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Search for a Novel Allergen in Hen ’s Egg Allergy Using an IgE Immunoblotting Assay
Conclusions: We identified YGP40 as a new hen ’s egg yolk allergen and detected 4 sites of YGP40 as linear epitopes.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 18, 2018 Category: Allergy & Immunology Source Type: research

The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice
Conclusion: Although MG132 administration temporarily alleviated AD pathogenesis in NC/Nga mice, prolonged MG132 treatment may result in immunopathogenesis leading to chronic AD due to its side effect of maintaining Th1 levels via autoreactive CD8+ T cells.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 18, 2018 Category: Allergy & Immunology Source Type: research

Contents Vol. 175, 2018
Int Arch Allergy Immunol 2018;175:I –IV (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 17, 2018 Category: Allergy & Immunology Source Type: research

C-Reactive Protein and Procalcitonin in Case Reports of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome
Conclusions: Evaluating CRP and PCT values might be of use in helping physicians to distinguish between cases of DRESS syndrome with and without concurrent infection or other causes of inflammation. Further prospective investigation is required to define the use of these inflammatory markers in the management of DRESS.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 13, 2018 Category: Allergy & Immunology Source Type: research

Activin-A Is a Pro-Inflammatory Regulator in Type-2-Driven Upper Airway Disease
Conclusion: Activin-A in allergic upper airway disease acts as a pro-inflammatory mediator and TGF- β1 modifier. Our data in the upper airways oppose the view of potentially anti-inflammatory properties in contrast to lymphatic compartments.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 13, 2018 Category: Allergy & Immunology Source Type: research

Transcription Elongation Factor P-TEFb Is Involved in IL-17F Signaling in Airway Smooth Muscle Cells
Conclusions: This is the first report that P-TEFb is involved in IL-17F-induced IL-8 expression and that steroids diminish it via the inhibition of CDK9 phosphorylation. IL-17F and P-TEFb might be novel therapeutic targets for airway inflammatory diseases.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 12, 2018 Category: Allergy & Immunology Source Type: research

Safety and Efficacy of a Progressively Prolonged Maintenance Interval of Venom Immunotherapy
Conclusions: Progressively prolonging the VIT maintenance interval up to 26 weeks appears to be safe and efficacious.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 12, 2018 Category: Allergy & Immunology Source Type: research

Increased Group 2 Innate Lymphoid Cells Are Correlated with Eosinophilic Granulocytes in Patients with Allergic Airway Inflammation
This study evaluated the ILC2 levels of asthma subjects, patients with asthma and AR, and healthy individuals, regarding how to investigate the relationship between clinical data and ILC2 levels. It was found that asthma patients and asthma with AR patients had higher ILC2 levels compared to healthy subjects. ILC2s were positively correlated with the percentage of eosinophils in patients with asthma and AR, but not with pulmonary function. ILC2 levels were higher in mild asthma subjects than in patients with severe asthma. This study provides a new interpretation of the pathogenesis of allergic airway inflammation and may ...
Source: International Archives of Allergy and Immunology - April 11, 2018 Category: Allergy & Immunology Source Type: research

Specific IgE for Fag e 3 Predicts Oral Buckwheat Food Challenge Test Results and Anaphylaxis: A Pilot Study
Conclusions: Fag e 3-sIgE predicted OFC results and OFC-induced anaphylaxis. We further emphasize paying careful attention to the risk of BW OFC-induced anaphylaxis.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 10, 2018 Category: Allergy & Immunology Source Type: research

Downregulation and Aberrant Localization of Forkhead Box J1 in Allergic Nasal Mucosa
Conclusion: Downregulation and aberrant localization of FOXJ1 may be crucial characteristics of the allergic nasal mucosa.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 10, 2018 Category: Allergy & Immunology Source Type: research

Enhanced Pro-Inflammatory Response of Macrophages to Interleukin-33 in an Allergic Environment
Conclusions: We conclude that IL-33-activated macrophages may contribute to the exaggerated airway inflammation in exacerbations of allergic asthma, and that RvE1 has potential as a therapeutic agent that targets macrophages.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 6, 2018 Category: Allergy & Immunology Source Type: research

