Recommendations for the Use of Tryptase in the Diagnosis of Anaphylaxis and Clonal Mastcell Disorders.
Authors: Platzgummer S, Bizzaro N, Bilò MB, Pravettoni V, Cecchi L, Sargentini V, Caponi L, Visentini D, Brusca I, Pesce G, Bagnasco M, Antico A, Montera MC, Quercia O, Musarra A, Bonazza L, Borrelli P, Cortellini G, Polillo BR, Valenti B, Zedda MT, Asero R, Villalta D Abstract Summary: Tryptase is a serin-protease produced and released by mast cells after IgE-mediated or non-IgE mediated stimuli. We here review the various aspects related to the molecular characteristics of the enzyme and its biological effects, the genetic basis of its production and the release kinetics. Recommendations for the clinical u...
Source: European Annals of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Correlations between disease activity, autoimmunity and biological parameters in patients with chronic spontaneous urticaria.
Conclusions. This study brings additional evidences of interest to investigate IgE, D-dimer serum/plasma levels and basophil blood counts in patients with CSU as they could be correlated to disease activity, response to treatment and/or autoimmunity. PMID: 31965967 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - January 24, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Evolution of Api m10 Specific IgE and IgG4 After One Year of Bee Venom Immunotherapy.
Conclusions. Although there was no increase in Api m10 sIgG4 levels after 1 year bVIT, we did not observe relevant differences in other outcomes between patients with predominant Api m1 or Api m10 sensitization. PMID: 31939631 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - January 17, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

The Changing Landscape of Atopic Dermatitis - Focusing on JAK Inhibitors.
Authors: Rodrigues MA, Torres T PMID: 31933476 [PubMed - in process] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - January 15, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Diagnostic approach to hypersensitivity reactions to iodinated contrast media: a single-center experience on 98 patients.
Authors: Meucci E, Radice A, Fassio F, Sibilio M, Iorno MLC, Testi S, Severino M, Macchia D Abstract Summary: Adverse reactions to iodinated contrast media (ICM) are reported in 1%-3% of diagnostic procedures. They represent a relevant problem involving patients' safety as well as relevant costs for healthcare systems. Premedication with antihistamines and corticosteroids is still widely used, but evidence of its efficacy is lacking and there is a risk for under-estimation of possible severe adverse reactions to ICM in those who undergo premedication. Data from 98 patients with a previous reaction to ICM that conse...
Source: European Annals of Allergy and Clinical Immunology - January 12, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Tree Nuts Anaphylaxis in Preschool Age Children.
Conclusions. In preschool age children with TNs-FIA, cashew and walnut were the commonest implicated nuts. Most reactions occurred briefly after exposure to minimal amounts of TNs, demonstrating the high potency of these allergens. About one-third also had peanut sensitization. Potentially life-threatening TNs allergy can occur early in childhood and adequate management should be undertaken. PMID: 31912691 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - January 9, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Healthcare costs associated with allergic rhinitis, asthma allergy immunotherapy.
This study estimated healthcare costs and utilisation for patients with AR and asthma. Mean annual outpatient visits, pharmaceutical costs and inpatient hospitalisations were calculated for 2010 and 2014, with pharmaceutical and inpatient costs stratified by AIT use. AR and asthma patients had a 35% higher mean number of physician visits and up to 90% higher mean pharmaceutical costs compared to controls. The cost of pharmaceuticals and inpatient hospitalisations were 54% lower in those prescribed AIT. Further research is recommended to understand the reasons for these cost differences. PMID: 31818082 [PubMed - as supp...
Source: European Annals of Allergy and Clinical Immunology - December 12, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Atopic Dermatitis Host and Environment Model: Revisiting Therapeutic Options.
Authors: Saenza De San Pedro A, Lopes MP, Sokolova A, Abreu C, Lopes C Abstract Summary: Atopic Dermatitis (AD) affects both children and adults and is a serious health concern in many countries. AD is a complex disease with host and environmental factors underlying its pathology. Its treatment is multidimensional reflecting the diverse nature of its triggers and includes emollients, topical steroids and calcineurin inhibitors among others. Immunological dysfunction can be addressed broadly with systemic immunosupressors and specifically with monoclonal antibodies. Dupilumab, which targets IL-4 and IL-13 was grante...
Source: European Annals of Allergy and Clinical Immunology - December 5, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Subcutaneous immunotherapy with aeroallergens Evaluation of adherence in real life.
