Comment on: “Neoadjuvant chemotherapy is noninferior to chemoradiotherapy for early-onset locally advanced rectal cancer in the FOWARC trial”
British Journal of Cancer, Published online: 22 April 2024; doi:10.1038/s41416-024-02690-yComment on: “Neoadjuvant chemotherapy is noninferior to chemoradiotherapy for early-onset locally advanced rectal cancer in the FOWARC trial” (Source: British Journal of Cancer)
Source: British Journal of Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Letian Qiao Yuan Liu Qiumin Yang Source Type: research
The urinary and sexual outcomes of robot-assisted versus laparoscopic rectal cancer surgery: a systematic review and meta-analysis
AbstractTo compare the urinary and sexual outcomes between robot-assisted rectal cancer (RC) surgery (RRCS) and laparoscopic RC surgery (LRCS) using a meta-analysis, searches were conducted of the Embase, PubMed, Cochrane Library, CNKI, and Wanfang databases. The International Prostate Symptom Score (IPSS) was the primary outcome. Eleven studies (790 patients with RRCS and 888 with LRCS) were included. The IPSS scores were significantly lower for RRCS than LRCS from baseline to 3 months (weighted mean difference [WMD] = − 1.21, 95% confidence interval [CI]: − 1.8,-0.62,I2 = 89.9%), to 6 months (WMD...
Source: Surgery Today - April 21, 2024 Category: Surgery Source Type: research
The Association Between Religiosity, Spirituality and Colorectal Cancer Screening: A Longitudinal Analysis of Alberta ’s Tomorrow Project in Canada
AbstractWe explored longitudinal associations between religion/spirituality (R/S) Salience and R/S Attendance, and colorectal cancer screening, among adults aged ≥ 50 years in Alberta, Canada. R/S Salience was not statistically significantly associated with colorectal cancer screening (adjusted odds ratio [aOR]: 1.06, 95% confidence interval [CI] 0.88–1.28). Conversely, R/S Attendance was statistically significantly associated with higher odds of colo rectal cancer screening: the aOR was 1.28 (95% CI 1.02–1.59) for participants attending services at least once a month and 1.31 (95% CI 1.01–1.69) for participants...
Source: Journal of Religion and Health - April 20, 2024 Category: Medical Ethics Source Type: research
Comparison of robotic versus laparoscopic surgery for visceral obesity in mid –low rectal cancer: a propensity-matched analysis
AbstractObesity is becoming more and more common, and measuring visceral fat area (VFA) is a useful diagnostic technique for visceral obesity (VO). The purpose of this research is to compare the surgical results of robotic versus laparoscopic rectal surgery, with a focus on assessing the benefits of the latter method for treating both VO and mid –low rectal cancer. Patients receiving laparoscopic or robotic anterior rectal excision at Northern Jiangsu People’s Hospital’s general surgery department were included in the retrospective analysis. 242 people in all took part in the study; 121 cases were assigned to the rob...
Source: Journal of Robotic Surgery - April 20, 2024 Category: Surgery Source Type: research
An Unauthorized Patient from Honduras Diagnosed with Rectal Cancer and the Role of Palliative Care in Preserving Life
1. Self-report their ability to identify common biases encountered by unauthorized patients in the healthcare setting.2. Self-report their ability to recognize the expanded role the Interdisciplinary Palliative Care Team plays in caring for unauthorized patients facing serious illnesses. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Suha Na Javeed, Tara McLaughlin-Whyte, Marta Gordon-Duffis, Grace N. La Torre Source Type: research
Watch & wait - Post neoadjuvant imaging for rectal cancer
Rectal cancer management has evolved over the past decade with the emergence of total neoadjuvant therapy (TNT). For select patients who achieve a clinical complete response following TNT, organ preservation by means of the watch-and-wait (WW) strategy is an increasingly adopted alternative that preserves rectal function and quality of life without compromising oncologic outcomes. Recently, published 5-year results from the OPRA trial demonstrated that organ preservation can be achieved in approximately half of patients managed with the WW strategy, with most local regrowth events occurring within two years. (Source: Clinical Imaging)
Source: Clinical Imaging - April 19, 2024 Category: Radiology Authors: Maria El Homsi, Aron Bercz, Stephanie Chahwan, Maria Clara Fernandes, Sidra Javed-Tayyab, Jennifer S. Golia Pernicka, Josip Nincevic, Viktoriya Paroder, Lisa Ruby, J. Joshua Smith, Iva Petkovska Tags: Body Imaging Source Type: research
The efficacy and safety of short-course radiotherapy followed by sequential chemotherapy and Cadonilimab for locally advanced rectal cancer: a protocol of a phase II study
For patients with locally advanced rectal cancer (LARC), total neoadjuvant therapy (TNT), namely, intensifying preoperative treatment through the integration of radiotherapy and systemic chemotherapy before su... (Source: BMC Cancer)
Source: BMC Cancer - April 19, 2024 Category: Cancer & Oncology Authors: Tongzhen Xu, Lingling Feng, Wenjue Zhang, Haoyue Li, Huiying Ma, Muyasha Abulimiti, Yutong Tan, Feiyan Deng, Wenting Huang, Shuangmei Zou, Wenyan Kang, Liming Jiang, Ying Wang, Chen Hu, Yinggang Chen, Haitao Zhou & hellip; Tags: Study Protocol Source Type: research
Analysis of Bacterial Culture of Fluid in the Surgical Area in Transanal Total Mesorectal Excision and Laparoscopic Total Mesorectal Excision
Conclusion: Positive bacterial culture of fluid during Lap-taTME indicates an increased risk of pelvic infection after operation. Lap-taTME is more prone to intraoperative contamination than Lap-TME but does not significantly increase the risk of postoperative pelvic infection.PMID:38634816 | DOI:10.1089/lap.2024.0104 (Source: Adv Data)
Source: Adv Data - April 18, 2024 Category: Epidemiology Authors: Yang Xie Jie Li Liping Ding Hongyu Zhang Source Type: research
Number of Healthy Teeth Can Predict the Response of Rectal Cancer to Chemoradiotherapy: A Retrospective Study
This study is the first to identify a correlation between the number of healthy teeth, which is an oral health indicator, and the efficacy of preoperative chemotherapy for rectal cancer.METHODS: This retrospective single-center study included 30 patients who underwent radical surgery after preoperative chemoradiotherapy (CRT) between December 2013 and June 2021. The relationship between number of teeth before CRT and the efficacy of CRT, CRT-related adverse events, postoperative complications, and long-term postoperative outcomes was examined.RESULTS: The number of healthy teeth was significantly greater in patients with d...
