Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1

Conclusions: These data suggest that SPTAN1 levels decreased in concordance with MLH1 reduction and impaired cellular mobility in MLH1 deficient colon cancer cells. Therefore, aggressiveness of MLH1-positive CRC might be related to SPTAN1.

http://www.molecular-cancer.com/content/13/1/11

Source: Molecular Cancer - January 24, 2014 Category: Cancer & Oncology Authors: Inga HinrichsenBenjamin ErnstFranziska NuberSandra PassmannDieter SchäferVerena SteinkeNicolaus FriedrichsGuido PlotzStefan ZeuzemAngela Brieger Source Type: research