Conclusion. Adherence rate in our study was 77%. Economic reasons were the main cause of abandonment in the first year, while the perception of non improvement was the main reason for abandonment in subsequent years. Adequate information on SCIT prescribing and rigorous monitoring of patients during the treatment can improve adherence. PMID: 31789490 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - December 5, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Blood or skin: what is best in predicting cow's milk allergy diagnosis?
This study is a retrospective analysis of consecutive children (0-18 years-old) with suspected CMA tested with SPT and sIgE for cow's milk (CM) and its fractions between 2016-2017. CMA diagnosis was defined by a positive oral food challenge or a highly suggestive clinical history of CMA and SPT and/or sIgE positive to CM and/or its fractions. One hundred and five patients were included, 58% males with a median age of 2.5 (P25-P75:1-6) years and the diagnosis was confirmed in 83 patients (79%). The variables associated with CMA diagnosis were SPT with CM (p minor 0,05) and casein (p minor 0,05) and all sIgE to CM and its fr...
Source: European Annals of Allergy and Clinical Immunology - December 5, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Clinical assessment of tolerability, immunological and cutaneous reactivity effects of an abbreviated schedule with Olea europaeanative extract of subcutaneous immunotherapy.
Conclusions. Olea europaea SCIT (Allergovac® depot ROXALL Medicina España S.A.) showed a good safety and tolerability profile. Immunological changes with induction of blocking IgG and decreases in cutaneous reactivity were detected in the patients. PMID: 31789492 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - December 5, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Histamine-release test in angioedema patients without urticaria - a retrospective cohort study of 404 patients.
Authors: Authried G, Prasad SC, Rasmussen ER, Bygum A Abstract Summary: A subset of patients with angioedema (AE) and urticaria has histamine releasing autoantibodies. The histamine release test (HR-test) has been used as a tool in chronic urticaria to define the autoimmune subgroup and may possibly guide the clinician to a more personalized therapy, like omalizumab and cyclosporine. The prevalence and value of positive histamine releasing autoantibodies in monosymptomatic AE is sparsely described in the literature. The purpose of this study was to report the prevalence of positive histamine releasing autoantibodie...
Source: European Annals of Allergy and Clinical Immunology - November 11, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Prevalence of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Patients using Two Different Diagnostic Criteria.
Conclusions. The applied diagnostic criteria had no significant effect on the reported rate of ABPA prevalence. PMID: 31702121 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - November 11, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Anaphylaxis to baobab fruit: the paradox of "natural healthy food".
Anaphylaxis to baobab fruit: the paradox of "natural healthy food". Eur Ann Allergy Clin Immunol. 2019 Nov;51(6):282-284 Authors: Martini M, Mistrello G, Amato S, Bilò MB, Agolini S, Corsi A, Tontini A, Antonicelli L Abstract Summary: The nocebo reaction, namely the undesirable effect of an inert substance (placebo), is a phenomenon rarely investigated in literature. A better knowledge of this reaction may help clinicians in the management of these patients in clinical practice. Patients with drug adverse reactions (ADR) undergoing the drug challenge test are an ideal model for studyin...
Source: European Annals of Allergy and Clinical Immunology - November 8, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Two case reports of delayed-allergic reactions to clindamycin confirmed with a positive lymphocyte transformation test.
We reported two cases of delayed allergic reaction to clindamycin, confirmed with a positive lymphocyte transformation test, showing this in vitro test like a promising diagnostic method because of its usefulness and safety. PMID: 31668055 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - November 2, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Use of a comprehensive diagnostic algorithm for anisakis allergy in a high seropreva-lence Mediterranean setting.
Conclusions. Our preliminary findings support the high clinical specificity of BAT for AA diagnosis, suggesting implementing this method in a comprehensive diagnostic algorithm. PMID: 31668056 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - November 2, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Prevalence of allergic rhinitis in children with otitis media with effusion.
Conclusion. Allergic rhinitis and larger family household appeared to be common risk factors in children with persistent otitis media with effusion. There is significant hearing loss noted in children suffering from otitis media with effusion and allergic rhinitis. The hearing threshold improved remarkably with medical therapy. This study hence clarifies the controversy on the association between allergic rhinitis and otitis media with effusion. PMID: 31668057 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - November 2, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Fatal asthma after omalizumab and controller therapy discontinuation.
Authors: Lombardi C, Cottini M, Passalacqua G PMID: 30039694 [PubMed - indexed for MEDLINE] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - October 17, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Can an otorhinolaryngological visit induce the suspect of allergic rhinitis in children?
