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Condition: Cardiomyopathy

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Total 155 results found since Jan 2013.

Small interfering RNA therapy against carbohydrate sulfotransferase 15 inhibits cardiac remodeling in rats with dilated cardiomyopathy.
Abstract Carbohydrate sulfotransferase 15 (CHST15) is a sulfotransferase responsible for biosynthesis of chondroitin sulfate E (CS-E), which plays important roles in numerous biological events such as biosynthesis of proinflammatory cytokines. However, the effects of CHST15 siRNA in rats with chronic heart failure (CHF) after experimental autoimmune myocarditis (EAM) have not yet been investigated. CHF was elicited in Lewis rats by immunization with cardiac myosin, and after immunization, the rats were divided into two groups and treated with either CHST15 siRNA (2μg/week) or vehicle. Age matched normal rats with...
Source: Cellular Signalling - March 14, 2015 Category: Cytology Authors: Watanabe K, Arumugam S, Sreedhar R, Thandavarayan RA, Nakamura T, Nakamura M, Harima M, Yoneyama H, Suzuki K Tags: Cell Signal Source Type: research

Inhibition of prolyl hydroxylase 3 ameliorates cardiac dysfunction in diabetic cardiomyopathy
Publication date: 5 March 2015 Source:Molecular and Cellular Endocrinology, Volume 403 Author(s): Yanfei Xia , Luwei Gong , Hui Liu , Beibei Luo , Bo Li , Rui Li , Beibei Li , Mei Lv , Jinyu Pan , Fengshuang An Prolyl hydroxylase 3 (PHD3) is a member of the prolyl hydroxylases (PHDs) family and is induced by hypoxia. It plays a critical role in regulating the abundance of hypoxia-inducible factor (HIF). Its expression is increased in diabetic rat hearts; however, its role remains unclear. We investigated the potential role and mechanism of action of PHD3 in the setting of diabetes-induced myocardial dysfunction in rats. ...
Source: Molecular and Cellular Endocrinology - January 27, 2015 Category: Endocrinology Source Type: research

Ascribing novel functions to the sarcomeric protein, myosin binding protein H (MyBPH) in cardiac sarcomere contraction.
This study provides evidence for a potential role of MyBPH in HCM, which warrants further investigation. PMID: 25449695 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - November 18, 2014 Category: Cytology Authors: Mouton J, Loos B, Moolman-Smook H, Kinnear C Tags: Exp Cell Res Source Type: research

NOS1AP modulates intracellular Ca(2+) in cardiac myocytes and is up-regulated in dystrophic cardiomyopathy.
Authors: Treuer AV, Gonzalez DR Abstract NOS1AP gene (nitric oxide synthase 1-adaptor protein) is strongly associated with abnormalities in the QT interval of the electrocardiogram and with sudden cardiac death. To determine the role of NOS1AP in the physiology of the cardiac myocyte, we assessed the impact of silencing NOS1AP, using siRNA, on [Ca(2+)]i transients in neonatal cardiomyocytes. In addition, we examined the co-localization of NOS1AP with cardiac ion channels, and finally, evaluated the expression of NOS1AP in a mouse model of dystrophic cardiomyopathy. Using siRNA, NOS1AP levels were reduced to ~30% of...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - November 16, 2014 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Effects of methylglyoxal on human cardiac fibroblast: Roles of transient receptor potential ankyrin 1 (TRPA1)channels.
Abstract Cardiac fibroblasts contribute to the pathogenesis of cardiac remodeling. Methylglyoxal (MG) is an endogenous carbonyl compound produced under hyperglycemic conditions, which may play a role in the development of pathophysiological conditions including diabetic cardiomyopathy. However, the mechanism by which this occurs and the molecular targets of MG are unclear. We investigated the effects of MG on Ca(2+) signals, its underlying mechanism and cell cycle progression/cell differentiation in human cardiac fibroblasts. The conventional and quantitative real-time RT-PCR, western blot, immunocytochemical anal...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 29, 2014 Category: Physiology Authors: Oguri G, Nakajima T, Yamamoto Y, Takano N, Tanaka T, Kikuchi H, Morita T, Nakamura F, Yamasoba T, Komuro I Tags: Am J Physiol Heart Circ Physiol Source Type: research

