Corrigendum
(Source: Stem Cells)
Source: Stem Cells - October 23, 2021 Category: Stem Cells Tags: CORRIGENDUM Source Type: research

A preview of selected articles
(Source: Stem Cells)
Source: Stem Cells - September 27, 2021 Category: Stem Cells Authors: Stuart P. Atkinson Tags: PREVIEWS Source Type: research

Cover Image
The image shows swirls of mucus on the apical surface of a model of the human airway epithelium derived from induced pluripotent stem cells. The patterns created in this layer are due to the activity of motile cilia on specific epithelial cells within this model.See Djidrovski et al. beginning on page1310. (Source: Stem Cells)
Source: Stem Cells - September 27, 2021 Category: Stem Cells Tags: COVER IMAGE Source Type: research

Issue Information
(Source: Stem Cells)
Source: Stem Cells - September 27, 2021 Category: Stem Cells Tags: ISSUE INFORMATION Source Type: research

ELF3 mediates IL ‐1α induced differentiation of mesenchymal stem cells to inflammatory iCAFs
Mesenchymal stem cells are a progenitor of myofibroblasts and inflammatory carcinoma-associated fibroblasts. The present study identifies ELF3 as an essential transcription factor in the differentiation of this key pro-inflammatory stromal cell type. AbstractStromal cells in the tumor microenvironment regulate the immune landscape and tumor progression. Yet, the ontogeny and heterogeneity of reactive stromal cells within tumors is not well understood. Carcinoma-associated fibroblasts exhibiting an inflammatory phenotype (iCAFs) have been identified within multiple cancers, however mechanisms that lead to their recruitment ...
Source: Stem Cells - September 15, 2021 Category: Stem Cells Authors: Linda L. Tran, Truong Dang, Rintu Thomas, David R. Rowley Tags: Tissue ‐Specific Stem Cells Source Type: research

Dopamine regulates adult neurogenesis in the ventricular ‐subventricular zone via dopamine D3 angiotensin type 2 receptor interactions
Model of the effects of dopamine in the proliferation of ventricular-subventricular zone cells. Dopamine, via D2-like receptors, upregulates angiotensin AT2 receptor expression, which mediates D2-induced cell proliferation. Dopamine, through D1-like receptors, decreases angiotensin AT1 receptor expression, and AT1 receptors inhibit cell proliferation. See Figure 5 for additional details. AbstractAdult neurogenesis is a dynamic and highly regulated process and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the mechanisms/fact...
Source: Stem Cells - September 14, 2021 Category: Stem Cells Authors: Maria Garcia ‐Garrote, Juan A. Parga, Pablo J. Labandeira, Jose Luis Labandeira‐Garcia, Jannette Rodriguez‐Pallares Tags: Tissue ‐Specific Stem Cells Source Type: research

Intranasal delivery of mesenchymal stem cells ‐derived extracellular vesicles for the treatment of neurological diseases
Schematic diagram illustrating the major brain regions affected in neurodegenerative diseases, to which EVs actively migrate following IN administration. The figure presents the key mechanisms and cargo used by MSC-derived EVs to mitigate these pathologies and induce regeneration. AbstractNeurological disorders are diseases of the central nervous system (CNS), characterized by a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem cells (MSCs) are a promising therapy for diseases and disorders of the CNS. Increasing evidence suggests that their beneficial abilities can be attributed to t...
Source: Stem Cells - September 14, 2021 Category: Stem Cells Authors: Shay Herman, Idan Fishel, Daniel Offen Tags: Regenerative Medicine Source Type: research

Emerging roles of Bromodomain protein 4 in regulation of stem cell identity
BRD4 mediated transcription elongation in complex gene regulatory network during different stages of stem cell transitions. BRD4 modulates gene expression by recruiting PTEF-b for successful RNA polymerase II pause release and transcriptional elongation. Treatment with BET inhibitors blocks the transcriptional elongation and expression of pluripotency genes. AbstractUnderstanding the mechanism of fate decision and lineage commitment is the key step for developing novel stem cell applications in therapeutics. This process is coordinately regulated through systematic epigenetic reprogramming and concomitant changes in the tr...
Source: Stem Cells - September 14, 2021 Category: Stem Cells Authors: Anusree Dey, Sheetal Uppal, Jayeeta Giri, Hari Sharan Misra Tags: Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics Source Type: research