In conclusion this real-life study showed that during an ORL visit it is possible to suspect AR in children with turbinate hypertrophy, familial atopy, nasal pale mucosa, adenoid enlargement, and asthma comorbidity. PMID: 31594289 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy.
Conclusions. Most drug allergy diagnoses were based on multistep DCT. The identified predictors of DCT interruption during up-dosing can support the development of more personalized DCTs protocols. PMID: 31594290 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

House dust mite allergy and shrimp allergy: a complex interaction.
Conclusions. Shrimp allergy seems to occur uniquely in association with hypersensitivity to HDM allergens and tropomyosin is the main shrimp allergen but not a major one, at least in Italy. Along with tropomyosin-specific IgE levels, monosensitization to HDM seems to represent a risk factor for the development of shrimp allergy among HDM allergic patients. PMID: 31594291 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Severe CSU and activation of the coagulation/fibrinolysis system: clinical aspects.
Conclusions. Only 50% of patients with severe CSU show elevated D-dimer plasma levels. The activation of the coagulation/fibrinolysis system is associated with a systemic inflammatory milieu, suggesting the existence of a specific phenotype. Whether this reflects the existence of different endotypes in patients showing and not showing the activation of the coagulation cascade has still to be established. PMID: 31594292 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Drug allergy is associated with the development of extraintestinal manifestations in patients with ulcerative colitis.
Authors: Toledo-Maurino JJ Abstract Summary: Drug allergies are developed by antibody or cell-mediated reactions as immunologic mechanisms. It has been demonstrated that hypersensitivity reaction to certain allergens may play a role in the pathogenesis of inflammatory bowel disease (IBD) focused on food allergies. A total of 256 patients with UC were divided in two groups: 203 patients with active UC and 53 in remission UC were included in the present study. In the present study we found that 11.7% had allergy to at least one drug distributed. The most frequent drug-allergies were sulfonamides in 2.8% and penicilli...
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Study on the effect of phototherapy for inhibition of symptoms associated with allergic rhinitis.
The objective of the study was to compare the efficacy of the phototherapy device on the relief of a range of symptoms provoked by indoor and outdoor allergens. A phototherapy emits visible light (mUV/VIS) and infrared light, and was compared to a placebo device which did not emit light on two groups of allergic rhinitis sufferers. Rhinophototherapy improved nasal symptoms of allergic rhinitis arising from exposure to indoor and outdoor allergens. The difference in the intensity of symptoms scored at the baseline, and at the final visit for the group using the photoperiod device was significantly lower. The device could po...
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Familial clustering of hypereosinophilic diseases treated with mepolizumab: a case report from Japan.
We describe a female diagnosed with non-allergic asthma. On March 24, 2016, examination of the skin-biopsy specimen revealed dense eosinophilic infiltration, and the Fip-1-like 1-platelet-derived growth factor receptor a fusion gene in peripheral blood mononuclear cells was negative. She was diagnosed with idiopathic hypereosinophilic syndrome. She was treated with intravenous methylprednisolone (MPSL), and subsequent oral MPSL. Then, she started to receive a monthly mepolizumab in June 2016, and successfully withdrew from daily use of oral MPSL. The patient has a mother diagnosed with non-allergic asthma. In February 2005...
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Clinical aspects of hymenoptera venom allergy and venom immunotherapy.
Authors: Bilò MB, Tontini C, Martini M, Corsi A, Agolini S, Antonicelli L Abstract Summary: Hymenoptera venom allergy (HVA) is the most frequent cause of anaphylaxis in Europe, accounting for most of the severe reactions occurring in adults, and being the second cause of anaphylaxis in children. Prevention of further episodes in patients who developed a systemic reaction (SR) is based on the correct management of the allergic emergency, the referral to an allergist for a correct diagnosis, prescription of adrenaline auto-injectors (AAI) and specific venom immunotherapy (VIT), if recommended. Diagnosis is bas...
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Risk factors of zinc deficiency in children with atopic dermatitis.
Conclusions. Hypozincemia is rather prevalent in AD, and severe AD and high IgE increase its risk. An adjunct oral zinc may help reducing severe poorly responsive AD. PMID: 31594297 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Development and validation of the parent-reported Drug Hypersensitivity Quality of Life Questionnaire.
