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Cancer: Colon Cancer
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Total 665 results found since Jan 2013.
Inhibition of semaphorin 4D enhances chemosensitivity by increasing 5-fluorouracile-induced apoptosis in colorectal cancer cells.
This study implicates that the silencing of SEMA4D by siRNA promotes the chemosensitivity of SW48 cells to 5-FU and it may be a potential therapeutic agent for colon cancer therapy.
PMID: 32888127 [PubMed - as supplied by publisher]
Source: Molecular Biology Reports - September 3, 2020 Category: Molecular Biology Authors: Rashidi G, Rezaeepoor M, Mohammadi C, Solgi G, Najafi R Tags: Mol Biol Rep Source Type: research
Late Breaking Abstract - DCLK1 mediates thrombin-induced IL-8/CXCL8 expression in lung epithelial cells
Airway neutrophilia has been known correlated with asthma severity. Thrombin plays a crucial role in asthma. Thrombin can induce IL-8/CXCL8 expression, a potent chemoattractant for neutrophils, in lung epithelial cells. Doublecortin-like kinase 1 (DCLK1) is a protein kinase that has been identified as a tumor stem cell marker in colon and pancreatic cancer. Here we investigated the role of DCLK1 in thrombin-induced IL-8/CXCL8 expression in human lung epithelial cells. Thrombin-induced IL-8/CXCL8 release was attenuated by DCLK1 siRNA or LRKK2-IN-1 (DCLK1 inhibitor) in BEAS-2B and A549 cells. Moreover, thrombin-induced IL-8/...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Yuliani, F. S., Chen, J.-Y., Cheng, W.-H., Wen, H.-C., Chen, B.-C., Lin, C.-H. Tags: Allergy and immunology Source Type: research
Aberrant PI3K δ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers
ConclusionIn summary, our study has suggested a promising potential of utilizing PI3Kδ-S (an oncogenic isoform conferring drug resistance and exempt from PTEN regulation) as a prognostic biomarker and drug target in advanced endocrine cancers.
Source: Frontiers in Endocrinology - August 21, 2023 Category: Endocrinology Source Type: research
Distinct inhibitory efficiency of siRNAs and DNAzymes to β1 integrin subunit in blocking tumor growth.
In this study, we compared inhibitory efficiencies of siRNA and DNAzymes against the β1 integrin subunit (DEβ1), in a mouse xenograft model. Both inhibitors were used under their most favorable conditions, in terms of concentrations, incubation time and lack of cytotoxic effects. Transfection of siRNAβ1 or DEβ1 remarkably inhibited the growth of both PC3 and HT29 colon cancer cells in vitro, and decreased their capability of initiating tumor formation in the mouse xenograft model. siRNAβ1 appeared to be slightly more efficient than DEβ1 when tested in vitro, however it was comparably less proficient in blocking the t...
Source: Acta Biochim Pol - May 23, 2013 Category: Biochemistry Authors: Wiktorska M, Sacewicz-Hofman I, Stasikowska-Kanicka O, Danilewicz M, Niewiarowska J Tags: Acta Biochim Pol Source Type: research
Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.
In conclusion, there is a crosstalk between polyamines and MAT2A. Increased MAT2A expression provides more SAMe for polyamines biosynthesis; increased polyamine (putrescine in this case) can activate MAT2A at the transcriptional level. This along with increased ODC expression in cancer all feed forward to further enhance the proliferative capacity of the cancer cell.
PMID: 23588207 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - April 12, 2013 Category: Cytology Authors: Tomasi ML, Ryoo M, Skay A, Tomasi I, Giordano P, Mato JM, Lu SC Tags: Exp Cell Res Source Type: research
A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway.
Conclusion:CP is a broad-spectrum inhibitor of human carcinoma cells in vitro, and it also exerts significant inhibition on gastric cancer cell growth in vivo. CP induces human gastric cancer apoptosis via activation of the ERK1/2 signaling pathway.
PMID: 24241351 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - November 18, 2013 Category: Drugs & Pharmacology Authors: Wang HJ, Liu Y, Fan LQ, Han CL, Jiang Y, Cheng SJ, Li Y Tags: Acta Pharmacol Sin Source Type: research
Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation.
Abstract
Silibinin, an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration. However, the molecular mechanisms responsible for these effects are not fully understood. We observed that silibinin significantly induced the expression of the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) in both p53 wild-type and p53-null cancer cell lines, suggesting that silibinin-induced NAG-1 up-regulation is p53-independent manner. Silibinin up-regulates EGR-1 expression. The ectopic expression of EGR...
Source: Chemico-Biological Interactions - January 16, 2014 Category: Molecular Biology Authors: Woo SM, Min KJ, Kim S, Park JW, Kim DE, Chun KS, Kim YH, Lee TJ, Kim SH, Choi YH, Chang JS, Kwon TK Tags: Chem Biol Interact Source Type: research
Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1
Conclusions:
These data suggest that SPTAN1 levels decreased in concordance with MLH1 reduction and impaired cellular mobility in MLH1 deficient colon cancer cells. Therefore, aggressiveness of MLH1-positive CRC might be related to SPTAN1.
Source: Molecular Cancer - January 24, 2014 Category: Cancer & Oncology Authors: Inga HinrichsenBenjamin ErnstFranziska NuberSandra PassmannDieter SchäferVerena SteinkeNicolaus FriedrichsGuido PlotzStefan ZeuzemAngela Brieger Source Type: research
Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells
Conclusion:
Our overall results demonstrate that mPEPCK is a useful predictor of a response to chemoradiotherapy in patients with rectal cancer.
