Prevalence, etiology and risk factors for falls in neurological patients admitted to the hospital in northern turkey.
This study was carried out to determine the prevalence of falls, their etiology and risk factors in neurological patients admitted to the hospital in northern Turkey. A cross-sectional, descriptive design was used. Data were collected by survey that identified socio-demographic and clinical features of the subjects, Hendrich II fall risk model and Berg Balance Scale (BBS). Study results revealed approximately one-third of the study patients (33.1%) to have sustained falls before. Concerning the timing of falls, 24.9% of these incidents had occurred within the last year. The most common reason for falling was dizziness (14....
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Defining health-related quality of life in localized and advanced stages of breast cancer - the first step towards hereditary cancer genetic counseling.
Authors: Žigman T, Lukša I, Mihaljević G, Žarković M, Kirac I, Vrdoljak DV, Šerman L Abstract The important goal in breast cancer treatment is to improve patient quality of life. Due to the huge economic burden, it is necessary to estimate the health state utility values for different breast cancer stages accurately. A group of 114 women filled out the EuroQol-5D-3L questionnaire at two time points. The participants were divided into three groups, as follows: group 1 including healthy high-risk individuals; group 2 including patients with localized stage breast cancer; and group 3 including patien...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

THE Role of Preoperative carcinoembryonic antigen in recurrence of resectable colorectal carcinoma.
Authors: Khan MA, Maken RN, Nisar H, Fatima I, Khan IU, Masood M, Shahid AB Abstract In colorectal carcinoma, carcinoembryonic antigen (CEA) is a recommended marker for surveillance after curative resection. The aim of the present study was to determine the association of preoperative CEA with recurrence of colorectal carcinoma in our population. The study included 55 patients with all operable stages of colorectal adenocarcinoma treated during the 2012-2014 period, evaluated retrospectively and followed-up for recurrence for 2 years. Data on the baseline (preoperative) CEA levels were retrieved from patient files....
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The effect of atorvastatin on the common carotid artery intima-media thickness in patients with ischemic stroke.
Authors: Khazaei M, Khosravi M, Mazaheri S, Mazdeh M, Ghiasian M, Taheri M, Ghafouri-Fard S Abstract Occlusion of the initial segment of internal carotid artery is the most common reason for vascular events in the brain. The purpose of this study was to investigate the effect of one-year treatment with atorvastatin on intima-media thickness (IMT) of carotid arteries as a measure of atherosclerosis in stroke patients. In this prospective interventional study, 44 patients with ischemic stroke were investigated. Patients were treated with atorvastatin 40 mg once a day for one year. IMT of carotid arteries was measured...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Implementation of an Enhanced Recovery Program After Bariatric Surgery: clinical and cost-effectiveness analysis.
Authors: Agnoletti V, Bonilauri S, De Pietri L, Ferrara D, Lanaia A, Pipia N, Seligardi M, Padovani E, Corso RM Abstract Enhanced recovery after surgery (ERAS) programs are perioperative evidence-based interventions that have the purpose of making the perioperative pathway more efficient in safeguarding patient safety and quality of care. Recently, several ERAS components have been introduced in the setting of bariatric surgery (Enhanced Recovery After Bariatric Surgery, ERABS). The aim of the present study was to evaluate clinical efficiency and cost-effectiveness of the implementation of an ERABS program. It was ...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Importance of acute cardiac care registries at the national level.
Authors: Đuzel A, Pavlov M, Babić Z Abstract Improving organization and patient care quality in intensive care units is increasingly important as intensive care unit diagnostic and therapeutic procedures account for a growing proportion of hospital services. We identified the lack of comprehensive national and international registries available in the contemporary literature. This paper aims to describe and analyze cardiac intensive care unit (CICU) network at the national level in Croatia and its comparison with more developed countries. Thirty-four representatives from all Croatian acute hospitals (response rat...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Independent factors FOR poor prognosis in young patients with stage I-III breast cancer.
