Diagnostic Utility of Interferon-Gamma Release Assay in Tuberculous Lymphadenitis
Publication date: December 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 4Author(s): Xinchao Liu, Susu Ye, Wenze Wang, Yueqiu Zhang, Lifan Zhang, Xiaocheng Pan, Ziyue Zhou, Miaoyan Zhang, Jianghao Liu, Zhiyong Liang, Xiaoqing LiuObjectiveThe aim of this study was to evaluate the diagnostic performance of T-SPOT.TB for tuberculous lymphadenitis.MethodsSuspected tuberculous lymphadenitis patients between September 2010 and September 2018 who had both peripheral blood T-SPOT.TB test and lymph node biopsy were retrospectively enrolled in this study. The cutoff value of T-SPOT.TB test for peripheral blood was s...
Source: Chinese Medical Sciences Journal - January 10, 2020 Category: General Medicine Source Type: research

Correlation between C-reactive Protein and Morphology of Aortic Intramural Hematoma on CT Angiography
ConclusionCRP was mildly correlated with the severity of cross-sectional hematoma area of IMH, but not with Stanford types and the presence of intimal disruption. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - January 10, 2020 Category: General Medicine Source Type: research

Expression of PD1 and BTLA on the CD8+ T Cell and γδT Cell Subsets in Peripheral Blood of Non-Small Cell Lung Cancer Patients
Publication date: December 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 4Author(s): Yi Bao, Juanfen Mo, Jiayuan Wu, Chenxi CaoObjectiveTo investigate the expression and regulation of programmed cell death protein 1 (PD1), B lymphocyte and T lymphocyte attenuator (BTLA) in peripheral blood of patients with non-small cell lung cancer (NSCLC); to examine the correlation of the mRNA levels between PD and BTLA in NSCLC.MethodsFlow cytometry was used to detect the expression of PD1 and BTLA on the surfaces of CD8+T cells and γδ+ T cells in the peripheral blood samples collected from 32 in-patients w...
Source: Chinese Medical Sciences Journal - January 10, 2020 Category: General Medicine Source Type: research

A Single-center Retrospective Cohort Study on Cesarean Section under General Anesthesia
Publication date: December 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 4Author(s): Xu Li, Biye Wu, Mingzhu Zhang, Le ShenObjectiveNeuraxial block is the most common anesthesia method for cesarean section (CS). However, for some urgent and high-risk cesarean delivery, general anesthesia (GA) also plays a very important role. We aimed to find out the reasons of choosing GA for CS in our center and the factors that may be related to the maternal and fetal outcomes.MethodsWe retrospectively selected parturients who had CS procedures under GA in Peking Union Medical College Hospital from January 1, 2014 to De...
Source: Chinese Medical Sciences Journal - January 10, 2020 Category: General Medicine Source Type: research

Physiological Variables Associated with the Development of Acute Mountain Sickness
ConclusionThe ability to sustain SpO2 after altitude elevation and the increase of neutrophils were associated with the development of AMS in young males. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - January 10, 2020 Category: General Medicine Source Type: research

Antagonistic Effects of N-acetylcysteine on Mitogen-activated Protein Kinase Pathway Activation, Oxidative Stress and Inflammatory Responses in Rats with PM2.5 Induced Lung Injuries
Publication date: December 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 4Author(s): Fen Ping, Qin Cao, Hua Lin, Shuzhi HanObjectiveTo evaluate the antagonistic effects of N-acetylcysteine (NAC) on mitogen-activated protein kinases (MAPK) pathway activation, oxidative stress and inflammatory responses in rats with lung injury induced by fine particulate matter (PM2.5).MethodsForty eight male Wistar rats were randomly divided into six groups: blank control group (C1), water drip control group (C2), PM2.5 exposed group (P), low-dose NAC treated and PM2.5 exposed group (L), middle-dose NAC treated and PM2.5 e...
Source: Chinese Medical Sciences Journal - January 10, 2020 Category: General Medicine Source Type: research