The Cyclin ‐Like Protein SPY1 overrides Reprogramming Induced Senescence Through EZH2 Mediated H3K27me3
Reprogramming of normal fibroblasts to induced pluripotent stem cells is characterized by low efficiency due to the upregulation of tumour suppressors and reprogramming induced senescence (RIS). Spy1 can be combined with classical pluripotency factors to override RIS through activation of EZH2 followed by an increase in trimethylation of histone H3 at the lysine 27 residue. AbstractFully differentiated cells can be reprogrammed through ectopic expression of key transcription factors to create induced pluripotent stem cells. These cells share many characteristics of normal embryonic stem cells and have great promise in dise...
Source: Stem Cells - September 11, 2021 Category: Stem Cells Authors: Dorota Lubanska, Ingrid Qemo, Megan Byrne, Kaitlyn N. Matthews, Bre ‐Anne Fifield, Jillian Brown, Elizabeth Fidalgo Silva, Lisa A. Porter Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Increased Lipogenesis Is Critical for Self ‐Renewal and Growth of Breast Cancer Stem Cells: Impact of Omega‐3 Fatty Acids
Breast cancer stem cells (CSC) have a distinct fatty acid profile due to the aberrant expressions of lipogenic enzymes (eg, FAS, SCD1, and FADS1/2), which are highly involved in sustaining their self-renewal, and proliferative capabilities. Omega-3 PUFA can effectively suppress the self-renewal and growth of breast CSC by downregulation of the lipogenic enzymes, especially SCD1. AbstractAberrant lipid metabolism has recently been recognized as a new hallmark of malignancy, but the characteristics of fatty acid metabolism in breast cancer stem cells (BCSC) and potential interventions targeting this pathway remain to be addr...
Source: Stem Cells - September 6, 2021 Category: Stem Cells Authors: Haiqing Luo, Chih ‐Yu Chen, Xiangyong Li, Xin Zhang, Chien‐Wen Su, Yinhua Liu, Tinglan Cao, Lei Hao, Meng Wang, Jing Xuan Kang Tags: Cancer Stem Cells Source Type: research

Bidirectional relationship between cardiac extracellular matrix and cardiac cells in ischemic heart disease
Our review focuses on the cardiac extracellular matrix (ECM) and cardiac fibroblasts (CFs), cardiac-derived progenitor cells (CPCs), and mesenchymal stem cells (MSCs), and their constant interplay in response to tissue development, aging, disease progression, and repair. AbstractIschemic heart diseases (IHDs), including myocardial infarction and cardiomyopathies, are a leading cause of mortality and morbidity worldwide. Cardiac-derived stem and progenitor cells have shown promise as a therapeutic for IHD but are limited by poor cell survival, limited retention, and rapid washout. One mechanism to address this is to encapsu...
Source: Stem Cells - September 6, 2021 Category: Stem Cells Authors: Hyun ‐Ji Park, Kenneth J. De Jesus Morales, Sruti Bheri, Brandon P. Kassouf, Michael E. Davis Tags: Concise Review Source Type: research

Spatiotemporal extracellular matrix modeling for in situ cell niche studies
Spatiotemporal extracellular matrix modeling facilitates the identification of cell-niches by combining decellularized whole organ sections and recellularization with a new algorithm for automatic generation of density maps and cluster-analysis for identification of regions of interest. AbstractExtracellular matrix (ECM) components govern a range of cell functions, such as migration, proliferation, maintenance of stemness, and differentiation. Cell niches that harbor stem-/progenitor cells, with matching ECM, have been shown in a range of organs, although their presence in the heart is still under debate. Determining niche...
Source: Stem Cells - August 31, 2021 Category: Stem Cells Authors: Kim Olesen, Sergey Rodin, Wing Cheung Mak, Ulrika Felldin, Cecilia Österholm, Andreas Tilevik, Karl‐Henrik Grinnemo Tags: Tissue ‐Specific Stem Cells Source Type: research

