Regulation of Fluid Volume From the Outside: A Role of Glycosaminoglycans in the Skin Interstitium? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2018 Category: Cardiology Authors: Wiig, H. Tags: Heart Failure Editorial Source Type: research

The Luck of Having a Cardiac Implantable Electronic Device [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2018 Category: Cardiology Authors: Costanzo, M. R. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Heart Failure Editorial Source Type: research

Dermal Interstitial Alterations in Patients With Heart Failure and Reduced Ejection Fraction: A Potential Contributor to Fluid Accumulation? [Original Articles]
Background: Large networks of interstitial glycosaminoglycans help to regulate water and electrolyte homeostasis. The relation between dermal interstitial alterations and occurrence of edema in heart failure patients with reduced ejection fraction (HFrEF) is unknown. We hypothesize that in HFrEF patients (1) interstitial glycosaminoglycan density is increased, (2) changes in the interstitial glycosaminoglycan network are associated with interstitial fluid accumulation, and (3) there is a link between the interstitial glycosaminoglycan network and the renin-angiotensin-aldosterone system. Methods and Results: Two punch bio...
Source: Circulation: Heart Failure - July 12, 2018 Category: Cardiology Authors: Nijst, P., Olinevich, M., Hilkens, P., Martens, P., Dupont, M., Tang, W. H. W., Lambrichts, I., Noben, J.-P., Mullens, W. Tags: Pathophysiology, Heart Failure Original Articles Source Type: research

HeartLogic Multisensor Algorithm Identifies Patients During Periods of Significantly Increased Risk of Heart Failure Events: Results From the MultiSENSE Study [Original Articles]
Conclusions: Dynamic assessment using implantable device sensors within HeartLogic by itself or in conjunction with NT-proBNP measurements can identify time-intervals when patients are at significantly increased risk of worsening HF and potentially better triage resources to this vulnerable patient population. Clinical Trial Registration: https://www.clinicaltrials.gov. Unique identifier: NCT01128166. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2018 Category: Cardiology Authors: Gardner, R. S., Singh, J. P., Stancak, B., Nair, D. G., Cao, M., Schulze, C., Thakur, P. H., An, Q., Wehrenberg, S., Hammill, E. F., Zhang, Y., Boehmer, J. P. Tags: Heart Failure, Prognosis Original Articles Source Type: research

Embracing the Long Road to Precision Medicine [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 11, 2018 Category: Cardiology Authors: Chirinos, J. A., Lanfear, D. E. Tags: Heart Failure Editorial Source Type: research

Data-Driven Approach to Identify Subgroups of Heart Failure With Reduced Ejection Fraction Patients With Different Prognoses and Aldosterone Antagonist Response Patterns [Original Articles]
Conclusions: Using a data-driven approach, we identified heart failure with reduced ejection fraction subgroups with significantly different prognoses and potentially different responses to eplerenone. However, these data should be regarded as hypothesis-generating and prospective validation is warranted, to assess the potential clinical implications of these subgroups. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00232180. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 11, 2018 Category: Cardiology Authors: Ferreira, J. P., Duarte, K., McMurray, J. J. V., Pitt, B., van Veldhuisen, D. J., Vincent, J., Ahmad, T., Tromp, J., Rossignol, P., Zannad, F. Tags: Heart Failure Original Articles Source Type: research

Anthracycline Cardiomyopathy: The Plot Gets Thinner [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 10, 2018 Category: Cardiology Authors: Favreau-Lessard, A. J., Sawyer, D. B., Francis, S. A. Tags: Cardiomyopathy, Heart Failure Editorial Source Type: research

Left Ventricular Mass Change After Anthracycline Chemotherapy [Emerging Investigators]
Background: Myocardial atrophy and left ventricular (LV) mass reductions are associated with fatigue and exercise intolerance. The relationships between the receipt of anthracycline-based chemotherapy (Anth-bC) and changes in LV mass and heart failure (HF) symptomatology are unknown, as is their relationship to LV ejection fraction (LVEF), a widely used measurement performed in surveillance strategies designed to avert symptomatic HF associated with cancer treatment. Methods and Results: We performed blinded, serial assessments of body weight, LVEF and mass, LV-arterial coupling, aortic stiffness, and Minnesota Living wit...
Source: Circulation: Heart Failure - July 10, 2018 Category: Cardiology Authors: Jordan, J. H., Castellino, S. M., Melendez, G. C., Klepin, H. D., Ellis, L. R., Lamar, Z., Vasu, S., Kitzman, D. W., Ntim, W. O., Brubaker, P. H., Reichek, N., DAgostino, R. B., Hundley, W. G. Tags: Cardiomyopathy, Heart Failure, Remodeling, Magnetic Resonance Imaging (MRI) Emerging Investigators Source Type: research

