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Condition: Cardiomyopathy
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Total 155 results found since Jan 2013.
Hydrogen sulfide promoted retinoic acid-related orphan receptor α transcription to alleviate diabetic cardiomyopathy
Biochem Pharmacol. 2023 Aug 15:115748. doi: 10.1016/j.bcp.2023.115748. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is one serious and common complication in diabetes without effective treatments. Hydrogen sulfide (H2S) fights against a variety of cardiovascular diseases including DCM. Retinoic acid-related orphan receptor α (RORα) has protective effects on cardiovascular system. However, whether RORα mediates the protective effect of H2S against DCM remains unknown. The present research was to explore the roles and mechanisms of RORα in H2S against DCM. The study demonstrated that H2S donor sodium hydro...
Source: Biochemical Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Shuping Zhang Jieru Shen Yu Zhu Yangyang Zheng Wenqin San Danyi Cao Yun Chen Guoliang Meng Source Type: research
Puerarin Attenuates High-Glucose and High-Lipid-Induced Inflammatory Injury in H9c2 Cardiomyocytes via CAV3 Protein Upregulation
CONCLUSION: Puerarin upregulated CAV3 protein expression in H9c2 cardiomyocytes and inhibited the NF-κB and p38MAPK pathways, thereby reducing HGHL-induced inflammation and may related to the apoptosis and hypertrophy of cardiomyocytes.PMID:37404717 | PMC:PMC10317540 | DOI:10.2147/JIR.S408681
Source: Cell Research - July 5, 2023 Category: Cytology Authors: YiFu Tian CaiXia Zhou XiaoYang Bu Qian Lv Qin Huang Source Type: research
MIC26 and MIC27 are bona fide subunits of the MICOS complex in mitochondria and do not exist as glycosylated apolipoproteins
by Melissa Lubeck, Nick H. Derkum, Ritam Naha, Rebecca Strohm, Marc D. Driessen, Bengt-Frederik Belgardt, Michael Roden, Kai St ühler, Ruchika Anand, Andreas S. Reichert, Arun Kumar Kondadi
Impairments of mitochondrial functions are linked to human ageing and pathologies such as cancer, cardiomyopathy, neurodegeneration and diabetes. Specifically, aberrations in ultrastructure of mitochondrial inner membrane (IM) and factors regulating them are linked to diabetes. The development of diabetes is connected to the ‘Mitochondrial Contact Site and Cristae Organising System’ (MICOS) complex which is a large membrane protei...
Source: PLoS One - June 6, 2023 Category: Biomedical Science Authors: Melissa Lubeck Source Type: research
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1
Phytother Res. 2023 May 1. doi: 10.1002/ptr.7831. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism is a critical factor that affects the occurrence and development of DCM. Additionally, the upregulation/activation of silent information regulation 2 homolog-1 (SIRT1) has been shown to protect against DCM. Tanshinone II A (Tan IIA), the main active component of Salviae miltiorrhizae radix et rhizome (a valuable Chinese medicine), has protective effe...
Source: Cell Research - May 2, 2023 Category: Cytology Authors: Shun Wu Dingchun Lu Babu Gajendran Qilan Hu Jian Zhang Shengquan Wang Minzhen Han Yini Xu Xiangchun Shen Source Type: research
LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway
This study aims to evaluate underlying mechanisms of ADMA in DCM especially for EndMT under diabetic conditions. A diabetic rat model was induced by streptozotocin (STZ) injection, and human cardiac microvascular endothelial cells (HCMECs) were stimulated with high glucose to induce EndMT. Subsequently, the role of ADMA in EndMT was detected either by exogenous ADMA or by over-expressing dimethylarginine dimethylaminohydrolase 1 (DDAH1, degradation enzyme for ADMA) before high glucose stimulation. Furthermore, the relationships among forkhead box protein O1 (FoxO1), DDAH1 and ADMA were evaluated by FoxO1 over-expression or...
Source: European Journal of Pharmacology - April 28, 2023 Category: Drugs & Pharmacology Authors: Meiting Wu Ting Li Ge Li Bingxuan Niu Tian Wu Li Yan Shiming Wang Shuangyi He Chuyi Huang Weiqiang Tong Niansheng Li Junlin Jiang Source Type: research
LPS-aggravated Ferroptosis via Disrupting Circadian Rhythm by Bmal1/AKT/p53 in Sepsis-Induced Myocardial Injury
In this study, LPS was used to build SICM model in H9c2 cell. The results suggested that LPS induced cytotoxicity via increasing ferroptosis over the time of course. After screening the expressions of six circadian genes, the circadian swing of Bmal1 was dramatically restrained by LPS in H9c2 cell of SIMCvitro model. PcDNA and siRNA were used to upregulate and downregulate Bmal1 and confirmed that Bmal1 inhibited LPS-triggered ferroptosis in H9c2 cells. Then, the results suggested that AKT/p53 pathway was restrained by LPS in H9c2 cell. Rescue test indicated that Bmal1 inhibited LPS-triggered ferroptosis via AKT/p53 pathwa...
Source: Inflammation - April 13, 2023 Category: Allergy & Immunology Source Type: research
Cardiac sirtuin1 deficiency exacerbates ferroptosis in doxorubicin-induced cardiac injury through the Nrf2/Keap1 pathway
This study provides direct evidence that Sirt1 plays a protective role in DOX-induced cardiotoxicity by mediating ferroptosis reduction via the Nrf2/Keap1 pathway.PMID:37030624 | DOI:10.1016/j.cbi.2023.110469
Source: Chemico-Biological Interactions - April 8, 2023 Category: Molecular Biology Authors: Weiqi Wang Xin Zhong Zimin Fang Jianmin Li Hebo Li Xuesheng Liu Xindi Yuan Weijian Huang Zhouqing Huang Source Type: research
GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity
CONCLUSION: This research premise established that STING inhibition could alleviate Dox-triggered cardiotoxicity in mice. As a result, preventing DIC by repressing STING in cardiomyocytes might be a possible treatment approach.PMID:36964634 | PMC:PMC10037834 | DOI:10.1186/s40360-022-00631-0
Source: BMC Pharmacology and Toxicology - March 25, 2023 Category: Drugs & Pharmacology Authors: Zilong Xiao Ziqing Yu Chaofeng Chen Ruizhen Chen Yangang Su Source Type: research