Ontology: Footstone for Strong Artificial Intelligence
Publication date: December 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 4Author(s): Xiaolin Yang, Zhe Wang, Hongjie Pan, Yan ZhuAbstractIn the past ten years, the application of artificial intelligence (AI) in biomedicine has increased rapidly, which roots in the rapid growth of biomedicine data, the improvement of computing performance, and the development of deep learning methods. At present, there are great difficulties in front of AI for solving complex and comprehensive medical problems. Ontology can play an important role in how to make machines have stronger intelligence and has wider applications ...
Source: Chinese Medical Sciences Journal - January 10, 2020 Category: General Medicine Source Type: research

An Optimized Protocol of Azoxymethane-Dextran Sodium Sulfate Induced Colorectal Tumor Model in Mice
Publication date: December 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 4Author(s): Xi Liang, Jingnan Hu, Jianming HeAbstractSince azoxymethane (AOM)-dextran sodium sulfate (DSS) induced tumorigenesis was used to explore inflammation-associated carcinogenesis of sporadic colorectal cancer (CRC), different administration modes of AOM or DSS have been reported. In this article we optimized the protocol of the AOM-DSS modeling using C57BL/6 mice for study on sporadic CRC by intraperitoneal injecting AOM solution at a proper concentration with a 100 μl sterile syringe once, feeding with DSS solution for 7 ...
Source: Chinese Medical Sciences Journal - January 10, 2020 Category: General Medicine Source Type: research

Anesthetic Considerations in a 98-year-old Man with Periprosthetic Femoral Shaft Fracture
Publication date: December 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 4Author(s): Si Chen, Lijian PeiAbstractA 98-year-old male patient with history of hemiarthroplasty suffered periprosthetic fracture of right femoral shaft and developed acute coronary event in three days after hospitalization. Femoral nerve and lateral femoral cutaneous nerve blocks combined with general anesthesia were implemented for the internal fixation surgery. The recovery was uneventful after discharge. In this case report, we discussed the main considerations of anesthesia specifically for this complicated case. (Source: Chine...
Source: Chinese Medical Sciences Journal - January 10, 2020 Category: General Medicine Source Type: research

Bevacizumab Combined with Icotinib Overcomes Osimertinib Resistance in a Patient of Non-Small Cell Lung Cancer
Publication date: December 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 4Author(s): Ling Zhang, Lei Sun, Xiaoyan Mu, Youxin JiAbstractA 61-year-old Chinese woman was diagnosed as primary pulmonary adenocarcinoma of left superior lobe with epidermal growth factor receptor (EGFR) 19 del mutation positive. Treatment with icotinib was given, but her disease progressed after 6 months remission. CT-guide needle biopsy for the new lesion in inferior lobe of left lung demonstrated intrapulmonary metastasis, and EGFR gene panel by Amplification Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR) confir...
Source: Chinese Medical Sciences Journal - January 10, 2020 Category: General Medicine Source Type: research

A Severe Case of Reye's Syndrome with Multiorgan Dysfunction after Epstein-Barr Virus Infection
Publication date: December 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 4Author(s): Bingnan Liu, Ying QiAbstractA 20-month-old male infant with multiorgan dysfunction after Epstein-Barr virus (EBV) infection developed Reye's syndrome. He also suffered from acute liver failure, life-threatening cerebral edema, severe disseminated intravascular coagulation (DIC), and myocardial involvement. EBV infection aggravated the progress of Reye's syndrome, leading to death despite full supportive and symptomatic therapy. This critical case suggested that pediatricians should pay attention to multiorgan involvement o...
Source: Chinese Medical Sciences Journal - January 10, 2020 Category: General Medicine Source Type: research

Regional Differences of the Urinary Proteomes in Healthy Chinese Individuals
In this study, we investigate whether significant differences are present in the urinary proteomes of individuals from different regions in China.MethodsIn this study, morning urine samples were collected from healthy urban residents in three regions of China (Haikou, Xi'an and Xining) and urinary proteins were preserved using a membrane-based method (Urimem). The urine proteomes of 27 normal samples were analyzed using LC-MS/MS and compared among three regions. Functional annotation of the differential proteins among the three areas was analyzed using the DAVID online database, and pathway enrichment of the differential u...
Source: Chinese Medical Sciences Journal - October 17, 2019 Category: General Medicine Source Type: research