A protein ‐centric view of in vitro biological model systems for schizophrenia
Schematic diagram of stem-cell derived two-dimensional schizophrenia (SCZ) culture models (left column) vs three-dimensional (3D) SCZ brain organoid models (middle column) to engineer neural networks for translational medicine. SCZ patient cells are reprogrammed toward human induced pluripotent stem cells (hiPSC). Derived 3D brain organoids from hiPSCs serve as a model for further investigations. The application of proteomics and posttranslational modification specific proteomics (PTMomics) on 3D organoids could contribute to a wealth of information regarding the underlying mechanisms of the diseases and cell responses to ...
Source: Stem Cells - August 30, 2021 Category: Stem Cells Authors: Abinaya Chandrasekaran, Pia Jensen, Fadumo A. Mohamed, Madeline Lancaster, Michael E. Benros, Martin R. Larsen, Kristine K. Freude Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Cell cycle ‐coupled changes in the level of reactive oxygen species support the proliferation of human pluripotent stem cells
The progression of the cell cycle in human pluripotent stem cells is coupled with the oscillation of the ROS level. The decrease in this level results in the disturbance of the regulation and progression of S-phase, which, in turn, cause the accumulation of DNA breaks and subsequent apoptosis. AbstractThe study of proliferation regulation in human pluripotent stem cells is crucial to gain insights into understanding the physiology of these cells. However, redox regulation of the pluripotent cell cycle remains largely unexplored. Here, using human embryonic stem cells (hESCs) as well as human induced pluripotent stem cells ...
Source: Stem Cells - August 30, 2021 Category: Stem Cells Authors: Ju. S. Ivanova, N. A. Pugovkina, I. E. Neganova, I. V. Kozhukharova, N. N. Nikolsky, O. G. Lyublinskaya Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Human Induced Pluripotent Stem Cell ‐Derived Macrophages Ameliorate Liver Fibrosis
Human iPSCs are efficiently differentiated into both M1 and M2 macrophages. These cells were used to treat liver fibrosis in an immunodeficient mouse model. This treatment led to improvement in the fibrosis as measured by several complementary assays. ABSTRACTWith an increasing number of patients with degenerative hepatic diseases such as liver fibrosis, and a limited supply of donor organs, there is an unmet need for therapies that can repair or regenerate damaged liver tissue. Treatment with macrophages that are capable of phagocytosis and anti-inflammatory activities such as secretion of matrix metalloproteinases (MMPs)...
Source: Stem Cells - August 30, 2021 Category: Stem Cells Authors: Somayeh Pouyanfard, Nairika Meshgin, Luisjesus S Cruz, Karin Diggle, Hamidreza Hashemi, Timothy V Pham, Manuel Fierro, Pablo Tamayo, Andrea Fanjul, Tatiana Kisseleva, Dan S Kaufman Tags: Regenerative Medicine Source Type: research

Cell cycle ‐coupled changes in the level of reactive oxygen species support the proliferation of human pluripotent stem cells
The progression of the cell cycle in human pluripotent stem cells is coupled with the oscillation of the ROS level. The decrease in this level results in the disturbance of the regulation and progression of S-phase, which, in turn, cause the accumulation of DNA breaks and subsequent apoptosis. AbstractThe study of proliferation regulation in human pluripotent stem cells is crucial to gain insights into understanding the physiology of these cells. However, redox regulation of the pluripotent cell cycle remains largely unexplored. Here, using human embryonic stem cells (hESCs) as well as human induced pluripotent stem cells ...
Source: Stem Cells - August 30, 2021 Category: Stem Cells Authors: Ju. S. Ivanova, N. A. Pugovkina, I. E. Neganova, I. V. Kozhukharova, N. N. Nikolsky, O. G. Lyublinskaya Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

