Exploring treatment outcomes in Stage II-III rectal cancer patients undergoing neoadjuvant therapy at a tertiary care center in Pakistan: a comprehensive analysis of pathological outcomes
Rectal cancer treatment has transformed in recent years, with neoadjuvant treatment (NT) and total neoadjuvant treatment (TNT) aiming to enhance pathological responses. This pioneering study in our country del... (Source: BMC Cancer)
Source: BMC Cancer - April 16, 2024 Category: Cancer & Oncology Authors: Misbah Younus Soomro, Saqib Raza Khan, Hafiz Muhammad, Sujjawal Ahmad, Nawazish Zehra, Insia Ali, Mirza Rameez Samar, Arif Hameed, Munira Moosajee and Yasmin Abdul Rashid Tags: Research Source Type: research
Precision Medicine in the Era of Genetic Testing: Microsatellite Instability Evolved
Clin Colon Rectal Surg. 2023 Jul 25;37(3):157-171. doi: 10.1055/s-0043-1770385. eCollection 2024 May.ABSTRACTThe recognized importance of microsatellite instability (MSI) in cancer has evolved considerably in the past 30 years. From its beginnings as a molecular predictor for Lynch syndrome, MSI first transitioned to a universal screening test in all colorectal and endometrial cancers, substantially increasing the identification of patients with Lynch syndrome among cancer patients. More recently, MSI has been shown to be a powerful biomarker of response to immune checkpoint blockade therapy across a diversity of tumor typ...
Source: Clinical Colorectal Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Dina Ioffe Michelle McSweeny Michael J Hall Source Type: research
Comparison of the safety and efficacy of robotic natural orifice specimen extraction surgery and conventional robotic colorectal cancer resection: a propensity score matching study
AbstractRobotic resection is widely used to treat colorectal cancer. Although the novel natural orifice specimen extraction surgery (NOSES) results in less trauma, its safety and effectiveness are relatively unknown. In the present study, we used propensity score matching to compare the effectiveness and safety of NOSES and robotic resection for treating colorectal cancer. Present retrospective cohort study included patients who underwent robotic colon and rectal cancer surgery between January 2016 and December 2019 at the Department of Gastrointestinal Surgery, the Second Xiangya Hospital of Central South University. The ...
Source: Journal of Robotic Surgery - April 15, 2024 Category: Surgery Source Type: research
Cancers, Vol. 16, Pages 1496: Influence of Certification Program on Treatment Quality and Survival for Rectal Cancer Patients in Germany: Results of 13 Certified Centers in Collaboration with AN Institute
Conclusions: The results of the present study indicate an improvement in terms of the treatment quality and outcomes in certified CrCCs, which is enforced by certification-specific aspects such as a more differentiated surgical approach, a lower rate of certain postoperative complications, and a multidisciplinary approach. Further prospective clinical trials are necessary to investigate the influence of certification in the treatment of CRC patients. (Source: Cancers)
Source: Cancers - April 13, 2024 Category: Cancer & Oncology Authors: Mihailo Andric Jessica Stockheim Mirhasan Rahimli Sara Al-Madhi Sara Acciuffi Maximilian D ölling Roland Siegfried Croner Aristotelis Perrakis Tags: Article Source Type: research
Management of Rectal Cancer in Lynch Syndrome: Balancing Risk Reduction and Quality of Life
Clin Colon Rectal Surg. 2023 Aug 10;37(3):180-184. doi: 10.1055/s-0043-1770730. eCollection 2024 May.ABSTRACTPatients with Lynch syndrome are predisposed to developing colorectal cancer and a variety of extracolonic malignancies, at a young age. The management of rectal cancer in the setting of Lynch syndrome is a complex clinical scenario that requires the expertise of a multidisciplinary management team. In this review, we delve into the approach for rectal cancer in these patients, and specifically focus on several key aspects of treatment. Some unique aspects of rectal cancer in Lynch syndrome include the decision betw...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Bradley A Krasnick Matthew F Kalady Source Type: research
Management of Rectal Cancer in Lynch Syndrome: Balancing Risk Reduction and Quality of Life
