Sildenafil reverses the hypertrophy of mice right ventricle caused by hypoxia but does not reverse the changes in the myosin heavy chain isoforms.
Conclusion: sildenafil reversed the right ventricular hypertrophy induced by hypoxia but did not decrease the expression of MHC-β to normal levels. PMID: 32714496 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 28, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Effects of fingolimod treatments on alanine transaminase and aspartate transaminase levels in patients with multiple sclerosis.
Authors: Joni SS, Cheshmavar M, Shoureshi P, Zamani Z, Taoosi N, Akbari M, Afzali M Abstract INTRODUCTION: Multiple Sclerosis (MS) is a chronic neurological disorder with no known cause or cure. Fingolimod (FTY720) is an oral medication recently approved for the treatment of MS as well as other diseases with autoimmune aspects. However, the drug is not without side effects. The severity and prevalence of these side effects are not completely understood. One of the most common causes for the patient cessation of fingolimod is an increase in liver enzymes, indicating possible inflammation or damage to liver cells. Al...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 28, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Risk factors for excessive tidal volumes delivered during intraoperative mechanical ventilation, a retrospective study.
CONCLUSION: There is an association between female gender, obesity and excessive tidal volume ventilation. This may be addressed through formal, protocolized intraoperative ventilation setting. PMID: 32419900 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - May 19, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Alcohol and multiple sclerosis: an immune system-based review.
Authors: Fahim M, Rafiee Zadeh A, Shoureshi P, Ghadimi K, Cheshmavar M, Sheikhinia N, Afzali M Abstract Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS). Although the exact etiology of multiple sclerosis is unknown, researchers suggest that genetic, environmental, and microbial factors play a central role in causing multiple sclerosis. Pathology of multiple sclerosis is based on inflammation as T cells enter the brain via disruptions in the blood-brain barrier, recognizing myelin as foreign antigen; and as a result, the T cells attack myelin and start the inflammatory process...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - May 19, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

No tight junctions in tight junction protein-1 expressing HeLa and fibroblast cells.
Authors: Shi Y, Li R, Yang J, Li X Abstract Tight junctions are important structures that form the barrier of cells and tissues, and they play key roles in maintaining homeostasis of our body. The backbone of the tight junction proteins are claudins, which composed more than twenty members. The tight junction protein 1 (TJP1), also called ZO-1 (Zonula Occludens-1), is one of the tight junction related proteins, and it is widely used in literature to label tight junctions. Here we showed that TJP1 (ZO-1) is highly expressed in cancerous HeLa cells, fibroblast cells, HUVEC as well as MDCK cells, while claudin-1 is hi...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - May 19, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

ZO-1 associates with α3 integrin and connexin43 in trabecular meshwork and Schlemm's canal cells.
ZO-1 associates with α3 integrin and connexin43 in trabecular meshwork and Schlemm's canal cells. Int J Physiol Pathophysiol Pharmacol. 2020;12(1):1-10 Authors: Li X, Acott TS, Nagy JI, Kelley MJ Abstract Cellular structures that perform essential homeostatic functions include tight junctions, gap junctions, desmosomes and adherens junctions. The aqueous humor, produced by the ciliary body, passes into the anterior chamber of the eye and is filtered by the trabecular meshwork (TM), a tiny tissue found in the angle of the eye. This tissue, along with Schlemm's canal (SC) inner wall cells, is thoug...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - March 28, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Amniotic mesenchymal stem cells derived hepatocyte-like cells attenuated liver fibrosis more efficiently by mixed-cell transplantation.
CONCLUSIONS: The HLCs attenuated liver fibrosis more efficiently when transplanted along with HUVECs and AMSCs, and this suggested that we could improve the efficiency of cell therapy by transplanting functional cells partially along with stromal cells. PMID: 32211118 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - March 28, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Gap junction connexin43 is a key element in mediating phagocytosis activity in human trabecular meshwork cells.
