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Condition: Cardiomyopathy

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Total 155 results found since Jan 2013.

Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3/HIF-1 α pathway in H9c2 cardiomyocytes.
Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3/HIF-1α pathway in H9c2 cardiomyocytes. Exp Ther Med. 2019 Nov;18(5):3948-3958 Authors: Li J, Yuan YQ, Zhang L, Zhang H, Zhang SW, Zhang Y, Xuan XX, Wang MJ, Zhang JY Abstract Hydrogen sulfide (H2S), an endogenous gasotransmitter, possesses multiple physiological and pharmacological properties including anti-apoptotic, anti-oxidative stress and cardiac protective activities in diabetic cardiomyopathy. An increasing body of evidence has suggested that signal transducer and activator of...
Source: Experimental and Therapeutic Medicine - October 18, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Knockdown of ALK7 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells.
Abstract Diabetic retinopathy (DR) is one of the diabetic complications associated with hyperglycemia-mediated oxidative stress. Activin receptor-like kinase 7 (ALK7) has been proven to be a potential therapeutic approach for diabetic cardiomyopathy, which is another diabetic complication. However, the role of ALK7 in DR remains unclear. In the current study, ALK7 was found to be up-regulated in clinical samples from DR patients and high glucose (HG)-induced human retinal pigment epithelial cells (ARPE-19). In vitro studies demonstrated that knockdown of ALK7 in ARPE-19 cells through transfection with siRNA-ALK7 (...
Source: Clinical and Experimental Pharmacology and Physiology - October 13, 2019 Category: Drugs & Pharmacology Authors: Shi Q, Dong X, Zhang M, Cheng Y, Pei C Tags: Clin Exp Pharmacol Physiol Source Type: research

Downregulation of TRAP1 aggravates injury of H9c2 cardiomyocytes in a hyperglycemic state.
In conclusion, the present findings suggested that the decrease in cardiomyocyte TRAP1 expression under high glucose conditions was associated with myocardial injury. It was hypothesized that TRAP1 may have a protective role on cardiomyocytes under high glucose surroundings. PMID: 31572516 [PubMed]
Source: Experimental and Therapeutic Medicine - October 2, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Regulation of mitochondrial cristae remodelling by acetylcholine alleviates palmitate-induced cardiomyocyte hypertrophy.
This study investigated the role of cristae remodelling in palmitate (PA)-induced neonatal rat cardiomyocyte hypertrophy and explored the beneficial effects of ACh. We found loose, fragmented and even lysed cristae in PA-treated neonatal cardiomyocytes along with declines in mitochondrial network and complex expression and overproduction of mitochondrial reactive oxygen species (ROS); these changes ultimately resulted in increased myocardial size. Overexpression of mitofilin by adenoviral infection partly improved cristae shape, mitochondrial network, and ATP content and attenuated cell hypertrophy. Interestingly, siRNA-me...
Source: Free Radical Biology and Medicine - September 21, 2019 Category: Biology Authors: Xue RQ, Zhao M, Wu Q, Yang S, Cui YL, Yu XJ, Liu JK, Zang WJ Tags: Free Radic Biol Med Source Type: research

Klotho improves diabetic cardiomyopathy by suppressing the NLRP3 inflammasome pathway
Publication date: Available online 15 August 2019Source: Life SciencesAuthor(s): Xuelian Li, Zhiyang Li, Bingong Li, Xianjie Zhu, Xingjun LaiAbstractAimsNLRP3 inflammasome activation is essential for the development and prognosis of diabetic cardiomyopathy (DCM). The anti-aging protein Klotho is suggested to modulate tissue inflammatory responses. The aim of the present study was to examine the protective effects of Klotho on DCM.Main methodsA streptozotocin-induced diabetes mouse model was established to assess the effects of Klotho in vivo, which was administered for 12 weeks. The characteristics of type 1 DCM were eva...
Source: Life Sciences - August 18, 2019 Category: Biology Source Type: research

