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Condition: Autoimmune Disease
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Total 2213 results found since Jan 2013.
Eosinophilia and elevated IgE serum levels: a red flag: when your diagnosis is not a common atopic eczema or common allergy
ConclusionsWe should maintain a high level of suspicion about other differential diagnosis involving eosinophilia and IgE dysregulation, especially in patients very young (when innate errors of the immunity may present) and in middle to elderly patients classified as having atopic dermatitis, due to the possibility of cutaneous hematological malignancies, paraneoplasia or autoimmune blistering diseases.
Source: Inflammation Research - January 13, 2023 Category: Research Source Type: research
Occupational and Environmental Exposure Influences the Inflammatory (Pro-and Anti-) Status in Benign Prostate Hyperplasia and Prostate Carcinoma Patients: A Retrospective Analysis
AbstractMultiple diseases and disorders are connected with occupational and environmental exposure risk. It is also well-established that chemicals and chemical mixtures have an influence on the immune cells of humans. This is an important field of research that has been pursued extensively in relation to autoimmune illnesses, allergy/asthma, and lung cancer, but Prostate Carcinoma has received rare reports. Chronic chemical exposure is known to produce inflammation, which is one of the most prominent characteristics of all malignancies. Changes in the ratio of pro-inflammatory to anti-inflammatory molecules are thought to...
Source: Indian Journal of Clinical Biochemistry - January 13, 2023 Category: Biochemistry Source Type: research
Elevated Interleukin-10 Levels Are Associated with Low Platelet Count and Poor Prognosis in 90 Adult Patients with Hemophagocytic Lymphohistiocytosis
Conclusion: Infection and lymphoma are the leading causes of HLH in adult patients with heterogeneous clinical manifestations. Survival of adult HLH is frustrating, especially those associated with malignancies. Besides, elevated IL-10 levels were associated with lower platelet counts, and these two markers were independent risk factors for poor prognosis. Earlier treatment led to better outcomes.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - January 12, 2023 Category: Allergy & Immunology Source Type: research
Alpha-gal syndrome initially misdiagnosed as chronic spontaneous urticaria in a pediatric patient: a case report and review of the literature
ConclusionA detailed clinical history led to the diagnosis of alpha-gal syndrome. Although alpha-gal syndrome is typically seen in adults, our case illustrates that children can also present with this potentially life-threatening allergy. Since alpha-gal syndrome is rare in Europe, the disease is not well known and often overlooked for several years, especially in children.
Source: Journal of Medical Case Reports - January 8, 2023 Category: General Medicine Source Type: research
Tiny implantable device designed by UCLA scientists helps kill cancer
Many solid tumors resist treatment in part by turning human biology against itself. Tumors surround themselves with extra white blood cells known as regulatory T cells, which call off the body ’s natural defenses against the disease.Strategies to treat cancer by deactivating these cells risk creating other serious problems. Since regulatory T cells play an important role in safeguarding healthy tissues, diminishing them throughout the body can lead to other immune cells mistakenly attacking these tissues and causing autoimmune conditions that damage the colon, liver, heart and other organs.Now, an interdisciplinary UCLA ...
Source: UCLA Newsroom: Health Sciences - January 4, 2023 Category: Universities & Medical Training Source Type: news
Contribution of Genetic Variants associated with Primary Immunodeficiencies to Childhood-Onset Systemic Lupus Erythematous
A dysregulated immune response is a hallmark of autoimmune disorders. Evidence suggests that systemic autoimmune diseases and primary immunodeficiency disorders (PID) may be similar diseases with different clinical phenotypes.
