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Total 665 results found since Jan 2013.
Ki-1/57 and CGI-55 ectopic expression impact cellular pathways involved in proliferation and stress response regulation
Publication date: December 2014 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1843, Issue 12 Author(s): Fernanda C. Costa , Ângela Saito , Kaliandra A. Gonçalves , Pedro M. Vidigal , Gabriela V. Meirelles , Gustavo C. Bressan , Jörg Kobarg Ki-1/57 (HABP4) and CGI-55 (SERBP1) are regulatory proteins and paralogs with 40.7% amino acid sequence identity and 67.4% similarity. Functionally, they have been implicated in the regulation of gene expression on both the transcriptional and mRNA metabolism levels. A link with tumorigenesis is suggested, since both paralogs show altered expression le...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - November 11, 2014 Category: Molecular Biology Source Type: research
Abstract 120: Runx3 inhibited epithelial to mesenchymal transition promotes motility and invasiveness of colon cancer cells through reduction of ROS generation
In this study, we investigated the function of Runx3 in human colon cancer cells. The proliferation, migration, and invasion of colon cancer cells in response to using the Runx3 expression vector for various times were investigated using MTT, wound healing, and Matrigel invasion assay, respectively. The morphologic changes of colon cancer cells through the EMT process were monitored by immunofluorescence staining and Western blot assay for EMT markers Twist and Vimentin. We found that Runx3 overexpressing cell inhibited cell motility and invasiveness in colon cancer, and this process was enhanced by Runx3 siRNA. We observe...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Kim, B. R., Kang, M. H., Kim, J. L., Jang, Y. J., Lee, S. I., Kim, J. S., Oh, S. C. Tags: Tumor Biology Source Type: research
Abstract 5455: Resistance to a MEK inhibitor (AZD6244): Its association with increased expression of transcription factor 4
The important role of Ras/Raf/MEK/ERK pathway in carcinogenesis has led to clinical development of MEK inhibitors for treatment of various cancers. Although recent studies have demonstrated impressive antitumor activities of the agents, many tumors show intrinsic and acquired resistance to MEK inhibitors. We tried to find biomarkers that were associated with intrinsic or acquired resistance to a MEK inhibitor (AZD6244) by public microarray data acquisition and development of AZD6244-resistance cell lines. First, we analyzed a set of genome-wide gene expression profiling data from 6 sensitive and 6 resistant cell lines of v...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Goo, B.-K., Hur, E.-H., Choi, Y., Kim, S.-D., Hwang, J. J., Kim, C.-S., Bae, K. S., Choi, J., Cho, S. Y., Yang, S.-H., Lee, J.-H. Tags: Experimental and Molecular Therapeutics Source Type: research
Role of milk fat globule-epidermal growth factor 8 in colonic inflammation and carcinogenesis
Conclusions
MFG-E8 promotes tumor growth regardless of the presence or absence of colonic inflammation, whereas colon tumor development is initiated by MFG-E8 under inflammatory conditions. These MFG-E8 functions may be dependent on integrin-mediated cellular signaling.
Source: Journal of Gastroenterology - January 18, 2015 Category: Gastroenterology Source Type: research
Increased Sushi repeat-containing protein X-linked 2 is associated with progression of colorectal cancer
Abstract
Sushi repeat-containing protein X-linked 2 (SRPX2) is a novel chondroitin sulfate proteoglycan overexpressed in gastrointestinal cancer. Its role in tumor biology remains unknown. The aim of this study was to investigate the expression of SRPX2 in colorectal cancer and its potential association with cancer progression. The expression of SRPX2 and its clinicopathological significance was evaluated using immunohistochemistry in a tissue microarray including 88 colon cancer and pairing normal tissues. The impact of SRPX2 on behavior of colorectal cancer cells and possible mechanism was explored using gene t...
Source: Medical Oncology - March 3, 2015 Category: Cancer & Oncology Source Type: research
Increased SPHK2 transcription of human colon cancer cells in serum‐depleted culture: the involvement of CREB transcription factor
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Source: Journal of Cellular Biochemistry - March 24, 2015 Category: Biochemistry Authors: Naoki Mizutani, Yukari Omori, Koji Tanaka, Hiromi Ito, Akira Takagi, Tetsuhito Kojima, Masahiro Nakatochi, Hideo Ogiso, Yoshiyuki Kawamoto, Mitsuhiro Nakamura, Motoshi Suzuki, Mamoru Kyogashima, Keiko Tamiya‐Koizumi, Yoshinori Nozawa, Takashi Murate Tags: Article Source Type: research
Crosstalk between Hippo and TGFβ– subcellular localization of YAP/TAZ complexes
In conclusion, this study show localized, density dependent formation of Yap/Taz-Smad2/3 complexes in HaCaT cells and provides evidence supporting a crosstalk between the Hippo and the TGFβ signaling pathways. Graphical abstract
Source: Journal of Molecular Biology - May 4, 2015 Category: Molecular Biology Source Type: research
Crosstalk between Hippo and TGFβ: Subcellular Localization of YAP/TAZ/Smad Complexes
In conclusion, this study shows localized, density-dependent formation of YAP/TAZ–Smad2/3 complexes in HaCaT cells and provides evidence supporting a crosstalk between the Hippo and the TGFβ signaling pathways. Graphical abstract
Source: Journal of Molecular Biology - May 12, 2015 Category: Molecular Biology Source Type: research
TRAF4 promotes the growth and invasion of colon cancer through the Wnt/β-catenin pathway.