Authors: Li X, Nagy JI, Li D, Acott TS, Kelley MJ Abstract Human trabecular meshwork (TM) cells play pivotal roles in maintaining homeostasis of intraocular pressure via regulation of aqueous humor outflow. These cells are capable of phagocytosis, which is considered to be essential for their regulatory function. In addition, there is a strong expression of the gap junction protein connexin43 (Cx43) in the TM. Here, we investigated functional relationships between phagocytosis activity of TM cells and their expression of Cx43. Phagocytosis was measured by showing the ability of TM cells to engulf inert fluorescent ...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - March 28, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Association of CD49d expression with clinicopathological features of chronic lymphocytic leukemia patients in the Iranian population.
In this study, CD49d expression exhibited significant association with the Rai stage of the disease (P
Source: International Journal of Physiology, Pathophysiology and Pharmacology - March 28, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Pectoral Nerve (PECs) block for postoperative analgesia-a systematic review and meta-analysis with trial sequential analysis.
CONCLUSION: When compared to general anesthesia with systemic opioids, PECs block was associated with significantly better perioperative pain control. There are currently insufficient data on the complication and failure rate of PECs block in clinical practice. PMID: 32211121 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - March 28, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Hypoglycaemic and anti-diabetic activity of selected African medicinal plants.
Authors: Oguntibeju OO Abstract The use of medicinal plants in the treatment and management of diabetes mellitus is not very popular in Europe and USA as it is in Africa due to adequate availability of synthetic drugs and insulin for the effective management of diabetes in the western countries. In Africa, over 80% of the population live in poor resource settings and depend on medicinal plants for the treatment of various diseases including diabetes mellitus. Africa is very rich in medicinal plants and many of these plants are used in the treatment of diabetes mellitus. These plants play important role as alternati...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

How does the brain remove its waste metabolites from within?
Authors: Cheng Y, Haorah J Abstract The brain is the command center of the body that regulates the vital functions of circulation, respiration, motor function, metabolic activities, or autonomic nervous system outcomes. The brain coordinates these continuous activities at the expense of huge energy utilization. This energy demand is achieved by active transport of nutrients across the endothelial blood-brain barrier (BBB). This review discusses the barrier interfaces in the CNS that include the BBB, blood-spinal cord barrier, the epithelial choroid plexus, and the epithelial arachnoid. While transporting of nutrien...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Mechanism of membrane fusion: protein-protein interaction and beyond.
Authors: Wang H, Zhang C, Xiao H Abstract Membrane fusion is a universal event in all living organism. It is at the heart of intracellular organelle biogenesis and membrane traffic processes such as endocytosis and exocytosis, and is also used by enveloped viruses to enter hosting cells. Regarding the cellular mechanisms underlying membrane fusion, pioneering studies by Randy Schekman, James Rothman, Thomas C. Südhof and their colleagues have demonstrated the function of specific proteins and protein-protein interactions as essential fusogenic factor to initiate membrane fusion. Since then, function of lipids ...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Early consumption of high-fat diet worsens renal damage in spontaneously hypertensive rats in adulthood.
Authors: Pereira RO, Muller CR, de Nascimento NRF, Fonteles MC, Evangelista FS, Fiorino P, Farah V Abstract The association between hypertension and obesity has been shown to be an important cause of kidney disease. We aimed to investigate the impact of a high-fat diet (HFD) administered in spontaneously hypertensive rats (SHR) after weaning in renal morphology and functional parameters. Male post-weaned SHR were divided into two groups: standard control diet (CD) (3% lipids; n = 8) or HFD (30% lipids; n = 8) during 8 weeks. The group HFD showed an increase in serum triglycerides (HFD: 96 ± 7 vs. CD: 33 &plu...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Serum levels of IL-6 and IL-17 in multiple sclerosis, neuromyelitis optica patients and healthy subjects.
