Modified neoadjuvant rectal score as a novel prognostic model for rectal cancer patients who underwent chemoradiotherapy
CONCLUSION: We established a novel prognostic model, for rectal cancer patients that have undergone neoadjuvant chemoradiotherapy, using a combination of apoptosis-detecting immunohistochemistry and neoadjuvant rectal scores.PMID:38592641 | DOI:10.1007/s10147-024-02520-4 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Kazushige Kawai Kosuke Ozaki Daisuke Nakano Akira Dejima Ichiro Ise Sakiko Nakamori Hiroki Kato Soichiro Natsume Misato Takao Tatsuro Yamaguchi Soichiro Ishihara Source Type: research
Modified neoadjuvant rectal score as a novel prognostic model for rectal cancer patients who underwent chemoradiotherapy
ConclusionWe established a novel prognostic model, for rectal cancer patients that have undergone neoadjuvant chemoradiotherapy, using a combination of apoptosis-detecting immunohistochemistry and neoadjuvant rectal scores. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 9, 2024 Category: Cancer & Oncology Source Type: research
Minor impact of anastomotic leakage in anterior resection for rectal cancer on long-term male urinary and sexual function
ConclusionAnastomotic leakage after anterior resection had a minor negative impact on urinary and sexual function in men. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 9, 2024 Category: Gastroenterology Source Type: research
A retrospective cohort study of neoadjuvant chemoradiotherapy combined with immune checkpoint inhibitors in locally advanced rectal cancer
CONCLUSION: Neoadjuvant chemoradiotherapy combined with ICIs demonstrated favorable efficacy and safety in treating LARC patients.PMID:38583351 | DOI:10.1016/j.tranon.2024.101955 (Source: Translational Oncology)
Source: Translational Oncology - April 7, 2024 Category: Cancer & Oncology Authors: Zhuo Chen Zhuoling Zou Min Qian Qin Xu Guojuan Xue Juan Yang Tinglan Luo Lianjie Hu Bin Wang Source Type: research
A retrospective cohort study of neoadjuvant chemoradiotherapy combined with immune checkpoint inhibitors in locally advanced rectal cancer
CONCLUSION: Neoadjuvant chemoradiotherapy combined with ICIs demonstrated favorable efficacy and safety in treating LARC patients.PMID:38583351 | DOI:10.1016/j.tranon.2024.101955 (Source: Translational Oncology)
Source: Translational Oncology - April 7, 2024 Category: Cancer & Oncology Authors: Zhuo Chen Zhuoling Zou Min Qian Qin Xu Guojuan Xue Juan Yang Tinglan Luo Lianjie Hu Bin Wang Source Type: research
A retrospective cohort study of neoadjuvant chemoradiotherapy combined with immune checkpoint inhibitors in locally advanced rectal cancer
CONCLUSION: Neoadjuvant chemoradiotherapy combined with ICIs demonstrated favorable efficacy and safety in treating LARC patients.PMID:38583351 | DOI:10.1016/j.tranon.2024.101955 (Source: Translational Oncology)
Source: Translational Oncology - April 7, 2024 Category: Cancer & Oncology Authors: Zhuo Chen Zhuoling Zou Min Qian Qin Xu Guojuan Xue Juan Yang Tinglan Luo Lianjie Hu Bin Wang Source Type: research
MRI-based radiomic models for the preoperative prediction of extramural venous invasion in rectal cancer: A systematic review and meta-analysis
To estimate the diagnostic value of magnetic resonance imaging (MRI)-based radiomic models in detecting the extramural venous invasion (EMVI) of rectal cancer. (Source: Clinical Imaging)
Source: Clinical Imaging - April 7, 2024 Category: Radiology Authors: Yingying Liang, Yaxuan Wei, Fan Xu, Xinhua Wei Tags: Body Imaging Source Type: research
ASO Visual Abstract: Is Robotic Surgery Beneficial for Rectal Cancer Patients with Unfavorable Characteristic After Neoadjuvant Chemoradiotherapy?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 6, 2024 Category: Cancer & Oncology Source Type: research
PDCD4-induced oxidative stress through FGR/NF- κB axis in rectal cancer radiotherapy-induced AKI
This study aimed to investigate the molecular mechanism of the effect of PDCD4 on radiotherapy-induced acute kidney injury (AKI) in rectal cancer through the regulation of FGR/NF-κB signaling. Differentially expressed genes were identified using Gene Expression Omnibus (GEO) datasets (GSE90627 for rectal cancer and GSE145085 for AKI) and R software. The human renal tubular epithelial cell line, HK-2, was used to establish an in vitro model of radiotherapy-induced AKI. RT-qPCR and western blotting were used to detect gene and protein expression levels, respectively. Cell proliferation and apoptosis were assessed using the ...
