Retraction Note to multiple articles in Tumor Biology
(Source: Tumor Biology)
Source: Tumor Biology - April 20, 2017 Category: Cancer & Oncology Source Type: research

MicroRNA-638 inhibits cell proliferation by targeting suppress PIM1 expression in human osteosarcoma
This study will investigate the functions and the mechanism of miR-638 in osteosarcoma (OS). The expression of miR-638 in OS and the DNA copy number of miR-638 were detected by real-time PCR. The effect of miR-638 on cell proliferation was measured by CCK8 assay. Different assays, including bioinformatics algorithms, luciferase report assay, and Western blotting, were used to identify the target gene proviral integration site for Moloney murine leukemia virus 1 (PIM1) of miR-638 in OS. The expression of PIM1 in clinical OS tissues was also validated by immunohistochemical assay. From this research, we found that miR-638 wa...
Source: Tumor Biology - January 2, 2017 Category: Cancer & Oncology Source Type: research

RETRACTED ARTICLE: The value of U-NGAL expression as a potential prognostic biomarker in patients with renal cancer after neoadjuvant chemotherapy with cisplatin
(Source: Tumor Biology)
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research

RETRACTED ARTICLE: Upregulation of miR-300 and downregulation of miR-125b act as potential predictor biomarkers in progression, metastasis, and poor prognosis of osteosarcoma
(Source: Tumor Biology)
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research

RETRACTED ARTICLE: Downregulation of miR-133b/miR-503 acts as efficient prognostic and diagnostic factors in patients with osteosarcoma and these predictor biomarkers are correlated with overall survival
(Source: Tumor Biology)
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research

RETRACTED ARTICLE: Upregulation of miR-21 and downregulation of miR-494 may serve as emerging molecular biomarkers for prediagnostic samples of subjects who developed nasopharyngeal carcinoma associates with lymph node metastasis and poor prognosis
(Source: Tumor Biology)
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research

RETRACTED ARTICLE: Diagnostic and prognostic potentials of KLF6 and HER3 expression alterations in cutaneous malignant melanoma
(Source: Tumor Biology)
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research

RETRACTED ARTICLE: Upregulation of miR-20a and miR-10a expression levels act as potential biomarkers of aggressive progression and poor prognosis in cervical cancer
(Source: Tumor Biology)
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research

RETRACTED ARTICLE: Identification of microRNAs (miR-203/miR-7) as potential markers for the early detection of lymph node metastases in patients with cervical cancer
(Source: Tumor Biology)
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research

RETRACTED ARTICLE: Analysis of serum levels and tissue expression of galectin-1 and galectin-3 as noninvasive biomarkers in osteosarcoma patients
(Source: Tumor Biology)
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research

RETRACTED ARTICLE: The expression of mitochondrial complexes I and III correlates with prognosis or diagnosis in retinoblastoma: immunohistochemical and histopathological parameters
(Source: Tumor Biology)
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research

IL-17A produced by peritoneal macrophages promote the accumulation and function of granulocytic myeloid-derived suppressor cells in the development of colitis-associated cancer
In this study, we found the level of IL-17 was increased in pathogenic colon site during the early stage of CAC model. Further experiments showed the increased IL-17 was probably secreted by peritoneal macrophages when exposed to dextran sulfate sodium (DSS). In vitro, we found that IL-17 could enhance survival and suppressive function of granulocytic (G)-MDSCs, the subset associated with inflammation. With the development of CAC, the proportions of MDSCs and Th17 cells were continuously increased by the high level of IL-17 produced by macrophages. However, the increase of MDSCs was earlier and acuter than that of Th17 cel...
Source: Tumor Biology - November 30, 2016 Category: Cancer & Oncology Source Type: research

Effects of RNAi-mediated TUSC3 silencing on radiation-induced autophagy and radiation sensitivity of human lung adenocarcinoma cell line A549 under hypoxic condition
This study examined the effects of RNAi-mediated TUSC3 silencing on radiation-induced autophagy and radiation sensitivity of human lung adenocarcinoma cell line A549 under hypoxic condition. Different CoCl2 concentrations were used to treat A549 cells and establish a CoCl2-induced hypoxic model of A549 cells. MTT and clone formation assays were used to determine the effects of different concentrations of CoCl2 on the growth and proliferation of A549 cells treated by different doses of X-ray irradiation. The siRNA-expressing vector was transfected by liposomes and for silencing ofTUSC3. Flow cytometry was used to measure ce...
Source: Tumor Biology - November 29, 2016 Category: Cancer & Oncology Source Type: research