Expression of fibulin-6 in failing hearts and its role for cardiac fibroblast migration
Conclusion Fibulin-6, a fibroblast-released ECM protein, may play an important role during MR by imparting an effect on CF migration in close and complementary interplay with TGF-β1 signalling.
Source: Cardiovascular Research - August 26, 2014 Category: Cardiology Authors: Chowdhury, A., Herzog, C., Hasselbach, L., Khouzani, H. L., Zhang, J., Hammerschmidt, M., Rudat, C., Kispert, A., Gaestel, M., Menon, M. B., Tudorache, I., Hilfiker-Kleiner, D., Muhlfeld, C., Schmitto, J. D., Muller, M., Theilmeier, G. Tags: Cardiac biology and remodelling Source Type: research

Sumo E2 Ligase UBC9 is Required for Efficient Protein Quality Control in Cardiomyocytes.
Conclusions: UBC9 plays a significant role in cardiomyocyte PQC and its activity can be exploited to reduce toxic levels of misfolded or aggregated proteins in cardiomyopathy. PMID: 25097219 [PubMed - as supplied by publisher]
Source: Circulation Research - August 5, 2014 Category: Cardiology Authors: Gupta MK, Gulick J, Liu R, Wang X, Molkentin JD, Robbins J Tags: Circ Res Source Type: research

p38α Mitogen-Activated Kinase Mediates Cardiomyocyte Apoptosis Induced by Palmitate.
CONCLUSIONS: These results demonstrate that PA induces p38α activation, and reducing p38α expression attenuates PA-induced cardiomyocyte apoptosis. Our results support a potential mechanism by which high plasma SFA levels through p38α activation may lead to the development of lipotoxic/diabetic cardiomyopathy. PMID: 24931668 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - June 12, 2014 Category: Biochemistry Authors: Oh CC, Nguy MQ, Schwenke D, Migrino RQ, Thornburg K, Reaven P Tags: Biochem Biophys Res Commun Source Type: research

Quercetin Attenuates Doxorubicin Cardiotoxicity by Modulating Bmi‐1 Expression
Conclusions And ImplicationsOur results demonstrate that QCT abrogates Dox‐induced cardiotoxicity in vitro and in vivo by reducing oxidative stress by upregulation of Bmi‐1 expression. The novel findings presented in this study have potential applications in preventing Dox‐induced cardiomyopathy.
Source: British Journal of Pharmacology - June 5, 2014 Category: Drugs & Pharmacology Authors: Qinghua Dong, Long Chen, Qunwei Lu, Sherven Sharma, Lei Li, Sachio Morimoto, Guanyu Wang Tags: Research Paper Source Type: research

Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice.
Abstract Autophagic dysfunction is observed in diabetes mellitus. Resveratrol has a beneficial effect on diabetic cardiomyopathy. Whether the resveratrol-induced improvement in cardiac function in diabetes is via regulating autophagy remains unclear. We investigated the mechanisms underlying resveratrol-mediated protection against heart failure in diabetic mice, with a focus on the role of sirtuin 1 (SIRT1) in regulating autophagic flux. Diabetic cardiomyopathy in mice was induced by streptozotocin (STZ). Long-term resveratrol treatment improved cardiac function, ameliorated oxidative injury and reduced apoptosis ...
Source: J Cell Mol Med - June 1, 2014 Category: Molecular Biology Authors: Wang B, Yang Q, Sun YY, Xing YF, Wang YB, Lu XT, Bai WW, Liu XQ, Zhao YX Tags: J Cell Mol Med Source Type: research

