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Condition: Autoimmune Disease

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Total 230 results found since Jan 2013.

CRAC Channel Controls the Differentiation of Pathogenic B Cells in Lupus Nephritis
This study provides insights into the pathogenic mechanisms of LN and that CRAC channel could serve as a potential therapeutic target for LN.
Source: Frontiers in Immunology - October 22, 2021 Category: Allergy & Immunology Source Type: research

Upregulated IL ‐10 induced by E2F2‐miR‐17‐5p circuitry in extrafollicular effector B cells contributes to autoantibody production in systemic lupus erythematosus
ConclusionIL10 promotes extrafollicular autoimmune responses in active SLE patients, which might be dampened by targeting theE2F2-miR-17-5p circuitry.
Source: Arthritis and Rheumatology - September 27, 2021 Category: Rheumatology Authors: Lingxiao Xu, Lei Wang, Yumeng Shi, Yun Deng, Jim C. Oates, Diane L. Kamen, Gary S. Gilkeson, Fang Wang, Miaojia Zhang, Wenfeng Tan, Betty P. Tsao Tags: FULL LENGTH Source Type: research

Variants on the UBE2L3 ‐YDJC autoimmune disease risk haplotype increase UBE2L3 gene expression by modulating CTCF and YY1 binding
ConclusionTheUBE2L3-YDJC autoimmune risk haplotype increasesUBE2L3 expression through strengthening a YY1-mediated interaction between theUBE2L3 andYDJC promoters.
Source: Arthritis and Rheumatology - July 21, 2021 Category: Rheumatology Authors: Jaanam Gopalakrishnan, Kandice L. Tessneer, Yao Fu, Satish Pasula, Richard C. Pelikan, Jennifer A. Kelly, Graham B. Wiley, Patrick M. Gaffney Tags: FULL LENGTH Source Type: research

Histone Deacetylase 4 Controls Extracellular Matrix Production in Orbital Fibroblasts from Graves' Ophthalmopathy Patients
CONCLUSION: Our data indicated for the first time that altered HDAC4 regulation along with H3K9 hypoacetylation might represent a mechanism that contributes to excessive proliferation and extracellular matrix production by orbital fibroblasts in GO. HDAC4 might represent a novel target for GO therapy.PMID:34235979 | DOI:10.1089/thy.2020.0948
Source: Thyroid : official journal of the American Thyroid Association - July 8, 2021 Category: Endocrinology Authors: Supanuch Ekronarongchai Tanapat Palaga Preamjit Saonanon Vannakorn Pruksakorn Nattiya Hirankarn P Martin van Hagen Willem A Dik Sita Virakul Source Type: research

Transdermal Delivery of Adipocyte Phospholipase A2 siRNA using Microneedles to Treat Thyroid Associated Ophthalmopathy-Related Proptosis
This study sets the stage not only for future treatment of TAO-related proptosis using AdPLA siRNA, but also provides the foundation for targeted siRNA delivery by using microneedles.PMID:33880967 | DOI:10.1177/09636897211010633
Source: Cell Transplantation - April 21, 2021 Category: Cytology Authors: Guiqin Liu Yan Deng Yi Song Yi Sui Juan Cen Ziyu Shao Hu Li Tao Tang Source Type: research

lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast ‑like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR‑152‑3p.
lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast‑like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR‑152‑3p. Int J Mol Med. 2021 Mar;47(3): Authors: Jiang H, Liu J, Fan C, Wang J, Li W Abstract Rheumatoid arthritis (RA) is an autoimmune disease that occurs in approximately 1.0% of the general population. In RA patients, physical disability and joint damage are the major prognostic factors, which are associated with a reduction in the quality of life and early mortality. At present, the exact molecular mechanism of RA remains elusive. Long n...
Source: International Journal of Molecular Medicine - January 17, 2021 Category: Molecular Biology Authors: Jiang H, Liu J, Fan C, Wang J, Li W Tags: Int J Mol Med Source Type: research

Ganglioside GT1b increases hyaluronic acid synthase 2 via PI3K activation with TLR2 dependence in orbital fibroblasts from thyroid eye disease patients
In conclusion, GT1b induced HAS2 in orbital fibroblasts from TED patients via activation of the PI3K-related signaling pathway, dependent on TLR2.PMID:33407998
Source: BMB Reports - January 7, 2021 Category: Biochemistry Authors: Hyun Kyu Yoo Hyunju Park Hye Suk Hwang Hee Ja Kim Youn-Hee Choi Koung Hoon Kook Source Type: research

Ganglioside GT1b increases hyaluronic acid synthase 2 via PI3K activation with TLR2 dependence in orbital fibroblasts from thyroid eye disease patients.
In conclusion, GT1b induced HAS2 in orbital fibroblasts from TED patients via activation of the PI3K-related signaling pathway, dependent on TLR2. PMID: 33407998 [PubMed - as supplied by publisher]
Source: BMB Reports - January 7, 2021 Category: Biochemistry Authors: Yoo HK, Park H, Hwang HS, Kim HJ, Choi YH, Kook KH Tags: BMB Rep Source Type: research