This study aimed to compare the level of IL-6 and IL-17 in MS and NMO patients and healthy subjects. METHODS: This study is a case control study that evaluated the serum level of IL-6 and IL-17 in MS and NMO patients in comparison to controls in patients who referred to Kashani hospital clinics. The level of serum IL-6 and IL-17 were measured by ELISA test in all patients. Participants were divided in to three groups include MS patients, NMO patients and controls and the level of IL-6 and IL-17 were compared in this three groups. RESULTS: Mean of serum level of IL-6 in the NMO group was significantly lower than MS ...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Comparison of cognitive auditory event related potentials and executive functions in adolescent athletes and non-athletes - A cross sectional study.
Authors: Sharma VK, Subramanian SK, Rajendran R Abstract There is strong evidence for the positive physical health outcomes of physical conditioning (athletic training. But there is a dearth of data on the impact of exercise on cognition, particularly in the adolescent age group. Further, most of the studies done on this topic are mainly acute in nature, and few that have seen long term effect of exercise have very rarely used objective measures such as event-related potentials. Hence, the present study was conceived to compare cognition in athletes (individual who have undergone long term physical activity) and no...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

How is the association between urinary prostate cancer antigen 3 (PCA3) levels and Gleason scores in patients suspicious of prostate cancer?
DISCUSSION: Generally, urinary PCA3 test is indicated as a non-invasive method to improve the specificity of prostate cancer diagnosis and its potential predictive value was studied in numerous clinical researches, but here we found higher PCA3 levels in patients with prostate cancer than in patients with and other prostate problems. We conclude that PCA3 functions as a diagnostic test and its changes in prostate cancer need to be further studied in different populations and races. PMID: 31993103 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Comparing urine levels of BLCA-4 nuclear matrix protein in patients with bladder cancer and non-bladder cancer.
CONCLUSION: The present study indicated that high urine levels of BLCA-4 was presented in patients with bladder cancer and this tumor marker has a high capability for early diagnosis of the disease, which can be used for screening and follow-up of bladder cancer. PMID: 31993104 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Disseminated cryptococcosis with multiple and mediastinal lymph node enlargement and lung involvement in an immunocompetent child.
CONCLUSIONS: Disseminated cryptococcosis can occur in immunocompromised children without HIV infection. This case of multiple and mediastinal lymphadenopathy, easily misdiagnosed as "lymphoma", requires high clinical suspicion and early initiation of treatment to effectively identify and treat patients. PMID: 31993105 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

CD200-CD200R signaling and diseases: a potential therapeutic target?
Authors: Ngwa C, Liu F Abstract CD200 and its receptor, CD200R, constitutes an endogenous inhibitory signaling, and is being increasingly recognized in studies of various central nervous system (CNS) disorders. Emerging data have demonstrated that neuronal CD200 binds to CD200R to modulate immune responses to pathogenic stimuli. However, on which component of the immune response that CD200-CD200R signaling acts is not well understood. In this review, we focused on cellular expression of the signaling, the effects on immune cell activation, and the function in pathological procedures of neurodegenerative diseases, i...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Diabetes retinopathy and related health management in Asians versus whites using BRFSS 2005-2017 data.
Authors: Yan F, Guo J, Mayberry R, Luo Q, Li Y, Qin G Abstract PURPOSE: Asian Americans had high rate of type 2 diabetes and less risk for diabetes complications compared to white. The purpose of this study was to examine diabetic retinopathy and related healthcare management among Asian American adults with diabetes. MATERIALS AND METHOD: Asian and white type 2 diabetes participants from 2005-2017 Behavioral Risk Factor Surveillance System (BRFSS) data were used to perform the analysis. SAS 9.4 survey procedures were used to conduct the statistical test. Health care management variables (self-blood sugar check...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Nicotinamide phosphoribosyltransferase contributes to cocaine addiction through sirtuin 1.
Authors: Singh S, William M, Chu XP Abstract Drug addiction is a persistent mental illness and there is no effective treatment. The precise mechanisms underlying addictive responses have not been completely understood, although ion channels, neurotransmitters as well as their receptors, and intracellular endogenous molecules in the brain have been shown to play important roles in cocaine addiction. Nicotinamide phosphoribosyltransferase (NAMPT) is an important rate-limiting enzyme found throughout the body that converts the intracellular pool of nicotinamide adenine dinucleotide (NAD) into nicotinamide mononucleoti...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Role of mitochondrial depolarization and disrupted mitochondrial homeostasis in non-alcoholic steatohepatitis and fibrosis in mice.
