Filtered By:
Condition: Autoimmune Disease
This page shows you your search results in order of date. This is page number 3.
Order by Relevance | Date
Total 230 results found since Jan 2013.
The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential
In this study, we investigated the effects of GSK761 on in vitro human dendritic cell (DC) differentiation and maturation, assessing the expression of cytokines and co-stimulatory molecules and their capacity to stimulate T-cell activation and induce phenotypic changes. In DCs, lipopolysaccharide (LPS) stimulation induced an increase in SP140 expression and its recruitment to transcription start sites (TSS) of pro-inflammatory cytokine genes. Moreover, LPS-induced cytokines such as TNF, IL-6, and IL-1β were reduced in GSK761- or SP140 siRNA- treated DCs. Although GSK761 did not significantly affect the expression of surfa...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Mohammed Ghiboub Matthew Bell Dovile Sinkeviciute Rab K Prinjha Menno P J de Winther Nicola R Harker David F Tough Wouter J de Jonge Source Type: research
Novel therapeutic strategies for autoimmune and inflammatory rheumatic diseases
Drug Discov Today. 2023 May 8:103612. doi: 10.1016/j.drudis.2023.103612. Online ahead of print.ABSTRACTDrugs of unknown mechanisms of action are no longer being developed because we have largely capitalized on our improved understanding of the immunopathogenesis of immune-mediated inflammatory diseases (IMIDs) to develop therapeutic monoclonal antibodies (mAbs) and targeted treatments. These therapies have profoundly revolutionized the care of IMIDs. However, because of the heterogeneity of IMIDs and the redundancy of the targeted molecular pathways, some patients with IMIDs might not respond to a specific targeted drug or...
Source: Drug Discovery Today - May 10, 2023 Category: Drugs & Pharmacology Authors: Renaud Felten Philippe Mertz Eden Sebbag Marc Scherlinger Laurent Arnaud Source Type: research
Mettl14 sustains FOXP3 expression to promote the differentiation and functions of induced-regulatory T cells via the mTOR signaling pathway
In conclusion, our study revealed that Mettl14 plays a critical role in the development and suppressive function of iTregs in vitro and could thus serve as a regulatory element for stabilizing iTregs in cell-based therapy.PMID:37121553 | DOI:10.1016/j.imlet.2023.04.008
Source: Immunology Letters - April 30, 2023 Category: Allergy & Immunology Authors: Yanzhuo Liu Yinglin Yuan Zili Zhou Xiaomei Jiang Shu He Fan Wei Yuanyuan Cui Lu Yang Gaoping Zhao Source Type: research
1099 Rational development of JAK1-selective siRNA therapeutics for the treatment of autoimmune skin diseases
JAK inhibition has surged as a popular treatment strategy for many inflammatory and autoimmune skin diseases. Current available small molecule JAK inhibitors in the clinic show distinct efficacy and safety profiles, likely reflecting their selectivity for certain JAK subtypes (i.e., JAK1, JAK2, JAK3, and tyrosine kinase 2 —TYK2). Achieving absolute JAK subtype selectivity remains challenging. RNA therapeutics, such as mRNAs, small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs), and aptamers, are a new generation of drug modality expected to dramatically accelerate the development of human medicine.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: Q. Tang, H. Fakih, M. Zain Ul Abideen, K. Afshari, K. Gross, J. Alterman, A. Khvorova, J.E. Harris Source Type: research
m < sup > 6 < /sup > A methyltransferase METTL3 programs CD4 < sup > + < /sup > T-cell activation and effector T-cell differentiation in systemic lupus erythematosus
CONCLUSION: In summary, our findings demonstrated that METTL3 was required for stabilizing Foxp3 mRNA via m6A modification to maintain the Treg differentiation program. METTL3 inhibition contributed to the pathogenesis of SLE by participating in the activation of CD4+ T cells and imbalance of effector T-cell differentiation, which could serve as a potential target for therapeutic intervention in SLE.PMID:37013484 | PMC:PMC10068720 | DOI:10.1186/s10020-023-00643-4
Source: Molecular Medicine - April 4, 2023 Category: Molecular Biology Authors: Shuang Lu Xingyu Wei Huan Zhu Zhi Hu Meiling Zheng Jiali Wu Cheng Zhao Shuang Yang Delong Feng Sujie Jia Hongjun Zhao Ming Zhao Source Type: research
Excessive iodine induces thyroid follicular epithelial cells apoptosis by activating HIF-1 α-mediated hypoxia pathway in Hashimoto thyroiditis
CONCLUSION: Our study confirmed that excessive iodine adsorption activates the HIF-1α-mediated hypoxia pathway to promote apoptosis of TFCs, which may be an important risk factor contributing to HT development.PMID:36807042 | DOI:10.1007/s11033-023-08273-z
Source: Mol Biol Cell - February 22, 2023 Category: Molecular Biology Authors: Lili Zhang Xiaojing Sun Lin Liu Ping Wang Linxue Qian Source Type: research
CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren ’s Syndrome by Activating GRK2 to Promote T Lymphocyte Migration
AbstractPrimary Sjogren ’s syndrome (pSS) is a systemic autoimmune disease that causes dysfunction of secretory glands and the specific pathogenesis is still unknown. The CXCL9, 10, 11/CXCR3 axis and G protein-coupled receptor kinase 2 (GRK2) involved in many inflammation and immunity processes. We used NOD/Ltj mice, a s pontaneous SS animal model, to elucidate the pathological mechanism of CXCL9, 10, 11/CXCR3 axis promoting T lymphocyte migration by activating GRK2 in pSS. We found that CD4 + GRK2, Th17 + CXCR3 was apparently increased and Treg + CXCR3 was significantly decreased in the spleen of 4W NOD mice...
Source: Inflammation - February 18, 2023 Category: Allergy & Immunology Source Type: research
Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway
In this study, we carried out histological and physiological analyses in UC patients and UC mice. RNA sequencing (RNA-seq), assays for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq), chromatin immunoprecipitation (ChIP) assays and protein and mRNA expression were performed to analyze and identify the potential molecular mechanism in UC mice and lipopolysaccharide (LPS)-induced mouse intestinal epithelial cells (MIECs). Moreover, we established nucleotide-binding oligomerization domain (NOD)-like receptor protein nlrp6-/- mice and siRNA-NLRP6 MIECs to further characterize the role of NLRP6 in an...
Source: Frontiers in Immunology - February 8, 2023 Category: Allergy & Immunology Source Type: research
