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Condition: Autoimmune Disease

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Total 230 results found since Jan 2013.

Association of leukocyte immunoglobulin ‐like receptor A3 (LILRA3) with neutrophil activation and its susceptibility in adult‐onset Still's disease
ConclusionsOur study provides the first evidence that functionalLILRA3 is a novel genetic risk factor for AOSD, and functional LILRA3 may play a pathogenic role by inducing NETs formation.
Source: Arthritis and Rheumatology - December 31, 2020 Category: Rheumatology Authors: Mengyan Wang, Mengru Liu, Jinchao Jia, Hui Shi, Jialin Teng, Honglei Liu, Yue Sun, Xiaobing Cheng, Junna Ye, Yutong Su, Huihui Chi, Tingting Liu, Zhihong Wang, Liyan Wan, Jianfen Meng, Yuning Ma, Chengde Yang, Qiongyi Hu Tags: FULL LENGTH Source Type: research

Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling.
In conclusion, USP4 was significantly elevated in autoimmune hepatitis mice and Vialinin A reduced USP4 level and attenuate inflammation and fibrosis in the liver. The mechanism may be related to regulation of Rheb/mTOR signalling. PMID: 33295107 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - December 9, 2020 Category: Molecular Biology Authors: Xu J, Chen D, Jin L, Chen Z, Tu Y, Huang X, Xue F, Xu J, Chen M, Wang X, Chen Y Tags: J Cell Mol Med Source Type: research

Prospects for the potential of RNA interference in the treatment of autoimmune diseases: Small interfering RNAs in the spotlight.
Abstract The identification of RNA interference (RNAi) has caused a growing interest in harnessing its potential in the treatment of different diseases. Modulation of dysregulated genes through targeting by RNAi represents a potential approach with which to alter the biological pathways at a post-transcriptional level, especially as it pertains to autoimmunity and malignancy. Short hairpin RNAs (shRNA), short interfering RNAs (siRNA), and microRNAs (miRNA) are mainly involved as effector mechanisms in the targeting of RNAi biological pathways. The manipulation and delivery of these molecules in an efficient way pr...
Source: Journal of Autoimmunity - August 7, 2020 Category: Allergy & Immunology Authors: Gorabi AM, Kiaie N, Aslani S, Jamialahmadi T, Johnston TP, Sahebkar A Tags: J Autoimmun Source Type: research

TRIM28/TIF1 β and Fli-1 negatively regulate peroxynitrite generation via DUOX2 to decrease the shedding of membrane-bound fractalkine in human macrophages after exposure to substance P.
In conclusion, TRIM28/TIF1β and Fli-1 negatively regulate TGFβ1 expression to upregulate the generation of peroxynitrite, leading to increased shedding of membrane-bound fractalkine induced by SP. PMID: 32673994 [PubMed - as supplied by publisher]
Source: Cytokine - July 12, 2020 Category: Molecular Biology Authors: Yamaguchi R, Haraguchi M, Yamaguchi R, Sakamoto A, Narahara S, Sugiuchi H, Yamaguchi Y Tags: Cytokine Source Type: research

Apigenin Modulates Dendritic Cell Activities and Curbs Inflammation Via RelB Inhibition in the Context of Neuroinflammatory Diseases
AbstractNeuroinflammation leads to tissue injury causing many of the clinical symptoms of Multiple Sclerosis, an autoimmune disorder of the central nervous system (CNS). While T cells, specifically Th1 and Th17 cells, are the ultimate effectors of this disease, dendritic cells (DCs) mediate T cell polarization, activation, etc. In our previous study, Apigenin, a natural flavonoid, has been shown to reduce EAE disease severity through amelioration of demyelination in the CNS as well as the sequestering of DCs and other myeloid cells in the periphery. Here, we show that Apigenin exerts its effects possibly through shifting D...
Source: Journal of NeuroImmune Pharmacology - June 29, 2020 Category: Drugs & Pharmacology Source Type: research

Inhibition of BMP3 increases the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis.
Abstract Rheumatoid arthritis (RA) is a persistent autoimmune disease. Fibroblast-like synoviocytes (FLS) are a key component of invasive pannus and a pathogenetic mechanism in RA. Expression of bone morphogenetic protein 3 (BMP3) mRNA is reportedly decreased in the arthritic synovium. We previously showed that BMP3 expression is significantly downregulated in the synovial tissues of RA patients and models of adjuvant-induced arthritis (AIA). In the present study, we explored the association between BMP3 and FLS migration and secretion of proinflammatory factors in RA. We found that inhibition of BMP3 expression u...
Source: Aging - June 21, 2020 Category: Biomedical Science Authors: Song B, Li X, Xu Q, Yin S, Wu S, Meng X, Huang C, Li J Tags: Aging (Albany NY) Source Type: research

Interleukin ‑1β attenuates the proliferation and differentiation of oligodendrocyte precursor cells through regulation of the microRNA‑202‑3p/β‑catenin/Gli1 axis.
Interleukin‑1β attenuates the proliferation and differentiation of oligodendrocyte precursor cells through regulation of the microRNA‑202‑3p/β‑catenin/Gli1 axis. Int J Mol Med. 2020 Jun 18;: Authors: Li Y, Liu L, Ding X, Liu Y, Yang Q, Ren B Abstract The inflammatory cytokine interleukin (IL)‑1β has been implicated in demyelinating diseases, such as multiple sclerosis and experimental autoimmune encephalomyelitis, and brain degenerative diseases, such as Alzheimer's disease. However, the cellular and molecular mechanisms underlying the damaging effects of IL‑1β on myelination are poorl...
Source: International Journal of Molecular Medicine - June 17, 2020 Category: Molecular Biology Authors: Li Y, Liu L, Ding X, Liu Y, Yang Q, Ren B Tags: Int J Mol Med Source Type: research