Authors: Krishnasamy Y, Gooz M, Li L, Lemasters JJ, Zhong Z Abstract The pathogenesis of non-alcoholic steatohepatitis (NASH) is poorly understood. Here, relationships between mitochondrial depolarization (mtDepo) and mitochondrial homeostasis were studied in a mouse model of NASH. C57BL/6 mice were fed a Western diet (high fat, fructose and cholesterol) for 2 weeks, 2 months and 6 months, and livers were harvested for histology and biochemical analysis. Hepatic mtDepo was evaluated by intravital multiphoton microscopy. After Western diet feeding, mixed hepatic micro- and macrovesicular steatosis and leukocyte infi...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - November 30, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Nitric oxide represses the proliferation of Caco-2 cells by inducing S-G2/M cell cycle arrest.
Authors: Sakuma S, Ikeda Y, Inoue I, Yamaguchi K, Honkawa S, Kohda T, Minamino S, Fujimoto Y Abstract There is conflicting data regarding the ability of nitric oxide (NO) to promote or inhibit colorectal cancer cell proliferation. Furthermore, NO reacts rapidly with endogenous superoxide at a diffusion-controlled rate to give peroxynitrite (ONOO-), a strong oxidant and nitrating agent. The aim of this study was to assess the effects of exogenous NO and ONOO- on the proliferation of the colorectal cancer cell line Caco-2. NOR5 and SIN-1 were used as NO and ONOO- donors, respectively. Both NOR5 and SIN-1 inhibited th...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - November 30, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Gap junction protein connexin43 and tunneling nanotubes in human trabecular meshwork cells.
Authors: Li X Abstract Intercellular communication via gap junctions and tunneling nanotubes (TNT) play pivotal roles for cell differentiation and proliferation and homeostasis. Intercellular communication has been found in human trabecular meshwork cells, which are key elements for allowing the direct passing aqueous humor and for maintaining the homeostasis of intraocular pressure. Here we showed the expression of gap junction protein connexin43 in human trabecular meshwork cells, and the presence of TNTs in these cells labeled with enhanced GFP generated using highly efficient lentiviral transduction. More impor...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - November 30, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Intraoperative methadone for postoperative pain management - systematic review protocol.
Authors: Jin Z, Lin EJ, He Y, Lin J Abstract Methadone is a long acting opioid initially used to treat opioid withdrawal symptoms. It has been suggested that methadone, when given as a single bolus while under anesthesia, provides good postoperative analgesia and is associated with minimal risk of opioid adverse events. Several small studies have investigated the use of methadone for postoperative analgesia with some promising results. Here we describe our protocol for a meta-analysis to investigate the postoperative analgesic effect of methadone. PMID: 31777646 [PubMed] (Source: International Journal of Physio...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - November 30, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Mechanism and adverse effects of multiple sclerosis drugs: a review article. Part 1.
Authors: Rafiee Zadeh A, Askari M, Azadani NN, Ataei A, Ghadimi K, Tavoosi N, Falahatian M Abstract Multiple Sclerosis (MS) is chronic, inflammatory, a neurologic disorder of the central nervous system (CNS). Although the exact mechanisms of MS have not been yet discovered some drugs are found helpful for its treatment. These drugs which are divided into the first line, second line and third-line therapies, have demonstrated to be helpful for MS patients based on immune basic of the disease. Previous studies have been indicated that deterioration of MS condition is associated with a stronger immune system. Most of ...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 17, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Mechanism and adverse effects of multiple sclerosis drugs: a review article. Part 2.
