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Condition: Autoimmune Disease
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The T Cell Receptor Repertoire Diversity Following Hematopoietic Stem Cell Transplantation
This study aimed to assess the T cell receptor (TCR) repertoire diversity in CD4+ cells of patients with hematological malignancies who received allogeneic or autologous HSCT. The diversity of the TCR repertoire was evaluated in 13 patients with hematologic malignancies before and four months after HSCT. Amino acid changes in the 25 Vβ families were evaluated using Spectratyping and data were presented as Hamming distance (HD). HD more than 20% was considered a change in TCR repertoire after HSCT. The mean HD was significantly changed after transplantation in all Vβ gene families, with most amino acid changes in p4 and p...
Source: Iranian Journal of Allergy, Asthma and Immunology - November 7, 2022 Category: Allergy & Immunology Authors: Fahimeh Zamani Reza Mirfakhraie Sayyed Reza Safaee Nodehi Yaghoub Mollaei-Kandelous Hossein Jafari Mohammad Farahmand Farhad Rezaei Majid Teymoori-Rad Abolfazl Movafagh Source Type: research
