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Condition: Autoimmune Disease
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Total 2213 results found since Jan 2013.
Perspectives on Mycophenolate Mofetil in the Management of Autoimmunity
AbstractBefore becoming a cornerstone in the treatment of numerous immune-mediated diseases, mycophenolate mofetil (MMF) was first introduced as an immunosuppressive agent in transplant immunology and later received the attention of rheumatologists and clinicians involved in the management of autoimmune diseases. MMF is now a widespread immunosuppressive drug for the treatment of several conditions, including lupus nephritis, interstitial lung disease associated with systemic sclerosis, and anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis while being efficacious also as rescue therapy in various orphan disea...
Source: Clinical Reviews in Allergy and Immunology - June 20, 2023 Category: Allergy & Immunology Source Type: research
Case Report: A novel IRF2BP2 mutation in an IEI patient with recurrent infections and autoimmune disorders
ConclusionWe identified a novel IRF2BP2 mutation in a family with a member diagnosed with IEI. Immune monitoring and WGS as auxiliary tests are helpful in identifying genetic defects and assisting diagnosis in patients with clinically highly suspected immune abnormalities and deficiencies in inflammation regulation. In addition, mNGS techniques allow a more comprehensive assessment of the pathogenic characteristics of these patients. This report further validates the association of IRF2BP2 deficiency and IEI, and expands IEI phenotypes.
Source: Frontiers in Immunology - June 7, 2023 Category: Allergy & Immunology Source Type: research
Stepping up our game with secondary immune deficiency
Pharmacologic immune suppression in the past was dirty. I imagine many readers of this journal remember days when systemic corticosteroids were pretty much the only medication they had to effectively treat asthma and rheumatologic diseases. Fortunately, as the management of inflammatory and autoimmune conditions has been refined over the past few decades, our reliance on broad immune suppressants has decreased. Although we still have our “old faithful” prednisone to fall back on, we can now use more targeted therapies to improve outcomes.
Source: Annals of Allergy, Asthma and Immunology - June 1, 2023 Category: Allergy & Immunology Authors: Jay A. Lieberman Tags: Editorial Source Type: research
Neurosarcoidosis: Diagnostic Challenges and Mimics A Review
AbstractPurpose of ReviewNeurosarcoidosis is a rare manifestation of sarcoidosis that is challenging to diagnose. Biopsy confirmation of granulomas is not sufficient, as other granulomatous diseases can present similarly. This review is intended to guide the clinician in identifying key conditions to exclude prior to concluding a diagnosis of neurosarcoidosis.Recent FindingsAlthough new biomarkers are being studied, there are no reliable tests for neurosarcoidosis. Advances in serum testing and imaging have improved the diagnosis for key mimics of neurosarcoidosis in certain clinical scenarios, but biopsy remains an import...
Source: Current Allergy and Asthma Reports - May 31, 2023 Category: Allergy & Immunology Source Type: research
The Role of Innate Immune Cells in Allergen Immunotherapy
Abstract Purpose of reviewAllergic diseases have become a major health challenge across the world in recent years. Allergen immunotherapy (AIT) is the only disease-modifying therapy that can alter the natural course of allergic diseases. In this review, we aim to introduce the current study on innate immunity in AIT and the association between innate immune cells and the clinical efficacy of AIT briefly.Recent findingsAIT can induce long-term immune tolerance through induction of regulatory T cells, regulatory B cells, and inhibitory cytokines such as IL-10 and TGF- β, promotion of immunoglobulin class switching, and ...
Source: Current Treatment Options in Allergy - May 30, 2023 Category: Allergy & Immunology Source Type: research
The role of PD-1 signaling in health and immune-related diseases
Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to mediate the mechanism of immune tolerance and provide immune homeostasis. Significantly, the binding partners of PD-1 and its associated ligands are diverse, which facilitates immunosuppression in cooperation with other immune checkpoint proteins. Accumulating evidence has demonstrated the important immunosuppressive role of the PD-1 axis in the tumor microenvironment and in autoimmune diseases. In addition, PD-1 blockades have been approved to treat various cancers, including solid tumors and hematological malignancies. Here, we pr...