Cardiac Shock Revealing Systemic Lupus Erythematosus [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 6, 2018 Category: Cardiology Authors: Bouiller, K., Naudion, P., Humbert, S., Gil, H., Meaux-Ruault, N., Cravat, M., Revel, L., Molimard, C., Seronde, M.-F., Magy-Bertrand, N. Tags: Heart Failure, Pericardial Disease Images and Case Reports in Heart Failure Source Type: research

Baseline Characteristics of Patients With Heart Failure and Preserved Ejection Fraction in the PARAGON-HF Trial [Original Articles]
Conclusions: PARAGON-HF represents a contemporary group of patients with HFpEF with similar age and sex distribution compared with prior HFpEF trials but higher prevalence of comorbidities. These findings provide insights into the impact of inclusion criteria on, and regional variation in, HFpEF patient characteristics. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01920711. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 6, 2018 Category: Cardiology Authors: Solomon, S. D., Rizkala, A. R., Lefkowitz, M. P., Shi, V. C., Gong, J., Anavekar, N., Anker, S. D., Arango, J. L., Arenas, J. L., Atar, D., Ben-Gal, T., Boytsov, S. A., Chen, C.-H., Chopra, V. K., Cleland, J., Comin-Colet, J., Duengen, H.-D., Echeverria C Tags: Heart Failure Original Articles Source Type: research

Sarcomeric Auto-Oscillations in Single Myofibrils From the Heart of Patients With Dilated Cardiomyopathy [Original Articles]
Conclusions: Sarcomere dynamics was found to be depressed under loaded conditions in DCM myofibrils because of impairment of thick-thin filament sliding. Thus, microscopic analysis of Ca-SPOC in human cardiac myofibrils is beneficial to systematically unveil the kinetic properties of single sarcomeres in various types of heart disease. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 6, 2018 Category: Cardiology Authors: Kagemoto, T., Oyama, K., Yamane, M., Tsukamoto, S., Kobirumaki-Shimozawa, F., Li, A., Dos Remedios, C., Fukuda, N., Ishiwata, S. Tags: Basic Science Research, Contractile Function, Myocardial Biology, Pathophysiology, Heart Failure Original Articles Source Type: research

Unmasking Early Wild-Type Transthyretin Amyloidosis Cardiomyopathy in a Patient With Refractory Atrial Fibrillation and Unremarkable Cardiac Imaging [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 19, 2018 Category: Cardiology Authors: Varedi, D., Kovacsovics, T., Downs Kelly, E., Abraham, J., Cowley, J., Barrell, K., Revelo, M. P., Stehlik, J., Drakos, S., Marrouche, N., Wilson, B., Swanson, E. A., Fang, J., Nativi-Nicolau, J. Tags: Atrial Fibrillation, Cardiomyopathy Images and Case Reports in Heart Failure Source Type: research

Living Without a Pulse: The Vascular Implications of Continuous-Flow Left Ventricular Assist Devices [Advances in Mechanical Circulatory Support]
Pulsatility seems to have a teleological role because evolutionary hierarchy favors higher ordered animals with more complex, multichamber circulatory systems that generate higher pulse pressure compared with lower ordered animals. Yet despite years of such natural selection, the modern generation of continuous-flow left ventricular assist devices (CF-LVADs) that have been increasingly used for the last decade have created a unique physiology characterized by a nonpulsatile, nonlaminar blood flow profile with the absence of the usual large elastic artery Windkessel effect during diastole. Although outcomes and durability h...
Source: Circulation: Heart Failure - June 14, 2018 Category: Cardiology Authors: Purohit, S. N., Cornwell, W. K., Pal, J. D., Lindenfeld, J., Ambardekar, A. V. Tags: Translational Studies, Vascular Biology, Heart Failure, Cardiovascular Surgery, Transplantation Advances in Mechanical Circulatory Support Source Type: research

Predicting the Future of Cardiac Allograft Vasculopathy With Cardiac Positron Emission Tomography: Ready for Prime Time? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 11, 2018 Category: Cardiology Authors: DePasquale, E. C. Tags: Imaging, Nuclear Cardiology and PET, Transplantation, Coronary Artery Disease Editorial Source Type: research

