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Condition: Cardiomyopathy

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Total 155 results found since Jan 2013.

Sulfiredoxin involved in the protection of peroxiredoxins against hyperoxidation in the early hyperglycaemia.
Abstract As a direct consequence of hyperglycaemia, the excessive generation of ROS is central to the pathogenesis of diabetic cardiomyopathy. We hypothesize that stimulation of high glucose (HG) results in an increased sulfiredoxin (Srx) expression, which regulates ROS signaling through reducing the hyperoxidized peroxiredoxins (Prxs). We show that hyperoxidized Prxs were initially reduced in the preliminary stage but then dramatically increased in advanced stage and these changes corresponded to a significant increase of Srx expression in the heart of diabetic rats. These time-dependent changes were also confirm...
Source: Experimental Cell Research - February 11, 2017 Category: Cytology Authors: Shi S, Guo Y, Lou Y, Li Q, Cai X, Zhong X, Li H Tags: Exp Cell Res Source Type: research

Exogenous H2S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
CONCLUSION: Hyperglycemia stimulated ER interactions and mitochondrial apoptotic pathways, which were inhibited by exogenous H2S treatment through the regulation of Mfn-2 expression. PMID: 27998959 [PubMed - as supplied by publisher]
Source: Am J Physiol Endocri... - December 19, 2016 Category: Endocrinology Authors: Yang F, Yu X, Li T, Wu J, Zhao Y, Sun A, Dong S, Wu J, Zhong X, Xu C, Lu F, Zhang W Tags: Am J Physiol Endocrinol Metab Source Type: research

High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature
Conclusion Our results highlight EC-to-cardiomyocyte transfer of heparanase to modulate the cardiomyocyte cell death signature. This mechanism was observed in the acutely diabetic heart, and its interruption following chronic diabetes may contribute towards the development of diabetic cardiomyopathy.
Source: Cardiovascular Research - December 14, 2016 Category: Cardiology Authors: Wang, F., Jia, J., Lal, N., Zhang, D., Chiu, A. P.-L., Wan, A., Vlodavsky, I., Hussein, B., Rodrigues, B. Tags: Cardiac biology and remodelling Source Type: research

Atorvastatin Alleviates Experimental Diabetic Cardiomyopathy by Regulating the GSK-3 β-PP2Ac-NF-κB Signaling Axis
by Xiao-min Ren, Guang-feng Zuo, Wen Wu, Jie Luo, Peng Ye, Shao-liang Chen, Zuo-ying Hu Recent studies reported that atorvastatin (ATOR) alleviated progression of experimental diabetic cardiomyopathy (DCM), possibly by protecting against apoptosis. However, the underlying mechanisms of this protective effect remain unclear. Therefore, our study investigated the role of the glycogen s ynthase kinase (GSK)-3β-protein phosphatase 2A(PP2A)-NF-κB signaling pathway in the anti-apoptotic and cardioprotective effects of ATOR on cardiomyocytes cultured in high glucose (HG) and in DCM. Our results showed that, in HG-cultured card...
Source: PLoS One - November 15, 2016 Category: Biomedical Science Authors: Xiao-min Ren Source Type: research

Nrf2 Activation as a Protective Feedback to Limit Cell Death in High Glucose ‐Exposed Cardiomyocytes
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - November 8, 2016 Category: Biochemistry Authors: Cheng ‐Yen Tsai, Su‐Ying Wen, Shi‐Yann Cheng, Chung‐Hsing Wang, Yao‐Chih Yang, Chih‐Yang Huang, Wei‐Wen Kuo Tags: Article Source Type: research

Endothelin-1-Induced Cell Hypertrophy in Cardiomyocytes is Improved by Fenofibrate: Possible Roles of Adiponectin.
CONCLUSIONS: Our study shows that fenofibrate may protect against ET-1-induced cardiomyocyte hypertrophy and enhanced adiponectin expression through modulation of PPARα expression in vitro and limitation of daunorubicin cardiotoxicity in vivo, suggesting a novel mechanistic insight into the role of PPARα and adiponectin in cardiac hypertrophy and heart failure. PMID: 27629528 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - September 19, 2016 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

MiR-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats By Up-Regulating Mitochondrial Translation.
CONCLUSIONS: -Our findings reveal a positive function of miR-21 in mitochondrial translation, which is sufficient to reduce blood pressure and alleviate cardiac hypertrophy in SHRs. This observation indicates that induced miR-21 is part of the compensatory program and suggests a novel theoretical ground for developing miRNA-based therapeutics against hypertension. PMID: 27542393 [PubMed - as supplied by publisher]
Source: Circulation - August 18, 2016 Category: Cardiology Authors: Li H, Zhang X, Wang F, Zhou L, Yin Z, Fan J, Nie X, Wang P, Fu XD, Chen C, Wang D Tags: Circulation Source Type: research

Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - July 7, 2016 Category: Cytology Authors: Farzaneh G. Tahrir, Tijana Knezevic, Manish K. Gupta, Jennifer Gordon, Joseph Y. Cheung, Arthur M. Feldman, Kamel Khalili Tags: Original Research Article Source Type: research