LncRNA HOTAIR promotes cisplatin resistance in gastric cancer by targeting miR-126 to activate the PI3K/AKT/MRP1 genes
In conclusion, the data demonstrated that high HOTAIR expression acted as a competitive endogenous RNA to promote cisplatin resistance in gastric cancer. Further study will evaluate HOTAIR expression as a biomarker to predict treatment response of cisplatin and explore inhibition of HOTAIR expression as a novel strategy for anti-cisplatin resistance in human gastric cancer. (Source: Tumor Biology)
Source: Tumor Biology - November 29, 2016 Category: Cancer & Oncology Source Type: research

FAT4 functions as a tumor suppressor in triple-negative breast cancer
AbstractTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is often associated with biologic behavior with frequent distant metastasis. FAT tumor suppressor homolog 4 (FAT4), a cadherin-related protein, is involved in a variety of biological processes as a tumor suppressor; however, the role of FAT4 in TNBC is still unclear. The aim of our study was to identify the role of FAT4 in TNBC and examine the underlying molecular mechanisms. The expression of FAT4 was evaluated by immunohistochemistry, western blotting, and qRT-PCR in a series of TNBC tissues. The effects of FAT4 on the ability of ...
Source: Tumor Biology - November 27, 2016 Category: Cancer & Oncology Source Type: research

Regulation of autophagy by Ca 2+
AbstractAutophagy is an evolutionarily conserved lysosomal catabolic process used as an internal engine in response to nutrient starvation or metabolic stress. A number of protein complexes and an intricate network of stress signaling cascades impinge on the regulation of autophagy; the mammalian target of rapamycin serves as a canonical player. Ca2+, as a major intracellular second messenger, regulates multiple physiological and pathological functions. Although significant information is already well-established about the role of Ca2+ in apoptosis, its role in autophagy has been recently determined and is poorly understoo...
Source: Tumor Biology - November 17, 2016 Category: Cancer & Oncology Source Type: research

Integrated analysis identified an intestinal-like and a diffuse-like gene sets that predict gastric cancer outcome
AbstractThe two major histological types of gastric cancer, intestinal and diffuse subtypes, have distinct epidemiological and pathophysiological features and were also suggested to be of diverse clinical outcomes. Although the gene expression spectrum of gastric cancer subtypes has been reported by previous studies, its linkage with gastric cancer clinical features and outcomes remains elusive. We investigated large-sample online gastric cancer datasets for seeking genes correlated with the clinical diversities between gastric cancer intestinal and diffuse subtypes. Genes differently expressed between the two subtypes wer...
Source: Tumor Biology - November 16, 2016 Category: Cancer & Oncology Source Type: research

Expression pattern of BCCIP in hepatocellular carcinoma is correlated with poor prognosis and enhanced cell proliferation
AbstractBCCIP was originally identified as a BRCA2- and CDKN1A- (Cip1/waf1/p21) interacting protein, also known as BCCIP. It has been reported to express in various types of cancers, including colorectal cancer (CRC), astrocytic brain tumors, and glioblastomas. However, the relationship between BCCIP expression and clinicopathological features of hepatocellular carcinoma (HCC) remains to be determined. Herein, we demonstrated that BCCIP was downregulated in clinical HCC tissues; its level was inversely correlated with multiple clinicopathological factors, such as tumor grade, tumor size, and Ki67 expression. Cox regression...
Source: Tumor Biology - November 9, 2016 Category: Cancer & Oncology Source Type: research

A novel model for identification of prognostic indicator for clinical outcome of squamous cell lung carcinoma
AbstractSquamous cell carcinoma of the lung (SCCL) is the most common and aggressive lung tumor with poor clinical outcome. Identification and development of potential genes in prognostic process could be beneficial for clinical management. Sequencing data of 300 SCCL samples at level 3 were downloaded from The Cancer Genome Atlas (TCGA) data portal. Single-factor survival analysis was performed by the Kaplan-Meier method. Functional annotation was conducted on the high-frequency genes filtered out by 1000 times of the least absolute shrinkage and selectionator operator regression analysis. Meanwhile, multi-factor survival...
Source: Tumor Biology - November 8, 2016 Category: Cancer & Oncology Source Type: research

