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Condition: Cardiomyopathy

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Total 155 results found since Jan 2013.

Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPK α/TGF-β/Smad signalling in type 2 diabetic rats
This study aimed to evaluate the effect of SGLT2 inhibitor dapagliflozin (DAPA) on DCM especially for cardiac fibrosis and explore the underlying mechanism. In vivo, the model of type 2 diabetic rats was built with high-fat feeding and streptozotocin injection. Untreated diabetic rats showed cardiac dysfunction, increased myocardial fibrosis and EndMT, which was attenuated after treatment with DAPA and metformin. In vitro, HUVECs and primary cardiac fibroblasts were treated with DAPA and exposed to high glucose (HG). HG-induced EndMT in HUVECs and collagen secretion of fibroblasts were markedly inhibited by DAPA. Up-regula...
Source: Molecular Medicine - June 25, 2021 Category: Molecular Biology Authors: Jingjing Tian Mingjun Zhang Mengying Suo Dian Liu Xuyang Wang Ming Liu Jinyu Pan Tao Jin Fengshuang An Source Type: research

The Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy
Conclusions: Together, these findings suggest that the UPR exerts a protective effect in the setting of PLN R14del cardiomyopathy and that modulation of the UPR might be exploited therapeutically.PMID:33928785 | DOI:10.1161/CIRCULATIONAHA.120.049844
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Dries A M Feyen Isaac Perea-Gil Renee G C Maas Magdalena Harakalova Alexandra A Gavidia Jennifer Arthur Ataam Ting-Hsuan Wu Aryan Vink Jiayi Pei Nirmal Vadgama Albert J Suurmeijer Wouter P Te Rijdt Michelle Vu Prashila L Amatya Maricela Prado Yuan Zhang L Source Type: research

A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis
Conclusions: The present findings uncovered a novel pro-EndMT mechanism during the pathogenesis of diabetic cardiac fibrosis via the upregulation of KLK8, and may contribute to the development of future KLK8-based therapeutic strategies for diabetic cardiomyopathy.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Jian-Kui Du, Qing Yu, Yu-Jian Liu, Shu-Fang Du, Li-Yang Huang, Dan-Hong Xu, Xin Ni, Xiao-Yan Zhu Tags: Research Paper Source Type: research

Thyroid hormone plus dual-specificity phosphatase-5 siRNA increases the number of cardiac muscle cells and improves left ventricular contractile function in chronic doxorubicin-injured hearts
Conclusion: RNA therapies are showing great potential. Importantly, a GMP compliant in vivo-jetPEI system for delivery of siRNA is already in use in humans, as is T3. Given these considerations, our findings provide a potentially highly translatable strategy for addressing doxorubicin cardiomyopathy, a currently untreatable condition.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Lin Tan, Nikolay Bogush, Emmen Naqvi, John W. Calvert, Robert M. Graham, W. Robert Taylor, Nawazish Naqvi, Ahsan Husain Tags: Research Paper Source Type: research

Targeting transthyretin ‐ Mechanism‐based treatment approaches and future perspectives in hereditary amyloidosis
Transthyretin (TTR) is a tetrameric transport protein that causes amyloid formation if destabilized. ATTR ‐amyloidosis is a progressive systemic disease with polyneuropathy and cardiomyopathy as the most abundant manifestations. Approved treatment approaches comprise sequence‐specific mRNA degradation and tetramer stabilization. Ongoing clinical trials assess the potential of GalNAc formulations to improve the administration of small interfering RNA and antisense oligonucleotides. A future TTR‐stabilizer with the potential to cross the blood‐brain barrier is tolcapone. Amyloid‐directed antibodies aim at reducing ...
Source: Journal of Neurochemistry - April 2, 2021 Category: Neuroscience Authors: Maike F. Dohrn, Sandra Ihne, Ute Hegenbart, Jessica Medina, Stephan L. Z üchner, Teresa Coelho, Katrin Hahn Tags: Review Article Source Type: research

miR-106a –363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury
AbstractEndogenous capability of the post-mitotic human heart holds great promise to restore the injured myocardium. Recent evidence indicates that the extracellular vesicles (EVs) regulate cardiac homeostasis and regeneration. Here, we investigated the molecular mechanism of EVs for self-repair. We isolated EVs from human iPSC-derived cardiomyocytes (iCMs), which were exposed to hypoxic (hEVs) and normoxic conditions (nEVs), and examined their roles in in vitro and in vivo models of cardiac injury. hEV treatment significantly improved the viability of hypoxic iCMs in vitro and cardiac function of severely injured murine m...
Source: Basic Research in Cardiology - March 19, 2021 Category: Cardiology Source Type: research