Identification of CDK6 and RHOU in Serum Exosome as Biomarkers for the Invasiveness of Non-functioning Pituitary Adenoma
Publication date: September 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 3Author(s): Shan Yu, Xiaoshuang Wang, Kaican Cao, Xinjie Bao, Jia YuObjectiveTo explore circulating biomarkers for screening the invasiveness of non-functioning pituitary adenomas (NF-PAs).MethodsThe exosomal RNAs were extracted from serum of patients with invasive NF-PA (INF-PA) or noninvasive NF-PA (NNF-PA). Droplet digital PCR was adapted to detect the mRNA expression of candidate genes related to tumor progression or invasion, such as cyclin dependent kinase 6 (CDK6), ras homolog family member U (RHOU), and spire type actin nucle...
Source: Chinese Medical Sciences Journal - October 17, 2019 Category: General Medicine Source Type: research

Five-year Clinical Outcomes of CAD Patients Complicated with Diabetes after StentBoost-optimized Percutaneous Coronary Intervention
Publication date: September 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 3Author(s): Qiang Chen, Liwei Zhang, Dangsheng Huang, Chunhong Zhang, Qiushuang Wang, Dong Shen, Minjun Xiong, Feifei YangObjectiveTo evaluate the instant effects and five-year clinical outcomes of coronary artery disease patients complicated with diabetes mellitus after StentBoost-optimized percutaneous coronary intervention (PCI).MethodsFrom March 2009 to July 2010, 184 patients undergoing PCI at our hospital were found stent underexpansion or malapposition by StentBoost after stents implantation and were divided into the diabetic ...
Source: Chinese Medical Sciences Journal - October 17, 2019 Category: General Medicine Source Type: research

Downregulation of iASPP Expression Suppresses Proliferation, Invasion and Increases Chemosensitivity to Paclitaxel of Head and Neck Squamous Cell Carcinoma In Vitro
ConclusionThese results suggest iASPP may play an important role in progression and aggressive behavior of HNSCC and may be an efficient chemotherapeutic target for the treatment of HNSCC. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - October 17, 2019 Category: General Medicine Source Type: research

Value of CT-Angiography in the Emergency Management of Severe Hemoptysis
ConclusionsMDCTA provides useful information for identifying the anatomical characteristics of bleeding-related BAs and nonbronchial systemic arteries for the management of patients with severe hemoptysis. However, MDCTA could not determine the individuals who need BAE through measuring diameter of BAs. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - October 17, 2019 Category: General Medicine Source Type: research

IL-36β Promotes Inflammatory Activity and Inhibits Differentiation of Keratinocytes In Vitro
This study aimed to investigate the effects of interleukin-36β (IL-36β) on keratinocyte dysfunction in vitro.MethodsHuman keratinocyte cell lines, HaCaT cells, were treated with 0 (control), 50 or 100 ng/ml IL-36β respectively for 24 h. Cell viability was determined with a cell counting kit-8 assay. Flow cytometry was used to assess the effects of IL-36β on apoptosis and cell cycle distribution. Expressions of the differentiation markers, such as keratin 10 and involucrin, were evaluated by quantitative real-time polymerase chain reaction (RT-qPCR). Expressions of the inflammatory cytokines, IL-1β ...
Source: Chinese Medical Sciences Journal - October 17, 2019 Category: General Medicine Source Type: research

Association between GSTT1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis
ConclusionGSTT1 homozygous deletion individuals may have higher susceptibility to pancreatic cancer. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - October 17, 2019 Category: General Medicine Source Type: research