Expression and Implication of Clusterin in Left Ventricular Remodeling After Myocardial Infarction [Original Article]
Conclusions: Our results show for the first time that plasma CLU levels are associated with LVR post–myocardial infarction, have in part a cardiac origin, and are a predictor of early death in heart failure patients. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 11, 2018 Category: Cardiology Authors: Turkieh, A., Fertin, M., Bouvet, M., Mulder, P., Drobecq, H., Lemesle, G., Lamblin, N., de Groote, P., Porouchani, S., Chwastyniak, M., Beseme, O., Amouyel, P., Mouquet, F., Balligand, J.-L., Richard, V., Bauters, C., Pinet, F. Tags: Animal Models of Human Disease, Biomarkers, Myocardial Biology, Translational Studies, Heart Failure Original Article Source Type: research

Reduced Myocardial Flow Reserve by Positron Emission Tomography Predicts Cardiovascular Events After Cardiac Transplantation [Emerging Investigators]
Background: We evaluated the diagnostic and prognostic value of quantification of myocardial flow reserve (MFR) with positron emission tomography (PET) in orthotopic heart transplant patients. Methods and Results: We retrospectively identified orthotopic heart transplant patients who underwent rubidium-82 cardiac PET imaging. The primary outcome was the composite of cardiovascular death, acute coronary syndrome, coronary revascularization, and heart failure hospitalization. Cox regression was used to evaluate the association of MFR with the primary outcome. The relationship of MFR and cardiac allograft vasculopathy severi...
Source: Circulation: Heart Failure - June 11, 2018 Category: Cardiology Authors: Konerman, M. C., Lazarus, J. J., Weinberg, R. L., Shah, R. V., Ghannam, M., Hummel, S. L., Corbett, J. R., Ficaro, E. P., Aaronson, K. D., Colvin, M. M., Koelling, T. M., Murthy, V. L. Tags: Nuclear Cardiology and PET, Transplantation, Mortality/Survival Emerging Investigators Source Type: research

Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy [Original Articles]
Conclusions: Female patients with HCM are older at the time of myectomy and show greater impairment of diastolic function. Furthermore, left ventricular and left atrial remodeling is increased in women when corrected for body surface area. At a cellular level, HCM women showed increased compliant titin and a larger degree of interstitial fibrosis. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 31, 2018 Category: Cardiology Authors: Nijenkamp, L. L. A. M., Bollen, I. A. E., van Velzen, H. G., Regan, J. A., van Slegtenhorst, M., Niessen, H. W. M., Schinkel, A. F. L., Kruger, M., Poggesi, C., Ho, C. Y., Kuster, D. W. D., Michels, M., van der Velden, J. Tags: Contractile Function, Pathophysiology, Translational Studies, Cardiomyopathy Original Articles Source Type: research

Eosinophilic Myocarditis With Rapid Progression to Cardiogenic Shock, Managed With Mechanical Support and High-Dose Corticosteroids [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 30, 2018 Category: Cardiology Authors: Tandan, S., Meltzer, S. N., Davila, C. D., Konstam, M. A., LeWinter, M. M. Tags: Cardiopulmonary Resuscitation and Emergency Cardiac Care, Inflammatory Heart Disease Images and Case Reports in Heart Failure Source Type: research

Intake of Different Dietary Proteins and Risk of Heart Failure in Men: The Kuopio Ischaemic Heart Disease Risk Factor Study [Original Articles]
Conclusions: In middle-aged men, higher protein intake was marginally associated with increased risk of HF. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT03221127 (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 29, 2018 Category: Cardiology Authors: Virtanen, H. E. K., Voutilainen, S., Koskinen, T. T., Mursu, J., Tuomainen, T.-P., Virtanen, J. K. Tags: Diet and Nutrition, Epidemiology, Risk Factors, Heart Failure Original Articles Source Type: research

Trends in Noncardiovascular Comorbidities Among Patients Hospitalized for Heart Failure: Insights From the Get With The Guidelines-Heart Failure Registry [Original Articles]
Background: The increase in medical complexity among patients hospitalized with heart failure (HF) may be reflected by an increase in concomitant noncardiovascular comorbidities. Among patients hospitalized with HF, the temporal trends in the prevalence of noncardiovascular comorbidities have not been well described. Methods and Results: We used data from 207 984 patients in the Get With The Guidelines–Heart Failure registry (from 2005 to 2014) to evaluate the prevalence and trends of noncardiovascular comorbidities (chronic obstructive pulmonary disorder/asthma, anemia, diabetes mellitus, obesity [body mass index &...
Source: Circulation: Heart Failure - May 23, 2018 Category: Cardiology Authors: Sharma, A., Zhao, X., Hammill, B. G., Hernandez, A. F., Fonarow, G. C., Felker, G. M., Yancy, C. W., Heidenreich, P. A., Ezekowitz, J. A., DeVore, A. D. Tags: Heart Failure, Mortality/Survival Original Articles Source Type: research