Berberine improves dietary-induced cardiac remodeling by upregulating Kruppel-like factor 4-dependent mitochondrial function.
Authors: Ding L, Li S, Wang F, Xu J, Li S, Wang B, Kou J, Wang Y, Cao W Abstract Multiple studies have showed that berberine protects against heart diseases, including obesityassociated cardiomyopathy. However, it is not fully disclosed the potential molecular mechanisms of berberine on controlling cardiac remodelling. Kruppel-like factor (KLF) 4, identified as a critical transcriptional factor, participates in multiple cardiac injuries. The present study was to explore whether KLF4 determined the cardioprotective benefits of berberine in dietary-induced obese mice. High fat diet-induced obese mice were treated wit...
Source: Biological Chemistry - February 7, 2021 Category: Chemistry Tags: Biol Chem Source Type: research

Schisandrin B Protects against Acute Ethanol-Induced Cardiac Injury by Downregulating Autophagy via the NOX4/ROS Pathway
Conclusion: These results highlight that NOX4 is a critical mediator of ROS and elaborate the role of the NOX4/ROS axis in the effect of schisandrin B on autophagy and autophagy-mediated apoptosis in acute ethanol exposure, which suggests a therapeutic strategy for acute alcoholic cardiomyopathy.Pharmacology
Source: Pharmacology - January 22, 2021 Category: Drugs & Pharmacology Source Type: research

SGLT1 Inhibition Attenuates Apoptosis in Diabetic Cardiomyopathy via the JNK and p38 Pathway
Conclusion: SGLT1 can be used as a marker for the diagnosis of DCM, and SGLT1 inhibition can attenuate apoptosis, thereby suppressing DCM development via the JNK and p38 pathway.
Source: Frontiers in Pharmacology - January 12, 2021 Category: Drugs & Pharmacology Source Type: research

Exercise Training Reverses Lipotoxicity-induced Cardiomyopathy by Inhibiting HMGCS2
Conclusion Our results suggest that exercise limits lipid metabolic disorder, cardiac hypertrophy, and fibrosis and aids in the prevention of lipotoxic cardiomyopathy. Exercise-mediated cardioprotection by upregulating miR-344g-5p, which targets Hmgcs2 mRNA, prohibits HMGCS2 upregulation and thus lipotoxicity.
Source: Medicine and Science in Sports and Exercise - December 19, 2020 Category: Sports Medicine Tags: BASIC SCIENCES Source Type: research

Mitochondrial Fission and Mitophagy Coordinately Restrict High Glucose Toxicity in Cardiomyocytes
In this study, we determined the functional roles of mitochondrial fission and mitophagy in hyperglycemia-induced cardiomyocyte injury. High glucose (30 mM, HG) reduced mitochondrial connectivity and particle size and increased mitochondrial number in neonatal rat ventricular cardiomyocytes, suggesting an enhanced mitochondrial fragmentation. SiRNA knockdown of the pro-fission factor dynamin-related protein 1 (DRP1) restored mitochondrial size but did not affect HG toxicity, and Mdivi-1, a DRP1 inhibitor, even increased HG-induced cardiomyocyte injury, as shown by superoxide production, mitochondrial membrane potential and...
Source: Frontiers in Physiology - December 10, 2020 Category: Physiology Source Type: research

Targeting transthyretin ‐ Mechanism‐based treatment approaches and future perspectives in hereditary amyloidosis
Transthyretin (TTR) is a tetrameric transport protein that causes amyloid formation if destabilized. ATTR ‐amyloidosis is a progressive systemic disease with polyneuropathy and cardiomyopathy as the most abundant manifestations. Approved treatment approaches comprise sequence‐specific mRNA degradation and tetramer stabilization. Ongoing clinical trials assess the potential of GalNAc formulations to improve the administration of small interfering RNA and antisense oligonucleotides. A future TTR‐stabilizer with the potential to cross the blood‐brain barrier is tolcapone. Amyloid‐directed antibodies aim at reducing ...
Source: Journal of Neurochemistry - December 3, 2020 Category: Neuroscience Authors: Maike F. Dohrn, Sandra Ihne, Ute Hegenbart, Jessica Medina, Stephan L. Z üchner, Teresa Coelho, Katrin Hahn Tags: Review Article Source Type: research

Visfatin relieves myocardial ischemia-reperfusion injury through activation of PI3K/Akt/HSP70 signaling axis.
CONCLUSIONS: Visfatin reduces the inflammation and apoptosis levels of myocardial cells through the PI3K/Akt/HSP70 signaling axis, thereby reducing I/R-induced myocardial injury. PMID: 33155238 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 10, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research