Research Progress on Diagnosis and Treatment of Chronic Osteomyelitis
Publication date: September 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 3Author(s): Ziquan Wu, Delu Zeng, Jiangling Yao, Yangyang Bian, Yuntao Gu, Zhulong Meng, Jian Fu, Lei PengAbstractWe review the representatives literatures on chronic osteomyelitis, sum up the new insights in recent years into diagnostic options and treatment regimens, analyze the advantages and disadvantages of various diagnostic approaches and treatment strategies, and propose areas of interest to make current diagnostic and treatment strategies more specific. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - October 17, 2019 Category: General Medicine Source Type: research

Transvaginal Reduction of a Heterotopic Cornual Pregnancy with Conservation of Intrauterine Pregnancy
Publication date: September 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 3Author(s): Yingya Li, Liyan Duan, Fengli Chi, Kunming LiAbstractHere we report a case of heterotopic cornual pregnancy after in vitro fertilization who was diagnosed at 6 weeks after frozen embryos transfer. The heterotopic pregnancy was successfully terminated by transvaginal ultrasound-guided selective fetal reduction. At 38+1 weeks, she underwent a cesarean section and delivered a healthy 3300 g male infant with Apgar score of 10-10' evaluated at 1 min and 5 min. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - October 17, 2019 Category: General Medicine Source Type: research

Management of an Adult with Goodpasture's Syndrome Following Brain Trauma with Extracorporeal Membrane Oxygenation: A Case Report
Publication date: September 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 3Author(s): Shan Wang, Haiyan Yin, Youfeng Zhu, Pei Tao, Rui Zhang, Yonghui Ma, Jianrui WeiAbstractA 22-year-old man suffered from acute pulmonary hemorrhage and deteriorated renal function occurred within 3 days after traumatic brain injury. Mechanical ventilation cannot correct his severe hypoxemia, therefore, venoarterial extracorporeal membrane oxygenation (VA-ECMO) support was initiated and finally resolved his hypoxemia. Concomitantly, continuous renal replacement therapy was performed to improve his kidney function. Although n...
Source: Chinese Medical Sciences Journal - October 17, 2019 Category: General Medicine Source Type: research

The Next Era: Flourish of National Health Care & Medicine with the World Leading Artificial Intelligence
Publication date: June 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 2Author(s): Jian WuProf. Jian Wu graduated from Zhejiang University (ZJU) and obtained his Ph.D. degree at the College of Computer Science and Technology, ZJU. He is currently the vice president of National Academy of Health and Medical Big Data at ZJU, the director of the Real-doctor Artificial Intelligence (AI) Research Center of ZJU, and is also serving as members of China Computer Federation (CCF)'s Committee for Elite Young Professionals, and the Ministry of science and technology's key field innovation team. Prof. Wu's research focu...
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

The Artificial Intelligence-Enabled Medical Imaging: Today and Its Future
Publication date: June 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 2Author(s): Yinghuan Shi, Qian WangAbstractMedical imaging is now being reshaped by artificial intelligence (AI) and progressing rapidly toward future. In this article, we review the recent progress of AI-enabled medical imaging. Firstly, we briefly review the background about AI in its way of evolution. Then, we discuss the recent successes of AI in different medical imaging tasks, especially in image segmentation, registration, detection and recognition. Also, we illustrate several representative applications of AI-enabled medical imagi...
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

Artificial Intelligence in Healthcare and Medicine: Promises, Ethical Challenges and Governance
Publication date: June 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 2Author(s): Jian GuanAbstractArtificial intelligence (AI) is rapidly being applied to a wide range of fields, including medicine, and has been considered as an approach that may augment or substitute human professionals in primary healthcare. However, AI also raises several challenges and ethical concerns. In this article, the author investigates and discusses three aspects of AI in medicine and healthcare: the application and promises of AI, special ethical concerns pertaining to AI in some frontier fields, and suggestive ethical governa...
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

