Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review
AbstractCopper is a necessary micronutrient for maintaining the well-being of the human body. The biological activity of organic ligands, especially their anticancer activity, is often enhanced when they coordinate with copper(I) and (II) ions. Copper and its compounds are capable of inducing tumor cell death through various mechanisms of action, including activation of apoptosis signaling pathways by reactive oxygen species (ROS), inhibition of angiogenesis, induction of cuproptosis, and paraptosis. Some of the copper complexes are currently being evaluated in clinical trials for their ability to map tumor hypoxia in vari...
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
Evaluation of anorectal function using real-time tissue elastography before and after preoperative chemoradiotherapy
ConclusionInternal anal sphincter sclerosis due to chemoradiotherapy may correlate to anorectal dysfunction. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 25, 2024 Category: Gastroenterology Source Type: research
External validation of the colorectal cancer risk score LiFeCRC using food frequency questions in the HUNT study
ConclusionReadily available clinical variables and food frequency questions in a modified LiFeCRC score can identify patients at risk of CRC and may improve primary prevention by motivating to lifestyle change or participation in the CRC screening programme. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 25, 2024 Category: Gastroenterology Source Type: research
Great Debates: Surgery or Watch and Wait After Total Neoadjuvant Therapy for Rectal Cancer
Am Surg. 2024 Apr 24:31348241248812. doi: 10.1177/00031348241248812. Online ahead of print.ABSTRACTLocally advanced rectal cancer has traditionally been treated with multimodal therapy including neoadjuvant chemoradiotherapy followed by surgical resection. More recent data suggests that in appropriate patients, total neoadjuvant treatment (TNT) makes it possible to adopt a "watch and wait" approach. Advocates for watch and wait argue that patients with a complete or near-complete clinical response to TNT have comparable overall and disease-free survival to their counterparts who undergo surgical resection, and also have a ...
Source: The American Surgeon - April 24, 2024 Category: Surgery Authors: Ayaa Ali Wang Fai Lee Michael P O'Leary Matthew Whealon Source Type: research
Minimally invasive versus open multivisceral resection for rectal cancer clinically invading adjacent organs: a propensity score-matched analysis
ConclusionMIS had several short-term advantages over open surgery, such as lower complication rates, faster recovery, and a shorter hospital stay, in rectal cancer patients who underwent multivisceral resection.Graphical abstract (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 24, 2024 Category: Surgery Source Type: research
Imaging segmentation mechanism for rectal tumors using improved U-Net
In radiation therapy, cancerous region segmentation in magnetic resonance images (MRI) is a critical step. For rectal cancer, the automatic segmentation of rectal tumors from an MRI is a great challenge. There... (Source: BMC Medical Imaging)
Source: BMC Medical Imaging - April 23, 2024 Category: Radiology Authors: Kenan Zhang, Xiaotang Yang, Yanfen Cui, Jumin Zhao and Dengao Li Tags: Research Source Type: research
Robotic-Assisted Surgery for Rectal Cancer: An Expedited Summary of the Clinical Evidence
CONCLUSIONS: Robotic-assisted rectal cancer surgery may result in similar or improved clinical outcomes compared with laparoscopic and open rectal cancer surgery.PMID:38645608 | PMC:PMC11031254 (Source: Ontario Health Technology Assessment Series)
Source: Ontario Health Technology Assessment Series - April 22, 2024 Category: General Medicine Authors: Ontario Health Source Type: research
