The multidisciplinary management of locally advanced rectal cancer
Expert Rev Anticancer Ther. 2024 Apr 26. doi: 10.1080/14737140.2024.2349137. Online ahead of print.ABSTRACTINTRODUCTION: . The classic paradigm for the management of locally advanced rectal cancer (LARC) consists of (chemo)radiotherapy (C)RT), total mesorectal excision and adjuvant chemotherapy (CHT). At present, due to the high rate of distant metastasis (up to 30%), the total neoadjuvant therapy (TNT) with the administration of systemic CHT in the neoadjuvant setting has gained acceptance as standard of care.Our aim is to critically review current literature on LARC management and summarize the different approaches recen...
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Francesca De Felice Michelangelo Miccini Andrea Botticelli Michela Roberto Niccol ò Petrucciani Source Type: research
Total Neoadjuvant Therapy for Rectal Cancer
Surg Clin North Am. 2024 Jun;104(3):609-617. doi: 10.1016/j.suc.2023.11.010. Epub 2024 Feb 12.ABSTRACTThe treatment of locally advanced rectal cancer has traditionally included sequenced multimodal therapy including radiation, chemotherapy, and surgery. The relative contribution of each and the order of treatments have evolved over the years. By the early twenty-first century, there was widespread use of the German Rectal Cancer Trial approach: preoperative chemoradiation, followed by standardized surgery including total mesorectal excision, and finally adjuvant chemotherapy. Recent advances have defined the superiority of...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Arthur G Affleck Daniel Herzig Source Type: research
Retrospective Evaluation of the Efficacy of Total Neoadjuvant Therapy and Chemoradiotherapy Neoadjuvant Treatment in Relation to Surgery in Patients with Rectal Cancer
Conclusions: By using TNT, a higher rate of stage reduction is obtained compared to the neoadjuvant CRT treatment. The post-neoadjuvant-treatment imagistic evaluation fails to accurately evaluate the response. A better response to TNT was observed in young patients.PMID:38674302 | PMC:PMC11052151 | DOI:10.3390/medicina60040656 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Lucian Drago ș Bratu Michael Schenker Puiu Olivian Stovicek Ramona Adriana Schenker Alina Maria Mehedin țeanu Tradian Ciprian Berisha Andreas Donoiu Stelian Ștefăniță Mogoantă Source Type: research
Acute Infectious Purpura Fulminans Complicated by Bacterial Translocation after Rectal Cancer Surgery: A Case Report
Medicina (Kaunas). 2024 Apr 17;60(4):644. doi: 10.3390/medicina60040644.ABSTRACTThe patient was a man in his 80s who had undergone laparoscopic anterior resection for rectal cancer. Bowel obstruction occurred on the third postoperative day but improved with a decompression tube by the fifth postoperative day. A high fever (in the 38 °C range) was also observed. Blood culture tests detected two sets of the gram-negative bacilli Klebsiella aerogenes within 24 h of collection. On the seventh postoperative day, the patient subsequently went into septic shock with disseminated intravascular coagulation (DIC). On the eighth pos...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ryo Nakanishi Heita Ozawa Naoyuki Toyota Minori Mise Ritsuto Akutsu Shin Fujita Source Type: research
The multidisciplinary management of locally advanced rectal cancer
Expert Rev Anticancer Ther. 2024 Apr 26. doi: 10.1080/14737140.2024.2349137. Online ahead of print.ABSTRACTINTRODUCTION: . The classic paradigm for the management of locally advanced rectal cancer (LARC) consists of (chemo)radiotherapy (C)RT), total mesorectal excision and adjuvant chemotherapy (CHT). At present, due to the high rate of distant metastasis (up to 30%), the total neoadjuvant therapy (TNT) with the administration of systemic CHT in the neoadjuvant setting has gained acceptance as standard of care.Our aim is to critically review current literature on LARC management and summarize the different approaches recen...