GSE103273 RNA-Seq of lymphoblastoid cell line (GM12878) upon siRNA mediated knockdown of Aiolos transcription factor.
Contributors : Christopher A Odhams ; Andrea Cortini ; Timothy J Vyse ; Deborah S Cunninghame GrahamSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe Ikaros family transcription factors Helios (IKZF2) and Aiolos (IKZF3), critical to lymphocyte homeostasis, are genetically associated with multiple immunological disorders including the prototypic autoimmune disease SLE. Given the lack of understanding between the association of Aiolos and its physiological function in humans, we determined their gene-regulatory pathways by RNA-Seq in the B-lymphocyte cell-line GM12878.
Source: GEO: Gene Expression Omnibus - June 1, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Oligodendrocyte ARNT2 expression is altered in models of MS
Conclusion The analysis of ARNT2 expression in OLs demonstrates that OL ARNT2 expression is altered in EAE and during OL maturation. Findings point to ARNT2 as an important mediator of OL viability and differentiation and warrant further characterization as a target for intervention in demyelinating disorders such as MS.
Source: Neurology Neuroimmunology and Neuroinflammation - May 20, 2020 Category: Neurology Authors: Becquart, P., Johnston, J., Vilarino-Güell, C., Quandt, J. A. Tags: All Immunology, Autoimmune diseases, Multiple sclerosis Article Source Type: research

Fli1 Downregulation in Scleroderma Myeloid Cells Has Profibrotic and Proinflammatory Effects
Scleroderma (SSc) is an autoimmune connective tissue disease characterized by immune dysregulation, vasculopathy, and fibrosis. We have previously demonstrated that low Fli1 expression in SSc fibroblasts and endothelial cells plays an important role in SSc pathogenesis. Cells of myeloid and lymphoid origin also express Fli1 and are dysregulated in patients with SSc, playing key roles in disease pathogenesis. However, the role for immune Fli1 in SSc is not yet clear. Our aim was to elucidate whether Fli1 contributes to the immune dysregulation seen in SSc. Comparison of the expression of Fli1 in monocytes, B- and T-cell fra...
Source: Frontiers in Immunology - May 18, 2020 Category: Allergy & Immunology Source Type: research

FCRL3 promotes IL-10 expression in B cells through the SHP-1 and p38 MAPK signalling pathways.
This study further found that FCRL3 and IL-10 expression was downregulated in MS patients, but the expression of these proteins was higher in the remission phase than that in the acute phase. The C allele of rs7528684 was associated with MS, and the CC genotype could lead to the upregulation of FCRL3 expression and the increase in IL-10 secretion. Further in vitro experiments with B cells found that LPS promoted FCRL3 expression in a dose- and time-dependent manner, thereby promoting IL-10 secretion. LPS regulated SHP-1 expression and p38 MAPK pathway activation through FCRL3, and FCRL3 upregulated the SHP-1 expression and...
Source: Cell Biology International - May 5, 2020 Category: Cytology Authors: Cui X, Liu CM, Liu QB Tags: Cell Biol Int Source Type: research

Transforming growth factor- β1 suppress pentraxin-3 in human orbital fibroblasts
ConclusionThese findings indicated that TGF- β1 can inhibit PTX3 expression in human OFs, which may participate in inflammation and fibrosis in patients with TAO and provide a potential target for the antifibrotic treatment.
Source: Endocrine - April 15, 2020 Category: Endocrinology Source Type: research

TGF ‐β secreted by human umbilical cord blood‐derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF‐α and IgE
This study investigated the role of transforming growth factor‐beta (TGF‐β) in the therapeutic effect of hUCB‐MSCs on AD. Small interfering RNA (siRNA)‐ mediated depletion of TGF‐β disrupted the therapeutic effect of hUCB‐MSCs in a mouse model of AD by attenuating the beneficial changes in histopathology, mast cell infiltration, tumor necrosis factor‐alpha (TNF‐α) expression, and the serum IgE level. To confirm that hUCB‐MSCs regulate se cretion of TNF‐α, we investigated whether they inhibit TNF‐α secretion by activated LAD2 cells. Coculture with hUCB‐MSCs significantly inhibited secretion of T...
Source: Stem Cells - April 13, 2020 Category: Stem Cells Authors: Hwan hee Park, Seunghee Lee, Yeonsil Yu, Sae Mi Yoo, Song Yi Baek, Namhee Jung, Kwang ‐Won Seo, Kyung‐Sun Kang Tags: Translational and Clinical Research Source Type: research

Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene modulation: A comprehensive review
This article will give a new perspective on understanding immunopathogenesis of autoimmune diseases not only in animals but also in human. Emerging approaches to investigate cytokine regulation through gene modulation may be a potential approach for the tailored immunomodulation of some autoimmune diseases near in the future.
Source: Autoimmunity Reviews - February 6, 2020 Category: Allergy & Immunology Source Type: research