Authors: Erić I, Petek Erić A, Koprivčić I, Babić M, Pačarić S, Trogrlić B Abstract Breast cancer is the most common malignancy in the population of women under 40 years of age. Young age is an independent factor for poor prognosis. In this research, we tried to establish other factors for poor prognosis in stage I-III breast cancer. The following parameters were observed: tumor size, lymph node status, histologic grade, hormonal receptor status, Ki-67 prognostic index, Her2 neu status, histologic type of the tumor, local recurrence and metastases. Logistic regression was used to evaluate the effect of spec...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Localization and shape of stenoses in central lung carcinoma - Sensitivity and precision of MDCT VB and FB.
In conclusion, VB was found to be a successful noninvasive method for determining the localization of lung tumors and shape of stenoses, which are essential in the diagnosis of malignant processes. PMID: 33456112 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Prognostic value of cranial ultrasonography in comparison with magnetic resonance imaging in children with cerebral palsy: a population-based study.
Authors: Delin S, Bošnjak Nađ K, Martinec S, Čokolić Petrović D, Šimic Klarić A, Mejaški Bošnjak V Abstract The aim of this population-based study was to evaluate the characteristics of cerebral palsy (CP) in relation to the predominant pattern of the Magnetic Resonance Imaging Classification System (MRICS) that was analogously applied to the neonatal/early infant cranial ultrasound (CUS). The study included children born during the 2004-2007 period from the Croatian part (C28 RCP-HR) of the Surveillance of Cerebral Palsy in Europe (SCPE) CP register. Motor functions, accompanying i...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Calcific tendinopathy: calcium deposit morphology directly affects pain and function of the shoulder.
CALCIFIC TENDINOPATHY: CALCIUM DEPOSIT MORPHOLOGY DIRECTLY AFFECTS PAIN AND FUNCTION OF THE SHOULDER. Acta Clin Croat. 2020 Jun;59(2):270-276 Authors: Cesarec G, Martinec S, Čičak N Abstract The aim of this study was to determine conventional ultrasonography characteristics of calcium deposits in patients diagnosed with calcific tendinopathy, to determine vascularization around deposits by power Doppler, and to compare morphological and power Doppler findings with clinical findings by use of two questionnaires. Pain and function were evaluated using the visual analog scale and two questionnaires, Con...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The effect of age On cervical cancer screening in women aged 20-29.
Authors: Tuncer HA, Tuncer SF Abstract No definite consensus exists currently regarding the appropriate age at which to start cervical cancer screening. We analyzed the effectiveness of age in abnormal histology outcomes in women aged 20-29. Data on women aged 20-29 having undergone opportunistic cervical cancer screening with cytology during the 2014-2019 period were retrospectively reviewed. Based on cytology outcomes, human papillomavirus test results (if present), age and clinical decision, patients underwent either colposcopy or observation. The effects of age and other epidemiologic factors on histologic diag...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Assessment of the Quality of Public Hospital Healthcare Services by using SERVQUAL.
Authors: Ozretić Došen Đ, Škare V, Čerfalvi V, Benceković Ž, Komarac T Abstract Hospital healthcare service quality measurement represents an important approach for advancing healthcare systems. This paper presents preliminary results of a research on the quality of healthcare services provided by a large, public, university hospital centre in Croatia, based on the Gaps Model of Service Quality and the SERVQUAL instrument. The importance of particular service quality dimensions was analyzed, as well as the gaps between patient perceptions and expectations of healthcare services provided by 18 dep...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Hpv typing as a screening program for prevention and early detection of cervical cancer in different montenegro regions.
The objective of our research was to compare the results of human papillomavirus (HPV) typing and occurrence of the most important risk factors for cervical cancer obtained in the towns of northern, central and southern regions of Montenegro, in subjects between 30 and 35 years of age, in accordance with the new screening program introduced by the Ministry of Health of Montenegro in 2018. The study included 400 patients aged 30-35 years from Rožaje, Berane, Budva and Podgorica, 100 from each town, who underwent HPV typing in accordance with the latest screening program for early detection and prevention of cervical cancer...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Regional and sociodemographic determinants of the prevalence of overweight and obesity in children aged 7-9 years in Croatia.
