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Total 665 results found since Jan 2013.

Adenosine diphosphate-ribosylation factor-like 15 can regulate glycolysis and lipogenesis related genes in colon cancer
This study was designed to investigate the potential key genes of ADP-ribosylation factor-like 15 (ARL15) regulating glycolysis and lipogenesis in colon cancer. Hematoxylin-eosin (HE) staining and immunohistochemistry were used to observe the expression of ARL15 in 10 normal colon tissues and 10 colon cancer tissues. Immunofluorescence staining was used to observe the expression position of ARL15 in normal human colorectal mucosa cells (FHC) and colon cancer cells (HCT116 and SW620) with a confocal microscope. The ARL15 plasmid and small interfering RNA (siRNA) were constructed. After transfection, the expression levels of...
Source: Journal of Physiology and Pharmacology - October 27, 2022 Category: Drugs & Pharmacology Authors: F Du H-J Zhang W Shao Y-Y Tu K-J Yang L-S Piao Source Type: research

MLN4924 Genome-Wide RNAi Screen
MLN4924 is an investigational small-molecule inhibitor of the NEDD8-activating enzyme (NAE) in phase I clinical trials. NAE inhibition prevents the ubiquitination and proteasomal degradation of substrates for cullin-RING ubiquitin E3 ligases that support cancer pathophysiology, but the genetic determinants conferring sensitivity to NAE inhibition are unknown. To address this gap in knowledge, we conducted a genome-wide siRNA screen to identify genes and pathways that affect the lethality of MLN4924 in melanoma cells. Of the 154 genes identified, approximately one-half interfered with components of the cell cycle, apoptotic...
Source: Cancer Research - January 2, 2013 Category: Cancer & Oncology Authors: Blank, J. L., Liu, X. J., Cosmopoulos, K., Bouck, D. C., Garcia, K., Bernard, H., Tayber, O., Hather, G., Liu, R., Narayanan, U., Milhollen, M. A., Lightcap, E. S. Tags: Molecular and Cellular Pathobiology Source Type: research

Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
CONCLUSIONS: We demonstrate that activation of the PI3K/AKT pathway is a mechanism of both innate and acquired resistance to BRAF inhibitors in BRAFV600E CRC, and suggest combinatorial approaches to improve outcomes in this poor prognosis subset of patients. PMID: 23251002 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - December 18, 2012 Category: Cancer & Oncology Authors: Mao M, Tian F, Mariadason JM, Tsao L, Lemos R, Dayyani F, Yennu Nanda VG, Jiang ZQ, Wistuba I, Tang X, Bornmann WG, Bollag G, Mills GB, Powis G, Desai J, Gallick GE, Davies MA, Kopetz S Tags: Clin Cancer Res Source Type: research

Therapeutic Implications of MSC-mediated Delivery of SiRNA Via Gap Junctions in the Treatment of Colon Cancer
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: K. Chang, S. Kosari, J. Karas, T. Gregg, P. Brink, R. Bergamaschi Tags: Quickshot Session: Thursday 2/7 3:30 PM to 5:30 PM Source Type: research

The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK
Abstract Expression of T antigen (Galbeta1, 3GalNAc) is associated with enhanced metastatic potential and poor prognosis in colorectal cancer. Cosmc is a molecular chaperone required for the formation of an active T‐synthase, which catalyzes the synthesis of T antigen. However, the expression and role of Cosmc in colorectal cancer are still unclear. Here, real‐time PCR showed that overexpression of Cosmc mRNA in colorectal tumors compared with paired non‐tumorous tissues was associated with increased American Joint Committee on Cancer (AJCC) tumor stage. Forced expression of Cosmc in HCT116 cells significantly increa...
Source: Molecular Carcinogenesis - February 6, 2013 Category: Molecular Biology Authors: John Huang, Mei‐Ieng Che, Neng‐Yu Lin, Ji‐Shiang Hung, Yu‐Ting Huang, Wei‐Chou Lin, Hsiu‐Chin Huang, Po‐Huang Lee, Jin‐Tung Liang, Min‐Chuan Huang Tags: Research Article Source Type: research