Source: Frontiers in Immunology - May 16, 2023 Category: Allergy & Immunology Source Type: research
Immunosuppressive Polymeric Nanoparticles Targeting Dendritic Cells Alleviate Lupus Disease in < em > Fcgr2b < /em > < sup > -/- < /sup > Mice by Mediating Antigen-Specific Immune Tolerance
This study developed a new nanoparticle (NP) containing a biodegradable PDMAEMA-PLGA copolymer for target-oriented delivery to DCs in situ. PDMAEMA-PLGA NPs provided sustained drug release and exhibited immunosuppressive activity in FLT3L and GM-CSF-derived bone marrow in conventional DCs (BM-cDCs). PDMAEMA-PLGA NPs improved dexamethasone capability to convert wild-type and Fcgr2b-/- BM-cDCs from an immunogenic to tolerogenic state, and BM-cDCs treated with dexamethasone-incorporated PDMAEMA-PLGA NPs (Dex-NPs) efficiently mediated regulatory T cell (Treg) expansion in vitro. Dex-NP therapy potentially alleviated lupus dise...
Source: Cell Research - May 13, 2023 Category: Cytology Authors: Phuriwat Khiewkamrop Chamraj Kaewraemruaen Chonnavee Manipuntee Chalathan Saengruengrit Numpon Insin Asada Leelahavanichkul Warerat Kaewduangduen Opor Sonpoung Kasirapat Ariya-Anandech Nattiya Hirankarn Patcharee Ritprajak Source Type: research
COVID-19 risk perception and vaccine acceptance in individuals with self-reported chronic respiratory or autoimmune conditions
COVID-19 disproportionately affects those with preexisting conditions, but little research has determined whether those with chronic diseases view the pandemic itself differently - and whether there are differ...
Source: Allergy, Asthma and Clinical Immunology - May 4, 2023 Category: Allergy & Immunology Authors: Brianna A. Smith, Emily E. Ricotta, Jennifer L. Kwan and Nicholas G. Evans Tags: Research Source Type: research
Researchers Seek to Understand Post-COVID Autoimmune Risk Researchers Seek to Understand Post-COVID Autoimmune Risk
Three large studies link past SARS-CoV-2 infection to new-onset autoimmune disease, but it is not yet clear what drives this relationship.Medscape Medical News
Source: Medscape Allergy Headlines - May 1, 2023 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news
Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic
CONCLUSION: Our results contribute to the body of literature that observes the immunosuppressive effect of PFAS exposure during eczemas and allergies, both for PFASs individually and as a mixture.PMID:37116680 | DOI:10.1016/j.envres.2023.115969
Source: Environmental Research - April 28, 2023 Category: Environmental Health Authors: Barbora Rudzanova Jelle Vlaanderen Ji ří Kalina Pavel Piler Martin Zvonar Jana Klanova Ludek Blaha Ondrej Adamovsky Source Type: research
Immune Responses at Host Barriers and Their Importance in Systemic Autoimmune Diseases
Adv Exp Med Biol. 2023;1408:3-24. doi: 10.1007/978-3-031-26163-3_1.ABSTRACTHost barriers such as the skin, the lung mucosa, the intestinal mucosa and the oral cavity are crucial at preventing contact with potential threats and are populated by a diverse population of innate and adaptive immune cells. Alterations in antigen recognition driven by genetic and environmental factors can lead to autoimmune systemic diseases such rheumatoid arthritis, systemic lupus erythematosus and food allergy. Here we review how different immune cells residing at epithelial barriers, host-derived signals and environmental signals are involved...
Source: Advances in Experimental Medicine and Biology - April 24, 2023 Category: Research Authors: Katina Schinnerling Hugo A Penny Jorge A Soto Felipe Melo-Gonzalez Source Type: research
