A rare variant of mullerian agenesis: a case report and review of the literature
ConclusionMullerian agenesis is the most common cause of primary amenorrhea with well-developed secondary sexual characteristics. There are various forms of mullerian agenesis. Most of the cases are managed by a multidisciplinary team. Rare variants warrant an individualized approach to management. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 25, 2024 Category: General Medicine Source Type: research
Effectiveness of metformin to pregnant women with PCOS to reduce spontaneous abortion and gestational diabetes mellitus: a protocol for an overview of reviews
Introduction
Polycystic ovary syndrome (PCOS) is a globally prevalent endocrinological disorder and has been associated with poor pregnancy outcomes, including a higher rate of gestational diabetes and miscarriage. Metformin is among the drugs investigated to improve the prognosis of pregnant women with PCOS.
Objective
To conduct an overview of systematic reviews examining the effects of metformin versus placebo or no intervention throughout pregnancy among pregnant women with a preconception PCOS diagnosis to reduce the incidence of miscarriage and gestational diabetes.
Methods and analysis
We will perform an overview o...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Nassif, D. S., Januario, B. L., Sousa, B. A., Thabane, L., Abbade, J. F. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Role of circular RNA/miRNA axes in the pathophysiology of polycystic ovary syndrome
Mol Biol Rep. 2024 Mar 23;51(1):437. doi: 10.1007/s11033-024-09376-x.ABSTRACTPolycystic ovary syndrome (PCOS) is a disorder resulted from interactions between genetic and environmental factors. Based on the importance of epigenetic factors in the pathoetiology of PCOS, the current review focused on identification of circular RNAs (circRNAs) that are involved in PCOS through acting as molecular sponges for microRNAs (miRNAs). The literature search led to identification of circ_0043533/miR-1179, circ_0030018/miR-136, circ_FURIN/miR-423-5p, circ-FURIN/miR-195-5p, circ_0043532/miR-182, circ_RANBP9/miR-136-5p, circRHBG/miR-515-...
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Mohsen Ahmadi Mohadeseh Fathi Ali Malmir Soudeh Ghafouri-Fard Source Type: research
Role of circular RNA/miRNA axes in the pathophysiology of polycystic ovary syndrome
Mol Biol Rep. 2024 Mar 23;51(1):437. doi: 10.1007/s11033-024-09376-x.ABSTRACTPolycystic ovary syndrome (PCOS) is a disorder resulted from interactions between genetic and environmental factors. Based on the importance of epigenetic factors in the pathoetiology of PCOS, the current review focused on identification of circular RNAs (circRNAs) that are involved in PCOS through acting as molecular sponges for microRNAs (miRNAs). The literature search led to identification of circ_0043533/miR-1179, circ_0030018/miR-136, circ_FURIN/miR-423-5p, circ-FURIN/miR-195-5p, circ_0043532/miR-182, circ_RANBP9/miR-136-5p, circRHBG/miR-515-...
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Mohsen Ahmadi Mohadeseh Fathi Ali Malmir Soudeh Ghafouri-Fard Source Type: research
Role of circular RNA/miRNA axes in the pathophysiology of polycystic ovary syndrome
Mol Biol Rep. 2024 Mar 23;51(1):437. doi: 10.1007/s11033-024-09376-x.ABSTRACTPolycystic ovary syndrome (PCOS) is a disorder resulted from interactions between genetic and environmental factors. Based on the importance of epigenetic factors in the pathoetiology of PCOS, the current review focused on identification of circular RNAs (circRNAs) that are involved in PCOS through acting as molecular sponges for microRNAs (miRNAs). The literature search led to identification of circ_0043533/miR-1179, circ_0030018/miR-136, circ_FURIN/miR-423-5p, circ-FURIN/miR-195-5p, circ_0043532/miR-182, circ_RANBP9/miR-136-5p, circRHBG/miR-515-...
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Mohsen Ahmadi Mohadeseh Fathi Ali Malmir Soudeh Ghafouri-Fard Source Type: research
Role of circular RNA/miRNA axes in the pathophysiology of polycystic ovary syndrome
Mol Biol Rep. 2024 Mar 23;51(1):437. doi: 10.1007/s11033-024-09376-x.ABSTRACTPolycystic ovary syndrome (PCOS) is a disorder resulted from interactions between genetic and environmental factors. Based on the importance of epigenetic factors in the pathoetiology of PCOS, the current review focused on identification of circular RNAs (circRNAs) that are involved in PCOS through acting as molecular sponges for microRNAs (miRNAs). The literature search led to identification of circ_0043533/miR-1179, circ_0030018/miR-136, circ_FURIN/miR-423-5p, circ-FURIN/miR-195-5p, circ_0043532/miR-182, circ_RANBP9/miR-136-5p, circRHBG/miR-515-...
