Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: ENDOCR REV - April 23, 2024 Category: Endocrinology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome
CONCLUSION: This study demonstrates that the rhythm gene PER1 promotes ferroptosis and dysfunctional lipid metabolism in granulosa cells in PCOS by inhibiting SREBF2/ALOX15 signaling.PMID:38653359 | DOI:10.1016/j.bbadis.2024.167182 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yuanyuan Chen Zhaohua Liu Hongmei Chen Yi Wen Lang Fan Man Luo Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: ENDOCR REV - April 23, 2024 Category: Endocrinology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome
CONCLUSION: This study demonstrates that the rhythm gene PER1 promotes ferroptosis and dysfunctional lipid metabolism in granulosa cells in PCOS by inhibiting SREBF2/ALOX15 signaling.PMID:38653359 | DOI:10.1016/j.bbadis.2024.167182 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yuanyuan Chen Zhaohua Liu Hongmei Chen Yi Wen Lang Fan Man Luo Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: ENDOCR REV - April 23, 2024 Category: Endocrinology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
AbstractProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system,progesterone contributes to the control ofluteinizing hormone andfollicle-stimulating hormone secretion and their pulsatility,via itsreceptors on thekisspeptin,neurokinin B, anddynorphin neurons in the hypothalamus.Progesterone together withestradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; regulates normal menstrual bleeding; contributes to fertilization and pregnancy maintenance; participate...
Source: Reviews in Endocrine and Metabolic Disorders - April 23, 2024 Category: Endocrinology Source Type: research
Circulating levels of irisin and Meteorin-like protein in PCOS and its correlation with metabolic parameters
CONCLUSIONS: Although irisin seems to be a promising biomarker, inconsistent research limits its value in clinical use in the assessment or treatment of obesity. Metrnl level was not affected in the study population, but it might be connected to the severity of metabolic disturbances.PMID:38646985 | DOI:10.5603/ep.99111 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Katarzyna Paczkowska Joachim Sobczuk Katarzyna Zawadzka Diana J ędrzejuk Agnieszka Zembska Jacek Konieczny Dorota Kaszubkiewicz-Ward ęga Marek Bolanowski Jacek Daroszewski Source Type: research
Circulating levels of irisin and Meteorin-like protein in PCOS and its correlation with metabolic parameters
CONCLUSIONS: Although irisin seems to be a promising biomarker, inconsistent research limits its value in clinical use in the assessment or treatment of obesity. Metrnl level was not affected in the study population, but it might be connected to the severity of metabolic disturbances.PMID:38646985 | DOI:10.5603/ep.99111 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Katarzyna Paczkowska Joachim Sobczuk Katarzyna Zawadzka Diana J ędrzejuk Agnieszka Zembska Jacek Konieczny Dorota Kaszubkiewicz-Ward ęga Marek Bolanowski Jacek Daroszewski Source Type: research
Circulating levels of irisin and Meteorin-like protein in PCOS and its correlation with metabolic parameters
CONCLUSIONS: Although irisin seems to be a promising biomarker, inconsistent research limits its value in clinical use in the assessment or treatment of obesity. Metrnl level was not affected in the study population, but it might be connected to the severity of metabolic disturbances.PMID:38646985 | DOI:10.5603/ep.99111 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Katarzyna Paczkowska Joachim Sobczuk Katarzyna Zawadzka Diana J ędrzejuk Agnieszka Zembska Jacek Konieczny Dorota Kaszubkiewicz-Ward ęga Marek Bolanowski Jacek Daroszewski Source Type: research
Circulating levels of irisin and Meteorin-like protein in PCOS and its correlation with metabolic parameters
CONCLUSIONS: Although irisin seems to be a promising biomarker, inconsistent research limits its value in clinical use in the assessment or treatment of obesity. Metrnl level was not affected in the study population, but it might be connected to the severity of metabolic disturbances.PMID:38646985 | DOI:10.5603/ep.99111 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Katarzyna Paczkowska Joachim Sobczuk Katarzyna Zawadzka Diana J ędrzejuk Agnieszka Zembska Jacek Konieczny Dorota Kaszubkiewicz-Ward ęga Marek Bolanowski Jacek Daroszewski Source Type: research
Circulating levels of irisin and Meteorin-like protein in PCOS and its correlation with metabolic parameters
CONCLUSIONS: Although irisin seems to be a promising biomarker, inconsistent research limits its value in clinical use in the assessment or treatment of obesity. Metrnl level was not affected in the study population, but it might be connected to the severity of metabolic disturbances.PMID:38646985 | DOI:10.5603/ep.99111 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Katarzyna Paczkowska Joachim Sobczuk Katarzyna Zawadzka Diana J ędrzejuk Agnieszka Zembska Jacek Konieczny Dorota Kaszubkiewicz-Ward ęga Marek Bolanowski Jacek Daroszewski Source Type: research
Circulating levels of irisin and Meteorin-like protein in PCOS and its correlation with metabolic parameters
CONCLUSIONS: Although irisin seems to be a promising biomarker, inconsistent research limits its value in clinical use in the assessment or treatment of obesity. Metrnl level was not affected in the study population, but it might be connected to the severity of metabolic disturbances.PMID:38646985 | DOI:10.5603/ep.99111 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Katarzyna Paczkowska Joachim Sobczuk Katarzyna Zawadzka Diana J ędrzejuk Agnieszka Zembska Jacek Konieczny Dorota Kaszubkiewicz-Ward ęga Marek Bolanowski Jacek Daroszewski Source Type: research
Circulating levels of irisin and Meteorin-like protein in PCOS and its correlation with metabolic parameters
CONCLUSIONS: Although irisin seems to be a promising biomarker, inconsistent research limits its value in clinical use in the assessment or treatment of obesity. Metrnl level was not affected in the study population, but it might be connected to the severity of metabolic disturbances.PMID:38646985 | DOI:10.5603/ep.99111 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Katarzyna Paczkowska Joachim Sobczuk Katarzyna Zawadzka Diana J ędrzejuk Agnieszka Zembska Jacek Konieczny Dorota Kaszubkiewicz-Ward ęga Marek Bolanowski Jacek Daroszewski Source Type: research
Yishen Huatan Huoxue decoction and quercetin ameliorate decidualization dysfunction in polycystic ovary syndrome: A comprehensive investigation combining clinical trial and experimental studies
This study provides valuable molecular insights of YHHD and highlight the therapeutic potential of quercetin in treating decidualization dysfunction in PCOS.PMID:38644207 | DOI:10.5582/ddt.2024.01003 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - April 21, 2024 Category: Drugs & Pharmacology Authors: Jing Wang Lisha Li Jing Zhou Xinyao Pan Qing Qi Hongmei Sun Ling Wang Source Type: research