Source: Journal of Allergy and Clinical Immunology - December 28, 2022 Category: Allergy & Immunology Authors: Chao-Yi Wu, Wen-Lang Fan, Huang-Yu Yang, Pi-Shuang Chu, Pei-Chun Liao, Li-Chen Chen, Tsung-Chieh Yao, Kuo-Wei Yeh, Liang-Shiou Ou, Syh-Jae Lin, Wen-I Lee, Jing-Long Huang Source Type: research
Science ’s 2022 Breakthrough of the Year: A telescope’s golden eye sees the universe anew
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Source: ScienceNOW - December 15, 2022 Category: Science Source Type: news
Nasal polyposis in severe asthma is associated with airway autoimmunity towards eosinophils and macrophages
Conclusion: Nasal polyposis was associated with airway autoantibodies towards eosinophils and macrophages in patients with severe asthma, suggesting that co-existing asthma and NP may have an autoimmune genesis.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Eriksen, L. L., Von Bülow, A., Frossing, L., Hvidtfeldt, M., Kjaersgaard Klein, D., Mukherjee, M., Nair, P., Porsbjerg, C. Tags: 05.03 - Allergy and immunology Source Type: research
Airway autoantibodies are determinants of asthma severity
Conclusion
We report 55% of moderate–severe asthmatic patients to have airway autoreactivity that persists despite anti-inflammatory treatment and is associated with exacerbations.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Salter, B., Zhao, N., Son, K., Tan, N. S., Dvorkin-Gheva, A., Radford, K., LaVigne, N., Huang, C., Kjarsgaard, M., Li, Q.-Z., Tselios, K., Lim, H. F., Khalidi, N., Nair, P., Mukherjee, M. Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Germinal Center-Related G Protein-Coupled Receptors in Antibody-Mediated Autoimmune Skin Diseases: from Basic Research to Clinical Trials
AbstractGerminal center (GC) reaction greatly contributes to the humoral immune response, which begins in lymph nodes or other secondary lymphoid organs after follicular B cells are activated by T-dependent antigens. The GCs then serve as a platform for follicular B cells to complete clonal expansion and somatic hypermutation and then interact with follicular dendritic cells (FDC) and follicular helper T cells (Tfh). Through the interaction between the immune cells, significant processes of the humoral immune response are accomplished, such as antibody affinity maturation, class switching, and production of memory B cells ...
Source: Clinical Reviews in Allergy and Immunology - December 1, 2022 Category: Allergy & Immunology Source Type: research
A Contemporary Update on the Diagnosis of Systemic Lupus Erythematosus
AbstractSystemic lupus erythematosus (SLE) is a complicated autoimmune disease with female susceptibility. It is characterized by over-activation of the immune system and deposit of autoimmune complex in multiple organs. High heterogeneity, unpredictable disease course of SLE as well as the lack of specific and sensitive biomarkers posed diagnostic challenges to clinicians. Despite the complicated clinical presentation and pathogenesis of SLE, research regarding this disease has made many significant breakthroughs over the past decades. Some new learning can potential ly be translated into clinical practice. In addition...
Source: Clinical Reviews in Allergy and Immunology - December 1, 2022 Category: Allergy & Immunology Source Type: research
Epigenetic Dysregulation in Autoimmune and Inflammatory Skin Diseases
AbstractEpigenetics is the study of heritable, reversible gene expression patterns that do not originate from alterations in the DNA sequence. Epigenetic modifications influence gene expression patterns and include DNA methylation, histone modifications, and gene regulation via non-coding RNAs. While the study of epigenetics has been most broadly applied to neoplastic diseases, the role of the epigenome in a wide range of disease processes including autoimmune, allergic, and inflammatory processes is increasingly being recognized. Recent advances in the study of the epigenome have led to novel insights into the pathogenesi...
Source: Clinical Reviews in Allergy and Immunology - December 1, 2022 Category: Allergy & Immunology Source Type: research
Serum Biomarkers for Autoimmune Hepatitis Type 1: the Case for CD48 and a Review of the Literature
In conclusion , sCD48 and sCD48-based predictive scores predict histological inflammation and fibrosis in AIH-1. Detecting sCD48 might help in the clinical management of AIH.
Source: Clinical Reviews in Allergy and Immunology - December 1, 2022 Category: Allergy & Immunology Source Type: research
Thoracic Involvement in Systemic Autoimmune Rheumatic Diseases: Pathogenesis and Management
AbstractThoracic involvement is one of the main determinants of morbidity and mortality in patients with autoimmune rheumatic diseases (ARDs), with different prevalence and manifestations according to the underlying disease. Interstitial lung disease (ILD) is the most common pulmonary complication, particularly in patients with systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIMs) and rheumatoid arthritis (RA). Other thoracic manifestations include pulmonary arterial hypertension (PAH), mostly in patients with SSc, airway disease, mainly in RA, and pleural involvement, which is common in systemic lupus erythe...
Source: Clinical Reviews in Allergy and Immunology - December 1, 2022 Category: Allergy & Immunology Source Type: research
A pilot trial of belimumab for atherosclerosis associated autoimmunity in COPD patients
Conclusion: Treatment with belimumab in COPD is safe and reduces anti-GRP78 levels, an autoantibody linked with CVD in this population.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Mkorombindo, T., Wade, R. C., Yuan, K., Robison, S. W., Christenson, A. E., Wells, J. M., Dransfield, M. T., Duncan, S. R. Tags: 05.03 - Allergy and immunology Source Type: research
