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Condition: Autoimmune Disease
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Total 230 results found since Jan 2013.
Early Growth Response Gene-1 Deficiency Interrupts TGF β1 Signaling Activation and Aggravates Neurodegeneration in Experimental Autoimmune Encephalomyelitis Mice
This study demonstrated that Egr-1 was down-regulated at mRNA and protein levels in the central nervous system (CNS) of experimental autoimmune encephalomyelitis (EAE) mice. Egr-1 knockout exacerbated EAE progression in mice, as shown by increased disease severity and incidence; it also aggravated neuronal apoptosis, which was associated with weakened activation of the BDNF/TGF β 1/MAPK/Akt signaling pathways in the CNS of EAE mice. Consistently, Egr-1 siRNA promoted apoptosis but mitigated the activation of BDNF/TGFβ 1/MAPK/Akt signaling in SH-SY5Y cells. Our results revealed that Egr-1 is a crucial regulator of neurona...
Source: Neuroscience Bulletin - September 19, 2023 Category: Neuroscience Source Type: research
Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1β/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.PMID:37715399 | DOI:10.14715/cmb/2023.69.8.27
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Ziqin Zhao Xinlong Ma Shuhui Dong Haibo Yin Yong Yang Guangyi Xiong Source Type: research
ATRA ameliorates fibrosis by suppressing the pro-fibrotic molecule Fra2/AP-1 in systemic sclerosis
In this study, the pro-fibrotic effect of Fra2 in SSc is confirmed. SSc dermal fibroblasts and bleomycin-induced fibrotic tissues of SSc animals exhibit increased levels of Fra2. Inhibition of Fra2 expression in SSc dermal fibroblasts with Fra2 siRNA markedly decreased collagen I expression. ATRA reduced the expressions of Fra2, collagen I, and α-smooth muscle actin(α-SMA) in SSc dermal fibroblasts and bleomycin-induced fibrotic tissues of SSc mice. In addition, chromatin immunoprecipitation and dual-luciferase assays demonstrated that retinoic acid receptor RARα binds to the FRA2 promoter and modulates its transcriptio...
Source: International Immunopharmacology - June 18, 2023 Category: Allergy & Immunology Authors: Zixin Pi Jiani Liu Yangfan Xiao Xinglan He Ruixuan Zhu Rui Tang Xiangning Qiu Yi Zhan Zhuotong Zeng Yaqian Shi Rong Xiao Source Type: research
The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential
In this study, we investigated the effects of GSK761 on in vitro human dendritic cell (DC) differentiation and maturation, assessing the expression of cytokines and co-stimulatory molecules and their capacity to stimulate T-cell activation and induce phenotypic changes. In DCs, lipopolysaccharide (LPS) stimulation induced an increase in SP140 expression and its recruitment to transcription start sites (TSS) of pro-inflammatory cytokine genes. Moreover, LPS-induced cytokines such as TNF, IL-6, and IL-1β were reduced in GSK761- or SP140 siRNA- treated DCs. Although GSK761 did not significantly affect the expression of surfa...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Mohammed Ghiboub Matthew Bell Dovile Sinkeviciute Rab K Prinjha Menno P J de Winther Nicola R Harker David F Tough Wouter J de Jonge Source Type: research
