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Condition: Autoimmune Disease
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Total 2213 results found since Jan 2013.
Immunosuppressive Effects of Two Probiotics, Lactobacillus paracasei DSM 13434 and Lactobacillus plantarum DSM 15312, on CD4+ T Cells of Multiple Sclerosis Patients
Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):34-45. doi: 10.18502/ijaai.v22i1.12004.ABSTRACTT cells play an important role in the development and progression of multiple sclerosis (MS), an autoimmune disease of the central nervous system. In the present study, the immunomodulatory impacts of two Lactobacillus strains, L paracasei DSM 13434 and L plantarum DSM 15312, on the frequency and cytokine production of CD4+ T cells in MS patients were explored. Thirty MS patients were enrolled in this study. The CD4+ T cells were isolated, cultured, and exposed to the media containing cell-free supernatants of L plantarum (group...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Khadijeh Chakamian Behrouz Robat-Jazi Abdorreza Naser Moghadasi Fatemeh Mansouri Masoumeh Nodehi Elahe Motevaseli Maryam Izad Saeed Yekaninejad Mahdieh Shirzad Kiana Bidad Mona Oraei Bita Ansaripour Ali Akbar Saboor-Yaraghi Source Type: research
Current research into A20 mediation of allergic respiratory diseases and its potential usefulness as a therapeutic target
Allergic airway diseases are characterized by excessive and prolonged type 2 immune responses to inhaled allergens. Nuclear factor κB (NF-κB) is a master regulator of the immune and inflammatory response, which has been implicated to play a prominent role in the pathogenesis of allergic airway diseases. The potent anti-inflammatory protein A20, termed tumor necrosis factor-α-inducible protein 3 (TNFAIP3), exerts its effects by inhibiting NF-κB signaling. The ubiquitin editing abilities of A20 have attracted much attention, resulting in its identification as a susceptibility gene in various autoimmune and inflammatory d...
Source: Frontiers in Immunology - March 28, 2023 Category: Allergy & Immunology Source Type: research
Autoimmune manifestations in VEXAS: Opportunities for integration and pitfalls to interpretation
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a novel entity manifesting with a multiplicity of clinical features. Somatic mutations of the UBA1 gene in hematopoietic stem cells constitute the genetic basis of VEXAS. As an X-linked disorder, most cases occur in men, classically developing symptoms during the fifth to sixth decade of life. Considering its multidisciplinary nature involving numerous branches of internal medicine, VEXAS has elicited a wide medical interest and several medical conditions have been associated with this disease.
Source: Journal of Allergy and Clinical Immunology - March 20, 2023 Category: Allergy & Immunology Authors: Alessandro Bruno, Carmelo Gurnari, Tobias Alexander, John A. Snowden, Raffaella Greco, Autoimmune Diseases Working Party of the European Society for Blood and Marrow Transplantation Source Type: research
Chromosome 22q11.2 Deletion (DiGeorge Syndrome): Immunologic Features, Diagnosis, and Management
AbstractPurpose of ReviewThis review focuses on immunologic findings, relationships among immunologic findings and associated conditions of autoimmunity and atopy, and management of immunologic disease in chromosome 22q11.2 deletion syndrome (22q11.2DS, historically known as DiGeorge syndrome).Recent FindingsThe implementation of assessment of T cell receptor excision circles (TRECs) in newborn screening has led to increased detection of 22q11.2 deletion syndrome. While not yet applied in clinical practice, cell-free DNA screening for 22q11.2DS also has the potential to improve early detection, which may benefit prompt eva...
Source: Current Allergy and Asthma Reports - March 10, 2023 Category: Allergy & Immunology Source Type: research
The Adaptation Model of Immunity: Signal IV Matters Most in Determining the Functional Outcomes of Immune Responses
J Immunol. 2023 Mar 1;210(5):521-530. doi: 10.4049/jimmunol.2200672.ABSTRACTCurrent research in immunology and immunotherapy is fully influenced by the self-nonself model of immunity. This theoretical model suggests that alloreactivity results in graft rejection, whereas tolerance toward self-antigens expressed by malignant cells facilitates cancer development. Similarly, breakage of immunological tolerance toward self-antigens results in autoimmune diseases. Accordingly, immune suppression is recommended for the management of autoimmune diseases, allergy, and organ transplantation, whereas immune inducers are used for the...
Source: Journal of Immunology - March 7, 2023 Category: Allergy & Immunology Authors: Masoud H Manjili Source Type: research
Connective Tissue Disease Associated Interstitial Lung Disease
Connective tissue disease associated interstitial lung disease (CTD-ILD) is a heterogenous collection of conditions with a diverse spectrum of interstitial lung disease (ILD) manifestations. Currently, clinical practice of lung-directed immunosuppression in CTD-ILD is supported by several randomized, placebo-controlled trials (RCTs) in patients with scleroderma and several observational, retrospective studies in other autoimmune conditions. However, given the harm of immunosuppression in idiopathic pulmonary fibrosis, there is an urgent need for RCTs of immunosuppression and antifibrotic agents in fibrotic CTD-ILD populati...
Source: Immunology and Allergy Clinics of North America - March 3, 2023 Category: Allergy & Immunology Authors: Scott M. Matson, M. Kristen Demoruelle Source Type: research
Distinct dynamics of antigen-specific induction and differentiation of different CD11c+ Tbet+ B cell subsets
CD11c+ B cells actively participate in humoral immune responses, and their phenotypic and functional diversity needs to be considered when studying these cells in the context of immune challenge in healthy individuals and autoimmune diseases.
Source: Journal of Allergy and Clinical Immunology - February 27, 2023 Category: Allergy & Immunology Authors: Juulke Steuten, Am élie V. Bos, Lisan H. Kuijper, Mathieu Claireaux, Wouter Olijhoek, George Elias, Mariel C. Duurland, Tineke Jorritsma, Casper Marsman, Alberta G.A. Paul, Juan J. Garcia Vallejo, Marit J. van Gils, Luuk Wieske, Taco W. Kuijpers, Filip E Source Type: research
Scabies cases misdiagnosed and treated as allergic diseases: itch as alarm
Acta Clin Croat. 2022 Aug;61(2):349-353. doi: 10.20471/acc.2022.61.02.22.ABSTRACTThe lack of scabies recognition by physicians is often caused by its similarity with other dermatoses and allergies such as eczema, urticaria, atopic dermatitis, allergic contact dermatitis, etc. The aim of this study was to present the most common misdiagnoses of scabies in physician's work. With the aim of preventing future misdiagnoses in physicians' work, we present 6 cases of patients (1 woman and 5 men, aged 23-82) who had been misdiagnosed prior to admission to our ward (tertiary care unit). In our patients, scabies was unrecognized for...
Source: Acta Clinica Croatica - February 23, 2023 Category: General Medicine Authors: Liborija Lugovi ć-Mihić Marija Dela š Aždajić Iva Be šlić Source Type: research
Health Plans Get Very Poor Scores for Access to Autoimmune Drugs Health Plans Get Very Poor Scores for Access to Autoimmune Drugs
Three out of four insurance plans use policies that result in significant to severe restriction of access to medications for seven autoimmune diseases, according to the analysis.Medscape Medical News
Source: Medscape Allergy Headlines - February 14, 2023 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news
