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Total 665 results found since Jan 2013.

Eukaryotic translation initiation factor 5A2 (eIF5A2) regulates chemoresistance in colorectal cancer through epithelial mesenchymal transition
Conclusion: Our present study demonstrated that eIF5A2 promoted the chemoresistance to doxorubicin via regulation of EMT in colon cancer cells. Therefore, eIF5A2 inhibition may be a new potential strategy for the reversal of drug resistance in colorectal cancer therapy.
Source: Cancer Cell International - November 17, 2015 Category: Cancer & Oncology Authors: Ying BaoYongliang LuXiang WangWenming FengXinrong SunHuihui GuoChengwu TangXiaojing ZhangQilin ShiHongbin Yu Source Type: research

DHA-induced stress response in human colon cancer cells-focus on oxidative stress and autophagy.
Abstract Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits of omega-3/n-3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) have been well documented in relation to several diseases. Increasing evidence suggests that n-3 PUFAs may have anticancer activity and improve the effect of conventional cancer therapy. The mechanisms behind these effects are still unclear and need to be elucidated. We have examined the DHA-induced stress response in two human colon cancer cell lines, SW620 and Caco-2. SW620 cells are growth-inhibited a...
Source: Free Radical Biology and Medicine - November 13, 2015 Category: Biology Authors: Pettersen K, Monsen VT, Hakvåg Pettersen CH, Overland HB, Pettersen G, Samdal H, Tesfahun AN, Lundemo AG, Bjørkøy G, Schønberg S Tags: Free Radic Biol Med Source Type: research

AKT and JNK Signaling Pathways Increase the Metastatic Potential of Colorectal Cancer Cells by Altering Transgelin Expression
Conclusion This study demonstrates, for the first time, that activated AKT and JNK signaling pathways promote the overexpression of transgelin, which potentially contributes to CRC progression and metastasis.
Source: Digestive Diseases and Sciences - December 22, 2015 Category: Gastroenterology Source Type: research

LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner
Liver receptor homologue 1 (LRH-1) is an orphan nuclear receptor that has been implicated in the progression of breast, pancreatic and colorectal cancer (CRC). To determine mechanisms underlying growth promotion by LRH-1 in CRC, we undertook global expression profiling following siRNA-mediated LRH-1 knockdown in HCT116 cells, which require LRH-1 for growth and in HT29 cells, in which LRH-1 does not regulate growth. Interestingly, expression of the cell cycle inhibitor p21 (CDKN1A) was regulated by LRH-1 in HCT116 cells. p21 regulation was not observed in HT29 cells, where p53 is mutated. p53 dependence for the regulation o...
Source: Nucleic Acids Research - January 29, 2016 Category: Research Authors: Kramer, H. B., Lai, C.-F., Patel, H., Periyasamy, M., Lin, M.-L., Feller, S. M., Fuller-Pace, F. V., Meek, D. W., Ali, S., Buluwela, L. Tags: Gene regulation, Chromatin and Epigenetics Source Type: research

Transcriptome-wide targets of alternative splicing by RBM4 and possible role in cancer.
In conclusion, our findings reveal transcriptome-wide targets of RBM4 and point to potential cancer-related targets and mechanisms that may involve RBM4. PMID: 26898347 [PubMed - as supplied by publisher]
Source: Genomics - February 17, 2016 Category: Genetics & Stem Cells Authors: Markus MA, Yang YH, Morris BJ Tags: Genomics Source Type: research

A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling
The objective of the present study was to determine whether ADAM17 regulates the CSC phenotype in CRC and to elucidate the downstream signaling mechanism that mediates cancer stemness. We treated established CRC cell lines and a newly established human CRC cell line HCP-1 with ADAM17-specific small interfering RNA (siRNA) or the synthetic peptide inhibitor TAPI-2. The effects of ADAM17 inhibition on the CSC phenotype and chemosensitivity to 5-fluorouracil (5-FU) in CRC cells were examined. siRNA knockdown and TAPI-2 decreased the protein levels of cleaved Notch1 (Notch1 intracellular domain) and HES-1 in CRC cells. A decre...
Source: Stem Cells Translational Medicine - February 24, 2016 Category: Stem Cells Authors: Wang, R., Ye, X., Bhattacharya, R., Boulbes, D. R., Fan, F., Xia, L., Ellis, L. M. Tags: Cancer Stem Cells, Colon Stem Cells Source Type: research

Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA.
CONCLUSIONS: Cellular genetic makeup (K-Ras-/p53-) was not likely to impose limitations on targeting EA in treatment of colon cancer. EA had a multi-disciplinary pro-apoptotic anti-proliferative approach, having inhibited Akt phosphorylation, induced cell cycle arrest and showed an anti-proliferative potential in HCT-116 cells (expressing mutant K-Ras). PMID: 26925673 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - March 3, 2016 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.
Abstract Deregulation of the ubiquitin-proteasome pathway has been frequently observed in a number of malignancies. Using quantitative Western blotting of normal and matched tumour tissue, we here identified a significant increase in the 19S proteasome subunit Rpt4 in response to chemoradiation in locally advanced rectal cancer patients with unfavourable outcome. We therefore explored the potential of Rpt4 reduction as a therapeutic strategy in colorectal cancer (CRC). Utilizing siRNA to down regulate Rpt4 expression, we show that silencing of Rpt4 reduced proteasomal activity and induced endoplasmic reticulum str...
Source: European Journal of Pharmacology - March 16, 2016 Category: Drugs & Pharmacology Authors: Boland K, Flanagan L, McCawley N, Pabari R, Kay EW, McNamara DA, Murray F, Byrne AT, Ramtoola Z, Concannon CG, Prehn JH Tags: Eur J Pharmacol Source Type: research

Resveratrol Treatment Inhibits Proliferation of and Induces Apoptosis in Human Colon Cancer Cells.
CONCLUSIONS These findings suggest that resveratrol treatment can be a promising strategy for the treatment of colon cancer. PMID: 27040803 [PubMed - in process]
Source: Medical Science Monitor - April 5, 2016 Category: Research Tags: Med Sci Monit Source Type: research

MiR-4282 suppresses proliferation and mobility of human colorectal carcinoma cells by targeting semaphorin 3E.
CONCLUSION: Our findings suggested that miR-4282 is a tumor suppressor in colorectal carcinoma cells and exerted its inhibitory effect on the tumor cells through targeting Sema3E by inhibiting Sema3E translation or enhancing Sema3E mRNA degradation. Thus, manipulation of miR-4282 and interfere with Sema3E might represent a potential target for the treatment of colorectal cancer. PMID: 27120047 [PubMed - as supplied by publisher]
Source: Panminerva Medica - April 28, 2016 Category: Journals (General) Tags: Panminerva Med Source Type: research

Knockdown of NDRG1 promote epithelial–mesenchymal transition of colorectal cancer via NF‐κB signaling
ConclusionsNDRG1 appears to prevent EMT‐induced metastasis by attenuating NF‐κB signaling in mCRC. NDRG1 may be an independent prognostic factor for good survival of mCRC. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc.
Source: Journal of Surgical Oncology - June 22, 2016 Category: Cancer & Oncology Authors: Junli Ma, Quanli Gao, Shan Zeng, Hong Shen Tags: Research Article Source Type: research

Knockdown of NDRG1 promote epithelial –mesenchymal transition of colorectal cancer via NF‐κB signaling
ConclusionsNDRG1 appears to prevent EMT‐induced metastasis by attenuating NF‐κB signaling in mCRC. NDRG1 may be an independent prognostic factor for good survival of mCRC. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc.
Source: Journal of Surgical Oncology - June 22, 2016 Category: Cancer & Oncology Authors: Junli Ma, Quanli Gao, Shan Zeng, Hong Shen Tags: Research Article Source Type: research

PLD4 promotes M1 macrophages to perform antitumor effects in colon cancer cells.
Authors: Gao L, Zhou Y, Zhou SX, Yu XJ, Xu JM, Zuo L, Luo YH, Li XA Abstract Phospholipase D4 (PLD4) is a newly identified protein expressed in microglia. However, the function of PLD4 in tumor-associated macrophages (TAMs) is unknown. In the present study, we revealed that the expression of PLD4 was located in macrophages in the colon cancer mesenchymal and lymph nodes as shown by immunohistochemical analysis. furthermore, its expression was associated with clinical staging of colon cancer. Then, THP-1 as a cell model induced into TAMs. Western blot and RT-PCR analysis showed that PLD4 was mainly presented in M1 p...
Source: Oncology Reports - November 16, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Fibroblast growth factor 18 promotes proliferation and migration of H460 cells via the ERK and p38 signaling pathways.
Authors: Chen T, Gong W, Tian H, Wang H, Chu S, Ma J, Yang H, Cheng J, Liu M, Li X, Jiang C Abstract Recently, fibroblast growth factor 18 (FGF18) expression was reported to be upregulated in colon cancer and ovarian cancer, and increased expression of FGF18 mRNA and protein is associated with tumor progression and poor overall survival in patients; however, its role in lung cancer remains to be explored. In the present study, the effect and underlying molecular mechanisms of FGF18 on H460 cells were investigated. Cell proliferation and cell cycle alterations were detected using a 3-(4, 5-dimethylthiazol-2-yl)-2, 5...
Source: Oncology Reports - December 15, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The role of metastasis ‐associated in colon cancer 1 (MACC1) in endometrial carcinoma tumorigenesis and progression
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - December 19, 2016 Category: Molecular Biology Authors: Shuo Chen, Zhi ‐Hong Zong, Dan‐dan Wu, Kai‐Xuan Sun, Bo‐Liang Liu, Yang Zhao Tags: Research Article Source Type: research