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Condition: Autoimmune Disease
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Total 2213 results found since Jan 2013.
CAR-T Therapy for NHL Treats Concurrent Rheumatic Disease CAR-T Therapy for NHL Treats Concurrent Rheumatic Disease
CAR –T cell therapy for non-Hodgkin lymphoma appeared as safe and effective in patients with rheumatic autoimmune disease as in those without and also improved control of the underlying autoimmunity.Medscape Medical News
Source: Medscape Allergy Headlines - August 24, 2023 Category: Allergy & Immunology Tags: Rheumatology Source Type: news
How Does Global Warming Contribute to Disorders Originating from an Impaired Epithelial Barrier?
Ann Allergy Asthma Immunol. 2023 Aug 22:S1081-1206(23)00588-4. doi: 10.1016/j.anai.2023.08.010. Online ahead of print.ABSTRACTThe epithelial barrier represents the point of contact between the host and the external environment. It is the first line of defense against external insults in the skin, gastrointestinal and upper and lower respiratory tracts. The steep increase in chronic disorders in recent decades, including allergies and autoimmune disorders, has prompted studies to investigate the immune mechanisms of their underlying pathogeneses, all of which point to a thought-provoking shared finding: disrupted epithelial...
Source: Annals of Allergy, Asthma and Immunology - August 24, 2023 Category: Allergy & Immunology Authors: Cevdet Ozdemir Umut Can Kucuksezer Ismail Ogulur Yagiz Pat Duygu Yazici Ioana Agache Marek Jutel Kari C Nadeau M übeccel Akdis Cezmi A Akdis Source Type: research
Neurological and endocrinological involvement in neonatal lupus erythematosus: a retrospective study at a tertiary hospital in Eastern China
ConclusionsAt our hospital, no significant gender differences were observed in the occurrence of NLE, and a predominance of skin, blood, liver, and heart involvement was observed. Patients with multiple central nervous system injuries and organ involvement are more likely to have growth retardation. Endocrine disorders are transient in NLE patients, and some showed feeding intolerance as the first manifestation.Key Points•A retrospective investigation of the clinical characteristics and prognosis of 39 NLE patients was performed, focusing on the clinical features of patients with neurological and endocrine system involve...
Source: Clinical Rheumatology - August 11, 2023 Category: Rheumatology Source Type: research
Autoimmune Inflammatory Eye Disease: Demystifying Clinical Presentations for the Internist
AbstractPurpose of ReviewProvide a framework for recognizing key symptoms and clinical findings in patients with autoimmune inflammatory eye disease.Recent FindingsThe most common manifestations of autoimmune inflammatory eye disease are episcleritis, scleritis, uveitis (anterior, intermediate, posterior, and panuveitis), and keratoconjunctivitis sicca. Etiologies can be idiopathic or in association with a systemic autoimmune condition. Referral of patients who may have scleritis is critical for patients presenting with red eyes. Referral of patients who may have uveitis is critical for patients presenting often with float...
Source: Current Allergy and Asthma Reports - August 1, 2023 Category: Allergy & Immunology Source Type: research
Shared Pathogenicity Features and Sequences between EBV, SARS-CoV-2, and HLA Class I Molecule-binding Motifs with a Potential Role in Autoimmunity
AbstractEpstein-Barr virus (EBV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are extraordinary in their ability to activate autoimmunity as well as to induce diverse autoimmune diseases. Here we reviewed the current knowledge on their relation. Further, we suggested that molecular mimicry could be a possible common mechanism of autoimmunity induction in the susceptible individuals infected with SARS-CoV-2. Molecular mimicry between SARS-CoV-2 and human proteins, and EBV and human proteins, are present. Besides, relation of the pathogenicity associated with both coronavirus diseases and EBV supports the...
Source: Clinical Reviews in Allergy and Immunology - July 28, 2023 Category: Allergy & Immunology Source Type: research
RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is IFN-independent
Autoimmune diseases are leading causes of ill health and morbidity and have diverse etiology. Two signaling pathways are key drivers of autoimmune pathology, interferon and NF κB/RelA, defining the two broad labels of interferonopathies and relopathies. Prior work established that genetic loss of function of the NFκB subunit RelB leads to autoimmune and inflammatory pathology in mice and humans.
Source: Journal of Allergy and Clinical Immunology - July 14, 2023 Category: Allergy & Immunology Authors: Hector I. Navarro, Yi Liu, Anna Fraser, Diane Lefaudeux, Jennifer J. Chia, Linda Vong, Chaim M. Roifman, Alexander Hoffmann Source Type: research
RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is interferon-independent
Autoimmune diseases are leading causes of ill health and morbidity and have diverse etiology. Two signaling pathways are key drivers of autoimmune pathology, interferon and nuclear factor- κB (NF-κB)/RelA, defining the 2 broad labels of interferonopathies and relopathies. Prior work has established that genetic loss of function of the NF-κB subunit RelB leads to autoimmune and inflammatory pathology in mice and humans.