This study used data that were gathered as part of the WHO Europe Childhood Obesity Surveillance Initiative in 2015/2016. The sample for the study was nationally representative. Anthropometric measurements of 5591 children, 2811 boys and 2780 girls, were collected during 8 weeks using standardized equipment. Studied variables included child's anthropometric measurements and demographics, maternal education and employment status. The results showed a 35.9% prevalence of overweight and obesity in Croatian 7-9-year-old children. Overweight and obesity were more frequent in boys in comparison to girls, especially among boys fr...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The effect of smoking on disease activity in rheumatoid arthritis - our experience.
In this study, we found no association between smoking status and disease activity, seropositivity, age or gender in rheumatoid arthritis patients. Furthermore, disease activity was not related to age, gender or seropositivity. Additional studies on the effects of smoking on rheumatoid arthritis activity are needed. PMID: 33456119 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Common allergies and allergens in oral and perioral diseases.
COMMON ALLERGIES AND ALLERGENS IN ORAL AND PERIORAL DISEASES. Acta Clin Croat. 2020 Jun;59(2):318-328 Authors: Lugović-Mihić L, Ilić I, Budimir J, Pondeljak N, Mravak Stipetić M Abstract Allergic reactions sometimes participate in the development of perioral and oral diseases, indicating the need for appropriate allergen assessment. This review discusses current knowledge on the potential allergic reactions to different dental materials in patients with oral and perioral diseases. Aside from allergies to various dental materials, similar non-allergic, non-immune contact reactions (irritant or toxic...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Myxopapillary ependymoma of the spinal cord in adults: a report of personal series and review of literature.
In conclusion, our findings suggest that MPE management based on the proposed 5-type tumor classification is favorable when total surgical resection is performed in carefully selected patients. Yet, further studies on a much broader model is obligatory to confirm this. PMID: 33456121 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Brucellosis in pregnancy: case reports with different outcomes in an endemic region.
Authors: Bosilkovski M, Stojovski M, Siskova D, Ridov A, Kostoska E, Krstevski K Abstract Different outcomes of brucellosis in pregnancy regarding the fetus/neonate and the mother are described. Medical records of five pregnant women with brucellosis were retrospectively analyzed. Patients were treated in several departments of infectious diseases in the Republic of Macedonia between 1995 and 2009. The diagnosis of brucellosis was based on clinical findings compatible with the disease supported by detection of specific antibodies. Pregnancy outcomes in patients were as follows: spontaneous abortion, intrauterine fe...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Adropin - potential link in cardiovascular protection for obese male type 2 diabetes mellitus patients treated with liraglutide.
ADROPIN - POTENTIAL LINK IN CARDIOVASCULAR PROTECTION FOR OBESE MALE TYPE 2 DIABETES MELLITUS PATIENTS TREATED WITH LIRAGLUTIDE. Acta Clin Croat. 2020 Jun;59(2):344-350 Authors: Tičinović Kurir T, Miličević T, Novak A, Vilović M, Božić J Abstract The aim of this study was to determine plasma adropin concentration and parameters of insulin resistance in obese male type 2 diabetes mellitus (T2DM) patients before and after 3-month liraglutide treatment. In this interventional study, we enrolled 15 obese male T2DM patients with body mass index (BMI)>35 kg/m2, uncontrolled disease and HbA1c>7.5...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The role of regulatory T lymphocytes in immune control of MC-2 fibrosarcoma.
Authors: Jukić T, Jurin Martić A, Ivanković S, Antica M, Pavan Jukić D, Rotim C, Jurin M Abstract The role of T regulatory lymphocytes (Treg) particularly in cancer is well known. The goal of the present study was to determine the contribution of these lymphocytes in the regulation of anti-tumor immunity of CBA/HZgr mice against MC-2 fibrosarcoma (4th generation of methylcholanthrene induced tumor). The levels of T lymphocytes (CD4+, CD8+ and CD4+CD25+) were determined 8 and 20 days after tumor transplantation. Further, the role of CD4+CD25+ (Tregs) in tumor-host interaction was evaluated in vitro and in vivo b...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The risk of multiple intracranial aneurysm formation in patients with malignant disease undergoing radiation therapy: a case report and literature review.
