Bioinformatics-based analysis of potential therapeutic target genes for polycystic ovary syndrome
This study represents the first application of a bioinformatics approach to identify and confirm high expression levels of RPL13, LEP, and ANXA1 in patients with Polycystic Ovary Syndrome (PCOS). These key genes-RPL13, LEP, and ANXA1-may present viable targets for therapeutic interventions in PCOS, underscoring their potential clinical importance.PMID:38678611 | DOI:10.14715/cmb/2024.70.4.27 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Ying Liu Jinwei Yu Jing Li Weihong Li Hongxia Ma Source Type: research
A review on the nexus of autophagy genes from the perspective of polycystic ovary syndrome
Biol Cell. 2024 Apr 28:e202300069. doi: 10.1111/boc.202300069. Online ahead of print.ABSTRACTPolycystic ovary syndrome or PCOS is an endocrine disorder in women of reproductive age. It is a diversified multi factorial disorder and diagnosis is very complicated because of its overlapping symptoms some of which are irregular menstrual cycle, acne in face, excess level of androgen (AE), insulin resistance, obesity, cardiovascular disease, mood disorder and type 2 diabetes (T2DM). PCOS may be caused by hormonal imbalance, genetic and epigenetic vulnerability, hypothalamic and ovarian troubles. PCOS is essentially hyperandrogen...
Source: Biology of the Cell - April 28, 2024 Category: Cytology Authors: Arifa Khatun Taslima Nasrin Md Samim Hassan Mehboob Hoque Muddasarul Hoda Safdar Ali Source Type: research
Bioinformatics-based analysis of potential therapeutic target genes for polycystic ovary syndrome
This study represents the first application of a bioinformatics approach to identify and confirm high expression levels of RPL13, LEP, and ANXA1 in patients with Polycystic Ovary Syndrome (PCOS). These key genes-RPL13, LEP, and ANXA1-may present viable targets for therapeutic interventions in PCOS, underscoring their potential clinical importance.PMID:38678611 | DOI:10.14715/cmb/2024.70.4.27 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ying Liu Jinwei Yu Jing Li Weihong Li Hongxia Ma Source Type: research
PPAR- α inhibits DHEA-induced ferroptosis in granulosa cells through upregulation of FADS2
CONCLUSIONS: Our study indicates that PPAR-α may have an inhibitory effect on DHEA-induced ferroptosis in GCs by enhancing the expression of FADS2. This discovery provides valuable insights into the pathophysiology and potential therapeutic targets for PCOS.PMID:38678785 | DOI:10.1016/j.bbrc.2024.150005 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 28, 2024 Category: Biochemistry Authors: Ying Liu Feng Ni Jing Huang Yuqin Hu Jing Wang Xuemei Wang Xin Du Hong Jiang Source Type: research
Bioinformatics-based analysis of potential therapeutic target genes for polycystic ovary syndrome
This study represents the first application of a bioinformatics approach to identify and confirm high expression levels of RPL13, LEP, and ANXA1 in patients with Polycystic Ovary Syndrome (PCOS). These key genes-RPL13, LEP, and ANXA1-may present viable targets for therapeutic interventions in PCOS, underscoring their potential clinical importance.PMID:38678611 | DOI:10.14715/cmb/2024.70.4.27 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Ying Liu Jinwei Yu Jing Li Weihong Li Hongxia Ma Source Type: research
A review on the nexus of autophagy genes from the perspective of polycystic ovary syndrome
Biol Cell. 2024 Apr 28:e202300069. doi: 10.1111/boc.202300069. Online ahead of print.ABSTRACTPolycystic ovary syndrome or PCOS is an endocrine disorder in women of reproductive age. It is a diversified multi factorial disorder and diagnosis is very complicated because of its overlapping symptoms some of which are irregular menstrual cycle, acne in face, excess level of androgen (AE), insulin resistance, obesity, cardiovascular disease, mood disorder and type 2 diabetes (T2DM). PCOS may be caused by hormonal imbalance, genetic and epigenetic vulnerability, hypothalamic and ovarian troubles. PCOS is essentially hyperandrogen...
Source: Biology of the Cell - April 28, 2024 Category: Cytology Authors: Arifa Khatun Taslima Nasrin Md Samim Hassan Mehboob Hoque Muddasarul Hoda Safdar Ali Source Type: research
Bioinformatics-based analysis of potential therapeutic target genes for polycystic ovary syndrome
This study represents the first application of a bioinformatics approach to identify and confirm high expression levels of RPL13, LEP, and ANXA1 in patients with Polycystic Ovary Syndrome (PCOS). These key genes-RPL13, LEP, and ANXA1-may present viable targets for therapeutic interventions in PCOS, underscoring their potential clinical importance.PMID:38678611 | DOI:10.14715/cmb/2024.70.4.27 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ying Liu Jinwei Yu Jing Li Weihong Li Hongxia Ma Source Type: research
A review on the nexus of autophagy genes from the perspective of polycystic ovary syndrome
Biol Cell. 2024 Apr 28:e202300069. doi: 10.1111/boc.202300069. Online ahead of print.ABSTRACTPolycystic ovary syndrome or PCOS is an endocrine disorder in women of reproductive age. It is a diversified multi factorial disorder and diagnosis is very complicated because of its overlapping symptoms some of which are irregular menstrual cycle, acne in face, excess level of androgen (AE), insulin resistance, obesity, cardiovascular disease, mood disorder and type 2 diabetes (T2DM). PCOS may be caused by hormonal imbalance, genetic and epigenetic vulnerability, hypothalamic and ovarian troubles. PCOS is essentially hyperandrogen...