MicroRNA-92 promotes invasion and chemoresistance by targeting GSK3 β and activating Wnt signaling in bladder cancer cells
In conclusion, our study demonstrated that upregulation of miR-92 is closel y related with malignant progression of bladder cancer and miR-92 promotes proliferation, invasion, and Wnt/c-myc/MMP7 signaling by targeting GSK3β. (Source: Tumor Biology)
Source: Tumor Biology - November 8, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Overexpression of interleukins IL-17 and IL-8 with poor prognosis in colorectal cancer induces metastasis
(Source: Tumor Biology)
Source: Tumor Biology - November 8, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Evaluation of gene expression level of CDC5L and MACC1 in poor prognosis and progression of osteosarcoma
(Source: Tumor Biology)
Source: Tumor Biology - November 8, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Prognostic investigations of B7-H1 and B7-H4 expression levels as independent predictor markers of renal cell carcinoma
(Source: Tumor Biology)
Source: Tumor Biology - November 8, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Diagnostic investigations of canine prostatitis incidence together with benign prostate hyperplasia, prostate malignancies, and biochemical recurrence in high-risk prostate cancer as a model for human study
(Source: Tumor Biology)
Source: Tumor Biology - November 7, 2016 Category: Cancer & Oncology Source Type: research

Potential role of Wnt/ β-catenin signaling in blastic transformation of chronic myeloid leukemia: cross talk between β-catenin and BCR-ABL
In conclusion, our data indicate a close relationship between β-catenin and BCR-ABL/PI3K/AKT in blastic phase CML. β-Catenin inhibition may be of therapeutic value by targeting LSCs in combination with a tyrosine kinase inhibitor, which may delay blas tic transformation of CML. (Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Diagnostic procedures for improving of the KIT (CD117) expressed allele burden for the liver metastases from uterus mast cell tumors: prognostic value of the metastatic pattern and tumor biology
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Expression and prognostic value of the aldehyde dehydrogenase 1 (ALDH1) and N-myc downstream regulated gene 2 (NDRG2) as potential markers in human astrocytomas
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Downregulation of miR-185 and upregulation of miR-218 expression may be potential diagnostic and prognostic biomarkers of human chondrosarcoma
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Urinary parameters predictive and electrolyte disturbances of cisplatin-induced acute renal associated with cancer as a critical target of the chemotherapeutic agent in patients with solid tumors
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Tissue expression levels of miR-29b and miR-422a in children, adolescents, and young adults ’ age groups and their association with prediction of poor prognosis in human osteosarcoma
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Downregulation of microRNA-217 and microRNA-646 acts as potential predictor biomarkers in progression, metastasis, and unfavorable prognosis of human osteosarcoma
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Canine transmissible venereal tumor and seminoma: a cytohistopathology and chemotherapy study of tumors in the growth phase and during regression after chemotherapy
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Clinical significance and expression of the PRSS3 and Wiskott –Aldrich syndrome protein family verprolin-homologous protein 1 for the early detection of epithelial ovarian cancer
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Improving the diagnosis, treatment, and biology patterns of feline mammary intraepithelial lesions: a potential model for human breast masses with evidence from epidemiologic and cytohistopathologic studies
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: Downregulation of miR-148b as biomarker for early detection of hepatocellular carcinoma and may serve as a prognostic marker
(Source: Tumor Biology)
Source: Tumor Biology - November 4, 2016 Category: Cancer & Oncology Source Type: research

Identification of miRNAs as non-invasive biomarkers for early diagnosis of lung cancers
AbstractCurrent clinical diagnostic methods lack the specificity in detecting lung cancer patients. The issue is particularly critical for stage I and II patients. Considerable evidence showed microRNA plays a very important role in lung carcinogenesis. Here, we identified a panel of 41 miRNAs significantly elevated in patients with lung cancer, of which eight miRNAs were further validated in an independent sample cohort. Classification analysis using the panel of eight miRNAs generated a discriminatory power of 93.3  % sensitivity and 93.8 % specificity in separating non-small-cell lung cancer (NSCLC) patients f...
Source: Tumor Biology - November 2, 2016 Category: Cancer & Oncology Source Type: research