Prognostic Significance of Creatinine Increases During an Acute Heart Failure Admission in Patients With and Without Residual Congestion: A Post Hoc Analysis of the PROTECT Data [Original Articles]
Conclusions: In patients admitted for acute heart failure, WRF defined as a creatinine increase of ≥0.3 mg/dL was associated with longer length of hospital stay, and worse 30- and 90-day outcomes. However, effects were largely driven by patients who had residual congestion at the time of renal function assessment. Clinical Trial Registration : URL: https://www.clinicaltrials.gov. Unique identifiers: NCT00328692 and NCT00354458. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 10, 2018 Category: Cardiology Authors: Metra, M., Cotter, G., Senger, S., Edwards, C., Cleland, J. G., Ponikowski, P., Cursack, G. C., Milo, O., Teerlink, J. R., Givertz, M. M., OConnor, C. M., Dittrich, H. C., Bloomfield, D. M., Voors, A. A., Davison, B. A. Tags: Heart Failure Original Articles Source Type: research

Independent Prognostic Value of Serum Soluble ST2 Measurements in Patients With Heart Failure and a Reduced Ejection Fraction in the PARADIGM-HF Trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) [Original Articles]
Conclusions: Sacubitril/valsartan resulted in greater reductions and less increases in sST2 levels than enalapril. No specific threshold was associated with risk, as linear relationships between baseline sST2 and outcomes were observed. Changes in sST2 from baseline to 1 month were independently associated with the risk of outcomes. Clinical Trial Registration : URL: https://www.clinicaltrials.gov. Unique identifier: NCT01035255. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 10, 2018 Category: Cardiology Authors: OMeara, E., Prescott, M. F., Claggett, B., Rouleau, J. L., Chiang, L.-M., Solomon, S. D., Packer, M., McMurray, J. J. V., Zile, M. R. Tags: Biomarkers, Clinical Studies, Fibrosis, Heart Failure, Prognosis Original Articles Source Type: research

Dog Model Holds Promise for Early Mechanical Unloading in Patients With Acute Myocardial Infarction [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 8, 2018 Category: Cardiology Authors: Guerrero-Miranda, C. Y., Hall, S. A. Tags: Cardiomyopathy, Heart Failure, Myocardial Infarction, Remodeling, Treatment Editorial Source Type: research

Left Ventricular Mechanical Unloading by Total Support of Impella in Myocardial Infarction Reduces Infarct Size, Preserves Left Ventricular Function, and Prevents Subsequent Heart Failure in Dogs [Original Article]
Background: Acute myocardial infarction remains a leading cause of chronic heart failure. Excessive myocardial oxygen demand relative to supply is the fundamental mechanism of myocardial infarction. We thus hypothesized that left ventricular (LV) mechanical unloading by the total support of transvascular LV assist device Impella could minimize oxygen demand, thereby reducing infarct size and preventing subsequent heart failure. Methods and Results: In 20 dogs, we ligated the left anterior descending coronary artery for 180 minutes and then reperfused. We introduced Impella from 60 minutes after the onset of ischemia to 60...
Source: Circulation: Heart Failure - May 8, 2018 Category: Cardiology Authors: Saku, K., Kakino, T., Arimura, T., Sunagawa, G., Nishikawa, T., Sakamoto, T., Kishi, T., Tsutsui, H., Sunagawa, K. Tags: Basic Science Research, Hemodynamics, Ischemia, Heart Failure Original Article Source Type: research

Coronary Artery Remodeling and Fibrosis With Continuous-Flow Left Ventricular Assist Device Support [Emerging Investigators]
Conclusions: Among patients supported with CF-LVADs, the coronary arteries develop marked remodeling with increased adventitial fibrosis. The physiological consequences of these structural changes are unknown, but it is possible that arterial contractility may be impaired, thus limiting coronary flow reserve and promoting myocardial ischemia. This may contribute to CF-LVAD complications, such as ventricular arrhythmias and right ventricular failure. As more patients receive CF-LVADs and new pump technology attempts to modulate flow profiles and pulsatility, further research is needed to understand the mechanisms and long-t...
Source: Circulation: Heart Failure - May 3, 2018 Category: Cardiology Authors: Ambardekar, A. V., Weiser-Evans, M. C. M., Li, M., Purohit, S. N., Aftab, M., Reece, T. B., Moulton, K. S. Tags: Coronary Circulation, Translational Studies, Vascular Biology, Heart Failure, Transplantation Emerging Investigators Source Type: research