Authors: Rafiee Zadeh A, Ghadimi K, Ataei A, Askari M, Sheikhinia N, Tavoosi N, Falahatian M Abstract Multiple Sclerosis (MS) is an autoimmune, inflammatory disease of the central nervous system (CNS) mostly affecting young adults. The exact mechanism and pathogenesis of MS remain still undiscovered but there have been useful treatments with different efficacy rates. Most of these therapies are divided into the first line, second line and third line, impact on the immune system and immune cells. These drugs are approved to be useful in MS, but like any other therapies, adverse effects (AE) are associated with these...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 17, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Neurexin-1 α regulates neurite growth of rat hippocampal neurons.
Neurexin-1α regulates neurite growth of rat hippocampal neurons. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):115-125 Authors: Wang A, Xiang YY, Yang BB, Lu WY Abstract The growth of neurites underlies the axonal pathfinding and synaptic formation during neuronal development and regeneration. Neurite growth is regulated by specific interactions between growth cone receptors and their ligands that function as molecular cues existing in microenvironments. Neurexins (NRXNs) are concentrated on growth cones and they may function to constrain axonal branches of invertebrate neurons. The present st...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 17, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Garlic antagonizes skeletal muscle ischemia reperfusion injury through regulating inflammation, apoptosis and desmin expression in adult male rats.
CONCLUSION: Garlic protected against IR-induced skeletal muscle damage through reducing inflammation, apoptosis score and elevating desmin expression. We recommend the earlier use of garlic as prophylactic natural medicine in skeletal muscle IR. PMID: 31523360 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 17, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Association between obesity and craniofacial muscles sensitivity: an experimental study in pain-free subjects.
The objective of this study was to investigate if any association exists between obesity and muscle sensitivity in the craniofacial region of healthy individuals with different body mass index (BMI). The study was designed as a parallel single blinded investigation approved by the North Denmark Region Committee on Health Research Ethics (N-20180029). Written informed consent was obtained from all participants. Subjects were divided into normal BMI (18.5-24.9 kg/m2) and high BMI (≥25.0 kg/m2). Measurement of body composition parameters was followed by pressure algometry applied on skin overlying masseter and temporalis m...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 17, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Antiretroviral drug-S for a possible HIV elimination.
Authors: Agas A, Schuetz H, Mishra V, Szlachetka AM, Haorah J Abstract Although the combination of highly active antiretroviral therapy (cART) can remarkably control human immunodeficiency virus type-1 (HIV-1) replication, it fails to cure HIV/AIDS disease. It is attributed to the incapability of cART to eliminate persistent HIV-1 contained in latent reservoirs in the central nervous system (CNS) and other tissue organs. Thus, withdrawal of cART causes rebound viral replication and resurgent of HIV/AIDS. The lack of success on non-ART approaches for elimination of HIV-1 include the targeted molecules not reaching t...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 17, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Differences between male and female rats in alcohol drinking, negative affects and neuronal activity after acute and prolonged abstinence.
In this study, we trained adult male and female Sprague-Dawley rats to drink alcohol in the intermittent access to 20% ethanol two-bottle free-choice paradigm for two months. Their behaviors and Fos expression in related brain regions were measured at acute (24 h) and after prolonged (28 days) abstinence. We found that female rats drank more alcohol than males. After acute abstinence, rats of both sexes showed higher sensitivity to depressive, thermal, and mechanical stimuli. Females also displayed higher anxiety levels. After prolonged abstinence, rats of both sexes displayed depressive-like behaviors; the males displayed...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 17, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Mesenchymal stem cell-derived exosomes do not promote the proliferation of cancer cells in vitro.
Authors: Karaoz E, Sun E, Demir CS Abstract Nowadays, the use of Mesenchymal stem cells (MSCs) in clinical therapies have an increased acceleration, while it constitutes two sides of yin-yang with its ameliorating effects in regenerative medicine and promoting effects in carcinogenesis. It has been shown that the treatment activities of MSCs are mediated by paracrine factors secreted. These paracrine factors are transmitting via exosomes secreted from MSCs. With the understanding of this mechanism, cell-free therapies have begun to create a new path in MSC based therapies. At this point, two sides of the yin-yang h...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 17, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.