Lin28a Protects against Diabetic cardiomyopathy via the PKA/ROCK2 pathway.
CONCLUSIONS: Lin28a protects against DCM through PKA/ROCK2 dependent pathway. Lin28a might serve as a potential therapeutic target for the treatment of the patients with DCM. PMID: 26626075 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - November 25, 2015 Category: Biochemistry Authors: Sun S, Zhang M, Lin J, Hu J, Zhang R, Li C, Wei T, Sun D, Wei J, Wang H Tags: Biochem Biophys Res Commun Source Type: research

Aralia taibaiensis Protects Cardiac Myocytes against High Glucose-Induced Oxidative Stress and Apoptosis.
Abstract Patients with type 2 diabetes have increased cardiovascular disease risk compared with those without diabetes. Hyperglycemia can induce reactive oxygen species (ROS) generation, which contributes to the development of diabetic cardiomyopathy. Our previous study has demonstrated that the total saponins of Aralia taibaiensis (sAT), a frequently-used antidiabetic medicine in traditional Chinese medicine (TCM), can scavenge free radicals in vitro and have good anti-oxidant ability on lipid peroxidation of rat liver microsomes. This work was designed to investigate whether sAT could protect the heart while it ...
Source: The American Journal of Chinese Medicine - October 11, 2015 Category: Complementary Medicine Authors: Duan J, Wei G, Guo C, Cui J, Yan J, Yin Y, Guan Y, Weng Y, Zhu Y, Wu X, Wang Y, Xi M, Wen A Tags: Am J Chin Med Source Type: research

Corin is down-regulated and exerts cardioprotective action via activating pro-atrial natriuretic peptide pathway in diabetic cardiomyopathy
Conclusions: Our results indicate that corin plays an important role in cardioprotection by activating pro-atrial natriuretic peptide pathway in DCM. Corin deficiency leads to endothelial dysfunction and vascular remodeling.
Source: Cardiovascular Diabetology - October 7, 2015 Category: Cardiology Authors: Aiming PangYahui HuPengfei ZhouGuangfeng LongXin TianLi MenYanna ShenYunde LiuYujie Cui Source Type: research

Circulating interleukin-1β promotes endoplasmic reticulum stress-induced myocytes apoptosis in diabetic cardiomyopathy via interleukin-1 receptor-associated kinase-2
Conclusions: Elevated circulating IL-1β contributed to promote ER stress- induced myocytes apoptosis by affecting IRAK-2/CHOP pathway in DCM.
Source: Cardiovascular Diabetology - September 23, 2015 Category: Cardiology Authors: Zhongwei LiuNa ZhaoHuolan ZhuShunming ZhuShuo PanJing XuXuejun ZhangYong ZhangJunkui Wang Source Type: research

Cardiomyocyte A Disintegrin And Metalloproteinase 17 (ADAM17) Is Essential in Post-Myocardial Infarction Repair by Regulating Angiogenesis Original Articles
Conclusions— This study highlights the key role of cardiomyocyte ADAM17 in post-MI recovery by regulating VEGFR2 transcription and angiogenesis, thereby limiting left ventricular dilation and dysfunction. Therefore, ADAM17 upregulation, within the physiological range, could provide protective effects in ischemic cardiomyopathy.
Source: Circulation: Heart Failure - September 15, 2015 Category: Cardiology Authors: Fan, D., Takawale, A., Shen, M., Wang, W., Wang, X., Basu, R., Oudit, G. Y., Kassiri, Z. Tags: Other heart failure, Angiogenesis, Cell signalling/signal transduction, Gene expression, Acute myocardial infarction Original Articles Source Type: research

Exogenous Hydrogen Sulfide Attenuates Cardiac Fibrosis Through Reactive Oxygen Species Signal Pathways in Experimental Diabetes Mellitus Models
Conclusion: The present study shows that enhanced NOX4 expression results in cardiac fibrosis through ROS-ERK1/2-MAPkinase-dependent mechanisms in diabetic cardiomyopathy. NOX4 could be an important target for H2S to regulate redox homeostasis in cardiac fibrosis of diabetic cardiomyopathy.Cell Physiol Biochem 2015;36:917-929
Source: Cellular Physiology and Biochemistry - June 16, 2015 Category: Cytology Source Type: research

Adiponectin Ameliorates Hyperglycemia-Induced Cardiac Hypertrophy and Dysfunction by Concomitantly Activating Nrf2 and Brg1.
Abstract Hyperglycemia-induced oxidative stress is implicated in the development of cardiomyopathy in diabetes that is associated with reduced adiponectin (APN) and heme oxygenase-1(HO-1). Brahma-related gene 1 (Brg1) assists nuclear factor-erythroid-2-related factor-2 (Nrf2) to activate HO-1 to increase myocardial antioxidant capacity in response to oxidative stress. We hypothesized that reduced adiponectin (APN) impairs HO-1 induction which contributes to the development of diabetic cardiomyopathy, and that supplementation of APN may ameliorate diabetic cardiomyopathy by activating HO-1 through Nrf2 and Brg1 in ...
Source: Free Radical Biology and Medicine - March 17, 2015 Category: Biology Authors: Li H, Yao W, Irwin MG, Wang T, Wang S, Zhang L, Xia Z Tags: Free Radic Biol Med Source Type: research