Risk Factor Burden, Heart Failure, and Survival in Women of Different Ethnic Groups: Insights From the Womens Health Initiative [Original Articles]
Background: The higher risk of heart failure (HF) in African-American and Hispanic women compared with white women is related to the higher burden of risk factors (RFs) in minorities. However, it is unclear if there are differences in the association between the number of RFs for HF and the risk of development of HF and death within racial/ethnic groups. Methods and Results: In the WHI (Women’s Health Initiative; 1993–2010), African-American (n=11 996), white (n=18 479), and Hispanic (n=5096) women with 1, 2, or 3+ baseline RFs were compared with women with 0 RF within their respective racial/ethnic groups to ...
Source: Circulation: Heart Failure - May 1, 2018 Category: Cardiology Authors: Breathett, K., Leng, I., Foraker, R. E., Abraham, W. T., Coker, L., Whitfield, K. E., Shumaker, S., Manson, J. E., Eaton, C. B., Howard, B. V., Ijioma, N., Cene, C. W., Martin, L. W., Johnson, K. C., Klein, L. Tags: Race and Ethnicity, Risk Factors, Women, Heart Failure, Mortality/Survival Original Articles Source Type: research

Load-Dependent Changes in Left Ventricular Structure and Function in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure [Original Articles]
Conclusions: Hemodynamic unloading of a pathophysiologically relevant mouse model of HF results in normalization of LV structure, incomplete recovery of LV function, and incomplete reversal of the HF transcriptional program. The HF-DB mouse model may provide novel insights into mechanisms of reverse LV remodeling. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 1, 2018 Category: Cardiology Authors: Weinheimer, C. J., Kovacs, A., Evans, S., Matkovich, S. J., Barger, P. M., Mann, D. L. Tags: Contractile Function, Fibrosis, Hemodynamics, Cardiomyopathy, Remodeling Original Articles Source Type: research

Internal Versus External Compression of a Left Ventricular Assist Device Outflow Graft: Diagnosis With Intravascular Ultrasound and Treatment With Stenting [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 25, 2018 Category: Cardiology Authors: Trankle, C. R., Quader, M. A., Grizzard, J. D., Tang, D. G., Shah, K. B., Paris, K., Shepard, C. K., Gertz, Z. M. Tags: Heart Failure, Stent Images and Case Reports in Heart Failure Source Type: research

Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure [Original Articles]
Background: Single measurements of left ventricular filling pressure at rest lack sensitivity for identifying heart failure with preserved ejection fraction (HFpEF) in patients with dyspnea on exertion. We hypothesized that exercise hemodynamic measurements (ie, changes in pulmonary capillary wedge pressure [PCWP] indexed to cardiac output [CO]) may more sensitively differentiate HFpEF and non-HFpEF disease states, reflect aerobic capacity, and forecast heart failure outcomes in individuals with normal PCWP at rest. Methods and Results: We studied 175 patients referred for cardiopulmonary exercise testing with hemodynamic...
Source: Circulation: Heart Failure - April 25, 2018 Category: Cardiology Authors: Eisman, A. S., Shah, R. V., Dhakal, B. P., Pappagianopoulos, P. P., Wooster, L., Bailey, C., Cunningham, T. F., Hardin,, K. M., Baggish, A. L., Ho, J. E., Malhotra, R., Lewis, G. D. Tags: Heart Failure Original Articles Source Type: research

Correction to: 2017 ACC/AHA/HFSA/ISHLT/ACP Advanced Training Statement on Advanced Heart Failure and Transplant Cardiology (Revision of the ACCF/AHA/ACP/HFSA/ISHLT 2010 Clinical Competence Statement on Management of Patients With Advanced Heart Failure and Cardiac Transplant): A Report of the ACC Competency Management Committee [Correction]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 24, 2018 Category: Cardiology Tags: Correction Source Type: research

When the VEST Does Not Fit: Representations of Trial Results Deviating From Rigorous Data Interpretation [On My Mind]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 17, 2018 Category: Cardiology Authors: Allen, L. A., Adler, E. D., Bayes-Genis, A., Brisco-Bacik, M. A., Chirinos, J. A., Claggett, B., Cook, J. L., Fang, J. C., Gustafsson, F., Ho, C. Y., Kapur, N. K., Klewer, S. E., Kociol, R. D., Lanfear, D. E., Vardeny, O., Sweitzer, N. K. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Sudden Cardiac Death, Heart Failure On My Mind Source Type: research