Clin Colon Rectal Surg. 2023 Aug 10;37(3):180-184. doi: 10.1055/s-0043-1770730. eCollection 2024 May.ABSTRACTPatients with Lynch syndrome are predisposed to developing colorectal cancer and a variety of extracolonic malignancies, at a young age. The management of rectal cancer in the setting of Lynch syndrome is a complex clinical scenario that requires the expertise of a multidisciplinary management team. In this review, we delve into the approach for rectal cancer in these patients, and specifically focus on several key aspects of treatment. Some unique aspects of rectal cancer in Lynch syndrome include the decision betw...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Bradley A Krasnick Matthew F Kalady Source Type: research
Preoperative risk factors and cumulative incidence of temporary ileostomy non-closure after sphincter-preserving surgery for rectal cancer: a meta-analysis
Temporary ileostomy (TI) has proven effective in reducing the severity of anastomotic leakage after rectal cancer surgery; however, some ileostomies fail to reverse over time, leading to conversion into a perm... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Fan He, Chenglin Tang, Fuyu Yang, Defei Chen, Junjie Xiong, Yu Zou, Dongqin Zhao and Kun Qian Tags: Research Source Type: research
LncRNAs: Emerging biomarkers and therapeutic targets in rectal cancer
Pathol Res Pract. 2024 Apr 4;257:155294. doi: 10.1016/j.prp.2024.155294. Online ahead of print.ABSTRACTAccording to findings, long non-coding RNAs (lncRNAs) have an important function in the onset and growth of various cancers, including rectal cancer (RC). RC offers unique issues in terms of diagnosis, treatment, and results, needing a full understanding of the cellular mechanisms that cause it to develop. This thorough study digs into the various functions that lncRNAs perform in RC, giving views into their multiple roles as well as possible therapeutic consequences. The function of lncRNAs in RC cell proliferation, apop...
Source: Cell Research - April 11, 2024 Category: Cytology Authors: None Abida Mohd Imran Lina Eltaib Akbar Ali Razan Abdulaziz Salem Alanazi Neelam Singla Syed Mohammed Basheeruddin Asdaq Marwan Al-Hajeili Fatemah Abdulaziz Alhakami Saleh Al-Abdulhadi Altaf A Abdulkhaliq Ali A Rabaan Source Type: research
Do beta-blockers reduce negative intrusive thoughts and anxiety in cancer survivors? - An emulated trial
CONCLUSIONS: The emulated trials demonstrated no evidence of a protective effect of beta-blocker therapy against intrusive thoughts. The Active group had reduced quality of life and elevated anxiety compared to the Control group.TRIAL REGISTRATION: The three cohort studies were registered at isrctn.com/clinicaltrials.gov (ISRCTN06393679, NCT02530593 and NCT01477229).PMID:38605350 | DOI:10.1186/s12885-024-12236-3 (Source: Cancer Control)
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Carolina Ehrencrona Ying Li Eva Angenete Eva Haglind Stefan Franz én Anna Grimby-Ekman David Bock Source Type: research
Proton beam reirradiation for locally recurrent rectal cancer patients with prior pelvic irradiation
J Radiat Res. 2024 Apr 10:rrae019. doi: 10.1093/jrr/rrae019. Online ahead of print.ABSTRACTThe aim of the present study was to report the feasibility of proton beam reirradiation for patients with locally recurrent rectal cancer (LRRC) with prior pelvic irradiation. The study population included patients who were treated with proton beam therapy (PBT) for LRRC between 2008 and December 2019 in our institution. Those who had a history of distant metastases of LRRC, with or without treatment, before reirradiation, were excluded. Overall survival (OS), progression-free survival (PFS) and local control (LC) were estimated usin...
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Yoshiaki Takagawa Motohisa Suzuki Ichiro Seto Yusuke Azami Masanori Machida Kanako Takayama Nor Shazrina Sulaiman Tatsuhiko Nakasato Yasuhiro Kikuchi Masao Murakami Michitaka Honda Yasushi Teranishi Koji Kono Source Type: research
LncRNAs: Emerging biomarkers and therapeutic targets in rectal cancer
Pathol Res Pract. 2024 Apr 4;257:155294. doi: 10.1016/j.prp.2024.155294. Online ahead of print.ABSTRACTAccording to findings, long non-coding RNAs (lncRNAs) have an important function in the onset and growth of various cancers, including rectal cancer (RC). RC offers unique issues in terms of diagnosis, treatment, and results, needing a full understanding of the cellular mechanisms that cause it to develop. This thorough study digs into the various functions that lncRNAs perform in RC, giving views into their multiple roles as well as possible therapeutic consequences. The function of lncRNAs in RC cell proliferation, apop...
