CRISPR-Cas9 system has revolutionized genome editing and has attracted attention as a powerful tool f...
Source: Biotechnology Advances - February 16, 2019 Category: Biotechnology Authors: Eş I, Gavahian M, Marti-Quijal FJ, Lorenzo JM, Khaneghah AM, Tsatsanis C, Kampranis SC, Barba FJ Tags: Biotechnol Adv Source Type: research

In vivo evaluation and Alzheimer's disease treatment outcome of siRNA loaded dual targeting drug delivery system.
Abstract To deliver drugs to treat Alzheimer's disease (AD), nanoparticles should firstly penetrate through blood brain barrier, and then target neurons. Recently, we developed an Apo A-I and NL4 dual modified nanoparticle (ANNP) to deliver beta-amyloid converting enzyme 1 (BACE1) siRNA. Although promising in vitro results were obtained, the in vivo performance was not clear. Therefore, in this study, we further evaluated the in vivo neuroprotective effect and toxicity of the ANNP/siRNA. The ANNP/siRNA was 80.6 nm with good stability when incubated with serum. The ANNP/siRNA could target both bEnd.3 and PC12 cells...
Source: Current Pharmaceutical Biotechnology - February 4, 2019 Category: Biotechnology Authors: Zhang C, Shen L, Gu Z, Liu X, Lin H Tags: Curr Pharm Biotechnol Source Type: research

Activation of MET promotes resistance to sorafenib in hepatocellular carcinoma cells via the AKT/ERK1/2-EGR1 pathway.
In this study, we found that addition of HGF to sorafenib-treated HCC cells activated MET and re-stimulated the downstream AKT and ERK1/2 pathways. Thereby, restored sorafenib-treated HCC cells proliferation, migration and invasion ability, and rescued cells from apoptosis. In addition, we found that HGF treatment of HCC cells induced early growth response protein (EGR1) expression, which is involved in sorafenib resistance. Importantly, the HGF rescued effect in sorafenib-treated HCC cells could be abrogated by inhibiting MET activation with PHA-665752 or by downregulating EGR1 expression with small interfering RNA (siRNA...
Source: Artificial Cells, Nanomedicine and Biotechnology - January 23, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Corin is a key regulator of endochondral ossification and bone development via modulation of vascular endothelial growth factor A expression
This study tested the hypothesis that, through modulation of angiogenic signalling pathways, corin is a critical regulator of osteogenic differentiation and endochondral ossification. In vitro, corin expression in hASC was suppressed via siRNA knockdown and vascular en dothelial growth factor A (VEGF‐A) expression was quantified via reverse transcription polymerase chain reaction. In vivo, a murine corin knockout model (female, 10 weeks) was used to determine the effect of corin deficiency on long bone development. Wild‐type and corin knockout long bones were compared via haematoxylin and eosin staining to assess tiss...
Source: Journal of Tissue Engineering and Regenerative Medicine - November 22, 2018 Category: Biotechnology Authors: Rachel C. Nordberg, Hao Wang, Qingyu Wu, Elizabeth G. Loboa Tags: RESEARCH ARTICLE Source Type: research

The hierarchical micro-/nanotextured topographies promote the proliferation and angiogenesis-related genes expression in human umbilical vein endothelial cells by initiation of Hedgehog-Gli1 signaling.
This study may contribute to the modification of biomaterial surfaces for better tissue integration and clinical performance. PMID: 30453796 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - November 21, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

GM-CSF Enhances Mobilization of Bone Marrow Mesenchymal Stem Cells via a CXCR4-Medicated Mechanism
Conclusion:These results suggest that GM-CSF is a useful tool for mobilizing BM MSCs into the PB.
Source: Tissue Engineering and Regenerative Medicine - November 15, 2018 Category: Biotechnology Source Type: research