Source: BMC Cancer - March 6, 2014 Category: Cancer & Oncology Authors: Ji-Won ParkSeung KimWon KimJun HongKyung-Hee KimHyun YeoJae LeeM KimJong KimSe YangDae KimJae OhJae ChoByong Yoo Source Type: research
PPARδ deficiency disrupts hypoxia‐mediated tumorigenic potential of colon cancer cells
Peroxisome proliferator‐activated receptor (PPAR) δ is highly expressed in colon epithelial cells and closely linked to colon carcinogenesis. However, the role of PPARδ in colon cancer cells in a hypoxic tumor microenvironment is not fully understood. We found that expression of the tumor‐promoting cytokines, IL‐8 and VEGF, induced by hypoxia (<1% O2) and deferoxamine (a hypoxia mimetic) was significantly attenuated in PPARδ‐deficient HCT116 colon cancer cells. Consequently, PPARδ‐knockout colon cancer cells exposed to hypoxia and deferoxamine failed to stimulate endothelial cell vascularization and macrop...
Source: Molecular Carcinogenesis - March 9, 2014 Category: Molecular Biology Authors: Eunshil Jeong, Jung Eun Koo, Sang Hyeon Yeon, Mi‐Kyoung Kwak, Daniel H. Hwang, Joo Young Lee Tags: Research Article Source Type: research
Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy.
CONCLUSION: SeV/dF/FIR showed strong tumor growth suppression with no significant side effects in an animal xenograft model, thus SeV/dF/FIR is potentially applicable for future clinical cancer treatment.
PMID: 24764668 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 21, 2014 Category: Gastroenterology Authors: Matsushita K, Shimada H, Ueda Y, Inoue M, Hasegawa M, Tomonaga T, Matsubara H, Nomura F Tags: World J Gastroenterol Source Type: research
Interference of Skp2 effectively inhibits the development and metastasis of colon carcinoma.
Abstract
Colon cancer is a common type of malignancy in the digestive system. The aim of the present study was to investigate the role of S-phase kinase-associated protein 2 (Skp2) in colon carcinoma and to identify whether depletion of Skp2 by Skp2‑RNA interference (RNAi) attenuates the proliferation and migration of colon carcinoma. Three pairs of small interfering (si)RNA were designed based on the Skp2 gene sequence and the most effective one was used to silence the Skp2 gene in SW620 cells. Subsequent to the interference, quantitative polymerase chain reaction and western blot analysis were used for detec...
Source: Molecular Medicine - June 15, 2014 Category: Molecular Biology Authors: Chen H, Mo X, Yu J, Huang S, Huang Z, Gao L Tags: Mol Med Rep Source Type: research
A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-8.
CONCLUSION: TIPE2 can inhibit caspase-8 activity in colon cancer cells. TIPE2 can regulate TLR4 inflammatory effect and inhibit further amplification of cascade reaction via caspase-8, which provides one new therapeutic target for clinical treatment schedule.
PMID: 24934366 [PubMed - in process]
Source: Cancer Biomarkers : Section A of Disease Markers - January 1, 2014 Category: Cancer & Oncology Authors: Li XM, Su JR, Yan SP, Cheng ZL, Yang TT, Zhu Q Tags: Cancer Biomark Source Type: research
Ki-1/57 and CGI-55 ectopic expression impact cellular pathways involved in proliferation and stress response regulation.
Abstract
Ki-1/57 (HABP4) and CGI-55 (SERBP1) are regulatory proteins and paralogs with 40.7% amino acid sequence identity and 67.4% similarity. Functionally, they have been implicated in the regulation of gene expression on both the transcriptional and mRNA metabolism levels. A link with tumorigenesis is suggested, since both paralogs show altered expression levels in tumor cells and the Ki-1/57 gene is found in a region of chromosome 9q that represents a haplotype for familiar colon cancer. However, the target genes regulated by Ki-1/57 and CGI-55 are unknown. Here, we analyzed the alterations of the global trans...
Source: Biochimica et Biophysica Acta - September 6, 2014 Category: Biochemistry Authors: Costa FC, Saito A, Gonçalves KA, Vidigal PM, Meirelles GV, Bressan GC, Kobarg J Tags: Biochim Biophys Acta Source Type: research
Cellular density‐dependent down‐regulation of EP4 prostanoid receptors via the up‐regulation of hypoxia‐inducible factor‐1α in HCA‐7 human colon cancer cells
Abstract
Increases in prostaglandin E2 (PGE2) and cyclooxygenase‐2 (COX‐2) levels are features of colon cancer. Among the different E‐type prostanoid receptor subtypes, EP4 receptors are considered to play a crucial role in carcinogenesis by, for example, inducing COX‐2 when stimulated with PGE2. However, EP4 receptor levels and PGE2‐induced cellular responses are inconsistent among the cellular conditions. Therefore, the connections responsible for the expression of EP4 receptors were investigated in the present study by focusing on cell density‐induced hypoxia‐inducible factor‐1α (HIF‐1α). The express...
Source: Pharmacology Research and Perspectives - November 7, 2014 Category: Drugs & Pharmacology Authors: Sho Otake, Kenji Yoshida, Naofumi Seira, Christopher M. Sanchez, John W. Regan, Hiromichi Fujino, Toshihiko Murayama Tags: Original Article Source Type: research