Conclusions. The P-DrHy-Q is the first scale for assessment to consider the interaction of biopsychosocial factors on drug allergy that includes the carer-child dyad. It shows good internal consistency and reliability. Its application might be relevant for future research, and provide clinicians and researchers with a solid tool to define which type of psychosocial support is required to provide more comprehensive care in drug hypersensitivity. PMID: 31594298 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Assessing clinical and psychological features: who are patients showing a nocebo re-action during the drug challenge test?
Authors: Bizzi F, Voltolini S, Fiaschi MD, Cavanna D Abstract Summary: The nocebo reaction, namely the undesirable effect of an inert substance (placebo), is a phenomenon rarely investigated in literature. A better knowledge of this reaction may help clinicians in the management of these patients in clinical practice. Patients with drug adverse reactions (ADR) undergoing the drug challenge test are an ideal model for studying the nocebo effect, and the study aims to investigate their clinical and psychological features. One hundred and twenty patients (Mage = 46.59, SD = 15.5; 82% female), of which 90 non responder...
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Availability of epinephrine auto-injectors and knowledge of community pharmacists about their use.
Authors: Pitsios C, Vasiliadis A, Karakatsanis KP, Matzaras R, Minasidis T, Nteveros A, Samanis G, Nikolopoulos G PMID: 31523943 [PubMed - in process] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - September 17, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Anxiety/depression changes are associated with improved asthma control perception in asthmatic adolescents after adequate management.
Authors: Licari A, Ciprandi R, Marseglia G, Ciprandi G PMID: 31305035 [PubMed - in process] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - July 17, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Metabolic interactions in asthma.
Authors: Farraia M, Cavaleiro Rufo J, Castro Mendes F, Delgado L, Laerte Boechat J, Moreira A Abstract Summary: Metabolomics can be used to explore altered metabolic pathways in asthma, giving insights into its pathophysiology. We aimed to review how metabolomics has been used to understand asthma by describing metabolic pathways under research and discussing clinical implications. The search was performed in PubMed, and studies published since 2000 using a metabolomics approach, were included. A total of 32 studies were analysed. Pathways related with cellular energy homeostasis, lipid metabolism and oxidative str...
Source: European Annals of Allergy and Clinical Immunology - July 11, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Occupational allergy to dog among police dog trainers.
This study was aimed to reveal the prevalence of dog allergy and other common allergy and allergic symptoms in police dog trainers. Fifty-six police dog trainers and 150 workers as control group were included in this study. Medical records of dog trainers including respiratory, skin, eye symptoms and physical examinations and skin prick test results are compared with the medical records of control group. Positive SPT to dog was present in 21.4% of dog trainers, whereas the frequency of sensitization to dog in the control group was 1.3% (p minor 0.001). Dog allergy development risk is found 20 times greater in dog trainers ...
Source: European Annals of Allergy and Clinical Immunology - July 11, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Clinical experience of a chronic urticaria university referral center.
Conclusion. Most of the patients presented CSU, associated frequently with CIndU. All patients were treated with antihistamines and there was a great need for doses above standardized, and also for combination with other medications, with improved quality of life during the follow-up period. PMID: 31287262 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - July 11, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Quality of life improvement with allergen immunotherapy treatment in patients with rhinoconjunctivitis in real life conditions. Results of an observational prospective study ( ÍCARA).
Conclusions. One-year AIT treatment significantly increases QoL in patients with AR. Moreover, high patients' satisfaction values were reported, together with an adequate safety profile. PMID: 31287263 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - July 11, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Anaphylaxis in an emergency department: a retrospective 10-year study in a tertiary hospital.
Conclusions. Anaphylaxis is a life-threatening condition that requires early recognition. Although most patients received adrenaline, administration was not always performed by the recommended route and only a few patients were prescribed adrenaline auto-injector. PMID: 31287264 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - July 11, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Pru p 3 sublingual immunotherapy ultra-rush protocol is safe and clinically effective.
Conclusion. The novel ultra-rush protocol halved the build-up time without increasing side effects. PMID: 31287265 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - July 11, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Allergy immunotherapies for allergic rhinitis: systematic review and assessment of evolving quality.
Conclusions. When as-sessing grass AIT, it is important to focus not only on endpoints but also on the quality of evidence. PMID: 31187972 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - June 14, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

A successful topical treatment for cutaneous inflammatory diseases:an additional or alternative therapy to topical steroids.
Authors: Tammaro A, Magri F, Chello C, Giordano D, Parisella FR, De Marco G, Persechino S PMID: 31081604 [PubMed - in process] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - May 15, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Methylchloroisothiazolinone / methylisothiazolinone: epidemiological retrospective study.