Hirsutanol A, a novel sesquiterpene compound from fungus Chondrostereum sp., induces apoptosis and inhibits tumor growth through mitochondrial-independent ROS production: Hirsutanol A inhibits tumor growth through ROS production
Conclusion: These data suggested that hirsutanol A inhibited tumor growth through triggering ROS production and apoptosis.
Source: BioMed Central - February 8, 2013 Category: Journals (General) Authors: Fen YangWen-Dan ChenRong DengHui ZhangJun TangKe-Wei WuDan-Dan LiGong-Kan FengWen-Jian LanHou-Jin LiXiao-Feng Zhu Source Type: research

Death-Associated Protein Kinase Controls STAT3 Activity in Intestinal Epithelial Cells.
ider-Stock R Abstract The TNF-IL-6-STAT3 pathway plays a crucial role in promoting ulcerative colitis-associated carcinoma (UCC). To date, the negative regulation of STAT3 is poorly understood. Interestingly, intestinal epithelial cells of UCC in comparison to ulcerative colitis show high expression levels of anti-inflammatory death-associated protein kinase (DAPK) and low levels of pSTAT3. Accordingly, epithelial DAPK expression was enhanced in STAT3(IEC-KO) mice. To unravel a possible regulatory mechanism, we used an in vitro TNF-treated intestinal epithelial cell model. We identified a new function of DAPK in ...
Source: The American Journal of Pathology - March 1, 2013 Category: Pathology Authors: Chakilam S, Gandesiri M, Rau TT, Agaimy A, Vijayalakshmi M, Ivanovska J, Wirtz RM, Schulze-Luehrmann J, Benderska N, Wittkopf N, Chellappan A, Ruemmele P, Vieth M, Rave-Fränk M, Christiansen H, Hartmann A, Neufert C, Atreya R, Becker C, Steinberg P, Schn Tags: Am J Pathol Source Type: research

Higher Order Chromatin Structure of the Gel-forming Mucin Gene Gene Regulation
Four of the genes that encode gel-forming mucins, which are major components of the mucus layer protecting many epithelial surfaces, are clustered at chromosome 11p15.5 and show both cell- and tissue-specific expression patterns. We aimed to determine whether the individual genes were coordinately regulated by mechanisms involving higher order chromatin structure. CCCTC-binding factor (CTCF) sites were predicted in silico and CTCF occupancy then evaluated by chromatin immunoprecipitation. CTCF was found at many sites across the gene cluster, and its binding was correlated with mucin gene expression. Next, siRNA-mediated de...
Source: Journal of Biological Chemistry - March 1, 2013 Category: Chemistry Authors: Gosalia, N., Leir, S.-H., Harris, A. Tags: Glycobiology and Extracellular Matrices Source Type: research

MicroRNA‐195 chemosensitizes colon cancer cells to the chemotherapeutic drug doxorubicin by targeting the first binding site of BCL2L2 mRNA
In this study, we utilized microRNA array and real‐time PCR to verify that some microRNAs including miR‐127, miR‐195, miR‐22, miR‐137 were significantly down‐regulated, while miR‐21, miR‐592 were up‐regulated in both HT29/DOX and LOVO/DOX cell lines. In vitro cell viability assay showed that knockdown of miR‐195 in HT29 and LOVO cells caused a marked inhibition of Dox‐induced cytotoxicity. Moreover, we explored that miR‐195 is involved in repression of BCL2L2 expression through targeting its 3'‐untranslated region, especially the first binding site within its mRNA. Furthermore, down‐regulation o...
Source: Journal of Cellular Physiology - March 22, 2013 Category: Cytology Authors: Juan Qu, Liang Zhao, Pengzhi Zhang, Juan Wang, Ning Xu, Wenjuan Mi, Xingwang Jiang, Changming Zhang, Juan Qu Tags: Original Research Article Source Type: research