Collaborations of Industry, Academia, Research and Application Improve the Healthy Development of Medical Imaging Artificial Intelligence Industry in China
This article introduces the current status of collaboration, the clinical demands for medical imaging AI technique, and the key points in AI technology transformation: robustness, usability and security. We are facing challenges of lacking industry standards, data desensitization standard, assessment system, as well as corresponding regulations and policies to realize the application values of AI products in medical imaging. Further development of AI in medical imaging requires breakthroughs of the core algorithm, deep involvement of doctors, input from capitals, patience from societies, and most importantly, the resolutio...
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

Releasing of The White Paper on Medical Imaging Artificial Intelligence in China
Publication date: June 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 2Author(s): Chinese Innovative Alliance of Industry, Education, Research and Application of Artificial Intelligence for Medical Imaging (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

Constructing Large Scale Cohort for Clinical Study on Heart Failure with Electronic Health Record in Regional Healthcare Platform: Challenges and Strategies in Data Reuse
Publication date: June 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 2Author(s): Daowen Liu, Liqi Lei, Tong Ruan, Ping HeAbstractRegional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management. It is a common requirement to reuse the data for clinical research. However, we have to face challenges like the inconsistence of terminology in electronic health records (EHR) and the complexities in data quality and data formats in regional healthcare platform. In this paper, we propose methodology and process on constructing large scale cohorts which f...
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

Application of Mixed Reality Technology in Visualization of Medical Operations
Publication date: June 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 2Author(s): Yuan Gao, Ke Tan, Jian Sun, Tao Jiang, Xiaowen ZouAbstractWith the continuous progress of virtual simulation technology, medical surgery visualization system has been developed from two-dimensional to three-dimensional, from digital to network and intelligentization. The visualization system with mixed reality technology will also be used in all stage of medical surgery, such as case discussion, surgical planning, intraoperative guidance, post-operative evaluation, rehabilitation, so as to further promote high intelligence, hi...
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

Multi-Atlas Based Methods in Brain MR Image Segmentation
Publication date: June 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 2Author(s): Liang Sun, Li Zhang, Daoqiang ZhangAbstractBrain region-of-interesting (ROI) segmentation is an important prerequisite step for many computer-aid brain disease analyses. However, the human brain has the complicated anatomical structure. Meanwhile, the brain MR images often suffer from the low intensity contrast around the boundary of ROIs, large inter-subject variance and large inner-subject variance. To address these issues, many multi-atlas based segmentation methods are proposed for brain ROI segmentation in the last decade...
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

A Survey on Intelligent Screening for Diabetic Retinopathy
Publication date: June 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 2Author(s): Yulan Dai, Chengzhang Zhu, Xi Shan, Zhenzhen Cheng, Beiji ZouAbstractDiabetic retinopathy (DR) is one of the leading causes of vision loss and can be effectively avoided by screening, early diagnosis and treatment. In order to increase the universality and efficiency of DR screening, many efforts have been invested in developing intelligent screening, and there have been great advances. In this paper, we survey DR screening from four perspectives: 1) public color fundus image datasets of DR; 2) DR classification and related le...
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

Medical Knowledge Extraction and Analysis from Electronic Medical Records Using Deep Learning
ConclusionThis study proved the good performance of deep learning on medical knowledge extraction. It also verified the feasibility of the BiLSTM-CRF model in different application scenarios, laying the foundation for the subsequent work in the EMR field. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

A Survey of Surgical Patient's Perception about Anesthesiologist in a Large Scale Comprehensive Hospital in China
This study aim to evaluate patient's perception about anesthesiologists' job roles and investigate their expectations for anesthesia care.MethodsWe designed a self-administered questionnaire for this cross-sectional survey study and delivered questionnaire forms to adult in-patients who were scheduled for elective surgery before pre-operative anesthetic visit the day before surgery. We collected information of respondents' demographic data, education background, health literacy and previous experience of anesthesia, perception of anesthesiologist's job, the expectation on anesthesia care. Descriptive analyses, χ2 test ...
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