Authors: Lorente-Lavirgen AI, Almeida C, Bernabeu J, Valero V, Lorente R PMID: 31081605 [PubMed - in process] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - May 15, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Methylchloroisothiazolinone / methylisothiazolinone: epidemiological retrospective study.
Authors: Bagnasco D, Aloè T, Sclifò F, Ferrantino MG, Marugo F, Arcadipane F, Manfredi A, Canonica GW, Passalacqua G PMID: 31081606 [PubMed - in process] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - May 15, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Frequency of allergic sensitization to Can f 5 in North East Italy. An analysis of 1403 ISACs 112 (Component Resolved Diagnosis) collected retrospectively.
In conclusions, our data confirmed that there is a high number of sensitized patients to Can f 5, which have a high degree of allergic sensitization. These results should be taken into account by allergists managing dog allergic patients. In fact, clinical consequences of this sensitization regard respiratory allergy (burden of rhinitis/asthma), systemic reactions (anaphylaxis during sexual intercourse from cross-reaction with human prostatic antigen), allergen immunotherapy-AIT (likely ineffective in patients with exclusive sensitization), and preventive measures (possibility to own a female dog and a likely reduction of ...
Source: European Annals of Allergy and Clinical Immunology - April 16, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Circulating microRNAs as potential non-invasive biomarkers in pediatric patients with celiac disease.
In conclusion, circulating miRNA-21 and miRNA-31 could serve as potential non-invasive biomarkers for pediatric CD patients. PMID: 30983306 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - April 16, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

The incidence of immunofluorescence patterns and specific autoantibodies observed in autoimmune patients in a tertiary care centre.
Conclusions: The presence of a particular IIF pattern is predictive of a specific autoantibody in the sample. Association of IIF patterns and specific autoantibody are relevant for a more accurate diagnosis of disease. PMID: 30983307 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - April 16, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Favorable clinical efficacy of mepolizumab on the upper and lower airways in severe eosinophilic asthma: a 48-week pilot study.
Conclusions. This pilot study showed mepolizumab improved nasal symptoms and lung function in severe eosinophilic asthma patients with CRS, suggesting efficacy of mepolizumab on the upper and lower airway symptoms in eosinophilic asthma. PMID: 30983308 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - April 16, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Isoforms of Group 1 Allergens from a Tropical/Subtropical Para Grass (Urochloa mutica) Display Different Levels of IgE Reactivity and Cross-reactivity.
This study aimed to investigate the sequence similarity, and immunoreactivity of group 1 allergens from Para grass (Urochloa mutica). Three isoforms (Uro m 1.01, Uro m 1.02, and Uro m 1.03) were cloned from cDNA of Para grass pollen. The acidic-neutral isoforms rUro m 1.01 and rUro m 1.02 could effectively inhibited beta-expansins in pollen extract of Bermuda and Johnson grasses, suggesting that these isoforms could be major cross-reacting allergens among these grasses. In contrast, the basic isoform rUro m 1.03 had limited IgE reactivity. Thus, group 1 allergens both acidic-neutral and basic isoforms could have markedly d...
Source: European Annals of Allergy and Clinical Immunology - April 16, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Migrants and allergy: a new view of the atopic march.
Authors: Biagioni B, Vitiello G, Bormioli S, Tarrini D, Lombardi C, Rossi O, Parronchi P Abstract Summary: Atopy is the result of the influence of environmental factors on genetically predisposed individuals. Migration flows represent an interesting model to study the possible reciprocal roles of genes and environment. In this review the following issues influencing the development of allergic sensitization and/or atopic disorders in migrants will be rooted out: 1) ethnicity, genetic polymorphisms and risk of atopy; 2) double faceted effects of parasitic infestations; 3) biodiversity loss and industrial progress. M...
Source: European Annals of Allergy and Clinical Immunology - April 16, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Pediatric food allergy prevention, "Much ado about nothing"?
Pediatric food allergy prevention, "Much ado about nothing"? Eur Ann Allergy Clin Immunol. 2019 Mar 05;: Authors: Scala G PMID: 30832467 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - March 6, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

LTP Allergy: a pragmatic and reasonable approach in clinical practice.
Authors: Ciprandi G, Tosca MA PMID: 30832468 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - March 6, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Evaluating the management of anaphylaxis in emergency departments: a survey in two French regions.
Authors: Lefèvre S, Klein R, De Blay F, Mertes PM PMID: 30832469 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - March 6, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research