Ventricular Assist Device Utilization in Heart Transplant Candidates: Nationwide Variability and Impact on Waitlist Outcomes [Emerging Investigators]
Background: Continuous-flow left ventricular assist devices (CF-LVADs) have become a standard treatment choice in advanced heart failure patients. We hypothesized that practice patterns with regards to CF-LVAD utilization vary significantly among transplant centers and impact waitlist outcomes. Methods and Results: The United Network for Organ Sharing registry was queried to identify adult patients who were waitlisted for heart transplantation (HT) between 2008 and 2015. Each patient was assigned a propensity score based on likelihood of receiving a durable CF-LVAD before or while waitlisted. The primary outcomes of inter...
Source: Circulation: Heart Failure - April 17, 2018 Category: Cardiology Authors: Truby, L. K., Garan, A. R., Givens, R. C., Takeda, K., Takayama, H., Trinh, P. N., Yuzefpolskaya, M., Farr, M. A., Naka, Y., Colombo, P. C., Topkara, V. K. Tags: Heart Failure, Transplantation Emerging Investigators Source Type: research

Left Ventricular Assist Device Inflow Cannula Angle and Thrombosis Risk [Original Articles]
Conclusions: Angulation of the inflow cannula>7° from the apical axis (axis connecting mitral valve and ventricular apex) leads to markedly unfavorable hemodynamics as determined by computational fluid dynamics. Computational hemodynamic simulations incorporating Lagrangian and Eulerian metrics are a powerful tool for studying optimization of LVAD implantation strategies, with the long-term potential of improving outcomes. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 17, 2018 Category: Cardiology Authors: Chivukula, V. K., Beckman, J. A., Prisco, A. R., Dardas, T., Lin, S., Smith, J. W., Mokadam, N. A., Aliseda, A., Mahr, C. Tags: Cardiomyopathy, Heart Failure, Complications Original Articles Source Type: research

Incidence, Predictors, and Outcomes Associated With Hypotensive Episodes Among Heart Failure Patients Receiving Sacubitril/Valsartan or Enalapril: The PARADIGM-HF Trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure) [Original Articles]
Conclusions: Hypotension was more common with sacubitril/valsartan relative to enalapril in PARADIGM-HF but did not differentially affect permanent discontinuations. Patients with hypotension during run-in derived similar benefit from sacubitril/valsartan compared with enalapril as those who did not experience hypotension. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 11, 2018 Category: Cardiology Authors: Vardeny, O., Claggett, B., Kachadourian, J., Pearson, S. M., Desai, A. S., Packer, M., Rouleau, J., Zile, M. R., Swedberg, K., Lefkowitz, M., Shi, V., McMurray, J. J. V., Solomon, S. D. Tags: Clinical Studies, Heart Failure Original Articles Source Type: research

Early Ambulation Among Hospitalized Heart Failure Patients Is Associated With Reduced Length of Stay and 30-Day Readmissions [Original Articles]
Background: Early ambulation (EA) is associated with improved outcomes for mechanically ventilated and stroke patients. Whether the same association exists for patients hospitalized with acute heart failure is unknown. We sought to determine whether EA among patients hospitalized with heart failure is associated with length of stay, discharge disposition, 30-day post discharge readmissions, and mortality. Methods and Results: The study population included 369 hospitals and 285 653 patients with heart failure enrolled in the Get With The Guidelines-Heart Failure registry. We used multivariate logistic regression with gener...
Source: Circulation: Heart Failure - April 11, 2018 Category: Cardiology Authors: Fleming, L. M., Zhao, X., DeVore, A. D., Heidenreich, P. A., Yancy, C. W., Fonarow, G. C., Hernandez, A. F., Kociol, R. D. Tags: Heart Failure, Mortality/Survival, Quality and Outcomes Original Articles Source Type: research

Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease [Original Articles]
Conclusions: Pulmonary Ea and pulmonary arterial compliance more consistently predicted mortality than pulmonary vascular resistance or transpulmonary gradient across a spectrum of left heart disease with pulmonary hypertension, including patients with heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, and pulmonary hypertension with a normal pulmonary vascular resistance. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 11, 2018 Category: Cardiology Authors: Tampakakis, E., Shah, S. J., Borlaug, B. A., Leary, P. J., Patel, H. H., Miller, W. L., Kelemen, B. W., Houston, B. A., Kolb, T. M., Damico, R., Mathai, S. C., Kasper, E. K., Hassoun, P. M., Kass, D. A., Tedford, R. J. Tags: Hemodynamics, Heart Failure, Pulmonary Hypertension Original Articles Source Type: research

Advanced Dilated Cardiomyopathy in a Patient With Hutterite Limb-Girdle Muscular Dystrophy: Use of a Left Ventricular Assist Device [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 6, 2018 Category: Cardiology Authors: Miskew Nichols, B., Nikhanj, A., Wang, F., Freed, D. H., Oudit, G. Y. Tags: Cardiomyopathy, Heart Failure, Hypertrophy, Remodeling Images and Case Reports in Heart Failure Source Type: research

