Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling.

In conclusion, USP4 was significantly elevated in autoimmune hepatitis mice and Vialinin A reduced USP4 level and attenuate inflammation and fibrosis in the liver. The mechanism may be related to regulation of Rheb/mTOR signalling. PMID: 33295107 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33295107?dopt=Abstract

Source: J Cell Mol Med - December 9, 2020 Category: Molecular Biology Authors: Xu J, Chen D, Jin L, Chen Z, Tu Y, Huang X, Xue F, Xu J, Chen M, Wang X, Chen Y Tags: J Cell Mol Med Source Type: research