In conclusion, the risk of multiple intracranial aneurysm formation in patients with breast cancer undergoing radiation therapy is low, but still possible. Long-term follow-up and regular cerebral angiographic check-up studies are necessary in selected malignant patients to decrease such a risk and to evade the worst outcome associated with aneurysm rupture. PMID: 33456125 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Primary hodgkin's lymphoma of the breast initially treated by surgical excision and axillary dissection.
We present a case of EBV-positive primary Hodgkin's lymphoma of the breast. Although there is no sufficient data on this challenging diagnosis, it is known that it could be misdiagnosed with inflammatory breast carcinoma. A crucial part of the proper histopathologic diagnosis is immunohistochemistry. Different modalities of treatment include operative procedure, chemotherapy and radiotherapy. Recent studies suggest chemotherapy and radiotherapy to be initial treatment for patients with primary breast lymphomas. PMID: 33456126 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Computed tomography scan for diagnosis of osteoarthritis: rare localization in the shoulder in a twelve-year-old boy.
We report a case of successful diagnosis and treatment in a 12-year-old boy with right shoulder joint osteoarthritis. On admission, he was febrile (39.0 ºC) with pain in his right shoulder. Laboratory and biochemistry findings were as follows: leukocytes 10.9x109/L; hemoglobin 122 g/l; fibrinogen 34.7; C-reactive protein 56.8. No changes were observed using conventional radiography. Computed tomography (CT) scan was conducted on the right limb using LightSpeed 16 slices in native and contrast series. The area of interest was shown on axial section, less dense fluid within the joint cavity with a thickened capsule and ...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

A 27-year-old patient with congenital bladder exstrophy and recurrent pelvic organ prolapse: a case report.
We report a case of BE and POP in a 27-year-old nulliparous Caucasian. Due to the patient's strong fertility desire, considering her extensive surgical history background, our approach was to correct POP via the Manchester-Fothergill procedure. After 36 months, the patient was still asymptomatic with no evidence for prolapse recurrence. This case demonstrates diagnostic challenges and surgical dilemmas in treatment strategy for patients with BE and co-existent POP. Furthermore, routine long-term surveillance is necessary in terms of renal function, urinary continence, malignancy and possible obstetric issues. PMID: 334...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Surgical aspect of blepharospasm treatment: a case report.
SURGICAL ASPECT OF BLEPHAROSPASM TREATMENT: A CASE REPORT. Acta Clin Croat. 2020 Jun;59(2):377-381 Authors: Dinjar K, Zubčić V, Kopić A, Kopić V, Popić B, Holik D Abstract Blepharospasm is an idiopathic condition characterized by involuntary eyelid closure mainly caused by bilateral tonic-clonic contractions of the orbicularis oculi muscle. It results in patient inability to open their eyes, thus significantly impairing their ability to perform activities of daily living. First-line treatment for blepharospasm are primarily botulinum toxin type A injections. However, surgical procedure as a treatm...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Orthodontist clinical experience and clinical situation significantly influence the retention protocol - a survey from croatia.
ORTHODONTIST CLINICAL EXPERIENCE AND CLINICAL SITUATION SIGNIFICANTLY INFLUENCE THE RETENTION PROTOCOL - A SURVEY FROM CROATIA. Acta Clin Croat. 2020 Mar;59(1):3-9 Authors: Popović Z, Trinajstić Zrinski M, Špalj S Abstract The aim was to assess the views and practice of Croatian orthodontists concerning retention protocols. A total of 150 questionnaire copies were distributed, of which 92 were validly completed. The survey included sociodemographic characteristics, practices of informing patients about retention options, commonly used appliances, and reasons for choosing a particular type of r...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The role of frequency doubling technology perimetry in early detection of diabetic retinopathy.
THE ROLE OF FREQUENCY DOUBLING TECHNOLOGY PERIMETRY IN EARLY DETECTION OF DIABETIC RETINOPATHY. Acta Clin Croat. 2020 Mar;59(1):10-18 Authors: Bradvica M, Biuk D, Štenc Bradvica I, Vinković M, Cerovski B, Barać I Abstract The aim was to assess whether standard automated perimetry (SAP) and frequency doubling technology (FDT) perimetry are able to detect the effect of diabetes mellitus (DM) on retinal function in DM patients in the early stage of disease and to analyze which method is more specific and sensitive. A randomized cross-sectional study was conducted in three different groups of pati...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Serum bilirubin correlates with serum adipokines in normal weight and overweight asymptomatic adults.
