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Condition: Cardiomyopathy
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Total 155 results found since Jan 2013.
Meta analysis of bioactive compounds, miRNA, siRNA and cell death regulators as sensitizers to doxorubicin induced chemoresistance
AbstractCancer has presented to be the most challenging disease, contributing to one in six mortalities worldwide. The current treatment regimen involves multiple rounds of chemotherapy administration, alone or in combination. The treatment has adverse effects including cardiomyopathy, hepatotoxicity, and nephrotoxicity. In addition, the development of resistance to chemo has been attributed to cancer relapse and low patient overall survivability. Multiple drug resistance development may be through numerous factors such as up-regulation of drug transporters, drug inactivation, alteration of drug targets and drug degradatio...
Source: Apoptosis - June 18, 2022 Category: Molecular Biology Source Type: research
Irisin attenuates sepsis-induced cardiac dysfunction by attenuating inflammation-induced pyroptosis through a mitochondrial ubiquitin ligase-dependent mechanism
Biomed Pharmacother. 2022 May 30;152:113199. doi: 10.1016/j.biopha.2022.113199. Online ahead of print.ABSTRACTSepsis-induced cardiac dysfunction is a leading cause of mortality in intensive care units. However, the molecular mechanisms underlying septic cardiomyopathy remain elusive. Irisin is a cleaved product of fibronectin type III domain-containing protein 5 (FNDC5) that protects the heart from ischemia/reperfusion injury through upregulation of mitochondrial ubiquitin ligase (MITOL). Gasdermin D (GSDMD)-dependent pyroptosis plays a pivotal role in septic cardiomyopathy by regulating mitochondrial homeostasis. However,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 2, 2022 Category: Drugs & Pharmacology Authors: Xiang Xiong Linhe Lu Zhenyi Wang Jipeng Ma Yalan Shao Yang Liu Mengen Zhai Ping Jin Jian Yang Qijun Zheng Jincheng Liu Lifang Yang Source Type: research
Gasdermin D mediates doxorubicin- induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage
Transl Res. 2022 May 8:S1931-5244(22)00100-1. doi: 10.1016/j.trsl.2022.05.001. Online ahead of print.ABSTRACTDoxorubicin (Dox), as a widely used anthracycline antitumor drug, can cause severe cardiotoxicity. Cardiomyocyte death and inflammation are involved in the pathophysiology of Dox-induced cardiotoxicity (DIC). Gasdermin D (GSDMD) is known as a key executioner of pyroptosis, which is a pro-inflammatory programmed cell death. We aimed to investigate the impact of GSDMD on DIC and systematically reveal its underlying mechanisms. Our findings indicated that Dox induced cardiomyocyte pyroptosis in a GSDMD-dependent manner...
Source: Translational Research : the journal of laboratory and clinical medicine - May 11, 2022 Category: Laboratory Medicine Authors: Bozhi Ye Xiaowen Shi Jianjiang Xu Shanshan Dai Jiajun Xu Xiaoxi Fan Bingjiang Han Jibo Han Source Type: research
Myeloid differentiation factor-2 activates monocytes in patients with dilated cardiomyopathy
This article is protected by copyright. All rights reserved.PMID:35502635 | DOI:10.1111/imm.13490
Source: Immunology - May 3, 2022 Category: Allergy & Immunology Authors: Rico Feldtmann Andreas K ümmel Bishwas Chamling Anne Strohbach Kristin Lehnert Stefan Gross Lisa Loerzer Alexander Riad Diana Lindner Dirk Westermann Jens Fielitz Marcus D örr Stephan B Felix Source Type: research
