FGF21 as Modulator of Metabolism in Health and Disease

In conclusion, FGF21 belongs to a promising class of cytokines that are induced in response to stress and that can be used as a drug, drug target, or through a biomarker, depending on the physio-pathological context. All these findings will become clear when FGF21 will be used as a therapeutic molecule, exploiting the beneficial effects of FGF21 for treating metabolic disease or when it will be blocked to ameliorate disease progression and the onset of disease. Author Contributions CT and MS wrote the manuscript. VR contributed to the discussion. Funding This work was supported from the AFM-Telethon (19524), Italian Ministry of Education (MiUR) (PRIN 2010/2011), AIRC (17388), H2020-MSCA-RISE-2014 project no 645648 “Muscle Stress Relief,” and CARIPARO to MS. Starting Grants CARIPARO to VR and MS. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References Adams, A. C., Astapova, I., Fisher, M., Badman, M. K., Kurgansky, K. E., Flier, J. S., et al. (2010). Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARα-dependent manner. J. Biol. Chem. 285, 14078–14082. doi: 10.1074/jbc.C110.107375 PubMed Abstract | CrossRef Full Text | Google Scholar Archer, A., Venteclef, N., Mode, A., Pedrelli, M., Gabbi, C., Clément, K., et al. (2012). Fasting-induced ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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