Source: Pathology, Research and Practice - April 11, 2024 Category: Pathology Authors: None Abida Mohd Imran Lina Eltaib Akbar Ali Razan Abdulaziz Salem Alanazi Neelam Singla Syed Mohammed Basheeruddin Asdaq Marwan Al-Hajeili Fatemah Abdulaziz Alhakami Saleh Al-Abdulhadi Altaf A Abdulkhaliq Ali A Rabaan Source Type: research
LncRNAs: Emerging biomarkers and therapeutic targets in rectal cancer
Pathol Res Pract. 2024 Apr 4;257:155294. doi: 10.1016/j.prp.2024.155294. Online ahead of print.ABSTRACTAccording to findings, long non-coding RNAs (lncRNAs) have an important function in the onset and growth of various cancers, including rectal cancer (RC). RC offers unique issues in terms of diagnosis, treatment, and results, needing a full understanding of the cellular mechanisms that cause it to develop. This thorough study digs into the various functions that lncRNAs perform in RC, giving views into their multiple roles as well as possible therapeutic consequences. The function of lncRNAs in RC cell proliferation, apop...
Source: Pathology, Research and Practice - April 11, 2024 Category: Pathology Authors: None Abida Mohd Imran Lina Eltaib Akbar Ali Razan Abdulaziz Salem Alanazi Neelam Singla Syed Mohammed Basheeruddin Asdaq Marwan Al-Hajeili Fatemah Abdulaziz Alhakami Saleh Al-Abdulhadi Altaf A Abdulkhaliq Ali A Rabaan Source Type: research
Modified neoadjuvant rectal score as a novel prognostic model for rectal cancer patients who underwent chemoradiotherapy
CONCLUSION: We established a novel prognostic model, for rectal cancer patients that have undergone neoadjuvant chemoradiotherapy, using a combination of apoptosis-detecting immunohistochemistry and neoadjuvant rectal scores.PMID:38592641 | DOI:10.1007/s10147-024-02520-4 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Kazushige Kawai Kosuke Ozaki Daisuke Nakano Akira Dejima Ichiro Ise Sakiko Nakamori Hiroki Kato Soichiro Natsume Misato Takao Tatsuro Yamaguchi Soichiro Ishihara Source Type: research
Treatment of rectal anastomotic atresia with transurethral prostate resection instrumentation: A report of three cases
Exp Ther Med. 2024 Mar 15;27(5):202. doi: 10.3892/etm.2024.12491. eCollection 2024 May.ABSTRACTDixon surgery for rectal cancer can lead to severe intestinal narrowing and blockage that is difficult to treat with open surgery or colonoscopy. The aim of the present study was to develop a minimally invasive approach for treating rectal anastomotic atresia based on three cases that were managed with transurethral prostate resection instrumentation. Preoperative imaging determined the distance from the anastomotic closure to the anal margin, the length of the anastomotic closure and the degree of proximal intestinal dilation fo...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Zhentao Hu Yujie Qin Xiaoyi Wei Jun Qian Song Tu Jiaxi Yao Source Type: research
Stroma AReactive Invasion Front Areas (SARIFA): a novel histopathologic biomarker in colorectal cancer patients and its association with the luminal tumour proportion
CONCLUSION: Here, we validated the relationship between SARIFA-status and prognosis in CRC patients and provided first evidence for a potential prognostic relevance in the subgroup of rectal cancer patients. Interestingly, CRCs with different SARIFA-status also showed histological differences measurable at the luminal tumour surface. Further studies to better understand the relationship between high luminal intratumoural stroma content and absence of a stroma reaction at the invasive front (SARIFA-positivity) are warranted and may inform future treatment decisions in CRC patients.PMID:38593584 | DOI:10.1016/j.tranon.2024.1...
Source: Translational Oncology - April 9, 2024 Category: Cancer & Oncology Authors: N G Reitsam B Grosser J S Enke W Mueller A Westwood N P West P Quirke B M ärkl H I Grabsch Source Type: research
