Cardiomyocyte A Disintegrin And Metalloproteinase 17 (ADAM17) Is Essential in Post-Myocardial Infarction Repair by Regulating Angiogenesis [Original Articles]

Conclusions— This study highlights the key role of cardiomyocyte ADAM17 in post-MI recovery by regulating VEGFR2 transcription and angiogenesis, thereby limiting left ventricular dilation and dysfunction. Therefore, ADAM17 upregulation, within the physiological range, could provide protective effects in ischemic cardiomyopathy.
Source: Circulation: Heart Failure - Category: Cardiology Authors: Tags: Other heart failure, Angiogenesis, Cell signalling/signal transduction, Gene expression, Acute myocardial infarction Original Articles Source Type: research