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Condition: Autoimmune Disease

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Total 230 results found since Jan 2013.

Knockdown of ADAM10 inhibits migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis.
Authors: Li D, Xiao Z, Wang G, Song X Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease with high rates of morbidity and mortality. Previous studies proposed that the A disintegrin and metalloprotease (ADAM) family is involved in the regulation of inflammation and arthritis. Thus, the present study investigated whether ADAM10 is involved in the progression of RA. The effects of ADAM10 small interfering (si)RNA on the expression levels of tumor necrosis factor (TNF)‑α, interleukin (IL)‑6, IL‑8 and chemokine (C-X-C motif) ligand 16 (CXCL16) were determined in fibroblast‑like synoviocytes (...
Source: Molecular Medicine Reports - July 3, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Inhibition of Interferon regulatory factor 4 Suppresses Th1 and Th17 Cell Differentiation and Ameliorates Experimental Autoimmune Encephalomyelitis
In conclusion, inhibition of IRF4 suppresses Th1 and Th17 cell differentiation and ameliorates EAE, via a direct regulation of DCs. This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - June 26, 2015 Category: Allergy & Immunology Authors: Chunsheng Yang, Dan He, Chuang Yin, Jun Tan Tags: Regular Manuscript Source Type: research

Increased expression of TLR2 in CD4(+) T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications.
This article is protected by copyright. All rights reserved. PMID: 26079624 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - June 15, 2015 Category: Allergy & Immunology Authors: Liu Y, Liao J, Zhao M, Wu H, Yung S, Chan TM, Akihiko Y, Lu Q Tags: Eur J Immunol Source Type: research

Increased expression of TLR2 in CD4+ T cells from SLE patients enhances immune reactivity and promotes IL‐17 expression through histone modifications
This article is protected by copyright. All rights reserved
Source: European Journal of Immunology - June 1, 2015 Category: Allergy & Immunology Authors: Yu Liu, Jieyue Liao, Ming Zhao, Haijing Wu, Susan Yung, Tak Mao Chan, Yoshimura Akihiko, Qianjin Lu Tags: Regular Article Source Type: research

Lipid-based nanocarriers for RNA delivery.
Abstract RNA-interference (RNAi) agents such as small-interfering RNA (siRNA) and micro-RNA (miRNA) have strong potential as therapeutic agents for the treatment of a broad range of diseases such as malignancies, infections, autoimmune diseases and neurological diseases that are associated with undesirable gene expression. In recent years, several clinical trials of RNAi therapeutics especially siRNAs have been conducted with limited success so far. For systemic administration of these poorly permeable and easily degradable macromolecules, it is obvious that a safe and efficient delivery platform is highly desirab...
Source: Current Pharmaceutical Design - May 31, 2015 Category: Drugs & Pharmacology Authors: Xue HY, Guo P, Wen WC, Wong HL Tags: Curr Pharm Des Source Type: research

Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells.
Abstract IL-12 p40, a common subunit for both IL-12 p70 and IL-23, plays a critical role in the development of Th1 and Th17 cells and autoimmune diseases. Regulation of IL-12 p40 expression is thus considered to be a strategy for developing therapies for Th1- and Th17-mediated autoimmune diseases. The mTOR protein is a subunit mTORC1 and mTORC2. Although mTORC1 has been shown to mediate IL-12 p40 expression in DCs and relevant signaling, the role of mTORC2 in IL-12 p40 expression remains largely unclear. In the present study, we demonstrate that blocking mTORC2 activity using the phytochemical cytopiloyne can spec...
Source: Journal of Leukocyte Biology - April 15, 2015 Category: Hematology Authors: Wei WC, Liu CP, Yang WC, Shyur LF, Sheu JH, Chen SS, Yang NS Tags: J Leukoc Biol Source Type: research