Source: Journal of Allergy and Clinical Immunology - July 14, 2023 Category: Allergy & Immunology Authors: H éctor I. Navarro, Yi Liu, Anna Fraser, Diane Lefaudeux, Jennifer J. Chia, Linda Vong, Chaim M. Roifman, Alexander Hoffmann Source Type: research
Autoimmune Inflammatory Eye Disease: Demystifying Clinical Presentations for the Internist
AbstractPurpose of ReviewProvide a framework for recognizing key symptoms and clinical findings in patients with autoimmune inflammatory eye disease.Recent FindingsThe most common manifestations of autoimmune inflammatory eye disease are episcleritis, scleritis, uveitis (anterior, intermediate, posterior, and panuveitis), and keratoconjunctivitis sicca. Etiologies can be idiopathic or in association with a systemic autoimmune condition. Referral of patients who may have scleritis is critical for patients presenting with red eyes. Referral of patients who may have uveitis is critical for patients presenting often with float...
Source: Current Allergy and Asthma Reports - July 12, 2023 Category: Allergy & Immunology Source Type: research
Autoimmune Connective Tissue Diseases: Systemic Lupus Erythematosus and Rheumatoid Arthritis
Systemic lupus erythematosus and rheumatoid arthritis are just 2 of several autoimmune connective tissue diseases that are primarily chronic in nature but can present to the emergency department by virtue of an acute exacerbation of disease. Beyond an acute exacerbation of disease, their predilection for invading multiple organ systems lends itself to the potential for patients presenting to the emergency department with either a single or isolated symptom or a myriad of signs and/or symptoms indicative of a degree of disease complexity and severity that warrant timely recognition and resuscitation.
Source: Immunology and Allergy Clinics of North America - July 1, 2023 Category: Allergy & Immunology Authors: Jonathan Rose Source Type: research
Achalasia is Strongly Associated with Eosinophilic Esophagitis and Other Allergic Disorders
Achalasia has been assumed to be an autoimmune disease targeting esophageal myenteric neurons. Recently, we proposed an alternative hypothesis that achalasia sometimes might be allergy-driven, caused by a form of eosinophilic esophagitis (EoE) in which activated eosinophils and/or mast cells infiltrating esophageal muscle release products that disrupt motility and damage myenteric neurons. To seek epidemiological support for this hypothesis, we identified achalasia patients in the Utah Population Database, and explored their frequency of having EoE and other allergic disorders.
Source: Clinical Gastroenterology and Hepatology - June 28, 2023 Category: Gastroenterology Authors: Chanakyaram A. Reddy, Kristina Allen-Brady, Amiko M. Uchida, Kathryn A. Peterson, Alessandrina M. Hoffman, Rhonda F. Souza, Stuart J. Spechler Source Type: research
Activated Phosphoinositide 3-Kinase δ Syndrome: Update from the ESID Registry and comparison with other autoimmune-lymphoproliferative inborn errors of immunity
When comparing the phenotypic overlap of autoimmune-lymphoproliferative inborn errors of immunity (IEI) APDS demonstrates high penetrance, low genetic heterogeneity, early-onset as risk factor for severe disease and high phenotypic overlap with other IEIs.
Source: Journal of Allergy and Clinical Immunology - June 27, 2023 Category: Allergy & Immunology Authors: Maria Elena Maccari, Martin Wolkewitz, Charlotte Schwab, Tiziana Lorenzini, Jennifer W. Leiding, Nathalie Aladjdi, Hassan Abolhassani, Wadih Abou-Chahla, Alessandro Aiuti, Saba Azarnoush, Safa Baris, Vincent Barlogis, Federica Barzaghi, Ulrich Baumann, Ma Source Type: research
Perspectives on Mycophenolate Mofetil in the Management of Autoimmunity
Clin Rev Allergy Immunol. 2023 Jun 20. doi: 10.1007/s12016-023-08963-3. Online ahead of print.ABSTRACTBefore becoming a cornerstone in the treatment of numerous immune-mediated diseases, mycophenolate mofetil (MMF) was first introduced as an immunosuppressive agent in transplant immunology and later received the attention of rheumatologists and clinicians involved in the management of autoimmune diseases. MMF is now a widespread immunosuppressive drug for the treatment of several conditions, including lupus nephritis, interstitial lung disease associated with systemic sclerosis, and anti-neutrophil cytoplasm antibody (ANCA...
Source: Clinical Lung Cancer - June 20, 2023 Category: Cancer & Oncology Authors: Rithika Bhat Antonio Tonutti Suraj Timilsina Carlo Selmi M Eric Gershwin Source Type: research
