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Specialty: Biotechnology
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Total 393 results found since Jan 2013.
Sevoflurane postconditioning reduces hypoxia/reoxygenation injury in cardiomyocytes via up-regulating heat shock proteins 70
In conclusion, this study demonstrated that SPostC reduced the HR injury of cardiomyocytes by inducing HSP70 expression.PMID:34226409 | DOI:10.4014/jmb.2103.03040
Source: Journal of Microbiology and Biotechnology - July 6, 2021 Category: Biotechnology Authors: Jun Zhang Haiyan Wang Xizhi Sun Source Type: research
A novel vector-based RNAi method using mouse U6 promoter-driven shRNA expression in the filamentous fungus Blakeslea trispora
CONCLUSIONS: The results suggest that the mouse U6 promoter that drives the expression of shRNA vectors may serve as a novel tool for RNAi induction in filamentous fungi.PMID:34185215 | DOI:10.1007/s10529-021-03155-5
Source: Biotechnology Letters - June 29, 2021 Category: Biotechnology Authors: Ye Li Hui Feng Lihua Jin Xiulan Xin Qipeng Yuan Source Type: research
Host-Guest Interaction-Based Dual response core/shell nanoparticles as efficient siRNA carrier for killing breast cancer cells
Colloids Surf B Biointerfaces. 2021 Jun 11;205:111918. doi: 10.1016/j.colsurfb.2021.111918. Online ahead of print.ABSTRACTHow to overcome multiple obstacles to achieve the efficient and safe delivery of therapeutic genes is still the key to gene therapy. To address this issue, a cationic carrier consisting of polyamide-amine (HPAA-peptide-Fc) modified by an enzyme-responsive polypeptide as the core and hyperbranched polyglycerol derivative (CD-HPG) as the shell was synthesized by self-assembly. The obtained HPAA-peptide-HPG could form the compact nanocomplex with siPlk1, thus confirming the stable load of genes and subsequ...
Source: Colloids and Surfaces - June 18, 2021 Category: Biotechnology Authors: Jinglan Liang Chengguang Wu Xiaoyan Zhou Yunfeng Shi Jun Xu Xiang Cai Tingling Fu Dong Ma Wei Xue Source Type: research
Recent advances in siRNA delivery systems for prostate cancer therapy
Curr Pharm Biotechnol. 2021 Jun 15. doi: 10.2174/1389201022666210615123211. Online ahead of print.ABSTRACTThe critical problems of conventional prostate cancer therapeutic strategies like nonspecific toxicity and multi-drug resistance prompted the development and application of countless nanoparticle-based siRNA therapeutics. The main challenges to siRNA-based therapeutics becoming a new paradigm in the treatment of prostate cancer stem from the lack of safe and effective delivery systems, immune system stimulation, poor knowledge of nano-bio interactions, and limitations concerning designing, manufacturing, clinical trans...
Source: Current Pharmaceutical Biotechnology - June 16, 2021 Category: Biotechnology Authors: Shahin Aghamiri Pourya Raee Shiva Shahmohamadnejad Sasan Shabani Jaber Ghorbani Marzieh Sameni Mohammad Taha Ebrahimi Source Type: research