Incidence of Antibiotic-Related Rash in Children with Epstein-Barr Virus Infection and Evaluation of the Frequency of Confirmed Antibiotic Hypersensitivity
Conclusion: In this study, the incidence of drug hyper ­sensitivity was much lower than previously reported. Some of the reactions that occur during infectious mononucleosis are transient, and some are true drug hypersensitivity reactions. Thus, these patients should be evaluated with allergy tests before these drugs are used again after EBV infection.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 4, 2018 Category: Allergy & Immunology Source Type: research

Prevalence of Hypersensitivity Reactions in Children Associated with Acetaminophen: A Systematic Review and Meta-Analysis
Conclusion: Future studies assessing the risk of immediate and nonimmediate hypersensitivity reactions to acetaminophen and elucidating the mechanism of acetaminophen hypersensitivity reactions are required.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 3, 2018 Category: Allergy & Immunology Source Type: research

The Staining of Mast Cells: A Historical Overview
The specificity of several staining methods for mast cells provides the pathologist with a useful means for the differential diagnosis of mast cell tumors. Mast cells stain metachromatically with toluidine blue with greater intensity in cells containing smaller granules. Most stains for mast cells rely on the cell ’s content of heparin, other glycosaminoglycans, and esterase. As an alternative to histochemical stains, different antibodies have been used to identify mast cells in humans.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - March 29, 2018 Category: Allergy & Immunology Source Type: research

Fc γRIIIA Negatively Impacts Humoral Immune Responses but Not Overall Lung Inflammation in an Ovalbumin-Induced Allergic Asthma Mouse Model
Conclusion: We did not find major evidence demonstrating an immune inhibitory role of mouse Fc γRIIIA in this OVA-induced mouse asthma model. As asthma is a complex disease and the immune regulatory responses involve sophisticated components and pathways, the exact roles of FcγRIIIA as well as its human functional homologue FcγRIIA in asthma still await further clarification using other mo use asthma models as well as clinical studies.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - March 29, 2018 Category: Allergy & Immunology Source Type: research

Misleading Allergens in the Diagnosis of Latex Allergy: Profilin and Cross-Reactive Carbohydrate Determinants
Conclusion: False positivity to latex-specific IgE in ImmunoCAP analysis may be observed in approximately 19% of patients with pollen allergy. Profilins and bromelain are the main contributors to clinically irrelevant positive latex-specific IgE.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - March 28, 2018 Category: Allergy & Immunology Source Type: research

The Frequency of Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Children with Asthma
Conclusions: In our study, NSAID-H was found more frequent in children with asthma than in the control group. Children with asthma should be evaluated for reactions to NSAIDs during hospital visits.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - March 28, 2018 Category: Allergy & Immunology Source Type: research

Verbascoside Alleviates Atopic Dermatitis-Like Symptoms in Mice via Its Potent Anti-Inflammatory Effect
Conclusion: Our results demonstrate that verbascoside could be a potential therapeutic agent for the treatment of AD.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - March 27, 2018 Category: Allergy & Immunology Source Type: research

Protein Biomarkers in Asthma
Asthma is a chronic disabling respiratory disease that can be triggered by a variety of factors, including allergens, respiratory infections, psychological factors, occupational agents, exercise, atmospheric pollutants, and drugs. The asthma syndrome has been treated for decades according to a “one-fits-all” treatment strategy based on bronchodilators and steroids. With the availability of new forms of treatment targeting the different pathomechanisms of the asthma syndrome, such as anti-immunoglobulin E and cytokine-targeting therapies, the interest in biomarkers that can dis crimina te different forms of asth...
Source: International Archives of Allergy and Immunology - March 26, 2018 Category: Allergy & Immunology Source Type: research