State ‐of‐play for cellular therapies in cardiac repair and regeneration
Cardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the “state-of-play” of cellular therapies for cardiac repair and regeneration. AbstractCardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the “state-of-play” of cellular therapies for cardiac repair and regeneration. We outline the progression of new ideas from the preclinical l...
Source: Stem Cells - August 28, 2021 Category: Stem Cells Authors: Ramana Vaka, Darryl R. Davis Tags: CONCISE REVIEW Source Type: research

A preview of selected articles
(Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Authors: Stuart P. Atkinson Tags: PREVIEWS Source Type: research

Cover Image
The image depicts aggregates of mouse embryonic stem cells grown without leukemia inhibitory factor after 4 days in stirred suspension bioreactor.See Nath et al. beginning on page1166. (Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Tags: COVER IMAGE Source Type: research

Issue Information
(Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Tags: ISSUE INFORMATION Source Type: research

Cancer stem cell ‐targeted therapeutic approaches for overcoming trastuzumab resistance in HER2‐positive breast cancer
Several reported targeted therapies against breast cancer stem cells (BCSCs) to overcome trastuzumab resistance in HER2-positive breast cancer. AbstractApplication of the anti-HER2 drug trastuzumab has significantly improved the prognosis of patients with the HER2-positive subtype of breast cancer. However, 50% of patients withHER2 amplification relapse due to trastuzumab resistance. Accumulating evidence indicates that breast cancer is driven by a small subset of cancer-initiating cells or breast cancer stem cells (BCSCs), which have the capacity to self-renew and differentiate to regenerate the tumor cell hierarchy. Incr...
Source: Stem Cells - August 26, 2021 Category: Stem Cells Authors: Yan Qiu, Libo Yang, Honghong Liu, Xiaobo Luo Tags: CONCISE REVIEW Source Type: research

Corrigendum
(Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Tags: CORRIGENDUM Source Type: research

A preview of selected articles
(Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Authors: Stuart P. Atkinson Tags: PREVIEWS Source Type: research

Cover Image
The image depicts aggregates of mouse embryonic stem cells grown without leukemia inhibitory factor after 4 days in stirred suspension bioreactor.See Nath et al. beginning on page1166. (Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Tags: COVER IMAGE Source Type: research

Issue Information
(Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Tags: ISSUE INFORMATION Source Type: research

Epigenetic regulation of neural stem cells: The emerging role of nucleoporins
Cartoon illustrating the contribution of Nups to epigenetic mechanisms in stem cells. (1) Transcription. (2) Heterochromatin formation. (3) Silencing. (4) Topological associated domain formation. (5) miRNA biogenesis and transport. (6) Protein SUMOylation. AbstractNucleoporins (Nups) are components of the nuclear pore complex that, besides regulating nucleus-cytoplasmic transport, emerged as a hub for chromatin interaction and gene expression modulation. Specifically, Nups act in a dynamic manner both at specific gene level and in the topological organization of chromatin domains. As such, they play a fundamental role duri...
Source: Stem Cells - August 25, 2021 Category: Stem Cells Authors: Claudia Colussi, Claudio Grassi Tags: CONCISE REVIEW Source Type: research