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Mohsen Ahmadi Mohadeseh Fathi Ali Malmir Soudeh Ghafouri-Fard Source Type: research
Thyroid function and polycystic ovary syndrome: a Mendelian randomization study
ConclusionsOur findings demonstrate a cause-and-effect connection between PCOS and hyperthyroidism. The study established foundation for further investigation for interaction between thyroid function and PCOS. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 22, 2024 Category: Endocrinology Source Type: research
Challenges encountered in predicting live birth following in vitro fertilization in the different phenotypes of polycystic ovary syndrome patients.
(Source: Fertility and Sterility)
Source: Fertility and Sterility - March 22, 2024 Category: Reproduction Medicine Authors: Raoul Orvieto Tags: Reflections Source Type: research
Challenges encountered in predicting live birth after in vitro fertilization in the different phenotypes of patients with polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility and endocrinopathy among women of reproductive age, with a reported prevalence of 10% –13% (1). Polycystic ovary syndrome is diagnosed using the latest international evidence–based guideline criteria (1, 2), necessitating the presence of two out of the following: clinical or biochemical hyperandrogenism; ovulatory dysfunction; and polycystic ovaries on ultrasound or specific anti müllerian hormone (AMH) levels. This approach has identified at least four distinct phenotypes: phenotype A-androgen excess + ovulatory dysfunction + polycys...
Source: Fertility and Sterility - March 22, 2024 Category: Reproduction Medicine Authors: Raoul Orvieto Tags: Reflections Source Type: research
Characterization of PCOS twitter: an analysis of users and trends
Polycystic Ovary Syndrome (PCOS) is a disorder affecting 6-12% of women of reproductive age, with life-long health implications. Despite prevalence, studies show dissatisfaction amongst patients regarding diagnosis, treatment, and accessible information. Social media has become a valuable resource for healthcare conversations for physicians and patients. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - March 21, 2024 Category: OBGYN Authors: M Glass, E Chorna, P Xu, F Ricciardi, S Ohrn, C Grimes Source Type: research
Biomarkers identification in follicular fluid in relation to live birth in in vitro fertilization of women with polycystic ovary syndrome in different subtypes by using UPLC-MS method
CONCLUSION: The follicular fluid of women with PCOS showed unique metabolic characteristics. Our study provides better identification of PCOS follicular fluid metabolic dynamics, which may serve as potential biomarkers of live birth.PMID:38508572 | DOI:10.1016/j.cca.2024.117860 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 20, 2024 Category: Chemistry Authors: Xitong Liu Chen Zhang Jianlei Huang Haiou Liu Bo Li Feifei Zhang Congjian Xu Source Type: research
Biomarkers identification in follicular fluid in relation to live birth in in vitro fertilization of women with polycystic ovary syndrome in different subtypes by using UPLC-MS method
CONCLUSION: The follicular fluid of women with PCOS showed unique metabolic characteristics. Our study provides better identification of PCOS follicular fluid metabolic dynamics, which may serve as potential biomarkers of live birth.PMID:38508572 | DOI:10.1016/j.cca.2024.117860 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 20, 2024 Category: Chemistry Authors: Xitong Liu Chen Zhang Jianlei Huang Haiou Liu Bo Li Feifei Zhang Congjian Xu Source Type: research
Adiponectin improves endometrial receptivity in rats with polycystic ovary syndrome by upregulating the PPAR α/HOXA10 pathway
CONCLUSION: APN can improve endometrial receptivity in PCOS rats by upregulating the PARα/HOXA10 pathway.PMID:38501415 | DOI:10.12122/j.issn.1673-4254.2024.02.12 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: J Wang W Yang J Liu J Shi P Xiao M Li Source Type: research
Comparative Effectiveness of Antidiabetic Drugs as an Additional Therapy to Metformin in Women with Polycystic Ovary Syndrome: A Systematic Review of Metabolic Approaches
CONCLUSION: Since PCOS is a metabolic disorder, choosing the best combination of antidiabetic drugs in the clinical course of PCOS patients will be very important. Today, it seems that we need a new metabolic approach for better treatment of the metabolic aspects of these patients.PMID:38500709 | PMC:PMC10948218 | DOI:10.1155/2024/9900213 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - March 19, 2024 Category: Endocrinology Authors: Maryam Heidarpour Mehrzad Mojarad Sadegh Mazaheri-Tehrani Ali Kachuei Arash Najimi Davood Shafie Hassan Rezvanian Source Type: research