Integrative Analysis Confirmed the Association between Osteoprotegerin and Osteoporosis
This study aimed to verify the association between osteoprotegerin gene (OPG) and its variants with osteoporosis (OP) by performing integrative analysis.MethodsWe used the KGG software to perform gene-based association analysis, which integrated all publicly available single-nucleotide polymorphism (SNP)-based P values and obtained an overall P value for the OPG. The significant SNPs were screened for expression quantitative trait loci (eQTLs). Meta-analysis was used to combine the associations between the variants of OPG and bone mineral density (BMD) reported in the literatures. Then we performed dual-luciferase reporter...
Source: Chinese Medical Sciences Journal - July 16, 2019 Category: General Medicine Source Type: research

Hospice and Palliative Care in Mainland China: History, Current Status and Challenges
This article gives an overview of the progress and the current status in multiple aspects of hospice and palliative care in mainland China, and points out the barriers and challenges for its further development in the future. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - January 18, 2019 Category: General Medicine Source Type: research

Value-based Practice: Integration of Cancer Rehabilitation and Palliative Care in Oncology Services
Publication date: December 2018Source: Chinese Medical Sciences Journal, Volume 33, Issue 4Author(s): Yi ZhuAbstractValue-based care model has been evolving to organize medical services around the patient and provide the full cycle of care for a medical condition. The full cycle of care model encompasses inpatient, outpatient, rehabilitation as well as supportive care such as palliative care and nutrition support. Cancer rehabilitation and palliative care have emerged as two important parts of value-based practice for oncology patients. More clinical evidence suggests that early intervention of oncology rehabilitation prog...
Source: Chinese Medical Sciences Journal - January 18, 2019 Category: General Medicine Source Type: research

Implement the Palliative Care in Medical Practice of a Tertiary Comprehensive Hospital in China
This article gives an overview of it, and the experiences in team building, promotion, support seaking and fund raising were also discussed in this article. We hope to explore an effective dilivering model of palliative care for end-stage patients that is adaptive to Chinese culture and social environment. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - January 18, 2019 Category: General Medicine Source Type: research

Running a Volunteer Program for Palliative Care in a Chinese Hospital: Our Practice and Experience
This article introduces the process of the establishment and development of palliative care volunteer team in PUMCH, aiming to provide practical references for hospitals in mainland China to develop their own palliative care volunteer team. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - January 18, 2019 Category: General Medicine Source Type: research

Recognition of Palliative Care in Chinese Clinicians: How They Feel and What They Know
Publication date: December 2018Source: Chinese Medical Sciences Journal, Volume 33, Issue 4Author(s): Yirong Xiang, Xiaohong NingObjectiveTo investigate doctors’ feelings when providing medical care to end-stage patients, and their understanding as well as reflection about theoretical concepts of palliative medicine.MethodsQuestionnaires were delivered through a social networking platform to 1500 clinicians of different specialties in 10 proviences of China. It covered issues of background information, self-assessment of familiarity to palliative care, prior training history, emotional attitude toward end-stage patie...
Source: Chinese Medical Sciences Journal - January 18, 2019 Category: General Medicine Source Type: research

Physicians' Perception of Palliative Care Consultation Service in a Major General Hospital in China
ConclusionPalliative care consultation service in a general hospital is efficacious and acclaimed. The primary care physicians and the PCC members hold positive attitudes to the benefits that the PCC services bring to patients, family members, and physicians themselves. PCC for terminal patients in a general hospital may serve as a good modle for promotion of palliative care in China. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - January 18, 2019 Category: General Medicine Source Type: research

Individualized Aromatherapy in End-of-Life Cancer Patients Care: A Case Report
Publication date: December 2018Source: Chinese Medical Sciences Journal, Volume 33, Issue 4Author(s): Qian Liu, Xiaohong Ning, Lei Wang, Wei LiuAbstractAs one of the methods of palliative care, aromatherapy has been applied gradually in clinical nursing work in China in recent years. Through aromatherapy, terminal cancer patients can get not only relieves of physical symptoms, but also spiritual relaxation and peace, thus have improved quality of life at the end stage. In this paper, we report in detail about how aromatherapy was applied for symptom control in a cancer patient with unknown primary malignancy and multiple m...
Source: Chinese Medical Sciences Journal - January 18, 2019 Category: General Medicine Source Type: research