Resveratrol‐enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice
Abstract Autophagic dysfunction is observed in diabetes mellitus. Resveratrol has a beneficial effect on diabetic cardiomyopathy. Whether the resveratrol‐induced improvement in cardiac function in diabetes is via regulating autophagy remains unclear. We investigated the mechanisms underlying resveratrol‐mediated protection against heart failure in diabetic mice, with a focus on the role of sirtuin 1 (SIRT1) in regulating autophagic flux. Diabetic cardiomyopathy in mice was induced by streptozotocin (STZ). Long‐term resveratrol treatment improved cardiac function, ameliorated oxidative injury and reduced apoptosis in ...
Source: Journal of Cellular and Molecular Medicine - June 1, 2014 Category: Molecular Biology Authors: Bo Wang, Qing Yang, Yuan‐yuan Sun, Yi‐fan Xing, Ying‐bin Wang, Xiao‐ting Lu, Wen‐wu Bai, Xiao‐qiong Liu, Yu‐xia Zhao Tags: Original Article Source Type: research

High glucose induces smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy
Background: Despite advances in the treatment of heart failure, mortality remains high, particularly in individuals with diabetes. Activated transforming growth factor beta (TGF-beta) contributes to the pathogenesis of the fibrotic interstitium observed in diabetic cardiomyopathy. We hypothesized that high glucose enhances the activity of the transcriptional co-activator p300, leading to the activation of TGF-beta via acetylation of Smad2; and that by inhibiting p300, TGF-beta activity will be reduced and heart failure prevented in a clinically relevant animal model of diabetic cardiomyopathy. Methods: p300 activity was as...
Source: Cardiovascular Diabetology - May 5, 2014 Category: Cardiology Authors: Antoinette Bugyei-TwumAndrew AdvaniSuzanne AdvaniYuan ZhangKerri ThaiDarren KellyKim Connelly Source Type: research

ARIA Regulates Cardiac PI3K/Akt Signals Signal Transduction
PI3K/Akt signaling plays an important role in the regulation of cardiomyocyte death machinery, which can cause stress-induced cardiac dysfunction. Here, we report that apoptosis regulator through modulating IAP expression (ARIA), a recently identified transmembrane protein, regulates the cardiac PI3K/Akt signaling and thus modifies the progression of doxorubicin (DOX)-induced cardiomyopathy. ARIA is highly expressed in the mouse heart relative to other tissues, and it is also expressed in isolated rat cardiomyocytes. The stable expression of ARIA in H9c2 cardiac muscle cells increased the levels of membrane-associated PTEN...
Source: Journal of Biological Chemistry - January 31, 2014 Category: Chemistry Authors: Kitamura, Y., Koide, M., Akakabe, Y., Matsuo, K., Shimoda, Y., Soma, Y., Ogata, T., Ueyama, T., Matoba, S., Yamada, H., Ikeda, K. Tags: Molecular Bases of Disease Source Type: research

Ferritin heavy chain as main mediator of preventive effect of metformin on mitochondrial damage induced by doxorubicin in cardiomyocyte.
In conclusion, these results deepen our knowledge of the protective action of MET against DOX-induced cardiotoxicity and suggest that therapeutic strategies based on FHC modulation could protect cardiomyocytes from the mitochondrial damage induced by DOX by restoring iron homeostasis. PMID: 24231192 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - November 11, 2013 Category: Biology Authors: Asensio-Lopez MC, Sanchez-Mas J, Pascual-Figal DA, de Torre C, Valdes M, Lax A Tags: Free Radic Biol Med Source Type: research

Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque
Conclusions (i) Super-resolution fluorescence microscopy, complemented with Monte–Carlo simulations and PLAs, allows the study of the nanoscale organization of an interactome in cardiomyocytes. (ii) PKP2 and Cx43 share a common hub that permits direct physical interaction. Its relevance to excitability, electrical coupling, and arrhythmogenic right ventricular cardiomyopathy, is discussed.
Source: Cardiovascular Research - October 16, 2013 Category: Cardiology Authors: Agullo-Pascual, E., Reid, D. A., Keegan, S., Sidhu, M., Fenyo, D., Rothenberg, E., Delmar, M. Tags: Cardiac biology and remodelling Source Type: research