Association Between rs2278426 Polymorphism of the ANGPTL8 Gene and Polycystic Ovary Syndrome
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 16, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Genome-wide association study (GWAS) identified PCOS susceptibility variants and replicates reported risk variants
ConclusionThe study suggests that multiple variants play an important role in PCOS pathogenesis and emphasizes the importance of further genetic studies among Indian subpopulations. The study also validates two previously reported SNPs in the Indian population.What this study adds to clinical workStudy summarizes the importance of candidate gene markers validated by replication and in-silico functional study, significantly involved in PCOS pathogenesis in the studied population. These markers can be used in the future as diagnostic markers for clinical phenotype identification. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - April 16, 2024 Category: OBGYN Source Type: research
Unmet clinical needs in women with polycystic ovary syndrome in regard to mental health: a cross-sectional study
ConclusionWomen affected by PCOS are not properly managed according to ESHRE guideline in regard to mental health issues. Overall consultation rates and corresponding satisfaction with management were poor, highlighting the need for significant improvements in healthcare provision. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - April 16, 2024 Category: OBGYN Source Type: research
Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese PCOS patients
Volume 40, Issue 1, December 2024 . (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - April 16, 2024 Category: Endocrinology Authors: Alessandro D. GenazzaniChristian BattipagliaLaura RusceGreta PrampoliniClaudia AioFrancesco RicciardielloMartina FoschiAlessandra SponzilliElisa SempriniTabatha PetrilloGynecological Endocrinology Center, Department of Obstetrics and Gynecology, Universit Source Type: research
Impact of dehydroepiandrosterone sulfate and free androgen index on pregnancy and neonatal outcomes in PCOS patients
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder associated with infertility and pregnancy complications. The pathogenesis of PCOS and its impact on reproductive function may be influenced by... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - April 16, 2024 Category: Endocrinology Authors: Wen Zhao, Zeting Li, Bing Cai, Canquan Zhou and Qingyun Mai Tags: Research Source Type: research
Special Aspects of Cholesterol Metabolism in Women
CONCLUSION: Lowering high cholesterol levels, especially in postmenopausal women, may prevent the development of cardiovascular diseases.PMID:38616556 | DOI:10.3238/arztebl.m2024.0063 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - April 15, 2024 Category: General Medicine Authors: Ioanna Gouni-Berthold Ulrich Laufs Source Type: research
Metformin ameliorates endometrial thickness in a rat model of thin endometrium
In conclusion, the study demonstrated that metformin ameliorates endometrial thickness in a rat model of thin endometrium by increasing endometrial proliferation and angiogenesis, without restoration of embryo implantation.PMID:38621769 | DOI:10.1111/1440-1681.13862 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: M Imran Aditya Khandvilkar Siddhanath Metkari Geetanjali Sachdeva Uddhav Chaudhari Source Type: research
Special Aspects of Cholesterol Metabolism in Women
CONCLUSION: Lowering high cholesterol levels, especially in postmenopausal women, may prevent the development of cardiovascular diseases.PMID:38616556 | DOI:10.3238/arztebl.m2024.0063 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - April 15, 2024 Category: General Medicine Authors: Ioanna Gouni-Berthold Ulrich Laufs Source Type: research
Metformin ameliorates endometrial thickness in a rat model of thin endometrium
In conclusion, the study demonstrated that metformin ameliorates endometrial thickness in a rat model of thin endometrium by increasing endometrial proliferation and angiogenesis, without restoration of embryo implantation.PMID:38621769 | DOI:10.1111/1440-1681.13862 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: M Imran Aditya Khandvilkar Siddhanath Metkari Geetanjali Sachdeva Uddhav Chaudhari Source Type: research
Special Aspects of Cholesterol Metabolism in Women
CONCLUSION: Lowering high cholesterol levels, especially in postmenopausal women, may prevent the development of cardiovascular diseases.PMID:38616556 | DOI:10.3238/arztebl.m2024.0063 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - April 15, 2024 Category: General Medicine Authors: Ioanna Gouni-Berthold Ulrich Laufs Source Type: research
Metformin ameliorates endometrial thickness in a rat model of thin endometrium
In conclusion, the study demonstrated that metformin ameliorates endometrial thickness in a rat model of thin endometrium by increasing endometrial proliferation and angiogenesis, without restoration of embryo implantation.PMID:38621769 | DOI:10.1111/1440-1681.13862 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: M Imran Aditya Khandvilkar Siddhanath Metkari Geetanjali Sachdeva Uddhav Chaudhari Source Type: research
Genes, Vol. 15, Pages 494: Identification of Key Genes and Imbalanced SNAREs Assembly in the Comorbidity of Polycystic Ovary Syndrome and Depression
Conclusions: Our study suggests that the SNAP23, PRKAR1A, and VTI1A genes can directly or indirectly participate in the imbalanced assembly of SNAREs in the pathogenesis of the comorbidity of PCOS and depression. These findings may provide new strategies in diagnosis and therapy for this comorbidity. (Source: Genes)
Source: Genes - April 15, 2024 Category: Genetics & Stem Cells Authors: Yi Cao Weijing Wang Xuxia Song Qian Wen Jing Xie Dongfeng Zhang Tags: Article Source Type: research
Corrigendum to 'Transcriptomic profile of GLCs of PCOS women highlights metabolic dysregulation as a plausible contributor to PCOS pathophysiology' Reproductive Biology, Volume 23, Issue 3 (2023), 100787
Reprod Biol. 2024 Apr 13:100885. doi: 10.1016/j.repbio.2024.100885. Online ahead of print.NO ABSTRACTPMID:38614814 | DOI:10.1016/j.repbio.2024.100885 (Source: Reproductive Biology)
Source: Reproductive Biology - April 13, 2024 Category: Reproduction Medicine Authors: Krutika Patil Aalaap Naigaonkar Indira Hinduja Srabani Mukherjee Source Type: research
Corrigendum to 'Transcriptomic profile of GLCs of PCOS women highlights metabolic dysregulation as a plausible contributor to PCOS pathophysiology' Reproductive Biology, Volume 23, Issue 3 (2023), 100787
Reprod Biol. 2024 Apr 13:100885. doi: 10.1016/j.repbio.2024.100885. Online ahead of print.NO ABSTRACTPMID:38614814 | DOI:10.1016/j.repbio.2024.100885 (Source: Reproductive Biology)
Source: Reproductive Biology - April 13, 2024 Category: Reproduction Medicine Authors: Krutika Patil Aalaap Naigaonkar Indira Hinduja Srabani Mukherjee Source Type: research
Depression, Anxiety, and Risk of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: A Longitudinal Study
CONCLUSIONS: Patients with PCOS and depression and/or anxiety have a high risk of developing MetSyn, with a stronger association between depression and MetSyn. Our findings highlight the urgent need for guideline-directed screening for depression and anxiety at time of diagnosis of PCOS as well as screening at subsequent visits to facilitate risk stratification for metabolic monitoring and early intervention in this high-risk group.PMID:38609160 | DOI:10.1210/clinem/dgae256 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2024 Category: Endocrinology Authors: Iris T Lee John Rees Shakira King Anne Kim Tess Cherlin Stefanie Hinkle Sunni L Mumford Anuja Dokras Source Type: research