Current Technologies of Synthetic Biosensors for Disease Detection: Design, Classification and Future Perspectives
Publication date: December 2018Source: Chinese Medical Sciences Journal, Volume 33, Issue 4Author(s): Xue Chen, Yi Lv, Rongqian WuAbstractSynthetic biology aims to endow living cells with new functions by incorporating functional gene networks into them. By overexpressing, blocking and rewiring native gene pathways, synthetic biologists have harnessed this promising technology to reprogram cells to perform diverse tasks such as drug discovery, biopharmaceutical manufacturing, gene therapy and tissue engineering, etc. In this review, we focus on current technologies of synthetic biosensors for disease detection. We start wi...
Source: Chinese Medical Sciences Journal - January 18, 2019 Category: General Medicine Source Type: research

Longitudinal Measurement of Hemodynamic Changes within the Posterior Optic Nerve Head in Rodent Nonarteritic Anterior Ischemic Optic Neuropathy
Publication date: December 2018Source: Chinese Medical Sciences Journal, Volume 33, Issue 4Author(s): Jin Ma, Ting Chen, Yiwei Wang, Chan Zhao, Donghui Li, Meng Wang, Linyang Gan, Yong ZhongObjectiveTo assess the in vivo dynamic blood flow features of posterior optic nerve head (ONH) in rat model of nonarteritic anterior ischemic optic neuropathy (rNAION).MethodsrNAION was established with Rose Bengal and argon green laser in Sprague-Dawley rats. Fundus photography and fundus fluorescein angiography (FFA) were performed to assess the dynamic changes of optic disc in morphology in 90 days and in blood perfusion in 3 hours a...
Source: Chinese Medical Sciences Journal - January 18, 2019 Category: General Medicine Source Type: research

Combined Effects of Chronic Obstructive Pulmonary Disease and Depression on Spatial Memory in Old Rats
ConclusionsCOPD in comorbidity of depression could induce spatial memory deficit in old rats. The mechanisms might be related to the overloaded and free radical metabolic imbalance. These results suggest a potential therapeutic target for comorbidity of COPD and depression in geriatric patients. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - January 18, 2019 Category: General Medicine Source Type: research

An Early Pregnant Chinese Woman with Cerebral Venous Sinus Thrombosis Succeeding in Induction of Labor in the Second Trimester
Publication date: December 2018Source: Chinese Medical Sciences Journal, Volume 33, Issue 4Author(s): Xuefang Zhang, Zhenyu Zhang, Nan LiAbstractCerebral venous sinus thrombosis (CVST) is a rare condition in early pregnancy. A 22-year-old Chinese woman at 10 weeks of pregnancy requested induced abortion and was diagnosed as CVST for a severe headache accompanying with nausea and vomiting. The patient was treated successfully with anticoagulation, followed by amniocentesis, and finally succeeded in induction of labor safely. The diagnosis, treatment and prognosis for this rare condition are discussed in this paper. (Source:...
Source: Chinese Medical Sciences Journal - January 18, 2019 Category: General Medicine Source Type: research

Resuscitation of Septic Patients with Target-and-endpoint Protocol: A Retrospective Study from a Chinese Tertiary Hospital ICU
Publication date: September 2018Source: Chinese Medical Sciences Journal, Volume 33, Issue 3Author(s): Hongmin Zhang, Xiaoting Wang, Qing Zhang, Dawei LiuObjectiveTo investigate the effect of target-and-endpoint protocol on the resuscitation of septic patients.MethodsThis is a retrospective study performed at the Peking Union Medical College Hospital Intensive Care Unit. We enrolled 545 septic patients who needed vasopressors on at least the first day of ICU admission. The general characteristics, blood lactate level, mean arterial pressure (MAP), central venous pressure (CVP) and saturation of central venous oxygen (ScvO2...
Source: Chinese Medical Sciences Journal - October 10, 2018 Category: General Medicine Source Type: research