Source: Expert Review of Anticancer Therapy - April 27, 2024 Category: Cancer & Oncology Authors: Francesca De Felice Michelangelo Miccini Andrea Botticelli Michela Roberto Niccol ò Petrucciani Source Type: research
Evaluation of Stages, Treatment Protocols, and Outcomes of Colorectal Cancer among West Bank Patients
Conclusions: A high percentage of patients were diagnosed in advanced CRC stages. The treatment modes were adopted from general international guidelines; however, the cure rates were low, and mortality was high. More studies need to be undertaken to investigate the actual application of chemotherapy protocols, and survival would benefit from the involvement of clinical pharmacists in the chemotherapy protocol selection, dosing, frequency, and follow-up. The present study advocates for greater public awareness of CRC and attests to the merits of screening by primary care professionals, which can help to avoid this serious i...
Source: Clinical Colorectal Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Ibrahim O Sawaid Abraham O Samson Rowa Al-Ramahi Source Type: research
Total Neoadjuvant Therapy for Rectal Cancer
Surg Clin North Am. 2024 Jun;104(3):609-617. doi: 10.1016/j.suc.2023.11.010. Epub 2024 Feb 12.ABSTRACTThe treatment of locally advanced rectal cancer has traditionally included sequenced multimodal therapy including radiation, chemotherapy, and surgery. The relative contribution of each and the order of treatments have evolved over the years. By the early twenty-first century, there was widespread use of the German Rectal Cancer Trial approach: preoperative chemoradiation, followed by standardized surgery including total mesorectal excision, and finally adjuvant chemotherapy. Recent advances have defined the superiority of...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Arthur G Affleck Daniel Herzig Source Type: research
Retrospective Evaluation of the Efficacy of Total Neoadjuvant Therapy and Chemoradiotherapy Neoadjuvant Treatment in Relation to Surgery in Patients with Rectal Cancer
Conclusions: By using TNT, a higher rate of stage reduction is obtained compared to the neoadjuvant CRT treatment. The post-neoadjuvant-treatment imagistic evaluation fails to accurately evaluate the response. A better response to TNT was observed in young patients.PMID:38674302 | PMC:PMC11052151 | DOI:10.3390/medicina60040656 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Lucian Drago ș Bratu Michael Schenker Puiu Olivian Stovicek Ramona Adriana Schenker Alina Maria Mehedin țeanu Tradian Ciprian Berisha Andreas Donoiu Stelian Ștefăniță Mogoantă Source Type: research
Acute Infectious Purpura Fulminans Complicated by Bacterial Translocation after Rectal Cancer Surgery: A Case Report
Medicina (Kaunas). 2024 Apr 17;60(4):644. doi: 10.3390/medicina60040644.ABSTRACTThe patient was a man in his 80s who had undergone laparoscopic anterior resection for rectal cancer. Bowel obstruction occurred on the third postoperative day but improved with a decompression tube by the fifth postoperative day. A high fever (in the 38 °C range) was also observed. Blood culture tests detected two sets of the gram-negative bacilli Klebsiella aerogenes within 24 h of collection. On the seventh postoperative day, the patient subsequently went into septic shock with disseminated intravascular coagulation (DIC). On the eighth pos...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ryo Nakanishi Heita Ozawa Naoyuki Toyota Minori Mise Ritsuto Akutsu Shin Fujita Source Type: research
The multidisciplinary management of locally advanced rectal cancer
Expert Rev Anticancer Ther. 2024 Apr 26. doi: 10.1080/14737140.2024.2349137. Online ahead of print.ABSTRACTINTRODUCTION: . The classic paradigm for the management of locally advanced rectal cancer (LARC) consists of (chemo)radiotherapy (C)RT), total mesorectal excision and adjuvant chemotherapy (CHT). At present, due to the high rate of distant metastasis (up to 30%), the total neoadjuvant therapy (TNT) with the administration of systemic CHT in the neoadjuvant setting has gained acceptance as standard of care.Our aim is to critically review current literature on LARC management and summarize the different approaches recen...