SERUM BILIRUBIN CORRELATES WITH SERUM ADIPOKINES IN NORMAL WEIGHT AND OVERWEIGHT ASYMPTOMATIC ADULTS. Acta Clin Croat. 2020 Mar;59(1):19-29 Authors: Petelin A, Jurdana M, Jenko Pražnikar Z, Žiberna L Abstract Overweight and obesity are considered as chronic low-grade inflammation accompanied by imbalanced production of adipokines. The aim of this study was to elucidate the relationship between serum bilirubin, which is an endogenous antioxidant with anti-inflammatory activity, and pro- and anti-inflammatory serum adipokines in asymptomatic normal weight and overweight individuals. Healthy men and wom...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Lifestyle and quality of life in working-age people after stroke.
LIFESTYLE AND QUALITY OF LIFE IN WORKING-AGE PEOPLE AFTER STROKE. Acta Clin Croat. 2020 Mar;59(1):30-36 Authors: Kowalczyk B, Zawadzka B Abstract Recommendations for changing one's lifestyle in the aspect of factors that increase the risk of another stroke are often included in the plan of caring for patients after stroke. The style of life is connected to the quality of life and can be formed not only by socialization but also by conscious work on its health-promoting aspect. Lifestyle is a unique configuration of everyday behavior depending mostly on the quality of life available. The aim of the rese...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The frequency of follicle-stimulating hormone receptor 2039a > g gene polymorphism and the risk of male infertility in albanian population.
In conclusion, our case-control study further confirmed previous reports on no significant association between the FSHR Asn680Ser polymorphisms and male infertility. Nevertheless, the data presented herein indicate that the Asn/Ser genotype may increase the risk of male infertility in Albanian population. PMID: 32724273 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Optic nerve sheath sonography is a promising tool for assessment of raised intracranial pressure in patients admitted to neurological intensive care unit.
OPTIC NERVE SHEATH SONOGRAPHY IS A PROMISING TOOL FOR ASSESSMENT OF RAISED INTRACRANIAL PRESSURE IN PATIENTS ADMITTED TO NEUROLOGICAL INTENSIVE CARE UNIT. Acta Clin Croat. 2020 Mar;59(1):50-54 Authors: Lovrenčić-Huzjan A, Bosnar-Puretić M, Hustić I, Kobasić I, Budišić M, Ćorić L, Roje-Bedeković M Abstract Optic nerve sheath diameter (ONSD) enlargement is detectable in traumatic brain injury patients with raised intracranial pressure (ICP). The aim was to assess its value in neurological patients suspected to have increased ICP. Patient clinical imaging data and hospitalization outcome w...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Neutrophil gelatinase-associated lipocalin as an early biomarker of acute kidney injury in newborns.
NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN AS AN EARLY BIOMARKER OF ACUTE KIDNEY INJURY IN NEWBORNS. Acta Clin Croat. 2020 Mar;59(1):55-62 Authors: Naunova-Timovska S, Cekovska S, Sahpazova E, Tasić V Abstract The aim of the study was to determine the incidence, risk factors and efficiency of the neutrophil gelatinase-associated lipocalin (NGAL) biomarker in early diagnosis of acute kidney injury (AKI) in newborns. The study was designed as a prospective, clinical, epidemiological investigation conducted in the period of three years, which included 50 newborns with AKI hospitalized in the Neonatal Int...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Prevalence of thrombocytosis, thrombocytopenia, lymphocytosis and lymphocytopenia in patients with lower respiratory tract infection and patients with urinary tract infection.