Versatile polyion complex micelles for peptide and siRNA vectorization to engineer tolerogenic dendritic cells.
Abstract Dendritic cells (DCs) are professional antigen-presenting cells that play a critical role in maintaining the balance between immunity and tolerance and, as such are a promising immunotherapy tool to induce immunity or to restore tolerance. The main challenge to harness the tolerogenic properties of DCs is to preserve their immature phenotype. We recently developed polyion complex micelles, formulated with double hydrophilic block copolymers of poly(methacrylic acid) and poly(ethylene oxide) blocks and able to entrap therapeutic molecules, that did not induce DC maturation. In the current study, the intrin...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 18, 2015 Category: Drugs & Pharmacology Authors: Mebarek N, Vicente R, Aubert-Pouëssel A, Quentin J, Mausset-Bonnefont AL, Devoisselle JM, Jorgensen C, Bégu S, Louis-Plence P Tags: Eur J Pharm Biopharm Source Type: research

Aurora Kinase A Regulates M1 Macrophage Polarization and Plays a Role in Experimental Autoimmune Encephalomyelitis
Abstract Macrophage polarization is a dynamic and integral process of tissue inflammation and remodeling. Here we demonstrate an important role of Aurora kinase A in the regulation of inflammatory M1 macrophage polarization. We found that there was an elevated expression of Aurora-A in M1 macrophages and inhibition of Aurora-A by small molecules or specific siRNA selectively led to the suppression of M1 polarization, sparing over the M2 macrophage differentiation. At the molecular level, we found that the effects of Aurora-A in M1 macrophages were mediated through the down-regulation of NF-κB pathway and subsequ...
Source: Inflammation - March 1, 2015 Category: Allergy & Immunology Source Type: research

RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9.
Abstract The retinoic acid-induced protein I (Rig-I/Ddx58), (RIG-I) initiates a signaling cascade that induces innate immune defences which is associated with the production of type I interferons (IFNs) and inflammatory cytokines to establish an antiviral state. Aberrant RIG-I signaling leads to inflammation, autoimmune diseases and cancer. However, the role of RIG-I in hepatocellular carcinoma (HCC) is still unknown. Here, we observed that RIG-I expression was downregulated in HCC tissues and loss of RIG-I expression was correlated with poor clinicopathological features. Additionally, we demonstrated that patien...
Source: International Journal of Oncology - January 26, 2015 Category: Cancer & Oncology Authors: Liu Z, Dou C, Jia Y, Li Q, Zheng X, Yao Y, Liu Q, Song T Tags: Int J Oncol Source Type: research

Progress of Targeting Transforming Growth Factor-β1 Small Interfering RNA in Liver Fibrosis
Publication date: December 2014 Source:Chinese Medical Sciences Journal, Volume 29, Issue 4 Author(s): Xuan Zhou , Xue-feng Yang Liver fibrosis is a common pathological consequence of a variety of chronic stimuli, including viral, autoimmune, drug-induced, cholestatic and metabolic diseases. Fibrosis is driven by a dynamic process involving increased synthesis of matrix components and a failure of physiological mechanisms of matrix turnover. Activation of hepatic stellate cells (HSCs) remains a central event in fibrosis. HSCs are the main source of extracellular matrix (ECM). Transforming growth factor-beta (TGF-β), whi...
Source: Chinese Medical Sciences Journal - December 5, 2014 Category: Journals (General) Source Type: research

Impact of suppressing retinoic acid‐related orphan receptor gamma t (ROR)γt in ameliorating central nervous system autoimmunity
In this study, we characterized the correlation between RORγt expression and other factors affecting T cell encephalitogenicity and evaluated the therapeutic potential of targeting RORγt by siRNA inhibition of RORγt. Our data showed that RORγt expression correlates with interleukin (IL)‐17 production, but not with the encephalitogenicity of myelin‐specific CD4 T cells. IL‐23, a cytokine that enhances encephalitogenicity, does not enhance RORγt expression significantly. Additionally, granulocyte–macrophage colony‐stimulating factor (GM‐CSF) levels, which correlate with the encephalitogenicity of different m...
Source: Clinical and Experimental Immunology - November 26, 2014 Category: Allergy & Immunology Authors: Y. Yang, R. C. Winger, P. W. Lee, P. K. Nuro‐Gyina, A. Minc, M. Larson, Y. Liu, W. Pei, E. Rieser, M. K. Racke, A. E. Lovett‐Racke Tags: Original Article Source Type: research

Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus
Publication date: May 2013 Source:Molecular Immunology, Volume 54, Issue 1 Author(s): Nicholas A. Young , Alexandra K. Friedman , Benjamin Kaffenberger , Murugesan V.S. Rajaram , Daniel J. Birmingham , Brad H. Rovin , Lee A. Hebert , Larry S. Schlesinger , Lai-Chu Wu , Wael N. Jarjour Systemic lupus erythematosus (SLE) is a prototypic, inflammatory autoimmune disease characterized by significant gender bias. Previous studies have established a role for hormones in SLE pathogenesis, including the sex hormone estrogen. Estrogen regulates gene expression by translocating estrogen receptors (ER) α and β into the nucleus wh...
Source: Molecular Immunology - November 3, 2014 Category: Allergy & Immunology Source Type: research

Impact of suppressing RORγt in ameliorating central nervous system autoimmunity.
In this study, we characterized the correlation between RORγt expression and other factors affecting T cell encephalitogenicity and evaluated the therapeutic potential of targeting RORγt by siRNA inhibition of RORγt. Our data showed that RORγt expression correlates with IL-17 production, but not with the encephalitogenicity of myelin-specific CD4 T cells. IL-23, a cytokine that enhances encephalitogenicity, does not enhance RORγt expression significantly. Additionally, GM-CSF levels, which correlate with the encephalitogenicity of different myelin-specific CD4 T cell populations, do not correlate with RORγt. More imp...
Source: Clinical and Developmental Immunology - August 20, 2014 Category: Allergy & Immunology Authors: Yang Y, Winger R, Lee PW, Nuro-Gyina PK, Minc A, Larson M, Liu Y, Pei W, Rieser E, Racke MK, Lovett-Racke AE Tags: Clin Exp Immunol Source Type: research

Impact of suppressing RORγt in ameliorating central nervous system autoimmunity
In this study, we characterized the correlation between RORγt expression and other factors affecting T cell encephalitogenicity and evaluated the therapeutic potential of targeting RORγt by siRNA inhibition of RORγt. Our data showed that RORγt expression correlates with IL‐17 production, but not with the encephalitogenicity of myelin‐specific CD4 T cells. IL‐23, a cytokine that enhances encephalitogenicity, does not enhance RORγt expression significantly. Additionally, GM‐CSF levels, which correlate with the encephalitogenicity of different myelin‐specific CD4 T cell populations, do not correlate with RORγt...
Source: Clinical and Experimental Immunology - August 20, 2014 Category: Allergy & Immunology Authors: Yuhong Yang, Ryan Winger, Priscilla W. Lee, Patrick K Nuro‐Gyina, Alexa Minc, Michelle Larson, Yue Liu, Wei Pei, Elizabeth Rieser, Michael K. Racke, Amy E. Lovett‐Racke Tags: Original Article Source Type: research

Programmed cell death 1 (PD-1) regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes.
Abstract Programmed cell death 1 (PD-1) is an inhibitory molecule expressed by activated T cells. Its ligands (PD-L1 and -L2; PD-Ls) are expressed not only by a variety of leukocytes but also by stromal cells. To assess the role of PD-1 in CD8 T cell-mediated diseases, we used PD-1-knockout (KO) OVA-specific T cell-receptor transgenic (Tg) CD8 T cells (OT-I cells) in a murine model of mucocutaneous graft-versus-host disease (GVHD). We found that mice expressing OVA on epidermal keratinocytes (K14-mOVA mice) developed markedly enhanced GVHD-like disease after transfer of PD-1-KO OT-I cells as compared to those mice...
Source: Journal of Autoimmunity - July 18, 2014 Category: Allergy & Immunology Authors: Okiyama N, Katz SI Tags: J Autoimmun Source Type: research