Source: Expert Review of Anticancer Therapy - April 27, 2024 Category: Cancer & Oncology Authors: Francesca De Felice Michelangelo Miccini Andrea Botticelli Michela Roberto Niccol ò Petrucciani Source Type: research
Total Neoadjuvant Therapy for Rectal Cancer
Surg Clin North Am. 2024 Jun;104(3):609-617. doi: 10.1016/j.suc.2023.11.010. Epub 2024 Feb 12.ABSTRACTThe treatment of locally advanced rectal cancer has traditionally included sequenced multimodal therapy including radiation, chemotherapy, and surgery. The relative contribution of each and the order of treatments have evolved over the years. By the early twenty-first century, there was widespread use of the German Rectal Cancer Trial approach: preoperative chemoradiation, followed by standardized surgery including total mesorectal excision, and finally adjuvant chemotherapy. Recent advances have defined the superiority of...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Arthur G Affleck Daniel Herzig Source Type: research
Retrospective Evaluation of the Efficacy of Total Neoadjuvant Therapy and Chemoradiotherapy Neoadjuvant Treatment in Relation to Surgery in Patients with Rectal Cancer
Conclusions: By using TNT, a higher rate of stage reduction is obtained compared to the neoadjuvant CRT treatment. The post-neoadjuvant-treatment imagistic evaluation fails to accurately evaluate the response. A better response to TNT was observed in young patients.PMID:38674302 | PMC:PMC11052151 | DOI:10.3390/medicina60040656 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Lucian Drago ș Bratu Michael Schenker Puiu Olivian Stovicek Ramona Adriana Schenker Alina Maria Mehedin țeanu Tradian Ciprian Berisha Andreas Donoiu Stelian Ștefăniță Mogoantă Source Type: research
Acute Infectious Purpura Fulminans Complicated by Bacterial Translocation after Rectal Cancer Surgery: A Case Report
Medicina (Kaunas). 2024 Apr 17;60(4):644. doi: 10.3390/medicina60040644.ABSTRACTThe patient was a man in his 80s who had undergone laparoscopic anterior resection for rectal cancer. Bowel obstruction occurred on the third postoperative day but improved with a decompression tube by the fifth postoperative day. A high fever (in the 38 °C range) was also observed. Blood culture tests detected two sets of the gram-negative bacilli Klebsiella aerogenes within 24 h of collection. On the seventh postoperative day, the patient subsequently went into septic shock with disseminated intravascular coagulation (DIC). On the eighth pos...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ryo Nakanishi Heita Ozawa Naoyuki Toyota Minori Mise Ritsuto Akutsu Shin Fujita Source Type: research
Total Neoadjuvant Therapy for Rectal Cancer
Surg Clin North Am. 2024 Jun;104(3):609-617. doi: 10.1016/j.suc.2023.11.010. Epub 2024 Feb 12.ABSTRACTThe treatment of locally advanced rectal cancer has traditionally included sequenced multimodal therapy including radiation, chemotherapy, and surgery. The relative contribution of each and the order of treatments have evolved over the years. By the early twenty-first century, there was widespread use of the German Rectal Cancer Trial approach: preoperative chemoradiation, followed by standardized surgery including total mesorectal excision, and finally adjuvant chemotherapy. Recent advances have defined the superiority of...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Arthur G Affleck Daniel Herzig Source Type: research
Retrospective Evaluation of the Efficacy of Total Neoadjuvant Therapy and Chemoradiotherapy Neoadjuvant Treatment in Relation to Surgery in Patients with Rectal Cancer
Conclusions: By using TNT, a higher rate of stage reduction is obtained compared to the neoadjuvant CRT treatment. The post-neoadjuvant-treatment imagistic evaluation fails to accurately evaluate the response. A better response to TNT was observed in young patients.PMID:38674302 | PMC:PMC11052151 | DOI:10.3390/medicina60040656 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Lucian Drago ș Bratu Michael Schenker Puiu Olivian Stovicek Ramona Adriana Schenker Alina Maria Mehedin țeanu Tradian Ciprian Berisha Andreas Donoiu Stelian Ștefăniță Mogoantă Source Type: research
