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Condition: Autoimmune Disease
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Total 2213 results found since Jan 2013.
Making a stat diagnosis in a patient presenting with villous atrophy
Signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) gene mutations are highly penetrant, resulting in enhanced STAT1-dependent responses to interferon-alpha/beta and interferon-gamma signaling, and impaired Th17 development. This manifests as recurrent infections, cytopenias, and autoimmune disease. Herein, we present a case of a child diagnosed with a STAT1 mutation.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: K. Dages, E. Ender, A. Joshi Tags: M216 Source Type: research
Refractory chronic spontaneous urticaria after treated graves' disease
Chronic spontaneous urticaria (CSU) has been well described in autoimmune thyroid disorders, but less associated with Graves' Disease (GD), and the mechanism of their relationship is still unknown. Thyroid-associated CSU has been shown to be more difficult to manage.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: S. Cheng, A. Freeman Tags: M142 Source Type: research
Syndrome of thyroid autoimmunity and idiopathic chronic urticaria and angioedema
We present a case of syndrome of thyroid autoimmunity and idiopathic chronic urticaria and angioedema progressing to anaphylaxis.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: A. Angirekula Tags: M139 Source Type: research
Systemic lupus erythematosus is associated with increased risk for radiocontrast allergy
Systemic lupus erythematosus (SLE) is a chronic autoimmune condition that can manifest in multiple organs. Imaging is common to confirm systemic involvement of disease and may frequently require the use of radioactive contrast. Hypersensitivity reaction to radioactive contrast media and dye is rare but moderate to severe reactions can complicate a patient's clinical course. Immunologic dysregulation plays a significant role in both SLE and radiocontrast allergy. We investigate the association between contrast allergy and SLE in this study using a large nationwide database.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: N. Rawal, S. Imam, A. Shaikh, E. Capitle Tags: P020 Source Type: research
Complete resolution of acquired angioedema from splenic marginal zone lymphoma after treatment with rituximab
Acquired angioedema (AAE) due to C1 esterase inhibitor (C1-INH) deficiency is clinically similar to hereditary angioedema (HAE), but typically develops in older patients. There is invariably an underlying disease such as a lymphoproliferative disorder, autoimmune condition, solid tumor, etc. that either drives autoantibody production against normal C1-INH and/or causes consumptive depletion of normally functioning C1-INH.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: B. Wang Tags: M124 Source Type: research
Autoimmune disease burden in children with eosinophilic esophagitis: a nationwide longitudinal study.
Eosinophilic Esophagitis (EoE) is a chronic immune mediated disorder involving eosinophils leading to esophageal dysfunction. In this retrospective multi-center study, we investigated the incidence and risk factors for comorbid autoimmune diseases (AiD) in children using Cerner Health Facts, a national longitudinal database representing approximately 69 million patients.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: I. Jakhar, M. Singh, S. Sahil, L. Bernstein, H. Ahmad Tags: P184 Source Type: research
D-dimer levels decline after immunosuppressive treatment rather than anticoagulant treatment in severe autoimmune chronic spontaneous urticaria
We report an omalizumab refractory case of severe CSU with high D-Dimer levels that declined only after disease remission with cyclosporine treatment but not with anticoagulation. Activation of coagulation cascade occurs secondary to the pro-inflammatory state in CSU patients and the correlation between D-dimer levels and disease activity may indicate the need for more studies to better understand the relationship of D-dimer levels and Omalizumab resistance. Clinicians should consider this relationship in CSU patients with significant D-dimer levels before considering treatment with anticoagulants.PMID:36305339 | DOI:10.23...
Source: European Annals of Allergy and Clinical Immunology - October 28, 2022 Category: Allergy & Immunology Authors: D Baskurt E Sarac R Asero E Kocat ürk Source Type: research