A protein ‐centric view of in vitro biological model systems for Schizophrenia
Schematic diagram of stem-cell derived 2D SCZ culture models (left column) vs 3D SCZ brain organoid models (middle column) to engineer neural networks for translational medicine. SCZ patient cells are reprogrammed towards human induced pluripotent stem cells (hiPSC). Derived 3D brain organoids from hiPSCs serve as a model for further investigations. The application of proteomics and Post-translational Modification specific proteomics (PTMomics) on 3D organoids could contribute to a wealth of information regarding the underlying mechanisms of the diseases and cell responses toin vivo settings (right column). AbstractSchizop...
Source: Stem Cells - August 25, 2021 Category: Stem Cells Authors: Abinaya Chandrasekaran, Pia Jensen, Fadumo A. Mohamed, Madeline Lancaster, Michael E. Benros, Martin R. Larsen, Kristine K. Freude Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis
As induced pluripotent stem cells (iPSCs) undergo chondrogenesis,Trpv4 expression mirrored the expression of other chondrogenic markers (eg,Sox9,Acan, andCol2a1). Using aCol2a1-GFP reporter, green fluorescent protein positive (GFP+) cells showed increased chondrogenesis and expression ofTrpv4. Daily activation of transient receptor potential vanilloid 4 (TRPV4) significantly increased cartilaginous matrix production in GFP+ cells. These findings suggest that TRPV4 serves as a marker as well as a regulator of iPSC chondrogenesis. AbstractTransient receptor potential vanilloid 4 (TRPV4) is a polymodal calcium-permeable catio...
Source: Stem Cells - August 24, 2021 Category: Stem Cells Authors: Vincent P. Willard, Holly A. Leddy, Daniel Palmer, Chia ‐Lung Wu, Wolfgang Liedtke, Farshid Guilak Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Aryl hydrocarbon receptor controls skin homeostasis, regeneration, and hair follicle cycling by adjusting epidermal stem cell function
Aryl hydrocarbon receptor (AhR) is required for skin homeostasis and hair growth. AhR depletion in keratinocytes and dermal fibroblasts compromises skin regeneration likely because of reduced epidermal stem cells (EpdSCs) numbers. Reconstitution assays suggest a cell autonomous role for AhR in the epidermis. Signaling networks controlling skin homeostasis are AhR regulated in EpdSCs. AhR modulation by physiological ligands may represent a strategy to treat skin pathology. AbstractSkin integrity requires constant maintenance of a quiescent, yet responsive, population of stem cells. While interfollicular epidermal progenitor...
Source: Stem Cells - August 24, 2021 Category: Stem Cells Authors: Eva Mar ía Rico‐Leo, Luis Francisco Lorenzo‐Martín, Ángel Carlos Román, Xosé Ramón Bustelo, Jaime María Merino, Pedro María Fernández‐Salguero Tags: Tissue ‐Specific Stem Cells Source Type: research

Spatiotemporal Extracellular Matrix Modelling (StEMM) for In Situ Cell Niche Studies
Spatiotemporal Extracellular Matrix Modeling (StEMM) facilitates the identification of cell-niches by combining decellularized whole organ sections and recellularization with a new algorithm for automatic generation of density maps and cluster-analysis for identification of regions of interest. AbstractExtracellular matrix (ECM) components govern a range of cell functions such as migration, proliferation, maintenance of stemness and differentiation. Cell niches that harbor stem −/progenitor cells, with matching ECM, have been shown in a range of organs, although their presence in the heart is still under debate. Dete...
Source: Stem Cells - August 22, 2021 Category: Stem Cells Authors: Kim Olesen, Sergey Rodin, Wing Cheung Mak, Ulrika Felldin, Cecilia Österholm, Andreas Tilevik, Karl‐Henrik Grinnemo Tags: Tissue ‐Specific Stem Cells Source Type: research

Single ‐cell transcriptomic sequencing analyses of cell heterogeneity during osteogenesis of human adipose‐derived mesenchymal stem cells
In this study, we investigated the cellular and molecular features of chemically induced osteogenesis from MSC isolated from human adipose tissue (human adipose MSCs, hAMSCs) using single-cell RNA-sequencing (scRNA-seq). We found that a near complete differentiation of osteogenic clusters from hAMSCs under a directional induction. Both groups of cells are heterogeneous, and some of the hAMSCs cells are intrinsically prepared for osteogenesis, while variant OS clusters seems in cooperation with a due division of the general function. We identified a set of genes related to cell stress response highly expressed during the di...
Source: Stem Cells - August 17, 2021 Category: Stem Cells Authors: Rongmei Qu, Kai He, Tingyu Fan, Yuchao Yang, Liyao Mai, Zhiwei Lian, Zhitao Zhou, Yan Peng, Asmat Ullah Khan, Bing Sun, Xiaolan Huang, Jun Ouyang, Xinghua Pan, Jingxing Dai, Wenhua Huang Tags: Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics Source Type: research