In this study, we aimed to assess the prevalence of thrombocytosis, thrombocytopenia, lymphocytosis and lymphocytopenia in patients with lower respiratory tract infection (LRTI) and patients with urinary tract infection (UTI). This retrospective study included 52 LRTI patients and 60 UTI patients. Control group consisted of 70 healthy individuals admitted to the infectiology outpatient unit. No statistically significant relationship was found between the groups of subjects and platelet count. Seven (11.7%) UTI patients and four (7.7%) LRTI patients had lymphocytopenia but there was no statistically significant relationship...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Interactions among interleukin-6, c-reactive protein and interleukin-6 (-174) g/c polymorphism in the pathogenesis of crohn's disease and ulcerative colitis.
INTERACTIONS AMONG INTERLEUKIN-6, C-REACTIVE PROTEIN AND INTERLEUKIN-6 (-174) G/C POLYMORPHISM IN THE PATHOGENESIS OF CROHN'S DISEASE AND ULCERATIVE COLITIS. Acta Clin Croat. 2020 Mar;59(1):67-80 Authors: Takač B, Mihaljević S, Glavaš-Obrovac L, Kibel A, Suver-Stević M, Canecki-Varžić S, Samardžija M, Rajkovac I, Kovač D, Štefanić M Abstract Inflammatory bowel diseases are multifactorial disorders the clinical manifestation of which depends on the interaction among immune response, genetic and environmental factors. There is growing evidence that cytokines and gene polymorphisms h...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Predictors of early-onset depression after first-ever stroke.
PREDICTORS OF EARLY-ONSET DEPRESSION AFTER FIRST-EVER STROKE. Acta Clin Croat. 2020 Mar;59(1):81-90 Authors: Rabi-Žikić T, Živanović Ž, Đajić V, Simić S, Ružička-Kaloci S, Slankamenac S, Žikić M Abstract Post-stroke depression (PSD) is a severe and frequent stroke complication and one of the crucial factors for the outcome of rehabilitation and life quality after stroke. However, mood disorders frequently remain unnoticed and therefore untreated. The aim of the study was to examine all the potential risk factors and determine the independent predictors of early-onset depression after first-...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Relationship between insulin-like growth factor type 1 and intrauterine growth.
RELATIONSHIP BETWEEN INSULIN-LIKE GROWTH FACTOR TYPE 1 AND INTRAUTERINE GROWTH. Acta Clin Croat. 2020 Mar;59(1):91-96 Authors: Banjac L, Kotur-Stevuljević J, Gojković T, Bokan-Mirković V, Banjac G, Banjac G Abstract Insulin-like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses. The aim of our study was to investigate the relationship between IGF-1 levels in newborns and intrauterine growth, expressed as birth weight (BW). The research was designed as a cross-sectional study. The study included 71 prema...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

CHARACTERISTICS AND PROGNOSIS OF TRIPLE-NEGATIVE BREAST CANCER PATIENTS: A CROATIAN SINGLE INstitution RETROSPECTIVE COHORT STUDY.
Authors: Tečić Vuger A, Šeparović R, Vazdar L, Pavlović M, Lepetić P, Šitić S, Bajić Ž, Šarčević B, Vrbanec D Abstract Triple-negative breast cancer (TNBC) occurs in around one-sixth of all breast cancer (BC) patients, with the most aggressive behavior and worst prognosis of all BC subtypes. It is a heterogeneous disease, with specific molecular characteristics and natural dynamics of early recurrence and fast progression. Due to the lack of biomarkers or any valid treatment targets, it can only be treated with classic cytotoxic chemotherapy. We analyzed a cohort of 152 patients, medi...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

High prevalence of untreated and undertreated vitamin d deficiency and insufficiency in patients with inflammatory bowel disease.
HIGH PREVALENCE OF UNTREATED AND UNDERTREATED VITAMIN D DEFICIENCY AND INSUFFICIENCY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE. Acta Clin Croat. 2020 Mar;59(1):109-118 Authors: Domislović V, Vranešić Bender D, Barišić A, Brinar M, Ljubas Kelečić D, Rotim C, Novosel M, Matašin M, Krznarić Ž Abstract Inflammatory bowel disease (IBD) patients with vitamin D deficiency show an increased risk of hospital admission, surgery, and loss of response to biologic therapy while high vitamin D levels are identified as a protective factor. Our goal was to investigate the prevalence of un...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Management of patients with cardiac implantable electronic devices undergoing magnetic resonance imaging - proposal for unified hospital protocol: croatian working group on arrhythmias and cardiac pacing.