Gastritis Can Cause and Trigger Chronic Spontaneous Urticaria Independent of the Presence of < b > < i > Helicobacter pylori < /i > < /b >
Conclusions: Upper gastrointestinal inflammatory disorders can cause CSU and trigger exacerbations independently of HP. This might imply that also in HP-positive patients, urticaria is not based on an immunological reaction against the germ but rather on the underlying inflammation. These findings also strengthen the importance of a gastroenterological workup of patients with CSU.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - March 22, 2018 Category: Allergy & Immunology Source Type: research

Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis
Conclusion: Our preliminary study showed that intranasal resveratrol is capable of significantly improving nasal symptoms in adults with AR.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - March 14, 2018 Category: Allergy & Immunology Source Type: research

SOCS3 Is Upregulated and Targeted by miR30a-5p in Allergic Rhinitis
Conclusions: SOCS3 was targeted by miR30a- 5p in AR. Further study should be performed to identify the regulatory effect of miR30a-5p in AR, which may provide insights into a new therapeutic strategy.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - February 22, 2018 Category: Allergy & Immunology Source Type: research

The Bioavailability of Allergens in Allergy Tablets Depends on Several Factors
Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - February 8, 2018 Category: Allergy & Immunology Source Type: research

Identification of Immunoglobulin E-Binding Proteins of the Xerophilic Fungus < b > < i > Aspergillus penicillioides < /i > < /b > Crude Mycelial Mat Extract and Serological Reactivity Assessment in Subjects with Different Allergen Reactivity Profiles
Conclusions: These results provide evidence of the presence of potential allergenic components inA. penicillioides. Further analysis of the putatively identified proteins should reveal their allergenic potential.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - February 2, 2018 Category: Allergy & Immunology Source Type: research

Basophil Membrane Expression of Epithelial Cytokine Receptors in Patients with Severe Asthma
Conclusions: The high expression of the IL-25 and IL-33 receptors on the basophil membrane of patients with severe asthma indicates an overstimulation of basophils by these cytokines in severe asthma. This finding can possibly be used as a biomarker of asthma severity.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - February 2, 2018 Category: Allergy & Immunology Source Type: research

Hereditary and Acquired Angioedema: Heterogeneity of Pathogenesis and Clinical Phenotypes
Recurrent angioedema (AE) without wheals is increasingly recognized as a clinical entity and a frequent cause of admission to the emergency room. The Hereditary Angioedema Working Group (HAWK) classification allowed the scientific community to go beyond the semantic confusion that dominated this topic for decades. This classification distinguishes hereditary and acquired forms of AE, either related or unrelated to C1 inhibitor deficiency. Recently, additional mechanisms have been involved in the AE pathogenesis, including the uncontrolled activation of factor XII, generation of vasoactive mediators that induce dysregulatio...
Source: International Archives of Allergy and Immunology - January 26, 2018 Category: Allergy & Immunology Source Type: research

Establishing a Safe Administration of ASA in Cardiovascular Patients with Nonsteroidal Anti-Inflammatory Drug Hypersensitivity with Skin and/or Respiratory Involvement
Conclusions: Our protocol addresses challenge or desensitization with the contribution of a specialist allergist. It provides an effective, dynamic, safe, and short administration of 81 mg or higher of ASA in patients with a history of NSAID hypersensitivity with skin involvement.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 26, 2018 Category: Allergy & Immunology Source Type: research

Activation of Bombesin Receptor Subtype-3 Promotes Antigen-Presenting Action in Human Bronchial Epithelial Cells
Conclusion: These data suggest that HBEC can present antigen to T cells and BRS-3 activation promotes the process of antigen presentation and subsequent T cell proliferation and Th1 differentiation.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 26, 2018 Category: Allergy & Immunology Source Type: research

Therapeutic Role for TSP-2 Antibody in a Murine Asthma Model
Conclusions: This study identifies a novel therapeutic strategy for AHR, which uses antibodies reactive against TLR2. It also provides theoretical evidence for the control of allergic asthma by targeting TLR2.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 26, 2018 Category: Allergy & Immunology Source Type: research

Fecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study
Conclusions: In this pilot study, we identified a microbial signature in children with AD that discriminates between the absence and presence of food allergy. Future studies are needed to confirm our findings.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 24, 2018 Category: Allergy & Immunology Source Type: research

Focus on the Involvement of the Nose and Paranasal Sinuses in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Nasal Cytology Reveals Infiltration of Eosinophils as a Very Common Feature
Conclusions: Even when the rheumatological assessment scored EGPA “under control” according to the Birmingham Vasculitis Activity Score and Vasculitis Damage Index, sinonasal diseases and related nasal inflammatory processes were not controlled. Therefore, there is a need for clinical monitoring and targeted treatment to control the inflammatory processes and improve the QoL of EGPA patients.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 23, 2018 Category: Allergy & Immunology Source Type: research

Predictors of Persistent Milk Allergy in Children: A Retrospective Cohort Study
Conclusions: The history of anaphylaxis and high milk-specific IgE levels were associated with persistent CM allergy.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 23, 2018 Category: Allergy & Immunology Source Type: research

Clinical Characteristics and Allergen Sensitization Patterns of Patients with Local Allergic Rhinitis in Southern China
Conclusion: The prevalence of LAR patients in Southern China was 7.7%. Pollen was the most common sensitizing allergen for the local LAR patients, which differs from Caucasian studies, in which house dust mite was the dominant sensitizing allergen. Monosensitization was the predominant pattern in both AR and LAR.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 19, 2018 Category: Allergy & Immunology Source Type: research

Clinicoepidemiologic Features of Chronic Urticaria in Patients with versus without Subclinical < b > < i > Helicobacter pylori < /i > < /b > Infection: A Cross-Sectional Study of 150 Patients
Conclusion: A subset of chronic urticaria patients appears to have asymptomaticH. pylori infection. However, its implications in chronicity, recurrences, the severity of urticaria, other systemic manifestations, and management remains conjectural in view of 33% of controls also having positiveH. pylori ELISA and the endemicity of infection in developing countries.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 18, 2018 Category: Allergy & Immunology Source Type: research

Hello, Goodbye!
Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 18, 2018 Category: Allergy & Immunology Source Type: research

Boiling and Pressure Cooking Impact on IgE Reactivity of Soybean Allergens
Conclusions: Thermal-processing methods able to attenuate the capacity of soybean proteins to bind IgE may contribute to the improvement of food safety and could constitute a potential strategy for the induction of tolerance to soybean.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 17, 2018 Category: Allergy & Immunology Source Type: research

Glucocorticoids Modulate Th1 and Th2 Responses in Asthmatic Mouse Models by Inhibition of Notch1 Signaling
Conclusions: Through the inhibition of Notch1 signaling, both GSI and GCs could regulate Th1/Th2 balance involved in allergic airway inflammation in OVA-induced asthma.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 17, 2018 Category: Allergy & Immunology Source Type: research

Risk Factors and Clinical Features in Cashew Nut Oral Food Challenges
Background: Cashew nuts (CN) are capable of causing severe allergic reactions. However, little has been reported about the details of CN oral food challenges (OFC).Methods: CN-specific IgE (sIgE) levels were measured for 1 year in 66 patients who underwent an OFC with>3 g CN for diagnosis or confirmation of tolerance acquisition between June 2006 and August 2014. We retrospectively analyzed the OFC and patient background.Results: The median (IQR) age of the 66 patients (48 boys/men and 18 girls/women) was 7.0 years (5.7-8.8). Twelve patients (18.2%) had a positive OFC result; 6 of 8 (75%) patients with a history of an i...
Source: International Archives of Allergy and Immunology - January 17, 2018 Category: Allergy & Immunology Source Type: research

Mechanism of Periostin Production in Human Bronchial Smooth Muscle Cells
Conclusions: BSM cells produced periostin after IL-13 stimulation, via the JAK/STAT6, ERK1/2, and PI3K/Akt pathways. Understanding the mechanism of periostin production in BSM cells may help to clarify asthma pathogenesis.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 17, 2018 Category: Allergy & Immunology Source Type: research