MiR-212/132 is epigenetically downregulated by SOX4/EZH2-H3K27me3 feedback loop in ovarian cancer cells
In this study, we investigated the regulative effects of miR-212 and miR-132 on SOX4 expression in ovarian cancer cells and also studied whether there is a feedback regulation between miR-212/miR-132 and SOX4 via an epigenetic mechanism. The results showed that both EZH2 and SOX4 overexpressions significantly repressed miR-212 and miR-132 expressions in SKOV3 and OV2008 cells. Immunoprecipitation assay showed that there are interactions among SOX4, EZH2, and H3K27me3, and ChIP assay confirmed significant enrichment of EZH2 and H3K27me3 in the promoter region of miR-212/132. Both pri-miR-212 and pri-miR-132 expressions decr...
Source: Tumor Biology - November 2, 2016 Category: Cancer & Oncology Source Type: research

The E6-TAp63 β-Dicer feedback loop involves in miR-375 downregulation and epithelial-to-mesenchymal transition in HR-HPV+ cervical cancer cells
In this study, we found that miR-375 overexpression restored TAp63β expression. TAp63β overexpression significantly enhanced transcription and translation of Dicer, which furth er led to increased mature miR-375 levels. Therefore, we infer that there is an E6-TAp63β-Dicer feedback loop involved in miR-375 dysregulation in cervical cancer. Besides, we observed that enforced TAp63β expression significantly reduced the mesenchymal markers including N-cadherin, Vimentin, Sna il, and Slug but increased the epithelial marker E-cadherin in both Hela and SiHa cells. The wound healing assay also confirmed that T...
Source: Tumor Biology - November 2, 2016 Category: Cancer & Oncology Source Type: research

Establishment of a miRNA-mRNA regulatory network in metastatic renal cell carcinoma and screening of potential therapeutic targets
This study aimed to screen effective diagnosis or treatment biomarkers for renal cell carcinoma, especially for metastatic renal cell carcinoma (mRCC) based on microRNA (miRNA) and messenger RNA (mRNA) genechip, and their regulatory network. The differential expressions of miRNAs and mRNAs were examined by miRNA and mRNA gene-chip analyses, respectively, in patients with either localized renal cell carcinoma (lRCC) or mRCC, and a miRNA-mRNA regulatory network was established. Subsequently, the regulation of selected mRNAs by miRNAs was validated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and ...
Source: Tumor Biology - November 1, 2016 Category: Cancer & Oncology Source Type: research

Retraction Note to: MicroRNA-495 mimics delivery inhibits lung tumor progression
(Source: Tumor Biology)
Source: Tumor Biology - November 1, 2016 Category: Cancer & Oncology Source Type: research

Transcriptome analysis of distinct long non-coding RNA transcriptional fingerprints in lung adenocarcinoma and squamous cell carcinoma
In this study, we tried to develop and validate novel long non-coding RNA (lncRNA)-based signatures to facilitate the diagnosis and individualized treatment of LUAD and LUSC. To analyze the distinct lncRNA profiling in LUAD and LUSC, the paired tissue samples of RNA sequencing or microarray data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) was used. We found that lncRNA expression pattern is different in LUAD and LUSC, and three up-regulated and down-regulated lncRNAs expressions in LUAD and LUSC tissues were validated. In addition, knockdown of the up-regulated lncRNA AFAP1-AS1 and LINC00511 impai...
Source: Tumor Biology - October 28, 2016 Category: Cancer & Oncology Source Type: research

Tissue transglutaminase 2 exerts a tumor-promoting role in hepatitis B virus-related hepatocellular carcinoma
In this study, we aimed to explore the expression and function of TG2 on HBV-related HCC progression. The expression levels of TG2 were examined in a series of HBV-related HCC tissues and a panel of HCC cell lines. The effects of TG2 knockdown on the proliferation and migration of HBV-related cells were determined. TG2 expression was found to be significantly upregulated in HBV-related HCC tissues. TG2 expression was higher in HBV-related HCC cell lines than HBV-unrelated HCC cell lines. Moreover, inhibition of TG2 in HCC cell lines HepG2.2.15 and Hep3B could inhibit cell proliferation, migration, and invasion in vitro. Ou...
Source: Tumor Biology - October 24, 2016 Category: Cancer & Oncology Source Type: research

The long non-coding RNA maternally expressed gene 3 activates p53 and is downregulated in esophageal squamous cell cancer
In this study, we used quantitative real-time polymerase chain reaction (qRT-PCR) to investigate expression of lncRNA, maternally expressed gene 3 (MEG3) in ESCC. Ectopic expression of MEG3 was performed in ESCC cell lines. Proliferation and apoptosis of ESCC cell lines were analyzed after ectopic expression of MEG3. We found MEG3 was significantly downregulated in ESCC tissues compared with normal tissues by qRT-PCR. Low expression of MEG3 was correlated with lymph node metastasis and advanced TNM stages of ESCC patients and indicated shorter survival (HR  = 0.471, 95 % CI 0.234–0.950,P = 0....
Source: Tumor Biology - October 23, 2016 Category: Cancer & Oncology Source Type: research