Devil in Disguise: Hints and Pitfalls in Diagnosis of Peripartum Cardiomyopathy [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 6, 2018 Category: Cardiology Authors: Bauersachs, J., Koenig, T. Tags: Cardiomyopathy, Heart Failure Editorial Source Type: research

Incidence, Risk Factors, and Clinical Characteristics of Peripartum Cardiomyopathy in South Korea [Original Articles]
Conclusions: The incidence of PPCM was 1 in 1741 deliveries in South Korea. Patients with PPCM were older, were more associated with primiparity and multiple pregnancy, had more pregnancy-related complications, and revealed higher in-hospital mortality than controls. The number of cases diagnosed as PPCM were decreased over time after delivery; however, a large number of patients were still noted through 12 months after delivery. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 6, 2018 Category: Cardiology Authors: Lee, S., Cho, G. J., Park, G. U., Kim, L. Y., Lee, T.-S., Kim, D. Y., Choi, S.-W., Youn, J.-C., Han, S. W., Ryu, K.-H., Na, J. O., Choi, C. U., Seo, H. S., Kim, E. J. Tags: Epidemiology, Cardiomyopathy, Heart Failure Original Articles Source Type: research

Causes and Predictors of 30-Day Readmission in Patients With Acute Myocardial Infarction and Cardiogenic Shock [Original Articles]
Background: Acute myocardial infarction (AMI) occurs as a result of irreversible damage to cardiac myocytes secondary to lack of blood supply. Cardiogenic shock complicating AMI has significant associated morbidity and mortality, and data on postdischarge outcomes are limited. Methods and Results: We derived the study cohort of patients with AMI and cardiogenic shock from the 2013 to 2014 Healthcare Cost and Utilization Project National Readmission Database. Incidence, predictors, and causes of 30-day readmissions were analyzed. From 43 212 index admissions for AMI with cardiogenic shock, 26 016 (60.2%) survived to discha...
Source: Circulation: Heart Failure - April 4, 2018 Category: Cardiology Authors: Shah, M., Patil, S., Patel, B., Agarwal, M., Davila, C. D., Garg, L., Agrawal, S., Kapur, N. K., Jorde, U. P. Tags: Heart Failure, Complications, Mortality/Survival, Quality and Outcomes, Acute Coronary Syndromes Original Articles Source Type: research

TTR (Transthyretin) Stabilizers Are Associated With Improved Survival in Patients With TTR Cardiac Amyloidosis [Original Articles]
Background: TTR (transthyretin) cardiac amyloidosis is caused by dissociation of TTR into monomers, which misassemble into amyloid fibrils. TTR stabilizers act at the dimer–dimer interface to prevent dissociation. We investigated differences in survival among patients with TTR cardiac amyloidosis on stabilizer medications compared with those not on stabilizers. Methods AND RESULTS: A retrospective study of patients with TTR cardiac amyloidosis presenting to a single center was conducted. Baseline characteristics were compared between those treated with stabilizers and those not treated with stabilizers. Cox proporti...
Source: Circulation: Heart Failure - April 3, 2018 Category: Cardiology Authors: Rosenblum, H., Castano, A., Alvarez, J., Goldsmith, J., Helmke, S., Maurer, M. S. Tags: Cardiomyopathy, Heart Failure Original Articles Source Type: research

Association of Biomarker Clusters With Cardiac Phenotypes and Mortality in Patients With HIV Infection [Original Articles]
Conclusions: Serum biomarkers can be used to classify HIV-infected individuals into separate clusters for differentiating cardiopulmonary structural and functional abnormalities and can predict mortality independent of these structural and functional measures. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - April 3, 2018 Category: Cardiology Authors: Scherzer, R., Shah, S. J., Secemsky, E., Butler, J., Grunfeld, C., Shlipak, M. G., Hsue, P. Y. Tags: Heart Failure Original Articles Source Type: research

Accelerated Cardiomyocyte Proliferation in the Heart of a Neonate With LEOPARD Syndrome-Associated Fatal Cardiomyopathy [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 30, 2018 Category: Cardiology Authors: Nakagama, Y., Inuzuka, R., Ichimura, K., Hinata, M., Takehara, H., Takeda, N., Kakiuchi, S., Shiraga, K., Asakai, H., Shindo, T., Hirata, Y., Saitoh, M., Oka, A. Tags: Developmental Biology, Genetics, Cardiomyopathy, Heart Failure, Hypertrophy Images and Case Reports in Heart Failure Source Type: research

Apophenia and the Crafting of a Circulation: Heart Failure Issue [Editor's Perspective]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Sweitzer, N. K. Tags: Heart Failure Editor ' s Perspective Source Type: research

