Cardiomyocyte A Disintegrin And Metalloproteinase 17 (ADAM17) Is Essential in Post-Myocardial Infarction Repair by Regulating Angiogenesis [Original Articles]
Conclusions—
This study highlights the key role of cardiomyocyte ADAM17 in post-MI recovery by regulating VEGFR2 transcription and angiogenesis, thereby limiting left ventricular dilation and dysfunction. Therefore, ADAM17 upregulation, within the physiological range, could provide protective effects in ischemic cardiomyopathy.
Source: Circulation: Heart Failure - Category: Cardiology Authors: Fan, D., Takawale, A., Shen, M., Wang, W., Wang, X., Basu, R., Oudit, G. Y., Kassiri, Z. Tags: Other heart failure, Angiogenesis, Cell signalling/signal transduction, Gene expression, Acute myocardial infarction Original Articles Source Type: research
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