Filtered By:
Specialty: Biotechnology
This page shows you your search results in order of date. This is page number 10.
Order by Relevance | Date
Total 393 results found since Jan 2013.
Comparative Transcriptome Reveals the Potential Modulation Mechanisms of Spfoxl-2 Affecting Ovarian Development of Scylla paramamosain
Mar Biotechnol (NY). 2022 Feb 2. doi: 10.1007/s10126-022-10091-6. Online ahead of print.ABSTRACTPreviously, we reported the identification, tissue distribution and confirmed the roles of Spfoxl-2 in regulating vitellogenin (vtg) expression in Scylla paramamosain. Here, we primally analyzed its potential target genes in the ovary with RNAi and RNA-Seq technology. By comparing the transcriptome data of two groups (ovaries that injected with EGFP and Foxl-2 siRNA, respectively), we found 645 DEGs (differentially expressed genes), including several conserved crucial genes involved in ovarian development, such as vtg, vitelloge...
Source: Marine Biotechnology - February 2, 2022 Category: Biotechnology Authors: Haifu Wan Jinying Zhong Ziping Zhang Pengfei Zou Yilei Wang Source Type: research
An integrative multiomics approach to characterize anti-adipogenic and anti-lipogenic effects of Akkermansia muciniphila in adipocytes
This article is protected by copyright. All rights reserved.PMID:34894414 | DOI:10.1002/biot.202100397
Source: Biotechnology Journal - December 11, 2021 Category: Biotechnology Authors: Jae-Seung Lee Won-Suk Song Jun Woo Lim Tae-Rim Choi Sung-Hyun Jo Hyo-Jin Jeon Ji-Eun Kwon Ji-Hyeon Park Ye-Rim Kim Yung-Hun Yang Jae Hyun Jeong Yun-Gon Kim Source Type: research
Advancements in nucleic acids-based techniques for bone regeneration
This article is protected by copyright. All rights reserved.PMID:34882984 | DOI:10.1002/biot.202100570
Source: Biotechnology Journal - December 9, 2021 Category: Biotechnology Authors: D Saleth Sidharthan R Abhinandan K Balagangadharan N Selvamurugan Source Type: research
Possibility for double optimization of siRNA intracellular delivery efficiency and antibacterial activity: Structure screening of pH-sensitive triblock amphiphilic polycation micelles
Colloids Surf B Biointerfaces. 2021 Oct 26;209(Pt 2):112178. doi: 10.1016/j.colsurfb.2021.112178. Online ahead of print.ABSTRACTOptimal combination of hydrophobic-hydrophilic balance, proton buffering and electrostatic interaction is the key issue for designing polycations as efficient gene vectors and antibacterial agents. Herein, we screened a series of pH-sensitive quaternary ammonium-based amphiphilic triblock copolymers, mPEG2k-P(DPAa/DMAb)-PQAc (TDDE-x), which had different pKa values and proton buffering capacities. Significantly, we found that both the highest siRNA intracellular delivery efficiency and the stronge...
Source: Colloids and Surfaces - November 6, 2021 Category: Biotechnology Authors: Yufeng Zhang Yanliang Dong Junhui Zhou Wenjun Huang Yidi Wu Shuyue Zhao Yongli Shi Suping Bai Chunhui Li Yuanyu Huang Anjie Dong Source Type: research
Morphological changes of macrophages and their potential contribution to tendon healing
Colloids Surf B Biointerfaces. 2021 Oct 1;209(Pt 1):112145. doi: 10.1016/j.colsurfb.2021.112145. Online ahead of print.ABSTRACTPoor healing ability and adhesion formation greatly hinder the recovery of injured tendon function. Previously, our local sustained gene delivery system by using cyclooxygenases (COX-1 and COX-2)-engineered miRNA plasmid/nanoparticles loaded hydrogel significantly inhibited adhesion formation and promoted tendon healing. The present study aims to study morphological changes of the macrophages in the healing tendons after above treatment with the hydrogel. Firstly, we assessed the therapeutic effect...
Source: Colloids and Surfaces - October 12, 2021 Category: Biotechnology Authors: Qian Qian Yang Luzhong Zhang You Lang Zhou Jin Bo Tang Source Type: research
A two-pronged approach to regulate the behaviors of ECs and SMCs by the dual targeting-nanoparticles
Colloids Surf B Biointerfaces. 2021 Aug 26;208:112068. doi: 10.1016/j.colsurfb.2021.112068. Online ahead of print.ABSTRACTInhibiting vascular restenosis remains a tricky challenge for the postoperative development of cardiovascular interventional therapy. The ideal approaches should activate endothelial cells (ECs) and restrain smooth muscle cells (SMCs), however, they are commonly contradictory. Herein, a strategy was developed for synchronizing ECs promotion and SMCs inhibition by codelivery DNA and siRNA for combination therapy. Thus, an easy and efficient strategy integrated dual-superiorities of precise targeting and ...
Source: Colloids and Surfaces - August 31, 2021 Category: Biotechnology Authors: Xiaoyu Wang Bin Gao Xiang-Kui Ren Jintang Guo Shihai Xia Wencheng Zhang Cheng Yang Yakai Feng Source Type: research