Same Story, Different Disease: It Is Time to Change the Storyline for Racial Minorities and Patients of Lower Socioeconomic Status [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Breathett, K. Tags: Race and Ethnicity, Transplantation, Health Services, Quality and Outcomes Editorial Source Type: research

Donation After Cardiac Death Heart Transplantation in America Is Clinically Necessary and Ethically Justified [On My Mind]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Rajab, T. K., Singh, S. K. Tags: Transplantation On My Mind Source Type: research

Mechanical Circulatory Support Device Utilization and Heart Transplant Waitlist Outcomes in Patients With Restrictive and Hypertrophic Cardiomyopathy [Original Articles]
This study characterized MCSD utilization and transplant waitlist outcomes in patients with RCM/HCM under the current allocation system and discusses changes in the era of the new donor allocation system. Methods and Results: Patients waitlisted from 2006 to 2016 in the United Network for Organ Sharing registry were stratified by RCM/HCM versus other diagnoses. MCSD utilization and waitlist duration were analyzed by propensity score models. Waitlist outcomes were assessed by cumulative incidence functions with competing events. Predictors of waitlist mortality or delisting for worsening status in patients with RCM/HCM wer...
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Sridharan, L., Wayda, B., Truby, L. K., Latif, F., Restaino, S., Takeda, K., Takayama, H., Naka, Y., Colombo, P. C., Maurer, M., Farr, M. A., Topkara, V. K. Tags: Cardiomyopathy, Heart Failure, Transplantation, Mortality/Survival, Statements and Guidelines Original Articles Source Type: research

Racial Differences in Characteristics and Outcomes of Patients With Heart Failure and Preserved Ejection Fraction in the Treatment of Preserved Cardiac Function Heart Failure Trial [Original Articles]
Conclusions: Black patients with HFpEF have a higher HF hospitalization risk than nonblack patients, but spironolactone is similarly effective and safe in both groups. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00094302. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Lewis, E. F., Claggett, B., Shah, A. M., Liu, J., Shah, S. J., Anand, I., OMeara, E., Sweitzer, N. K., Rouleau, J. L., Fang, J. C., Desai, A. S., Retta, T. M., Solomon, S. D., Heitner, J. F., Stamos, T. D., Boineau, R., Pitt, B., Pfeffer, M. A. Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Clinical Studies, Cardiomyopathy, Heart Failure Original Articles Source Type: research

Longitudinal Assessment of Vascular Function With Sunitinib in Patients With Metastatic Renal Cell Carcinoma [Emerging Investigators]
Background: Sunitinib, used widely in metastatic renal cell carcinoma, can result in hypertension, left ventricular dysfunction, and heart failure. However, the relationships between vascular function and cardiac dysfunction with sunitinib are poorly understood. Methods and Results: In a multicenter prospective study of 84 metastatic renal cell carcinoma patients, echocardiography, arterial tonometry, and BNP (B-type natriuretic peptide) measures were performed at baseline and at 3.5, 15, and 33 weeks after sunitinib initiation, correlating with sunitinib cycles 1, 3, and 6. Mean change in vascular function parameters and...
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Catino, A. B., Hubbard, R. A., Chirinos, J. A., Townsend, R., Keefe, S., Haas, N. B., Puzanov, I., Fang, J. C., Agarwal, N., Hyman, D., Smith, A. M., Gordon, M., Plappert, T., Englefield, V., Narayan, V., Ewer, S., ElAmm, C., Lenihan, D., Ky, B. Tags: Heart Failure, Hypertension Emerging Investigators Source Type: research

Outcomes in Patients With Hypertrophic Cardiomyopathy Awaiting Heart Transplantation [Original Articles]
Background: Current organ allocation policy and the rapid growth of mechanical support favor heart transplant (HT) candidates on left ventricular assist devices. HT candidates with hypertrophic cardiomyopathy (HCM) are usually not left ventricular assist device candidates and may have a disadvantage compared with dilated forms of cardiomyopathy. Methods and Results: Adult HT candidates registered in the Scientific Registry of Transplant Recipients database between 1999 and 2016 were included. HCM candidates were compared with ischemic cardiomyopathy (ICM) and non-ICM patients. Two eras were defined on the basis of the app...
Source: Circulation: Heart Failure - March 16, 2018 Category: Cardiology Authors: Zuniga Cisneros, J., Stehlik, J., Selzman, C. H., Drakos, S. G., McKellar, S. H., Wever-Pinzon, O. Tags: Risk Factors, Cardiomyopathy, Heart Failure, Transplantation, Mortality/Survival Original Articles Source Type: research