Epigenetic regulation of neural stem cells: the emerging role of nucleoporins
Cartoon illustrating the contribution of Nups to epigenetic mechanisms in stem cells. 1) Transcription. 2) Heterochromatin formation. 3) Silencing. 4) Topological associated domain formation. 5) miRNA biogenesis and transport 6) Protein SUMOylation. AbstractNucleoporins (Nups) are components of the nuclear pore complex that, besides regulating nucleus-cytoplasmic transport, emerged as a hub for chromatin interaction and gene expression modulation. Specifically, Nups act in a dynamic manner both at specific gene level and in the topological organization of chromatin domains. As such, they play a fundamental role during deve...
Source: Stem Cells - August 17, 2021 Category: Stem Cells Authors: Claudia Colussi, Claudio Grassi Tags: Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics Source Type: research

Bone marrow ‐derived progenitor cells contribute to remodeling of the postpartum uterus
In conclusion, BM-derived pro genitors were found to have a novel nonhematopoietic cellular contribution to postpartum uterus remodeling. This contribution may have an important functional role in physiological as well as pathological postpartum endometrial regeneration. (Source: Stem Cells)
Source: Stem Cells - August 7, 2021 Category: Stem Cells Authors: Reshef Tal, Jacqueline Kisa, Nafeesa Abuwala, Harvey J. Kliman, Shafiq Shaikh, Alice Y. Chen, Fang Lyu, Hugh S. Taylor Tags: Tissue ‐Specific Stem Cells Source Type: research

Three ‐dimensional migration of human amniotic fluid stem cells involves mesenchymal and amoeboid modes and is regulated by mTORC1
This study on human amniotic fluid stem cells (hAFSCs) provides the first demonstration that human stem cells exhibit mTORC1-dependent invasive capacity and can concurrently make use of mesenchymal and amoeboid 3D cell migration modes. These results represent an important step toward the full biological characterization of fetal human stem cells with relevance to developmental research and stem cell-based therapy. AbstractThree-dimensional (3D) cell migration is an integral part of many physiologic processes. Although being well studied in the context of adult tissue homeostasis and cancer development, remarkably little is...
Source: Stem Cells - August 4, 2021 Category: Stem Cells Authors: Margit Rosner, Markus Hengstschl äger Tags: Tissue ‐Specific Stem Cells Source Type: research

Single ‐cell transcriptomic sequencing analyses of cell heterogeneity during osteogenesis of human adipose‐derived mesenchymal stem cells
In this study, we investigated the cellular and molecular features of chemically induced osteogenesis from MSC isolated from human adipose tissue (human adipose MSCs, hAMSCs) using single-cell RNA-sequencing (scRNA-seq). We found that a near complete differentiation of osteogenic clusters from hAMSCs under a directional induction. Both groups of cells are heterogeneous, and some of the hAMSCs cells are intrinsically prepared for osteogenesis, while variant OS clusters seems in cooperation with a due division of the general function. We identified a set of genes related to cell stress response highly expressed during the di...
Source: Stem Cells - August 4, 2021 Category: Stem Cells Authors: Rongmei Qu, Kai He, Tingyu Fan, Yuchao Yang, Liyao Mai, Zhiwei Lian, Zhitao Zhou, Yan Peng, Asmat Ullah Khan, Bing Sun, Xiaolan Huang, Jun Ouyang, Xinghua Pan, Jingxing Dai, Wenhua Huang Tags: Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics Source Type: research

Downregulation of augmenter of liver regeneration impairs the therapeutic efficacy of liver epithelial progenitor cells against acute liver injury by enhancing mitochondrial fission
In conclusion, we demonstrated that the transplantation ofALR-transfected LEPCs protected mice against CCl4-induced ALI, thus offering immense curative potential in the clinic. (Source: Stem Cells)
Source: Stem Cells - August 4, 2021 Category: Stem Cells Authors: Yuan Dong, Weining Kong, Wei An Tags: Tissue ‐Specific Stem Cells Source Type: research