MANAGEMENT OF PATIENTS WITH CARDIAC IMPLANTABLE ELECTRONIC DEVICES UNDERGOING MAGNETIC RESONANCE IMAGING - PROPOSAL FOR UNIFIED HOSPITAL PROTOCOL: CROATIAN WORKING GROUP ON ARRHYTHMIAS AND CARDIAC PACING. Acta Clin Croat. 2020 Mar;59(1):119-125 Authors: Pavlović N, Đula K, Kuharić I, Brusich S, Velagić V, Jurišić Z, Bakotić Z, Anić A, Pezo Nikolić B, Radeljić V, Čubranić Z, Zeljković I, Zadravec D, Manola Š Abstract For many years, magnetic resonance imaging (MRI) was contraindicated in patients with cardiac implantable electronic devices (CIED). Today, there is a growing amou...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The impact of positive anti-hbc marker on permanent deferral of voluntary blood donors in eastern croatia and estimation of occult hepatitis b virus infection rate.
THE IMPACT OF POSITIVE ANTI-HBC MARKER ON PERMANENT DEFERRAL OF VOLUNTARY BLOOD DONORS IN EASTERN CROATIA AND ESTIMATION OF OCCULT HEPATITIS B VIRUS INFECTION RATE. Acta Clin Croat. 2020 Mar;59(1):126-134 Authors: Samardžija M, Drenjančević D, Miletić M, Slavulj B, Jukić I, Zibar L, Mihaljević S, Ferenac Kiš M, Samardžija M Abstract Recently an increase has been reported in the number of HBV transmissions from anti-HBc positive blood donors that were repeatedly negative in HBsAg and nucleic acid testing using the most sensitive tests available. The aim of the study was to show the effect ...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The beginnings of kidney transplantation in south-east europe.
THE BEGINNINGS OF KIDNEY TRANSPLANTATION IN SOUTH-EAST EUROPE. Acta Clin Croat. 2020 Mar;59(1):135-140 Authors: Primc D, Rački S, Arnol M, Marinović M, Fućak-Primc A, Muzur A, Hawlina S, Markić D Abstract Organ transplantation is one of the most important medical achievements of the 20th century. Kidney transplantation is the most efficient method of renal replacement therapy. The first successful kidney transplantation in human was performed in 1954 in Boston, USA. In former Yugoslavia, the first kidney transplantation was performed on April 16, 1970 in Ljubljana, Slovenia, and second one on Janua...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

The role of john the baptist lalangue in the development of croatian public health and midwifery in the context of implementation of the imperial public health law from 1770.
THE ROLE OF JOHN THE BAPTIST LALANGUE IN THE DEVELOPMENT OF CROATIAN PUBLIC HEALTH AND MIDWIFERY IN THE CONTEXT OF IMPLEMENTATION OF THE IMPERIAL PUBLIC HEALTH LAW FROM 1770. Acta Clin Croat. 2020 Mar;59(1):141-146 Authors: Fureš R, Habek D, Hrgović Z, Fureš D Abstract To understand the development of public health in Croatia, there are newer insights into the life and work of John the Baptist Lalangue. John the Baptist Lalangue is most valued for implementation of the imperial law on public health and promotion of midwifery in Croatia during the second half of the 18th century. Lalangue...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Neuroplasticity and Braille reading.
This article brings review of the studies and their findings about neuroplasticity of the brain and Braille reading, as well as some connections between the two. The goal of the article is to combine knowledge from different disciplines, thus enabling development of new efficient programs in rehabilitation. A lot of research has shown the possibility of brain reorganization (plasticity), indicating the creation of new neuron connections in people with vision loss which relate to Braille reading, especially in late-onset vision loss. PMID: 32724286 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Importance of zinc concentration in seminal fluid of men diagnosed with infertility.