Erratum to: miR-143 inhibits tumor progression by targeting FAM83F in esophageal squamous cell carcinoma
(Source: Tumor Biology)
Source: Tumor Biology - October 23, 2016 Category: Cancer & Oncology Source Type: research

Chloroquine inhibits tumor growth and angiogenesis in malignant pleural effusion
AbstractMalignant pleural effusion (MPE) is associated with a poor prognosis in lung cancer. Currently, no effective cure exists for MPE. Chloroquine (CQ) has been demonstrated to induce vascular normalization and inhibit tumor growth. The aim of this study was to assess whether CQ affects MPE. The xenografts mice were divided into normal saline (NS), CQ, or bevacizumab (BE) group. Tumor growth and microvascular density (MVD) were monitored. We explored the effect of CQ on the proliferation, survival, and proangiogenic signaling of tumor cells in vitro. We further evaluated the effects of CQ on the viability, migration, an...
Source: Tumor Biology - October 21, 2016 Category: Cancer & Oncology Source Type: research

Up-regulation of small nucleolar RNA 78 is correlated with aggressive phenotype and poor prognosis of hepatocellular carcinoma
This study aimed to profile SNORD78 expression signature and then to explore the pathogenesis of SNORD78 in HCC. The real-time PCR results showed that SNORD78 was greatly upregulated in HCC tissues than adjacent noncancerous tissues (p = 0.004). Correlation analysis showed that high-level expression of SNORD78 was notably associated with tumor number (single vs. multiply,p = 0.02), stage (I∼II vs. III∼IV,p = 0.014), and distant metastasis (absent vs. present,p = 0.01) in HCC patients. Univatiate and multivariate analyses showed that SNORD78 was a significant prognostic predic...
Source: Tumor Biology - October 20, 2016 Category: Cancer & Oncology Source Type: research

Demethoxycurcumin was superior to temozolomide in the inhibition of the growth of glioblastoma stem cells in vivo
AbstractTemozolomide (TMZ) is widely used in the treatment of glioblastoma multiforme (GBM) as it can effectively inhibit the growth of GBM for some months; however, this cancer type is still incurable. The existence of glioma stem cells (GSCs) is thought to be responsible for the invariable recurrence of GBM after treatment, but GSCs are insensitive to TMZ. Our recent research showed that demethoxycurcumin (DMC), a component of curcumin, was superior to TMZ in its ability to inhibit proliferation and induce apoptosis of GSCs in vitro. In addition, the combined treatment of TMZ + DMC induced more obvious anti-GSC effects. ...
Source: Tumor Biology - October 17, 2016 Category: Cancer & Oncology Source Type: research

The role of microRNA-196a in tumorigenesis, tumor progression, and prognosis
AbstractMicroRNAs are a large group of non-coding RNAs that have emerged as regulators of various biological processes, especially carcinogenesis and cancer progression. Recent evidence has shown that microRNA-196a (miR-196a) is upregulated in most types of tumors and involved in multiple biological processes via translational inhibition and mRNA cleavage, such as cell proliferation, migration, and invasion, mostly functioning as an oncogene. Dysregulation of miR-196a promotes oncogenesis and tumor progression. In this review, we summarize the upstream regulators, target genes, signaling pathways, and single nucleotide pol...
Source: Tumor Biology - October 17, 2016 Category: Cancer & Oncology Source Type: research

Overexpression of cannabinoid receptor 1 promotes renal cell carcinoma progression
AbstractRenal cell carcinoma (RCC) is a common urologic tumor with a poor prognosis. Cannabinoid receptor 1 (CB1), which is a G protein-coupled receptor, has recently been reported to participate in the genesis and development of various cancers. However, the exact role of CB1 in RCC is unknown. The aim of this study was to determine the role of CB1 in RCC cell lines and RCC prognosis, thus underlying its potential as a therapeutic target. Immunohistochemistry and western blots were performed to investigate the expression of CB1 in RCC tissues and to determine its clinicopathological significance in RCC patients. Additiona...
Source: Tumor Biology - October 17, 2016 Category: Cancer & Oncology Source Type: research