RNA-binding Protein UNR Promotes Glioma Cell Migration and Regulates the Expression of Ribosomal Protein L9
Publication date: September 2018Source: Chinese Medical Sciences Journal, Volume 33, Issue 3Author(s): Ningyu Tian, Yingjiao Qi, Yan Hu, Bin Yin, Jiangang Yuan, Boqin Qiang, Xiaozhong Peng, Wei HanObjectiveTo investigate the role of RNA binding protein—upstream-of-N-Ras (UNR) in the development of glioma and its molecular mechanism.MethodsFirst, bioinformatics analysis of CGGA database was performed to detect UNR expression level and prognosis of patients with glioma. Western blot and real-time PCR were used to detect UNR expression level in glioma cell lines and tissues. Next, UNR siRNAs were transfected in glioma c...
Source: Chinese Medical Sciences Journal - October 10, 2018 Category: General Medicine Source Type: research

Urinary Myeloperoxidase to Creatinine Ratio as a New Marker for Diagnosis of Urinary Tract Infection
ConclusionsMCR is positively correlated with WBC counts and could be served as a promising biomarker for diagnosis of UTI. MCR could be even used for initial inference of infectious bacteria types of UTI. (Source: Chinese Medical Sciences Journal)
Source: Chinese Medical Sciences Journal - October 10, 2018 Category: General Medicine Source Type: research

Clinical, Laboratory and Imaging Features of High Altitude Pulmonary Edema in Tibetan Plateau
Publication date: September 2018Source: Chinese Medical Sciences Journal, Volume 33, Issue 3Author(s): Zongbin Li, Hongyan Chen, Jiayue Li, Gaoyuan Li, Chunwei Liu, Yundai ChenObjectiveTo analyze characteristics of high altitude pulmonary edema (HAPE) in Chinese patients.MethodsWe performed a retrospective study of 98 patients with HAPE. We reviewed the medical records and summarized the clinical, laboratory and imaging characteristics of these cases, and compared the results on admission with those determined before discharge.ResultsForty-eight (49.0%) patients developed HAPE at the altitude of 2800 m to 3000 m. Ninty-fiv...
Source: Chinese Medical Sciences Journal - October 10, 2018 Category: General Medicine Source Type: research

Comparison of β-Amyloid Plaque Labeling Methods: Antibody Staining, Gallyas Silver Staining, and Thioflavin-S Staining
Publication date: September 2018Source: Chinese Medical Sciences Journal, Volume 33, Issue 3Author(s): Xinze Shi, Xuan Wei, Longze Sha, Qi XuObjectiveTo evaluate senile plaque formation and compare the sensitivity of three different β-amyloid (Aβ) labeling methods (antibody staining, Gallyas silver staining, and thioflavin-S staining) to detect Aβ deposition.MethodsAPPswe/PSEN1dE9 transgenic mice (APP/PS1) of different ages were used to examine spatiotemporal changes in Aβ plaque deposition. Antibody staining, Gallyas silver staining, and thioflavin-S staining were used to detect Aβ plaque depositi...
Source: Chinese Medical Sciences Journal - October 10, 2018 Category: General Medicine Source Type: research

Landscape of PD-1/PD-L1 Regulation and Targeted Immunotherapy
Publication date: September 2018Source: Chinese Medical Sciences Journal, Volume 33, Issue 3Author(s): Jieming Ni, Anping NiAbstractProgrammed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) is a significant immune checkpoint, and the dysfunction of this axis contributes to tumor metastasis and immune escape. PI3K/Akt/mTOR and MAPK signal network induces PD-1/PD-L1 expression and facilitates tumor progression. Transcriptional factors such as hypoxia induced factors, PTEN, p53, CDK5, BRD4, STAT modulate PD-1/PDL1 expression. PD-1/PD-L1 level is also regulated via epigenetic and post-translational manner. The u...
Source: Chinese Medical Sciences Journal - October 10, 2018 Category: General Medicine Source Type: research