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Qiang Ma Lu Zheng Hao Cheng Xiaoyang Li Zhining Liu Peng Gong Source Type: research
Extraperitoneal lateral pelvic sidewall excision: a novel rectal-sparing approach for lateral locally recurrent rectal cancer
Updates Surg. 2024 Apr 6. doi: 10.1007/s13304-024-01834-2. Online ahead of print.ABSTRACTLocally recurrent rectal cancer (LRRC) involving the lateral pelvic sidewall requires a complex approach to maximize the likelihood of R0 resection, which is the only predictor of survival. The purpose of this report is to describe a novel technique to resect a localized lateral pelvic sidewall LRRC. A 63-year-old male patient was referred for a 15-mm LRRC near the right internal iliac vessels. Endoscopic ultrasound and magnetic resonance imaging excluded any involvement of the pelvic colon or residual rectum. A combined extraperitonea...
Source: Cancer Control - April 6, 2024 Category: Cancer & Oncology Authors: Luca Sorrentino Gaia Colletti Filiberto Belli Alessandro Gronchi Source Type: research
Oncological outcomes after a pathological complete response following total neoadjuvant therapy or chemoradiotherapy for high-risk locally advanced rectal cancer in the RAPIDO trial
A pathological complete response (pCR) following chemoradiation (CRT) or short-course radiotherapy (scRT) leads to a favourable prognosis in patients with rectal cancer. Total neo-adjuvant therapy (TNT) doubles the pCR rate, but it is unknown whether oncological outcomes remain favourable and whether the same characteristics are associated with pCR as after CRT. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Wouter H. Zwart, Sofieke J.D. Temmink, Geke A.P. Hospers, Corrie A.M. Marijnen, Hein Putter, Iris D. Nagtegaal, Lennart Blomqvist, Elma Meershoek-Klein Kranenbarg, Annet G.H. Roodvoets, Anna Martling, Cornelis J.H. van de Velde, Bengt Glimelius, Koen C.M. Tags: Original Research Source Type: research
Extraperitoneal lateral pelvic sidewall excision: a novel rectal-sparing approach for lateral locally recurrent rectal cancer
AbstractLocally recurrent rectal cancer (LRRC) involving the lateral pelvic sidewall requires a complex approach to maximize the likelihood of R0 resection, which is the only predictor of survival. The purpose of this report is to describe a novel technique to resect a localized lateral pelvic sidewall LRRC. A 63-year-old male patient was referred for a 15-mm LRRC near the right internal iliac vessels. Endoscopic ultrasound and magnetic resonance imaging excluded any involvement of the pelvic colon or residual rectum. A combined extraperitoneal antero-lateral approach and gluteal access were used to optimize vascular contr...
Source: Updates in Surgery - April 6, 2024 Category: Surgery Source Type: research
Can robotic surgery lead the way in the treatment of rectal cancer?
Ann Coloproctol. 2024 Apr 5. doi: 10.3393/ac.2024.00234.0033. Online ahead of print.NO ABSTRACTPMID:38576078 | DOI:10.3393/ac.2024.00234.0033 (Source: Annals of Coloproctology)
Source: Annals of Coloproctology - April 5, 2024 Category: Gastroenterology Authors: Jeonghee Han Source Type: research