Abstract
The tumor necrosis factor receptor-associated factor 4 (TRAF4) has been linked to carcinogenesis. However, the role of TRAF4 in colon cancer is still unclear. Therefore, we investigated the role of TRAF4 in colon cancer and the underlying mechanism. In the present study, we found that TRAF4 was overexpressed in colon cancer tissues and cells, and small interfering RNA (siRNA)-mediated gene knockdown of TRAF4 significantly inhibited cell proliferation, invasion and tumorigenesis, both in vitro and in vivo, but induced apoptosis in colon cancer cells. Furthermore, siRNA-TRAF4 significantly inhibited the exp...
Source: Clinical Genitourinary Cancer - May 17, 2015 Category: Cancer & Oncology Authors: Yang K, Wang F, Han JJ Tags: Int J Clin Exp Pathol Source Type: research
Brain-derived neurotrophic factor regulates cell motility in human colon cancer
Brain-derived neurotrophic factor (BDNF) is a potent neurotrophic factor that has been shown to affect cancer cell metastasis and migration. In the present study, we investigated the mechanisms of BDNF-induced cell migration in colon cancer cells. The migratory activities of two colon cancer cell lines, HCT116 and SW480, were found to be increased in the presence of human BDNF. Heme oxygenase-1 (HO)-1 is known to be involved in the development and progression of tumors. However, the molecular mechanisms that underlie HO-1 in the regulation of colon cancer cell migration remain unclear. Expression of HO-1 protein and mRNA i...
Source: Endocrine-Related Cancer - June 1, 2015 Category: Endocrinology Authors: Huang, S.-M., Lin, C., Lin, H.-Y., Chiu, C.-M., Fang, C.-W., Liao, K.-F., Chen, D.-R., Yeh, W.-L. Tags: Research Source Type: research
Abstract 4360: Validation of phosphodiesterase 10A as a cancer target
Phosphodiesterase 10A (PDE10) is a cAMP and cGMP degrading PDE isozyme that is highly expressed in the brain striatum where it plays an important role in cognition and psychomotor activity. PDE10 inhibitors are being developed for the treatment of schizophrenia and Huntington's disease and are generally well tolerated, likely because of low expression levels in peripheral tissues. We recently reported high levels of PDE10 in tumors and that genetic silencing by siRNA inhibits tumor cell growth with a high degree of selectivity over normal cells (Li et al., Oncogene 2014). These observations suggest that PDE10 may have an u...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Lee, K., Li, N., Chen, X., Zhu, B., Yet, L., Madeira da Silva, L., Russo, S., Keeton, A. B., Boyd, M. R., Piazza, G. A. Tags: Experimental and Molecular Therapeutics Source Type: research
Abstract 4690: Next-generation screen for integrative subtyping and target discovery for KRAS-mutant cancer
Mutations in the small GTPase, KRAS, are found in ∼140,000 new cases of cancer every year in the United States. This heterogeneous class of cancers manifests primarily as adenocarcinomas of the lung, colon and pancreas. These cancers display a wide spectrum of KRAS-dependency and differentially activate downstream effector signaling. The tumors further diverge in their array of co-occurring secondary mutations, expression signatures and KRAS mutant allele. Ultimately, the sole trait these cancers share in common is an obstinate resistance to chemo- and targeted-therapies, making identification of effective treatments an ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Yuan, T. L., Bagni, R., Yi, M., Amzallag, A., Afghani, S., Beam, K., Burgan, W., Fer, N., Garvey, L., Smith, B., Waters, A., Stephens, R., Benes, C., McCormick, F. Tags: Experimental and Molecular Therapeutics Source Type: research
Abstract 4942: Activation of Phosphatase toward the Retinoblastoma protein in breast and colorectal cancer cell spheroids
Excessive phosphorylation of the Retinoblastoma protein is found in most cancer tumor types. Several cyclin dependent kinase (cdk) inhibitors are in development or in clinical trials at the present time. Our previous studies have focused on the regulation of Rb phosphorylation by the phosphatase, PP1. Specificity toward substrates is imparted onto PP1 by many different interacting proteins. In proliferating cells, PP1 is associated with a regulatory protein called PNUTS (Phosphatase Nuclear Targeting Subunit). Our previous experiments have shown that PNUTS inhibits PP1 activity toward specific Rb phosphorylation sites. Fur...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Egger, J., Antonucci, L., Lane, M., Krucher, N. A. Tags: Molecular and Cellular Biology Source Type: research
Abstract 5547: Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the inhibition of Wnt/{beta}-catenin signaling pathway via axin turnover in colon cancer cells
Abnormal activation of the canonical Wnt/β-catenin pathway and up-regulation of the β-catenin/T-cell factor (TCF) response to transcriptional signaling play critical roles early in colorectal carcinogenesis. Therefore, the Wnt/β-catenin signaling is considered an attractive target for cancer chemotherapeutic of chemopreventive agents, natural compounds were evaluated for β-catenin-mediated transcriptional activity. Hydnocarpin (HC), a natural lignan from Lonicera japonica was identified as a promising candidate because it effectively inhibited β-catenin/TCF reporter gene (TOPflash) activity. HC also exhibited potent g...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: KIM, W. K., LEE, M. A., PARK, H. J., HONG, J.-Y., KANG, S. S., LEE, S. K. Tags: Cancer Chemistry Source Type: research
Inhibition of human 67-kDa laminin receptor sensitizes multidrug resistance colon cancer cell line SW480 for apoptosis induction
In conclusion, our study demonstrated that 67LR plays a considerable role in the development of colon cancer MDR.
Source: Tumor Biology - August 21, 2015 Category: Cancer & Oncology Source Type: research