Authors: Oguntibeju OO Abstract Diabetes mellitus has been recognised as one of the four major non-communicable diseases that demands urgent attention from all key shareholders globally in an effort to address its prevalence and associated complications. It is considered as a top 10 cause of death globally, killing about 1.6 million people worldwide and is seen as the third highest risk factor for worldwide premature mortality due to hyperglycaemia and hyperglycaemic-induced oxidative stress and inflammation. There is a strong link between hyperglycaemia, hyperglycaemic-induced oxidative stress, inflammation and th...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 26, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Melatonin modulates inflammatory mediators and improves olanzapine-induced hepatic steatosis in rat model of schizophrenia.
CONCLUSION: Although ineffective as monotherapy, Mel co administration provides promising natural way to improve Ola-induced hepatic derangement in psychotic disorders. PMID: 31333809 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 26, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

The effect of Korean red ginseng on mesenchymal stem cells from healthy and osteoporotic human bone marrow.
CONCLUSION: KRG triggered an increase in intracellular ALP levels of osteoporotic MSCs. It suggests that KRG on osteoporotic cells is influential in stimulating osteogenesis and may be useful in osteoporotic patients. PMID: 31333810 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 26, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Long-term prognosis after cancer surgery with inhalational anesthesia and total intravenous anesthesia: a systematic review and meta-analysis.
CONCLUSION: Our meta-analysis suggests that TIVA is associated with lower all-cause mortality after cancer surgeries. As cancers of different origins can respond very differently to pharmacological intervention, more clinical trials are needed in each cancer types in order to substantiate the role of anesthesia in cancer surgery prognosis. PMID: 31333811 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 26, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Distinct plasma proteomic changes in male and female African American stroke patients.
CONCLUSION: Plasma proteins that differ in quantities between stroke patients and controls were readily detected using a simple proteomic approach. Sex-dependent changes and changes that have not been reported for African American stroke patients offer potentially novel biomarkers for stroke in this underserved population. PMID: 31149323 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - June 4, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Positive effects of systemic sodium benzoate and olanzapine treatment on activities of daily life, spatial learning and working memory in ketamine-induced rat model of schizophrenia.
CONCLUSION: Both Ola and SB improved ADL, cognitive and memory functions. Although SB saved testicular and renal functions, it worsened liver function compared to Ola. PMID: 31149324 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - June 4, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

The rise of circulatory endothelin (ET)-1 and endothelin receptors (ETA, ETB) expression in kidney of obese wistar rat.
CONCLUSION: Obesity in elder obese rats leads to dysregulation of kidney vessels through activity of ET-1 and ETA/ETB. PMID: 31149325 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - June 4, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Nephroprotective effect of Costus afer on lead induced kidney damage in albino rats.
Authors: Ezejiofor AN, Orisakwe OE Abstract BACKGROUND: Lead is a nephrotoxicant probably implicated in the rising incidence of chronic kidney injury in sub-Sahara Africa. With the prohibitive cost and unavailability of metal chelators, chronic kidney disease CKD prevention is very difficult hence the search for affordable alternative. Costus afer have been shown to be organo-protective. The present research investigated the nephroprotective effect of aqueous leaf extract of Costus afer on lead induced nephrotoxicity in male rats. METHODS: Adult male rats were weight matched into five groups of five rats each. ...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - June 4, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Post-stroke neuronal circuits and mental illnesses.
Authors: Naghavi FS, Koffman EE, Lin B, Du J Abstract Stroke is one of the leading causes of death in the United States. It is also associated with severe mental illnesses, such as depression and anxiety, that hinder the rehabilitation of surviving patients. Thus, a better understanding of how stroke causes mental illnesses is crucial, but little is known about the neurological mechanisms involved. In this review, we summarized the most common mental illnesses developed after stroke, as well as the underlying mechanisms at the neuronal circuit level. PMID: 30911356 [PubMed] (Source: International Journal of Phy...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - March 27, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

The effect of lunasin from Indonesian soybean extract on histopatologic examination and cox-2 expression in dextran sodium sulfate-induced mice colon.