Familial Left Ventricular Non-Compaction Is Associated With a Rare p.V407I Variant in Bone Morphogenetic Protein 10.
CONCLUSIONS: The W143*-NRG1and V470I-BMP10variants are associated with LVNC. Impaired BMPR-binding ability, perturbed proliferation and differentiation processes and intolerance to stretch in V407I-BMP10 mutant cardiomyoblasts may underlie myocardial non-compaction. PMID: 31243186 [PubMed - as supplied by publisher]
Source: Circulation Journal - June 25, 2019 Category: Cardiology Authors: Hirono K, Saito K, Munkhsaikhan U, Xu F, Wang C, Lu L, Ichida F, Towbin JA, Purevjav E Tags: Circ J Source Type: research

FGF21 as Modulator of Metabolism in Health and Disease
In conclusion, FGF21 belongs to a promising class of cytokines that are induced in response to stress and that can be used as a drug, drug target, or through a biomarker, depending on the physio-pathological context. All these findings will become clear when FGF21 will be used as a therapeutic molecule, exploiting the beneficial effects of FGF21 for treating metabolic disease or when it will be blocked to ameliorate disease progression and the onset of disease. Author Contributions CT and MS wrote the manuscript. VR contributed to the discussion. Funding This work was supported from the AFM-Telethon (19524), Italian Mi...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Spleen tyrosine kinase ‑induced JNK‑dependent NLRP3 activation is involved in diabetic cardiomyopathy.
Spleen tyrosine kinase‑induced JNK‑dependent NLRP3 activation is involved in diabetic cardiomyopathy. Int J Mol Med. 2019 Mar 27;: Authors: Li S, Liu R, Xue M, Qiao Y, Chen Y, Long G, Tian X, Hu Y, Zhou P, Dong X, Qi Z, Cui Y, Shen Y Abstract Diabetic cardiomyopathy (DCM) is a leading contributor to the increased morbidity and mortality rates associated with diabetes. Persistent inflammation has previously been reported to be involved in the pathogenesis of DCM. However, the exact underlying molecular mechanisms remain to be fully elucidated. In the present study, the role of spleen tyrosine kinas...
Source: International Journal of Molecular Medicine - March 26, 2019 Category: Molecular Biology Authors: Li S, Liu R, Xue M, Qiao Y, Chen Y, Long G, Tian X, Hu Y, Zhou P, Dong X, Qi Z, Cui Y, Shen Y Tags: Int J Mol Med Source Type: research

MiR-451 antagonist protects against cardiac fibrosis in streptozotocin-induced diabetic mouse heart
Publication date: Available online 11 March 2019Source: Life SciencesAuthor(s): Cui Liang, Lu Gao, Yuan Liu, Yuzhou Liu, Rui Yao, Yapeng Li, Lili Xiao, Leiming Wu, Binbin Du, Zhen Huang, Yanzhou ZhangAbstractAimsMicroRNAs (miRNAs or miRs) are a large class of small noncoding RNAs. The present study aims to evaluate the effect of miR-451 on cardiac remodeling in diabetic cardiomyopathy.Main methodsMice were injected with streptozotocin (STZ) to induce diabetes. Twelve weeks after final STZ injection, mice were subjected to myocardial injection of adenovirus (Ad)-shmiR-451 to knock down miR-451. Mouse heart endothelial cells...
Source: Life Sciences - March 12, 2019 Category: Biology Source Type: research

Vascular peroxidase 1 is a novel regulator of cardiac fibrosis after myocardial infarction
Publication date: Available online 27 February 2019Source: Redox BiologyAuthor(s): Zhaoya Liu, Qian Xu, Qixin Yang, Jing Cao, Cong Wu, Huihui Peng, Xinyi Zhang, Jia Chen, Guangjie Cheng, Yueheng Wu, Ruizheng Shi, Guogang ZhangAbstractCardiac fibrosis is the most important mechanism contributing to cardiac remodeling after myocardial infarction (MI). VPO1 is a heme enzyme that uses hydrogen peroxide (H2O2) to produce hypochlorous acid (HOCl). Our previous study has demonstrated that VPO1 regulates myocardial ischemic reperfusion and renal fibrosis. We investigated the role of VPO1 in cardiac fibrosis after MI. The results s...
Source: Redox Biology - February 27, 2019 Category: Biology Source Type: research

AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model
Publication date: Available online 18 February 2019Source: Life SciencesAuthor(s): Xuyang Wang, Jinyu Pan, Hui Liu, Mingjun Zhang, Dian Liu, Lu Lu, Jingjing Tian, Ming Liu, Tao Jin, Fengshuang AnAbstractAimsAbsent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its potential molecular mechanism.Main methodsSprague-Dawley rats were randomly divided into 4 groups: Control,...
Source: Life Sciences - February 18, 2019 Category: Biology Source Type: research

Down-regulation of myocardial infarction associated transcript 1 improves myocardial ischemia-reperfusion injury in aged diabetic rats by inhibition of activation of NF-κB signaling pathway
ConclusionOur study highlights that down-regulation of MIRT1 improves myocardial I/R injury in aged diabetic rats by inhibition of activation of NF-κB signaling pathway.
Source: Chemico Biological Interactions - January 4, 2019 Category: Biochemistry Source Type: research

Down-regulation of myocardial infarction associated transcript 1 improves myocardial ischemia-reperfusion injury in aged diabetic rats by inhibition of activation of NF- κB signaling pathway.
CONCLUSION: Our study highlights that down-regulation of MIRT1 improves myocardial I/R injury in aged diabetic rats by inhibition of activation of NF-κB signaling pathway. PMID: 30611788 [PubMed - as supplied by publisher]
Source: Chemico-Biological Interactions - January 3, 2019 Category: Molecular Biology Authors: Liu Y, Wang T, Zhang M, Chen P, Yu Y Tags: Chem Biol Interact Source Type: research

Resveratrol attenuates high fat diet-induced mouse cardiomyopathy through upregulation of estrogen related receptor- α.
Resveratrol attenuates high fat diet-induced mouse cardiomyopathy through upregulation of estrogen related receptor-α. Eur J Pharmacol. 2018 Oct 17;: Authors: Lu Y, Lu X, Wang L, Yang W Abstract Resveratrol reportedly promotes the improvement of cardiac dysfunction and other cardiovascular diseases. Studies demonstrate resveratrol exhibits a set of benefits, including anti-oxidative property, anti-apoptosis and anti-inflammation. However, the molecular mediators of resveratrol-induced cardiac benefits are still not fully disclosed. Present study aims to investigate whether estrogen-related receptor (...
Source: European Journal of Pharmacology - October 17, 2018 Category: Drugs & Pharmacology Authors: Lu Y, Lu X, Wang L, Yang W Tags: Eur J Pharmacol Source Type: research

Fibroblast growth factor 19 improves cardiac function and mitochondrial energy homoeostasis in the diabetic heart.
In this study, we investigated the effects of FGF19 on energy metabolism. FGF19 treatment of diabetic hearts exhibited higher glucose uptake and lower lipid profiles, suggesting changes in energy metabolism. The protective effects of FGF19 prevented ventricular dysfunction in diabetic hearts and improved mitochondrial function by the upregulation of PGC-1α expression. On the other side, knockdown of PGC-1α by siRNA attenuated the effects of FGF19 on the enhancement of mitochondrial function and energy efficiency. Taken together, these results show that FGF19 exhibited improved mitochondrial efficiency, which might be ass...
Source: Biochemical and Biophysical Research communications - September 19, 2018 Category: Biochemistry Authors: Xu W, Wang Y, Guo Y, Liu J, Ma L, Cao W, Yu B, Zhou Y Tags: Biochem Biophys Res Commun Source Type: research