Source: The American Surgeon - April 18, 2024 Category: Surgery Authors: Toshihiro Nakao Mitsuo Shimada Kozo Yoshikawa Takuya Tokunaga Masaaki Nishi Hideya Kashihara Chie Takasu Yuma Wada Toshiaki Yoshimoto Source Type: research
Cancers, Vol. 16, Pages 1539: Surgical Outcomes after Radiotherapy in Rectal Cancer
de Velde
Over the past decade, the treatment of rectal cancer has changed considerably. The implementation of TME surgery has, in addition to decreasing the number of local recurrences, improved surgical morbidity and mortality. At the same time, the optimisation of radiotherapy in the preoperative setting has improved oncological outcomes even further, although higher perineal infection rates have been reported. Radiotherapy regimens have evolved through the adjustment of radiotherapy techniques and fields, increased waiting intervals, and, for more advanced tumours, adding chemotherapy. Concurrently, imaging techniq...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Sofieke J. D. Temmink Koen C. M. J. Peeters Per J. Nilsson Anna Martling Cornelis J. H. van de Velde Tags: Review Source Type: research
Dutch national guidelines for locally recurrent rectal cancer
After the introduction of total mesorectal excision (TME) and neoadjuvant treatment, the incidence of locally recurrent rectal cancer (LRRC) has decreased, but 6 –12 % of patients will still develop LRRC after primary rectal cancer.[1–5] At diagnosis, 40–60 % of patients present with distant metastases.[6–9] Detection of LRRC can be a challenge in itself, due to distorted anatomical planes and absence of the mesorectal fascia after primary rectal cancer surgery, the extra-luminal location of recurrences, and the presence of fibrosis or chronic inflammatory changes within the pelvis. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - April 18, 2024 Category: Cancer & Oncology Authors: Floor Piqeur, Davy M.J. Creemers, Evi Banken, Li ën Coolen, Pieter J. Tanis, Monique Maas, Mark Roef, Corrie A.M. Marijnen, Irene E.G. van Hellemond, Joost Nederend, Harm J.T. Rutten, Heike M.U. Peulen, Jacobus W.A. Burger Source Type: research
BRAF-mutant microsatellite-stable rectal cancer with acquired KRAS mutation leading to drug resistance in liver metastasis
AbstractBRAF-mutant microsatellite-stable colorectal cancer (CRC), metastasized to distant sites, is associated with a poor prognosis. However, the BEACON CRC regimen, comprising a BRAF inhibitor, MEK inhibitor, and anti-EGFR antibody, offered a prolonged prognosis. Nonetheless, resistance to this regimen may occur, as observed in our reported case of CRC, where aKRAS mutation was identified in addition to theBRAF V600E mutation. Here, we present a case of 74-year-old woman with rectal cancer (pT4bN1bM0 Stage IIIc) harboring theBRAF V600E mutation. After resection of the primary tumor and during adjuvant chemotherapy using...
Source: International Cancer Conference Journal - April 18, 2024 Category: Cancer & Oncology Source Type: research
Single-cell transcriptomic landscape reveals distinct tumourigenesis and immune microenvironments in secondary radiation-exposed rectal cancer
Clin Transl Med. 2024 Apr;14(4):e1659. doi: 10.1002/ctm2.1659.NO ABSTRACTPMID:38629628 | DOI:10.1002/ctm2.1659 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Xu Guan Xiaoman Bi Ran Wei Zhixun Zhao Zhao Lu Zheng Jiang Xishan Wang Deng Wu Source Type: research
Single-cell transcriptomic landscape reveals distinct tumourigenesis and immune microenvironments in secondary radiation-exposed rectal cancer
Clin Transl Med. 2024 Apr;14(4):e1659. doi: 10.1002/ctm2.1659.NO ABSTRACTPMID:38629628 | PMC:PMC11022289 | DOI:10.1002/ctm2.1659 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Xu Guan Xiaoman Bi Ran Wei Zhixun Zhao Zhao Lu Zheng Jiang Xishan Wang Deng Wu Source Type: research
Novel radiation and targeted therapy combinations for improving rectal cancer outcomes
Expert Rev Mol Med. 2024 Apr 16:1-26. doi: 10.1017/erm.2024.15. Online ahead of print.NO ABSTRACTPMID:38623751 | DOI:10.1017/erm.2024.15 (Source: Molecular Medicine)
Source: Molecular Medicine - April 16, 2024 Category: Molecular Biology Authors: Kathryn Pennel Louise Dutton Lydia Melissourgou-Syka Campbell Roxburgh Joanna Birch Joanne Edwards Source Type: research