Fc & #x03B3;R/ROS/CK2 α Is the Key Inducer of NF- & #x03BA;B Activation in a Murine Model of Asthma
Conclusions: These data suggest that Fc#x03B3; receptor/reactive oxygen species/CK2 α is a key inducer of NF-#x03BA;B activation in airway epithelial cells in a murine model of asthma.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 17, 2018 Category: Allergy & Immunology Source Type: research

Oral Immunotherapy in Japanese Children with Anaphylactic Peanut Allergy
Conclusions: These data suggest that for patients with peanut anaphylaxis, OIT can increase the threshold and support achieving sustained unresponsiveness with relative safety.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 16, 2018 Category: Allergy & Immunology Source Type: research

Low-Dose Oral Immunotherapy Using Low-Egg-Allergen Cookies for Severe Egg-Allergic Children Reduces Allergy Severity and Affects Allergen-Specific Antibodies in Serum
Conclusion: Our findings suggest that low-dose OIT using LAC is an effective and safe treatment for patients with severe egg allergy.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 12, 2018 Category: Allergy & Immunology Source Type: research

Is the Atopy Patch Test Reliable in the Evaluation of Food Allergy-Related Atopic Dermatitis?
Conclusions: Our data demonstrate that the APT is a reliable diagnostic tool to evaluate suspected food allergy-related skin symptoms in childhood and infancy.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 12, 2018 Category: Allergy & Immunology Source Type: research

The Draft Genome Assembly of < b > < i > Dermatophagoides pteronyssinus < /i > < /b > Supports Identification of Novel Allergen Isoforms in < b > < i > Dermatophagoides < /i > < /b > Species
(Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 10, 2018 Category: Allergy & Immunology Source Type: research

< b > < i > International Archives of Allergy and Immunology < /i > < /b > : A Commitment to Serving the Community Worldwide
Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 9, 2018 Category: Allergy & Immunology Source Type: research

Targeting Neutrophils in Severe Asthma via Siglec-9
Severe asthma comprises only 5% of patients with asthma, but the burden it brings to the social health system accounts for more than half of all asthmatics. Clinical evidence shows that severe asthma is often linked to the recruitment and activation of neutrophils in the airways. However, the underlying molecular and immunological mechanisms of neutrophilia in severe asthma are not clear and currently available drugs exert only limited effects on neutrophilic inflammation. Great efforts are underway to address the mystery of neutrophilic inflammation in chronic respiratory disorders. Sialic acid-binding immunoglobulin-like...
Source: International Archives of Allergy and Immunology - January 5, 2018 Category: Allergy & Immunology Source Type: research

Blueprint for the House Dust Mite
Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - January 4, 2018 Category: Allergy & Immunology Source Type: research

Cause and Clinical Presentation of Anaphylaxis in Singapore: From Infancy to Old Age
Background: The study objective was to compare age-related differences in the cause and clinical presentation of anaphylaxis.Methods: We conducted a prospective study of patients visiting the emergency department for anaphylaxis. Data were collected from 3 emergency departments from 1 April 2014 to 31 December 2015. Patient electronic records with the diagnoses of allergy, angioedema, urticaria, and anaphylaxis (ICD-9 codes 9953, 9951, 7080, 9950, 7089) were screened and cases fulfilling World Allergy Organisation criteria for anaphylaxis were included.Results: A total of 426 cases of anaphylaxis were identified with a med...
Source: International Archives of Allergy and Immunology - January 4, 2018 Category: Allergy & Immunology Source Type: research

Acknowledgement to the Reviewers
Int Arch Allergy Immunol 2017;174:205-208 (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 14, 2017 Category: Allergy & Immunology Source Type: research

Contents Vol. 174, 2017
Int Arch Allergy Immunol 2017;174:I-IV (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 14, 2017 Category: Allergy & Immunology Source Type: research