In this study, we analyzed the effect of lunasin from soybean to decrease the risk of inflammation by analyzing histopathologic feature and the expression of COX-2. 30 mice are divided into 6 groups. Normal group was not induced by dextran sodium sulfate (DSS). The other groups were induced by 2% DSS through drinking water for 9 days. After 9 days, negative control group did not receive any treatment. The other groups received treatment given lunasin dose 20 mg/kg body weight (BW) and 40 mg/kg BW, commercial lunasin and positive control given aspirin. Treatment was performed for 5 weeks. Inflammatory colon histopathologic ...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - February 1, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Does β-caryophyllene protect against renal dysfunction following ischemia-reperfusion injury in the rat?
CONCLUSION: Our study results demonstrate that BCP attenuated the alterations in some of the oxidative stress markers. However, these were not translated in to the protective effects on the haemodynamic and tubular glomerular functions when measured seven days post-IRI. This suggests that BCP has a weak reno-protective effect under ischemic conditions. PMID: 30697363 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - February 1, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Profiling of Argonaute-2-loaded microRNAs in a mouse model of frontotemporal dementia with parkinsonism-17.
Authors: Kenny A, Hernández F, Avila J, Lucas JJ, Henshall DC, Prehn JH, Jiménez-Mateos EM, Engel T Abstract Tauopathies are a group of neurodegenerative diseases characterized by the pathological aggregation of the microtubule-associated protein tau. These include more than 20 diseases, with Alzheimer's disease being the most frequent. While pathological and neurotoxic effects of tau are well documented, the mechanisms by which tau can promote neurodegeneration are less clear. Increasing evidence suggests a functional role for microRNAs in the pathogenesis of tauopathies, with altered expression and ...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - February 1, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Evaluate neuroprotective effect of silibinin using chronic unpredictable stress (cus) model.
CONCLUSION: The study revealed that silibinin exerted effects in behavioral despair paradigm in chronically stressed mice, specifically by modulating central oxidative stress and inflammation. PMID: 30697365 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - February 1, 2019 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Role of adenylyl cyclase activator in controlling experimental diabetic nephropathy in rats.
In conclusion, treatment with adenylyl cyclase activator, Forskolin in diabetic rats reduced the elevated serum glucose level, biomarkers of renal morphological dysfunction, renal hypertrophy, dyslipidaemia, oxidative stress and improved renal structure, function and enhanced level of endogenous antioxidants. Forskolin has a potential to prevent nephropathy without showing any effect on body weight in diabetic rats. PMID: 30515257 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - December 6, 2018 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

The evaluation of malignant mucosal melanoma of nasal cavity with a rare occasion.
Authors: Kepekci AH, Kig C, Gundogan GI Abstract Malignant mucosal melanoma is an uncommon disease with a low rate of survival. Malignancies of nasal mucosa which usually presents with nasal obstruction, epistaxis and back drip are difficult to treat and often have poor prognosis. The present case had presented to our clinic with classic symptoms and diagnostic findings of nasal polyposis. Consistently, the patient had previously been diagnosed with and treated for nasal polyposis in another ENT clinic. Physical examination, rhinoscopic examination, computed tomography (CT) scan of the head did not reveal any findi...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 26, 2018 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

The role of PPAR- γ and NFKB genes expression in muscle to improve hyperglycemia in STZ-induced diabetic rat following magnesium sulfate administration.
The role of PPAR-γ and NFKB genes expression in muscle to improve hyperglycemia in STZ-induced diabetic rat following magnesium sulfate administration. Int J Physiol Pathophysiol Pharmacol. 2018;10(3):124-131 Authors: Khosravi F, Kharazmi F, Kamran M, Malekzadeh K, Talebi A, Soltani N Abstract The present study was designed to investigate the possible role of magnesium (Mg2+) on activation of the peroxisome proliferator-activated receptor gamma (PPAR-γ) and inhibition of nuclear factor-KB (NFKB p65) in muscle to increase glucose transporter 4 (GLUT4) gene expression. Fifty rats were divided...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - July 27, 2018 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research