IMPORTANCE OF ZINC CONCENTRATION IN SEMINAL FLUID OF MEN DIAGNOSED WITH INFERTILITY. Acta Clin Croat. 2020 Mar;59(1):154-160 Authors: Milostić-Srb A, Včev A, Tandara M, Marić S, Kuić-Vadlja V, Srb N, Holik D Abstract The prevalence and importance of male infertility make it a serious worldwide medical and social problem. The aim of this study was to determine if there were any significant differences in zinc concentrations in seminal fluid in men diagnosed with infertility compared to control group, and if there were, to determine how it affected the number and percentage of sperm cells with normal...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

How to treat patients after serious adverse effects caused by tnf inhibitors?
We report on serious adverse events during treatment with anti-tumor necrosis factor antibody in two of our patients with juvenile idiopathic arthritis. One patient was treated with a biological agent due to juvenile idiopathic arthritis complicated by uveitis, developing miliary tuberculosis during treatment. After treatment with antituberculotics, she recovered completely. Her underlying disease is currently in remission. Another patient was treated for juvenile spondyloarthritis and developed an inflammatory process of the central nervous system with serious neurological deficits. He was treated with high-dose corticost...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Large aneurysm of basilar artery tip mimicking midbrain tumor and causing unilateral obstructive hydrocephalus: a case report and technical note.
In conclusion, large basilar tip aneurysms associated with obstructive hydrocephalus are rare and best treated by a combination of endovascular obliteration and cerebrospinal fluid ventricular diversion. The possibility of such an aneurysm should always be considered on the differential diagnosis of cerebral ventricular growths. PMID: 32724289 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

From erectile dysfunction to brain subependymoma: a case report.
We present a clinical case of a 27-year-old male with suspected infertility and recent symptoms of erectile dysfunction. Additional radiological and endocrinologic workup revealed underlying subependymoma, which was expanding in the sellar and suprasellar regions, causing pressure against the pituitary gland. The resulting endocrine disorder caused problems that were subjectively at first manifested mainly as erectile dysfunction. The case is an educative example pointing to the need of taking possible intracranial lesions in consideration when starting workup in a patient presenting with erectile dysfunction. It may be of...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Minimally invasive treatment of idiopathic syringomyelia using myringotomy t-tubes: a case report and technical note.
We present a case of a 44-year-old male without a history of spinal cord trauma, infection, or other pathologic processes, who presented for thoracic pain. Due to progressive pain and left leg paresis, magnetic resonance imaging (MRI) was performed and revealed extensive septated syringomyelia from T5 to T7 and hydromyelia cranially. We applied minimally invasive technique for shunting the idiopathic syrinx into the subarachnoid space using two Richards modified myringotomy T-tubes. Postoperative MRI revealed significant decrease in the syrinx size and clinical six-month follow-up showed improvement of clinical symptoms. T...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Giant cavernous malformation with unusually aggressive clinical course: a case report.
GIANT CAVERNOUS MALFORMATION WITH UNUSUALLY AGGRESSIVE CLINICAL COURSE: A CASE REPORT. Acta Clin Croat. 2020 Mar;59(1):183-187 Authors: Grujić J, Jovanović V, Tasić G, Savić A, Stojiljković A, Matić S, Lepić M, Rotim K, Rasulić L Abstract Giant cavernomas (GC) are rare lesions, with less than 50 cases reported so far. Clinical presentation usually involves epileptic seizures and less typically focal neurological deficit, due to repeated hemorrhages and GC mass effect and consequentially increased intracranial pressure. Although individual cases have been reported, due to the rarity and variable...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Torsades de pointes in elderly patient with paroxysmal atrial fibrillation treated by short-term parenteral amiodarone therapy.
TORSADES DE POINTES IN ELDERLY PATIENT WITH PAROXYSMAL ATRIAL FIBRILLATION TREATED BY SHORT-TERM PARENTERAL AMIODARONE THERAPY. Acta Clin Croat. 2019 Dec;58(4):751-756 Authors: Lakušić N, Slivnjak V, Ciglenečki N, Cerovec D Abstract One of the drugs that are widely used in the treatment of atrial fibrillation is amiodarone. Despite considerable prolongation of the corrected QT interval and a substantial degree of bradycardia, amiodarone exhibits a remarkably low frequency of pro-arrhythmic events and
Source: Acta Clinica Croatica - July 17, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research