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Condition: Autoimmune Disease

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Total 2213 results found since Jan 2013.

A new autoimmune disease: atopic dermatitis in children
Allergol Immunopathol (Madr). 2022 Nov 1;50(6):17-21. doi: 10.15586/aei.v50i6.655. eCollection 2022.ABSTRACTAtopic dermatitis (AD) is mainly considered an allergy, exacerbated by allergic factors. Is there evidence to suggest the existence of autoimmune components in the pathophysiology of the illness? Studies in the literature that dealt with the occurrence of autoimmunity in children with AD were analyzed. We followed the studies published in PubMed for 10 years, from 2001 to 2021. Clinical signs and symptoms were similar to other autoimmune diseases, having periods of remission and relapses. Other correlations between A...
Source: Allergologia et Immunopathologia - November 6, 2022 Category: Allergy & Immunology Authors: Emanuela Floca Remus Gaga Genel Sur Iulia Lupan Ionel Armat Gabriel Samasca Lucia M Sur Source Type: research

Autoimmune and autoinflammatory manifestations in inborn errors of immunity
Purpose of review Autoimmune and inflammatory complications have been shown to arise in all age groups and across the spectrum of inborn errors of immunity (IEI). This review aims to highlight recent ground-breaking research and its impact on our understanding of IEI. Recent findings Three registry-based studies of unprecedented size revealed the high prevalence of autoimmune, inflammatory and malignant complications in IEI. Two novel IEI were discovered: an autoinflammatory relopathy, cleavage-resistant RIPK1-induced autoinflammatory syndrome, as well as an inheritable phenocopy of PD-1 blockade-associated comp...
Source: Current Opinion in Allergy and Clinical Immunology - November 4, 2022 Category: Allergy & Immunology Tags: PRIMARY IMMUNE DEFICIENCY DISEASE: Edited by M. Teresa de la Morena and Stephen Jolles Source Type: research

Post thymectomy: an example of immune dysregulation?
The thymus is essential for creating the T cell repertoire while maintaining self-tolerance. Systemic autoimmune diseases (AD's) such as Rheumatoid Arthritis, Systemic Lupus Erythematous (SLE), and Sjogren's Disease, may unveil many years after thymectomy in patients with Myasthenia Gravis. Immunoglobulin G4-Related Disease (IgG4-RD) characterized by dysregulation of immune system affecting a single or multiple organs, has not been described post thymectomy.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: N. Sosa-Castellanos, S. Serrano-Santiago, C. Munet-Colon, J. Cheverez, S. Nazario Tags: M274 Source Type: research

Autoimmune lymphoproliferative syndrome with initial presentation of hodgkin's lymphoma
We describe a case of FAS-ALPS with initial presentation of Hodgkin's lymphoma (HL).
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: E. Fox, R. Grohman, R. Eisenberg Tags: M266 Source Type: research

Comprehensive overview of autoantibody isotype and subclass distribution
The presence of autoreactive antibodies is a hallmark of many autoimmune diseases. The effector functions of (auto)antibodies are determined by their constant domain, which defines the antibody isotype and subclass. The most prevalent isotype in serum is IgG, which is often the only isotype used in diagnostic testing. Nevertheless, autoantibody responses can have their own unique isotype/subclass profile. Because comparing autoantibody isotype profiles may yield new insights into disease pathophysiology, here we summarize the isotype/subclass profiles of the most prominent autoantibodies.
Source: Journal of Allergy and Clinical Immunology - November 1, 2022 Category: Allergy & Immunology Authors: Mikhail Volkov, Mariateresa Coppola, Ruth Huizinga, Filip Eftimov, Tom W.J. Huizinga, Anneke J. van der Kooi, Liesbeth E.M. Oosten, Joost Raaphorst, Theo Rispens, Rocco Sciarrillo, Maarten J. Titulaer, Luuk Wieske, Ren é E.M. Toes, Maartje G.M. Huijbers, Tags: Review article Source Type: research

Asymptomatic eosinophilia with reactive hypergammaglobulinemia
Eosinophilia is commonly reactive (secondary eosinophilia) involving polyclonal expansion of eosinophils due to infection, atopic disease, drug allergy, or autoimmune conditions. More rarely, primary eosinophilia occurs from clonal expansion of eosinophils from underlying hematologic malignancies or idiopathic hypereosinophilic syndrome.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: G. Tan, M. Kraft Tags: M361 Source Type: research