Source: Biology of the Cell - April 28, 2024 Category: Cytology Authors: Arifa Khatun Taslima Nasrin Md Samim Hassan Mehboob Hoque Muddasarul Hoda Safdar Ali Source Type: research
Bioinformatics-based analysis of potential therapeutic target genes for polycystic ovary syndrome
This study represents the first application of a bioinformatics approach to identify and confirm high expression levels of RPL13, LEP, and ANXA1 in patients with Polycystic Ovary Syndrome (PCOS). These key genes-RPL13, LEP, and ANXA1-may present viable targets for therapeutic interventions in PCOS, underscoring their potential clinical importance.PMID:38678611 | DOI:10.14715/cmb/2024.70.4.27 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ying Liu Jinwei Yu Jing Li Weihong Li Hongxia Ma Source Type: research
Decreased Serum Levels of the Insulin Resistance-Related microRNA miR-320a in Patients with Polycystic Ovary Syndrome
In conclusion, we demonstrated a significantly reduced serum level of the IR-associated miR-320a in our patient cohort. This result once again demonstrates the close relationship between metabolic disorders and the dysregulation of microRNA expression patterns in PCOS.PMID:38666942 | PMC:PMC11049427 | DOI:10.3390/cimb46040212 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Sarina Vogt Diana Handke Hermann M Behre Thomas Greither Source Type: research
Decreased Serum Levels of the Insulin Resistance-Related microRNA miR-320a in Patients with Polycystic Ovary Syndrome
In conclusion, we demonstrated a significantly reduced serum level of the IR-associated miR-320a in our patient cohort. This result once again demonstrates the close relationship between metabolic disorders and the dysregulation of microRNA expression patterns in PCOS.PMID:38666942 | PMC:PMC11049427 | DOI:10.3390/cimb46040212 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Sarina Vogt Diana Handke Hermann M Behre Thomas Greither Source Type: research
Tenascin C activates the toll ‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome
In conclusion, knockdown of TNC could ameliorate PCOS in both rats and a cell model by inhibiting cell apoptosis, oxidative stress and inflammation via the suppression of the TLR4/NF‑κB signaling pathway.PMID:38666538 | DOI:10.3892/mmr.2024.13230 (Source: Molecular Medicine)
Source: Molecular Medicine - April 26, 2024 Category: Molecular Biology Authors: Han Wu Mo Yang Cuiping Yan Mengchen Liu Haoran Wang Wenjuan Zhang Source Type: research
Tenascin C activates the toll ‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome
In conclusion, knockdown of TNC could ameliorate PCOS in both rats and a cell model by inhibiting cell apoptosis, oxidative stress and inflammation via the suppression of the TLR4/NF‑κB signaling pathway.PMID:38666538 | DOI:10.3892/mmr.2024.13230 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - April 26, 2024 Category: Molecular Biology Authors: Han Wu Mo Yang Cuiping Yan Mengchen Liu Haoran Wang Wenjuan Zhang Source Type: research
Effects of MTHFR C677T polymorphism on homocysteine and vitamin D in women with polycystic ovary syndrome
CONCLUSIONS: No significant differences were found in the distributions of MTHFR C677T genotypes between the PCOS and control groups but these genotypes affected the patients' serum homocysteine and vitamin D concentrations. Women with the TT genotype have significantly lower vitamin D levels and higher homocysteine levels than women with the CC and CT genotypes. However, because of the limitations of this investigation, large-sample, high-quality prospective studies are needed to further verify these results in the future.PMID:38670392 | DOI:10.1016/j.gene.2024.148504 (Source: Gene)
Source: Gene - April 26, 2024 Category: Genetics & Stem Cells Authors: Jinyan Zhao Xianghong Li Qing Chen Source Type: research
Decreased Serum Levels of the Insulin Resistance-Related microRNA miR-320a in Patients with Polycystic Ovary Syndrome
In conclusion, we demonstrated a significantly reduced serum level of the IR-associated miR-320a in our patient cohort. This result once again demonstrates the close relationship between metabolic disorders and the dysregulation of microRNA expression patterns in PCOS.PMID:38666942 | PMC:PMC11049427 | DOI:10.3390/cimb46040212 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Sarina Vogt Diana Handke Hermann M Behre Thomas Greither Source Type: research
