GSE103273 RNA-Seq of lymphoblastoid cell line (GM12878) upon siRNA mediated knockdown of Aiolos transcription factor.

Contributors : Christopher A Odhams ; Andrea Cortini ; Timothy J Vyse ; Deborah S Cunninghame GrahamSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe Ikaros family transcription factors Helios (IKZF2) and Aiolos (IKZF3), critical to lymphocyte homeostasis, are genetically associated with multiple immunological disorders including the prototypic autoimmune disease SLE. Given the lack of understanding between the association of Aiolos and its physiological function in humans, we determined their gene-regulatory pathways by RNA-Seq in the B-lymphocyte cell-line GM12878.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research