High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature

Conclusion
Our results highlight EC-to-cardiomyocyte transfer of heparanase to modulate the cardiomyocyte cell death signature. This mechanism was observed in the acutely diabetic heart, and its interruption following chronic diabetes may contribute towards the development of diabetic cardiomyopathy.

Source: Cardiovascular Research - December 14, 2016 Category: Cardiology Authors: Wang, F., Jia, J., Lal, N., Zhang, D., Chiu, A. P.-L., Wan, A., Vlodavsky, I., Hussein, B., Rodrigues, B. Tags: Cardiac biology and remodelling Source Type: research